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Table 3 Stimulators of iodide uptake in breast cancer cell lines

From: Sodium iodide symporter (NIS) in extrathyroidal malignancies: focus on breast and urological cancer

Cell line Stimulator Mechanism of action I- uptake (fold of induction) References
MCF7 tRA,9-cis RA RAR/RXR agonist 10 ~ 13 [68]
MCF7 AGN190168 RARβ/γ agonist 10 ~ 13 [52]
MCF7 Am80 RARα/β agonist ~7 [56]
MCF7 Theophylline PDE antagonist/P2R inhibitor ~4.7 [69]
MCF7 LBH589 HDAC inhibitor ~2.3 [67]
T47D LBH589 HDAC inhibitor ~4.8 [67]
MDA-MB231 LBH589 HDAC inhibitor ~2.7 [67]
MCF7 Insulin Insulin receptor ~12 [66]
MCF7 IGF-I IGF-I receptor ~7.8 [66]
MCF7 IGF-II IGF-II receptor ~10.3 [66]
MCF7 Prolactin Cytosolic PKs activation ~9 [66]
MCF7 Forskolin Adenilyl-cyclase/PKA activation ~3.1 [66]
MCF7 TPA PKC activation ~2.6 [66]
MCF7 (Bu)2-cAMP PKA activation ~3.4 [66]
  1. Abbreviations: tRA trans retinoic acid, RAR retinoic acid receptor, PDE phosphodiesterase, HDAC histone deacetylase, IGF insulin growth factor, PK protein kinase.