Jing K, Wu T, Lim K: Omega-3 polyunsaturated fatty acids and cancer. Anticancer Agents Med Chem. 2013, 13: 1162-1177.
Article
CAS
PubMed
Google Scholar
Calder PC: Dietary modification of inflammation with lipids. Proc Nutr Soc. 2002, 61: 345-358.
Article
CAS
PubMed
Google Scholar
Jump DB: Dietary polyunsaturated fatty acids and regulation of gene transcription. Curr Opin Lipidol. 2002, 13: 155-164.
Article
CAS
PubMed
Google Scholar
Siddiqui RA, Harvey K, Stillwell W: Anticancer properties of oxidation products of docosahexaenoic acid. Chem Phys Lipids. 2008, 153: 47-56.
Article
CAS
PubMed
Google Scholar
Lim K, Han C, Dai Y, Shen M, Wu T: Omega-3 polyunsaturated fatty acids inhibit hepatocellular carcinoma cell growth through blocking beta-catenin and cyclooxygenase-2. Mol Cancer Ther. 2009, 8: 3046-3055.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lim K, Han C, Xu L, Isse K, Demetris AJ, Wu T: Cyclooxygenase-2-derived prostaglandin E2 activates beta-catenin in human cholangiocarcinoma cells: evidence for inhibition of these signaling pathways by omega 3 polyunsaturated fatty acids. Cancer Res. 2008, 68: 553-560.
Article
CAS
PubMed
Google Scholar
Jing K, Song KS, Shin S, Kim N, Jeong S, Oh HR, Park JH, Seo KS, Heo JY, Han J, Park JI, Han C, Wu T, Kweon GR, Park SK, Yoon WH, Hwang BD, Lim K: Docosahexaenoic acid induces autophagy through p53/AMPK/mTOR signaling and promotes apoptosis in human cancer cells harboring wild-type p53. Autophagy. 2011, 7: 1348-1358.
Article
CAS
PubMed
PubMed Central
Google Scholar
Gorjao R, Azevedo-Martins AK, Rodrigues HG, Abdulkader F, Arcisio-Miranda M, Procopio J, Curi R: Comparative effects of DHA and EPA on cell function. Pharmacol Ther. 2009, 122: 56-64.
Article
CAS
PubMed
Google Scholar
D’Autreaux B, Toledano MB: ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis. Nat Rev Mol Cell Biol. 2007, 8: 813-824.
Article
PubMed
Google Scholar
Thannickal VJ, Fanburg BL: Reactive oxygen species in cell signaling. Am J Physiol Lung Cell Mol Physiol. 2000, 279: L1005-L1028.
CAS
PubMed
Google Scholar
Zhang DX, Gutterman DD: Mitochondrial reactive oxygen species-mediated signaling in endothelial cells. Am J Physiol Heart Circ Physiol. 2007, 292: H2023-H2031.
Article
CAS
PubMed
Google Scholar
McCubrey JA, Lahair MM, Franklin RA: Reactive oxygen species-induced activation of the MAP kinase signaling pathways. Antioxid Redox Signal. 2006, 8: 1775-1789.
Article
CAS
PubMed
Google Scholar
Wagner EF, Nebreda AR: Signal integration by JNK and p38 MAPK pathways in cancer development. Nat Rev Cancer. 2009, 9: 537-549.
Article
CAS
PubMed
Google Scholar
Wada T, Penninger JM: Mitogen-activated protein kinases in apoptosis regulation. Oncogene. 2004, 23: 2838-2849.
Article
CAS
PubMed
Google Scholar
Cagnol S, Chambard JC: ERK and cell death: mechanisms of ERK-induced cell death–apoptosis, autophagy and senescence. FEBS J. 2010, 277: 2-21.
Article
CAS
PubMed
Google Scholar
Wang X, Martindale JL, Holbrook NJ: Requirement for ERK activation in cisplatin-induced apoptosis. J Biol Chem. 2000, 275: 39435-39443.
Article
CAS
PubMed
Google Scholar
Shin S, Jing K, Jeong S, Kim N, Song KS, Heo JY, Park JH, Seo KS, Han J, Park JI, Kweon GR, Park SK, Wu T, Hwang BD, Lim K: The omega-3 polyunsaturated fatty acid DHA induces simultaneous apoptosis and autophagy via mitochondrial ROS-mediated Akt-mTOR signaling in prostate cancer cells expressing mutant p53. Biomed Res Int. 2013, 2013: 568671-
Article
PubMed
PubMed Central
Google Scholar
Kroemer G, El-Deiry WS, Golstein P, Peter ME, Vaux D, Vandenabeele P, Zhivotovsky B, Blagosklonny MV, Malorni W, Knight RA, Piacentini M, Nagata S, Melino G: Classification of cell death: recommendations of the Nomenclature Committee on Cell Death. Cell Death Differ. 2005, 12 (Suppl 2): 1463-1467.
Article
CAS
PubMed
Google Scholar
Deveraux QL, Reed JC: IAP family proteins–suppressors of apoptosis. Genes Dev. 1999, 13: 239-252.
Article
CAS
PubMed
Google Scholar
Zhuang S, Schnellmann RG: A death-promoting role for extracellular signal-regulated kinase. J Pharmacol Exp Ther. 2006, 319: 991-997.
Article
CAS
PubMed
Google Scholar
Guyton KZ, Liu Y, Gorospe M, Xu Q, Holbrook NJ: Activation of mitogen-activated protein kinase by H2O2. Role in cell survival following oxidant injury. J Biol Chem. 1996, 271: 4138-4142.
Article
CAS
PubMed
Google Scholar
Kroemer G, Galluzzi L, Brenner C: Mitochondrial membrane permeabilization in cell death. Physiol Rev. 2007, 87: 99-163.
Article
CAS
PubMed
Google Scholar
Albino AP, Juan G, Traganos F, Reinhart L, Connolly J, Rose DP, Darzynkiewicz Z: Cell cycle arrest and apoptosis of melanoma cells by docosahexaenoic acid: association with decreased pRb phosphorylation. Cancer Res. 2000, 60: 4139-4145.
CAS
PubMed
Google Scholar
Brown I, Cascio MG, Wahle KW, Smoum R, Mechoulam R, Ross RA, Pertwee RG, Heys SD: Cannabinoid receptor-dependent and -independent anti-proliferative effects of omega-3 ethanolamides in androgen receptor-positive and -negative prostate cancer cell lines. Carcinogenesis. 2010, 31: 1584-1591.
Article
CAS
PubMed
PubMed Central
Google Scholar
Diep QN, Touyz RM, Schiffrin EL: Docosahexaenoic acid, a peroxisome proliferator-activated receptor-alpha ligand, induces apoptosis in vascular smooth muscle cells by stimulation of p38 mitogen-activated protein kinase. Hypertension. 2000, 36: 851-855.
Article
CAS
PubMed
Google Scholar
Slagsvold JE, Pettersen CH, Storvold GL, Follestad T, Krokan HE, Schonberg SA: DHA alters expression of target proteins of cancer therapy in chemotherapy resistant SW620 colon cancer cells. Nutr Cancer. 2010, 62: 611-621.
Article
CAS
PubMed
Google Scholar
Toit-Kohn JL, Louw L, Engelbrecht AM: Docosahexaenoic acid induces apoptosis in colorectal carcinoma cells by modulating the PI3 kinase and p38 MAPK pathways. J Nutr Biochem. 2009, 20: 106-114.
Article
PubMed
Google Scholar
Kim BJ, Ryu SW, Song BJ: JNK- and p38 kinase-mediated phosphorylation of Bax leads to its activation and mitochondrial translocation and to apoptosis of human hepatoma HepG2 cells. J Biol Chem. 2006, 281: 21256-21265.
Article
CAS
PubMed
Google Scholar
Lei K, Nimnual A, Zong WX, Kennedy NJ, Flavell RA, Thompson CB, Bar-Sagi D, Davis RJ: The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase. Mol Cell Biol. 2002, 22: 4929-4942.
Article
CAS
PubMed
PubMed Central
Google Scholar
Fasano E, Serini S, Piccioni E, Toesca A, Monego G, Cittadini AR, Ranelletti FO, Calviello G: DHA induces apoptosis by altering the expression and cellular location of GRP78 in colon cancer cell lines. Biochim Biophys Acta. 1822, 2012: 1762-1772.
Google Scholar
Lu IF, Hasio AC, Hu MC, Yang FM, Su HM: Docosahexaenoic acid induces proteasome-dependent degradation of estrogen receptor alpha and inhibits the downstream signaling target in MCF-7 breast cancer cells. J Nutr Biochem. 2010, 21: 512-517.
Article
CAS
PubMed
Google Scholar
Serini S, Trombino S, Oliva F, Piccioni E, Monego G, Resci F, Boninsegna A, Picci N, Ranelletti FO, Calviello G: Docosahexaenoic acid induces apoptosis in lung cancer cells by increasing MKP-1 and down-regulating p-ERK1/2 and p-p38 expression. Apoptosis. 2008, 13: 1172-1183.
Article
CAS
PubMed
Google Scholar
Sun H, Hu Y, Gu Z, Owens RT, Chen YQ, Edwards IJ: Omega-3 fatty acids induce apoptosis in human breast cancer cells and mouse mammary tissue through syndecan-1 inhibition of the MEK-Erk pathway. Carcinogenesis. 2011, 32: 1518-1524.
Article
CAS
PubMed
PubMed Central
Google Scholar
Watkins SM, Carter LC, German JB: Docosahexaenoic acid accumulates in cardiolipin and enhances HT-29 cell oxidant production. J Lipid Res. 1998, 39: 1583-1588.
CAS
PubMed
Google Scholar
Tobiume K, Matsuzawa A, Takahashi T, Nishitoh H, Morita K, Takeda K, Minowa O, Miyazono K, Noda T, Ichijo H: ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis. EMBO Rep. 2001, 2: 222-228.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yang TC, Lai CC, Shiu SL, Chuang PH, Tzou BC, Lin YY, Tsai FJ, Lin CW: Japanese encephalitis virus down-regulates thioredoxin and induces ROS-mediated ASK1-ERK/p38 MAPK activation in human promonocyte cells. Microbes Infect. 2010, 12: 643-651.
Article
CAS
PubMed
Google Scholar