This article has Open Peer Review reports available.
Primary ectopic atypical meningioma in the renal hilum: a case report
© Mao et al.; licensee BioMed Central Ltd. 2014
Received: 16 March 2014
Accepted: 7 October 2014
Published: 14 October 2014
Primary ectopic atypical meningioma involving the renal hilum is rare. This is, to our knowledge, only the second case report of a primary retroperitoneal meningioma and the first case of an atypical subtype in this location.
A 53-year-old Han Chinese man presented with a 2-year history of left-side flank pain. An oval-shaped retroperitoneal mass was found in the left renal hilum on computed tomography, which was resected en bloc along with the kidney via laparotomy. According to the World Health Organization criteria, the tumor was histopathologically classified as a meningioma (Grade II, atypical). Five years later, the tumor recurred at the primary site with a similar histopathology. The patient received palliative resection, followed by radiotherapy (4500 cGy in 25 fractions). No relapse was found at 6-month follow-up.
We describe the clinical, radiographic and histopathological features of an unusual case of aggressive ectopic meningioma in the renal hilum. The patient presented with a massive retroperitoneal tumor without primary cerebral or secondary metastatic lesions; the preoperative diagnosis was naturally confined to the common retroperitoneal malignancies. This case is of interest to oncologists, because of both its rare location and aggressiveness; it not only enriched the spectrum of primary ectopic meningioma, but also reminded us of potential recurrence of an atypical meningioma. This case raises the issue of the etiology of such a rare tumor that needs further investigation, and more importantly demands long-term follow-up result.
Meningioma is a central nervous system (CNS) tumor arising from arachnoidal or meningothelial cells . It is one of the most frequently diagnosed primary brain tumors, comprising approximately one-third of CNS tumors in adults in the United States . Meningioma is normally of slow-growing type, with the aggressive lesion accounting for <10% of cases .
Despite being a common intracranial tumor, meningioma has been reported to originate from unexpected sites such as bone, scalp, paranasal sinuses, parotid gland, parapharyngeal space, mediastinum, lung, and even the abdomen [1, 2]. Ectopic meningiomas are empirically defined as primary tumors located in sites without arachnoidal cells, ruling out local extension or metastasis. In 1996, Huszar et al. reported the first case of primary ectopic meningioma in the retroperitoneum . Here, we present a case of primary meningioma in the renal hilum with atypical presentation.
The histological origin of ectopic meningioma is still elusive. Some authors believe that the tumors might derive from ectopic, misplaced, or migrating arachnoid cells [3–5]. A recent analysis of oncogenesis have suggested a different histogenesis between ectopic and CNS lesions . Some investigators have demonstrated that the tumor may originate from perineurial cells or pluripotent mesenchymal cells . Therefore, we speculate that the meningioma in our case might have arisen from a nest of trapped arachnoid cells in the retroperitoneum during embryogenesis, or more likely from nerve sheath cells, given the existing reports of renal schwannoma involving the renal hilum .
An accurate preoperative diagnosis of ectopic meningioma can be challenging. Despite radiographic similarities between our case and aggressive intracranial meningioma on retrospective review, including lobulation, cyst formation, hemorrhage, necrosis, local invasion and heterogeneity with brisk enhancement , there is a long list of differential diagnosis of retroperitoneal tumors.
A preoperative differential diagnosis of benign and malignant tumors at and around the renal bed can be difficult. The topographic location of the tumor in our case is reminiscent of renal cell cancer (RCC). As the largest subtype, clear-cell RCC is a heterogeneous regular mass with destruction of the parenchyma and kidney contours, and it shows strong contrast enhancement and rapid attenuation on CT. Papillary and chromophobic RCCs tend to be homogeneous and undergo mild enhancement without frequent necrosis. After a RCC invades the renal pelvis, it is often accompanied by hematuria. Large RCCs often portend nodal disease, extension into vessels, and distant metastasis.
Epithelioid angiomyolipoma, an unusual subtype of renal angiomyolipoma, has been recently identified as a potential malignancy. These non-fatty lesions invariably appear as heterogeneous soft-tissue masses on CT; some giant angiomyolipomas even exhibit local invasiveness and lymph node metastasis. Enlarged vessels, hemorrhage, and spontaneous kidney rupture are helpful for diagnosis if identified .
Leiomyosarcomas are arguably the most common retroperitoneal sarcomas. These hypervascular malignancies, mainly originating from vessel smooth muscle cells, are more frequently located in the uterine or gastrointestinal tracts. They appear as poorly circumscribed, lobulated masses with iso/hypodensity and delayed circumferential contrast enhancement on CT. They may also have extensive necrosis, cystic degeneration, and hemorrhage. Imaging findings of compression, invasion, or obstruction of the vena cava could be regarded as a characteristic of leiomyosarcoma .
Liposarcomas, another group of common sarcomas of the retroperitoneum, are considered relatively easy to recognize. However, the rare pleomorphic liposarcoma may pose a challenge for differentiation because of a non-fatty appearance. Extensive necrosis, hemorrhage and metastasis are inadequate to discriminate them from other soft-tissue malignancies .
Considering the non-pathognomonic imaging presentations of this case and unexpectedly overlap in imaging features of many retroperitoneal tumors, pathological analysis through core biopsy is still a determinate diagnostic tool.
According to the WHO 2007 standards, meningioma is histologically classified into three types: predominant Grade I, benign tumors; and rare Grade II and III, aggressive tumors. Histological Grade II meningioma, also termed atypical meningioma, is estimated to account for 4.7–7.2% of the entity . It is diagnosed when four or more mitotic cells per 10 high-power fields and/or three or more of the following: increased cellularity, small cells, necrosis, prominent nucleoli, sheeting growth, and/or brain invasion in an otherwise Grade I tumor .
Although the pathological guidelines are straightforward, the criterion resembles a series of carcinomas and sarcomas that need differentiation. In this case, the tumor should be distinguished from several retroperitoneal masses by means of immunohistochemistry and fluorescence in situ hybridization. The biphasic subtype of synovial sarcoma exhibits epithelioid and mesenchymal differentiation, typically supported by positive staining of EMA, vimentin, and CK. However, the cells grow in nested acinar patterns, and more importantly, the characteristic SYT-SSX fusion gene is diagnostic [13, 14], which was negative in our case (data not shown). Epithelioid variant of hemangiopericytoma may also present with positive staining of EMA and vimentin, but positive bcl-2 and CD34 are helpful for differentiation [15, 16]. Soft-tissue perineurioma, a rare subtype not arising from an identifiable nerve, is found mainly in the superficial layers of the limbs and trunk; its typical profile is strong positive staining of EMA and CD34 .
The microscopic presentation and clinical features of the tumor in our case were in line with the WHO 2007 Meningioma Classification (Grade II), and it could be distinguished from the differential candidates above. Despite a controversial marker to predict tumor prognosis, the relatively high level of Ki67 did indicate later recurrence in our case . In addition, it is noteworthy that the PR staining in our case was negative. PR staining positivity has been reported to appear mainly in classic meningioma with good prognosis. Therefore, the negative staining might suggest tumor aggressiveness .
The only definitive treatment for meningioma is curative resection. However, no successful precedent could be found for treating retroperitoneal meningioma. In the case reported by Huszar et al., the patient relapsed 6 months after surgical resection and survived for only 2 years under chemotherapy . Our case was milder, but it still demonstrates certain aggressiveness including infiltration into the muscle and intestine, and more extensive positive markers (EMA and vimentin) and necrosis. Finally, the patient was recommended to receive radiotherapy, the standard adjuvant therapy for inoperable or recurrence-prone intracranial meningioma . The outcome remains to be seen.
To the best of our knowledge, this is only the second case report of a primary retroperitoneal meningioma and the first case of an atypical subtype in this location. Like the previously reported one, our case presented with invasiveness and gross volume, which warranted regular examination and timely treatment. Considering its rarity and non-pathognomonic presentation, the best method of preoperative diagnosis might be core biopsy. Surgical resection combined with adjuvant radiotherapy may be an alternative treatment, but urgently needs assessment.
Written informed consent was obtained from the patient for publication of this Case report and any accompanying images. A copy of the written consent is available for review by the Editor of this journal.
We thank Professor Jian Wang from Fudan University Shanghai Cancer Center, who provided precious advises on pathological diagnosis; we especially thank Professor Bo Shen, M.D. from Cleveland Clinic for his language polishing; we also thank the staff of Edanz Group.
- Claus EB, Morrison AL: Epidemiology of Meningiomas. Al-Mefty’s Meningioma. Edited by: DeMonte F, McDermott MW, Al-Mefty O. 2011, New York: Thieme Medical, 35-39. 2Google Scholar
- Huszar M, Fanburg JC, Dickersin GR, Kirshner JJ, Rosenberg AE: Retroperitoneal malignant meningioma: A light microscopic, immunohistochemical, and ultrastructural study. Am J Surg Pathol. 1996, 20 (4): 492-499. 10.1097/00000478-199604000-00014.View ArticlePubMedGoogle Scholar
- Ishigaki D, Arai H, Sasoh M, Ogasawara K, Uesugi N, Sugai T, Nakamura S, Ogawa A: Meningioma in the posterior fossa without dural attachment. Neurol Med Chir. 2007, 47 (8): 364-366. 10.2176/nmc.47.364.View ArticleGoogle Scholar
- Llauger J, Aixut S, Canete N, Palmer J, Sola M, Bague S: Meningioma of the scapula. Skeletal Radiol. 2008, 37 (2): 169-171. 10.1007/s00256-007-0366-7.View ArticlePubMedGoogle Scholar
- Lockett L, Chiang V, Scully N: Primary pulmonary meningioma: report of a case and review of the literature. Am J Surg Pathol. 1997, 21 (4): 453-460. 10.1097/00000478-199704000-00012.View ArticlePubMedGoogle Scholar
- Liu Y, Wang C, Zhu S, Li F, Wang H, Liu M, Zhang L, Wu C: Clinical characteristics and treatment of ectopic meningiomas. J Neurooncol. 2011, 102 (1): 81-87. 10.1007/s11060-010-0288-4.View ArticlePubMedGoogle Scholar
- Hung SF, Chung SD, Lai MK, Chueh SC, Yu HJ: Renal Schwannoma: case report and literature review. Urology. 2008, 72 (3): e713-716. 716View ArticleGoogle Scholar
- Thurnher MM: Anatomy-based diagnosis: Skull, Scalp and Me ninges Neoplasms. Diagnostic Imaging: Brain. Edited by: Osborn AG, Salzman KL, Barkovich AJ. 2009, Salt Lake City: Amirsys, 72-77. 2Google Scholar
- Froemming AT, Boland J, Cheville J, Takahashi N, Kawashima A: Renal epithelioid angiomyolipoma: imaging characteristics in nine cases with radiologic-pathologic correlation and review of the literature. AJR Am J Roentgenol. 2013, 200 (2): W178-186. 10.2214/AJR.12.8776.View ArticlePubMedGoogle Scholar
- O’Sullivan PJ, Harris AC, Munk PL: Radiological imaging features of non-uterine leiomyosarcoma. Br J Radiol. 2008, 81 (961): 73-81. 10.1259/bjr/18595145.View ArticlePubMedGoogle Scholar
- Kumarasamy NA, Gayer G: Retroperitoneal sarcomas. Semin Ultrasound CT MR. 2011, 32 (5): 422-432. 10.1053/j.sult.2011.06.002.View ArticlePubMedGoogle Scholar
- Perry A: Meningiomas. World Health Organization Classification of Tumours of the Central Nervous System. Edited by: Louis DN, Ohgaki H, Wiestler OD, Cavenee WK. 2007, Lyon: IARC, 164-172. 4Google Scholar
- Weiss SW, Goldblum JR: Malignant soft tissue tumors of uncertain type. Enzinger and Weiss’s Soft Tissue Tumors. Edited by: Weiss SW, Goldblum JR. 2001, St. Louis: Mosby, 1483-1571.Google Scholar
- Fisher C, De Bruijin DHR, Geurts Van Kessel A: Synovial sarcoma. Pathology and Genetics. Tumours of Soft Tissue and Bone. Edited by: Fletcher CDM, Unni KK, Mertens F. 2002, Lyon: IARC, 200-204.Google Scholar
- Rajaram V, Brat DJ, Perry A: Anaplastic meningioma versus meningeal hemangiopericytoma: immunohistochemical and genetic markers. Hum Pathol. 2004, 35 (11): 1413-1418. 10.1016/j.humpath.2004.07.017.View ArticlePubMedGoogle Scholar
- Commins DL, Atkinson RD, Burnett ME: Review of meningioma histopathology. Neurosurg Focus. 2007, 23 (4): E3-10.3171/FOC-07/10/E3.View ArticlePubMedGoogle Scholar
- Hornick JL, Fletcher CD: Soft tissue perineurioma: clinicopathologic analysis of 81 cases including those with atypical histologic features. Am J Surg Pathol. 2005, 29 (7): 845-858. 10.1097/01.pas.0000155166.86409.d2.View ArticlePubMedGoogle Scholar
- Roser F, Samii M, Ostertag H, Bellinzona M: The Ki-67 proliferation antigen in meningiomas. Experience in 600 cases. Acta Neurochir. 2004, 146 (1): 37-44. 10.1007/s00701-003-0173-4.View ArticlePubMedGoogle Scholar
- Roser F, Nakamura M, Bellinzona M, Rosahl SK, Ostertag H, Samii M: The prognostic value of progesterone receptor status in meningiomas. J Clin Pathol. 2004, 57 (10): 1033-1037. 10.1136/jcp.2004.018333.View ArticlePubMedPubMed CentralGoogle Scholar
- Combs SE, Schulz-Ertner D, Debus J, von Deimling A, Hartmann C: Improved correlation of the neuropathologic classification according to adapted world health organization classification and outcome after radiotherapy in patients with atypical and anaplastic meningiomas. Int J Radiat Oncol Biol Phys. 2011, 81 (5): 1415-1421. 10.1016/j.ijrobp.2010.07.039.View ArticlePubMedGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2407/14/763/prepub
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.