Solcia E, Capella C, Klöppel G: Tumors of the exocrine pancreas. Atlas of Tumor Pathology. Tumors of the Pancreas. Third series, fascicle 20. 1997, Washington, D.C: AFIP, 64-88.
Google Scholar
Ozawa F, Friess H, Tempia-Caliera A, Kleeff J, Büchler MW: Growth factors and their receptors in pancreatic cancer. Teratog Carcinog Mutagen. 2001, 21: 27-44. 10.1002/1520-6866(2001)21:1<27::AID-TCM4>3.0.CO;2-9.
Article
CAS
PubMed
Google Scholar
Itakura J, Ishiwata T, Shen B, Kornmann M, Korc M: Concomitant over-expression of vascular endothelial growth factor and its receptors in pancreatic cancer. Int J Cancer. 2000, 85: 27-34. 10.1002/(SICI)1097-0215(20000101)85:1<27::AID-IJC5>3.0.CO;2-8.
Article
CAS
PubMed
Google Scholar
Karademir S, Sökmen S, Terzi C, Sağol Ö, Özer E, Astarcıoğlu H, Çoker A, Astarcıoğlu İ: Tumor angiogenesis as a prognostic predictor in pancreatic cancer. J Hepatobiliary Pancreat Surg. 2000, 7: 489-495. 10.1007/s005340070020.
Article
CAS
PubMed
Google Scholar
Apple SK, Hecht JR, Lewin DN, Jahromi SA, Grody WW, Nieberg RK: Immunohistochemical evaluation of K-ras, p53, and HER-2/neu expression in hyperplastic, dysplastic, and carcinomatous lesions of the pancreas: evidence for multistep carcinogenesis. Hum Pathol. 1999, 30: 123-129. 10.1016/S0046-8177(99)90265-4.
Article
CAS
PubMed
Google Scholar
Eskelinen MJ, Haglund UH: Prognosis of human pancreatic adenocarcinoma: review of clinical and histopathological variables and possible uses of new molecular methods. Eur J Surg. 1999, 165: 292-306. 10.1080/110241599750006811.
Article
CAS
PubMed
Google Scholar
Hruban RH, Offerhaus GJA, Kern SE, Goggins M, Wilentz RE, Yeo CJ: Tumor-suppresor genes in pancreatic cancer. J Hepatobiliary Pancreat Surg. 1998, 5: 383-391. 10.1007/s005340050062.
Article
CAS
PubMed
Google Scholar
Wei D, Le X, Zheng L, Wang L, Frey JA, GAo AC, Peng Z, Huang S, Xiong HQ, Abbruzzese JL, Xie K: Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis. Oncogene. 2003, 22: 319-329. 10.1038/sj.onc.1206122.
Article
CAS
PubMed
Google Scholar
Akhurst R, Derynck R: TGF-beta signaling in cancer- a double-edged sword. Trends Cell Biol. 2001, 11: S44-S51.
CAS
PubMed
Google Scholar
Lu Z, Friess H, Graber HU, Gou X, Schilling M, Zimmermann A, Korc M, Büchler MW: Presence of two signaling TGF-β receptors in human pancreatic cancer cor TGF-β relates with advanced tumor stage. Dig Dis Sci. 1997, 42: 2054-2063. 10.1023/A:1018814416903.
Article
CAS
PubMed
Google Scholar
Grau AM, Zhang L, Wang W, Ruan S, Evans DB, Abbruzzese JL, Zhang W, Chiao PJ: Induction of p21waf1 expression and growth inhibition by transforming growth factor β involve the tumor suppresor gene DPC4 in human pancreatic adenocarcinoma cells. Cancer Res. 1997, 57: 3929-3934.
CAS
PubMed
Google Scholar
Govinden R, Bhoola KH: Genealogy, expression, and cellular function of transforming growth factor-β. Pharmacol Ther. 2003, 98: 257-265. 10.1016/S0163-7258(03)00035-4.
Article
CAS
PubMed
Google Scholar
Michalides RJAM: Cell cycle regulators: mechanisms and their role in aetiology, prognosis, and treatment of cancer. J Clin Pathol. 1999, 52: 555-568.
Article
CAS
PubMed
PubMed Central
Google Scholar
Mineta H, Miura K, Suzuki I, Takebayashi S, Amano H, Araki K, Harada H, Ichimura K, Wennerberg JP, Dictor MR: Low p27 expression correlates with poor prognosis for patients with oral tongue squamous cell carcinoma. Cancer. 1999, 85: 1011-1017. 10.1002/(SICI)1097-0142(19990301)85:5<1011::AID-CNCR1>3.0.CO;2-0.
Article
CAS
PubMed
Google Scholar
Yang RM, Naitoh J, Murphy M, Wang H, Phillipson J, Dekernion JB, Loda M, Reiter RE: Low p27 expression predicts poor disease-free survival in patients with prostate cancer. J Urol. 1998, 159: 941-945. 10.1097/00005392-199803000-00088.
Article
CAS
PubMed
Google Scholar
Thomas GV, Schrage MI, Rosenfelt L, Kim JH, Salur G, Dekernion JB, Dorey F, Said J, Reiter RE: Preoperative prostate needle biopsy p27 correlates with subsequent radical prostatectomy p27, Gleason grade and pathological stage. J Urol. 2000, 164: 1987-1991. 10.1097/00005392-200012000-00028.
Article
CAS
PubMed
Google Scholar
Vis AN, Noordzij MA, Fitoz K, Wildhagen MF, Schröder FH, VanDerKwast TH: Prognostic value of cell cycle proteins p27Kip1 and MIB-1, and the cell adhesion protein CD44s in surgically treated patients with prostate cancer. J Urol. 2000, 164: 2156-2161. 10.1097/00005392-200012000-00083.
Article
CAS
PubMed
Google Scholar
Claudio PP, Zamparelli A, Garcia FU, Claudio L, Ammirati G, Farina A, Bovicelli A, Russo G, Giordano GG, McGinnis DE, Giordano A, Cardi G: Expression of cell-cycle-regulated proteins pRb2/p130, p107, p27Kip1, p53, and Ki-67 (MIB-1) in prostatic gland adenocarcinoma. Clin Cancer Res. 2002, 8: 1808-1815.
CAS
PubMed
Google Scholar
Coppola D, Lu L, Fruehauf JP, Kyshtoobayeva A, Karl RC, Nicosia SV, Yeatman TJ: Analysis of p53, p21WAF1, and TGF-β1 in human ductal adenocarcinoma of the pancreas. Am J Clin Pathol. 1998, 110: 16-23.
Article
CAS
PubMed
Google Scholar
De Manzoni G, Verlato G, Tomezzoli A: Study on Ki-67 immunoreactivity as a prognostic indicator in patients with advanced gastric cancer. Jpn J Clin Oncol. 1998, 28: 534-537. 10.1093/jjco/28.9.534.
Article
CAS
PubMed
Google Scholar
Holland TA, Elder J, McCloud JM, Hall C, Deakin M, Fryer AA, Elder JA, Hoban PR: Subcellular localisation of cyclin D1 protein in colorectal tumors is associated with p21 WAF1/CIP1 expression and correlates with patient survival. Int J Cancer. 2001, 95: 302-306. 10.1002/1097-0215(20010920)95:5<302::AID-IJC1052>3.0.CO;2-#.
Article
CAS
PubMed
Google Scholar
Oh YL, Choi JS, Song SY, Ko YH, Han BK, Nam SJ, Yang JH: Expression of p21Waf1, p27Kip1 and cyclin D1 proteins in breast ductal carcinoma in situ: relation with clinicopathologic characteristics and with p53 expression and estrogen receptor status. Pathol Int. 2001, 51: 94-99. 10.1046/j.1440-1827.2001.01173.x.
Article
CAS
PubMed
Google Scholar
Tallini G, Garcia-Rostan G, Herrero A, Zelterman D, Viale G, Bosari S, Carcangiu ML: Downregulation of p27kıp1 and Ki67/Mib1 labeling index support the classification of thyroid carcinoma into prognostically relevant categories. Am J Surg Pathol. 1999, 23: 678-685. 10.1097/00000478-199906000-00007.
Article
CAS
PubMed
Google Scholar
Lu CD, Morita S, Ishibashi T, Hara H, Isozaki H, Tanigawa N: Loss of p27Kip1 expression independently predicts poor prognosis for patients with resectable pancreatic adenocarcinoma. Cancer. 1999, 85: 1250-1260. 10.1002/(SICI)1097-0142(19990315)85:6<1250::AID-CNCR6>3.0.CO;2-#.
Article
CAS
PubMed
Google Scholar
Guo SS, Wu X, Shimoide AT, Wong J, Sawicki MP: Anomalous overexpression of p27Kip1 in sporadic pancreatic endocrine tumors. J Surg Res. 2001, 96: 284-288. 10.1006/jsre.2001.6085.
Article
CAS
PubMed
Google Scholar
Chetty R: p27 protein and cancers of the gastrointestinal tract and liver: an Overview. J Clin Gastroenterolog. 2003, 37: 23-27. 10.1097/00004836-200307000-00008.
Article
CAS
Google Scholar
Hirai T, Hayashi K, Takumida M, Ueda T, Hirakawa K, Yajin K: Reduced expression of p27 is correlated with progression in precancerous lesions of the larynx. Auris Nasus Larynx. 2003, 30: 163-168. 10.1016/S0385-8146(03)00007-5.
Article
PubMed
Google Scholar
Zamparelli A, Mascıullo V, Bovicelli A, Santini D, Ferrandina G, Minimo C, Terzano P, Costa S, Cinti C, Ceccarelli C, Mancuso S, Scambia G, Bovicelli L, Giordano S: Expression of cell-cycle-associated proteins pRb2/p130 and p27Kip1 in vulvar squamous cell carcinomas. Hum Pathol. 2001, 32: 4-9. 10.1053/hupa.2001.20371.
Article
CAS
PubMed
Google Scholar
Hashimoto K, Nio Y, Sumi S, Toga T, Omori H, Itakura M, Yano S: Correlation between TGF-beta1 and p21 (WAF1/CIP1) expression and prognosis in resectable invasive ductal carcinoma of the pancreas. Pancreas. 2001, 22: 341-347. 10.1097/00006676-200105000-00002.
Article
CAS
PubMed
Google Scholar
Del Pizzo JJ, Borkowski A, Jacobs SC, Kyprianou N: Loss of cell cycle regulators p27Kip1 and cyclin E in transitional cell carcinoma of the bladder correlates with tumor grade and patient survival. Am J Pathol. 1999, 155: 1129-1136.
Article
CAS
PubMed
PubMed Central
Google Scholar
Armengol C, Boix L, Bachs O, Sole M, Fuster J, Sala M, Llovet JM, Rodes J, Bruix J: p27Kip1 is an independent predictor of recurrence after surgical resection in patients with small hepatocellular carcinoma. J Hepatol. 2003, 38: 591-597. 10.1016/S0168-8278(03)00025-4.
Article
CAS
PubMed
Google Scholar
Gelen T, Elpek GO, Aksoy NH, Ogus M, Keles N: p27 labeling index and proliferation in gastrointestinal stromal tumors: correlations with clinicopathologic factors and recurrence. Jpn J Clin Oncol. 2003, 33: 346-352. 10.1093/jjco/hyg071.
Article
PubMed
Google Scholar
Bellone G, Carbone A, Tibaudi D, Mauri F, Ferrero I, Smirne C, Suman F, Rivetti C, Migliaretti G, Camandona M, Palestro G, Emanuelli G, Rodeck U: Differential expression of transforming growth factors-β1, -β2 and -β3 in human colon carcinoma. Eur J Cancer. 2001, 37: 224-233. 10.1016/S0959-8049(00)00391-9.
Article
CAS
PubMed
Google Scholar
Friess H, Yamanaka Y, Büchler M, Ebert M, Beger HG, Gold LI, Korc M: Enhanced expression of transforming growth factor β isoforms in pancreatic cancer correlates with decreased survival. Gastroenterology. 1993, 105: 1846-1856.
Article
CAS
PubMed
Google Scholar
Abou-Shady M, Baer HU, Friess H, Berberat P, Zimmermann A, Graber H, Gold LI, Korc M, Büchler MW: Transforming growth factor betas and their signaling receptors in human hepatocellular carcinoma. Am J Surg. 1999, 177: 209-215. 10.1016/S0002-9610(99)00012-4.
Article
CAS
PubMed
Google Scholar
Wikstrom P, Stattin P, Franck-Lissbrant I, Damber JE, Bergh A: Transforming growth factor beta1 is associated with angiogenesis, metastasis, and poor clinical outcome in prostate cancer. Prostate. 1998, 37: 19-29. 10.1002/(SICI)1097-0045(19980915)37:1<19::AID-PROS4>3.0.CO;2-3.
Article
CAS
PubMed
Google Scholar
Logullo AF, Nonogaki S, Miguel RE, Kowalski LP, Nishimoto IN, Pasini FS, Federico MHH, Brentani RR, Brentani MM: Transforming growth factor β1 (TGF β1) expression in head and neck squamous cell carcinoma patients as related to prognosis. J Oral Pathol Med. 2003, 32: 139-145. 10.1034/j.1600-0714.2003.00012.x.
Article
CAS
PubMed
Google Scholar
Ito D, Fujimoto K, Doi R, Koizumi M, Toyoda E, Mori T, Kami K, Kawagucgi Y, Whitehead R, Imamura M: Chronic exposure of transforming growth factor beta 1 confers a more aggressive tumor phenotype through downregulation of p21Waf1/Cip1 in conditionally immortalized pancreatic epithelial cells. Surgery. 2004, 136: 364-374. 10.1016/j.surg.2004.05.012.
Article
PubMed
Google Scholar
Sears D, Erickson RA, Sayage-Rabie L, Escobar MC: TGF-β1 and p53 staining in CT-guided and endoscopic ultrasound fine-needle aspirates of pancreatic adenocarcinoma. Dig Dis Sci. 2004, 49: 828-832. 10.1023/B:DDAS.0000030095.71501.04.
Article
CAS
PubMed
Google Scholar