Sodium iodide symporter (NIS) in extrathyroidal malignancies: focus on breast and urological cancer

BMC Cancer

Table 3 Stimulators of iodide uptake in breast cancer cell lines

Cell line	Stimulator	Mechanism of action	I^- uptake (fold of induction)	References
MCF7	tRA,9-cis RA	RAR/RXR agonist	10 ~ 13	[68]
MCF7	AGN190168	RARβ/γ agonist	10 ~ 13	[52]
MCF7	Am80	RARα/β agonist	~7	[56]
MCF7	Theophylline	PDE antagonist/P2R inhibitor	~4.7	[69]
MCF7	LBH589	HDAC inhibitor	~2.3	[67]
T47D	LBH589	HDAC inhibitor	~4.8	[67]
MDA-MB231	LBH589	HDAC inhibitor	~2.7	[67]
MCF7	Insulin	Insulin receptor	~12	[66]
MCF7	IGF-I	IGF-I receptor	~7.8	[66]
MCF7	IGF-II	IGF-II receptor	~10.3	[66]
MCF7	Prolactin	Cytosolic PKs activation	~9	[66]
MCF7	Forskolin	Adenilyl-cyclase/PKA activation	~3.1	[66]
MCF7	TPA	PKC activation	~2.6	[66]
MCF7	(Bu)2-cAMP	PKA activation	~3.4	[66]

Abbreviations: tRA trans retinoic acid, RAR retinoic acid receptor, PDE phosphodiesterase, HDAC histone deacetylase, IGF insulin growth factor, PK protein kinase.

ISSN: 1471-2407