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Synchronous adenocarcinoma and carcinoid tumor of the terminal ileum in a Crohn's disease patient
© Cioffi et al; licensee BioMed Central Ltd. 2005
Received: 12 July 2005
Accepted: 08 December 2005
Published: 08 December 2005
Several malignancies have been described in association with inflammatory bowel diseases, the most common being adenocarcinoma. Carcinoid tumor and Crohn disease has also been previously reported, however the coexistence of both neoplasms is quite rare and the clinical diagnosis is very difficult. Here we report what we believe to be the fourth case of a mixed adenocarcinoid tumor coexisting with Crohn's disease.
The patient presented with clinical and radiological features of intestinal obstruction. Laparotomy showed a stricturing lesion in the last 6 cm of the terminal ileum with proximal dilation. Only the histology of the resected surgical specimen proved the presence of a mixed adenocarcinoid tumor involving the terminal ileum.
Carcinoid tumor should be suspected in elderly patients with Crohn's disease presenting with intestinal obstruction and laparotomy should be considered to exclude malignancy.
It has been recognized that patients with Crohn's disease (CD) are at increased risk of developing malignant lesions [1, 2]. Adenocarcinoma is one of the most common malignant tumors of the small intestine complicating CD, even if it remains quite rare compared with the large bowel malignancies [3–5]. Carcinoid tumors have also been described in association with CD [6, 7].
We report here a case of ileal Crohn's disease associated with both adenocarcinoma and carcinoid tumor.
A 64-year old woman was admitted to the Gastroenterology Unit of another Hospital for abdominal pain, nausea, weight loss, and recurrent episodes of constipation. She had suffered from intermittent pain located in the right lower quadrant for 2 years, but denied chronic diarrhea. She was diagnosed as having Crohn's disease of the terminal ileum by ileocolonoscopy and histology. An upper gastrointestinal series excluded CD in the upper gastrointestinal tract.
At operation, there was a stricturing lesion in the last 6 cm of the terminal ileum with proximal dilation. The wall of the affected ileal loop and caecum was thick and fibrous. Resection of the terminal ileum and caecum was performed. The intestinal continuity was obtained with an end-to-end ileocolic hand-sewn anastomosis.
Malignant tumors of the small intestine are very rare in the general population, so even the few cases reported in the Literature in association with CD are enough to consider CD patients at 4–20 fold increased risk for small bowel malignant neoplasm [3–5].
About 2% of patients affected by CD will develop cancer in the course of their disease, and, in contrast to the patients with ulcerative colitis (UC), those with CD are at risk for developing malignancy even in the first decade of their disease . The coexistence of CD with adenocarcinoma is predominantly seen in men, in the patients with excluded loop, and most frequently in the distal ileum in an area of active disease [2, 5]. Most patients presenting with adenocarcinoma complicating CD have a high-grade malignancy with lymph node involvement or distant metastases, because the similarity of the presenting symptoms and of the radiography of these pathologies creates diagnostic problems for the physician and make an early diagnosis impossible .
Until now, there is no epidemiological evidence that patients with CD are at increased risk for carcinoid tumor . However, when associated with CD, carcinoid tumors tend to be malignant and have a worse prognosis . The majority of carcinoid tumors are asymptomatic and discovered at histology. When symptomatic, they may cause pain due to the intestinal obstruction or perforation mimicking CD clinically and radiologically and creating difficulty in the differential diagnosis.
Only three cases of a coexistent CD and mixed adenocarcinoid tumor have been reported in the English Literature [8–10]. Ours is the fourth case in the Literature, and the third in which the CD and the mixed adenocarcinoid tumor were located in the terminal ileum. As in the three previous reported cases, the definitive diagnosis of mixed adenocarcinoid tumor associated with CD was possible only on histology of the resected surgical specimen. Despite the unfavourable prognosis, our patient is still alive and free from malignancy recurrence at 18-months follow-up.
Reviewing the Literature [1, 6, 7], we believe that an ileal carcinoid tumor should be suspected in elderly CD patients presenting with obstructive symptoms as in our case. Moreover, when technically feasible, an ileoscopy with biopsy may play a role in the differential diagnosis between CD and small bowel malignancy favoring a precise early diagnosis and a more appropriate treatment. However, laparotomy should immediately be considered in CD patients presenting a diagnostic dilemma.
- Kortbeek J, Kelly JK, Preshaw RM: Carcinoid tumors and inflammatory bowel disease. J Surg Oncol. 1992, 49: 122-126.View ArticlePubMedGoogle Scholar
- Baisse B, Fontolliet C, Bian YS, Vuilleumier H, Benhattar J: Synchronous ileal and colonic adenocarcinomas associated with Crohn's disease: report of a case with focus on genetic alterations and carcinogenesis. J Clin Pathol. 2004, 57: 885-87. 10.1136/jcp.2003.014811.View ArticlePubMedPubMed CentralGoogle Scholar
- Solem CA, Harmsen WS, Zinsmeister AR, Loftus EV: Small intestinal adenocarcinoma in Crohn's disease. A case control study. Inflamm Bowel Dis. 2004, 10 (1): 32-35. 10.1097/00054725-200401000-00005.View ArticlePubMedGoogle Scholar
- Mellemkjaer L, Johansen C, Gridley G, Linet MS, Kjaer SK, Olsen JH: Crohn's disease and cancer risk (Denmark). Cancer Causes and Control. 2000, 11: 145-50. 10.1023/A:1008988215904.View ArticlePubMedGoogle Scholar
- Savoca PE, Ballantyne GH, Cahow CE: Gastrointestinal malignancies in Crohn's disease. A 20-year experience. Dis Colon Rectum. 1990, 33: 7-11. 10.1007/BF02053192.View ArticlePubMedGoogle Scholar
- Bassi A, Loughran C, Foster P: Carcinoid tumour of the terminal ileum simulating Crohn Disease. Scand J Gastroenterol. 2003, 38: 1004-1006. 10.1080/00365520310003930.View ArticlePubMedGoogle Scholar
- Hsu EY, Feldman JM, Lichtenstein GR: Ileal carcinoid tumors simulating Crohn's Disease: Incidence among 176 consecutive cases of ileal carcinoid. Am J Gastroenterol. 1997, 92 (11): 2062-64.PubMedGoogle Scholar
- Auber F, Gambiez L, Desreumaux P, Mudry J, Lecomte-Houcke M, Cortot A, Quandalle P, Colombel JF: Mixed adenocarcinoid tumor and Crohn's disease. J Clin Gastroenterol. 1998, 26 (4): 353-54. 10.1097/00004836-199806000-00035.View ArticlePubMedGoogle Scholar
- Van Landingham SB, Kluppel S, Symmonds R, Snyder SK: Coexisting carcinoid tumor and Crohn's disease. J Surg Oncol. 1983, 24 (4): 310-4.View ArticlePubMedGoogle Scholar
- Hock YL, Scott KWM, Grace RH: Mixed adenocarcinoma/carcinoid tumour of large bowel in a patient with Crohn's disease. J Clin Pathol. 1993, 46: 183-5.View ArticlePubMedPubMed CentralGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2407/5/157/prepub
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