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Table 1 Genes included on the angiogenesis PCR array and expressed by Caco-2 cells

From: Identification of the angiogenic gene signature induced by EGF and hypoxia in colorectal cancer

Symbol

Gene name

Description

Stimulus

Hypoxia

DMOG

EGF

EGF + DMOG

AKT1

PKB/PRKBA

V-akt murine thymoma viral oncogene homolog 1

−1.1

1.3

1.2

1.1

ANGPT1

AGP1/AGPT

Angiopoietin 1

2.3

2.1

1.6

2.3

ANGPTL3

ANGPT5

Angiopoietin-like 3

2.1

2.4

1.3

2.4

ANGPTL4

ANGPTL2/ARP4

Angiopoietin-like 4

3.1

3.9

1.4

5.8

ANPEP

CD13/LAP1

Alanyl (membrane) aminopeptidase (aminopeptidase N, aminopeptidase M, microsomal aminopeptidase, CD13, p150)

1.5

1.3

−1.4

1.4

CCL11

SCYA11

Chemokine (C-C motif) ligand 11

1.9

1.1

1.5

3.5

CCL2

GDCF-2/GDCF-2 HC11

Chemokine (C-C motif) ligand 2

1.4

−1.5

1.6

1.4

COL18A1

KNO

Collagen, type XVIII, alpha 1

1.8

1.2

1.0

1.3

COL4A3

TUMSTATIN

Collagen, type IV, alpha 3 (Goodpasture antigen)

1.7

−1.1

1.3

2.2

EDG1

CHEDG1/D1S3362

Endothelial differentiation, sphingolipid G-protein-coupled receptor 1, SIPR1

1.7

1.5

1.7

3.0

EFNA1

B61/ECKLG

Ephrin-A1

2.6

2.4

1.0

2.0

EFNA3

EFL2/EPLG3

Ephrin-A3

7.2

6.6

1.3

4.9

EFNB2

EPLG5/HTKL

Ephrin-B2

1.4

1.3

1.3

1.6

ENG

CD105/END

Endoglin

1.1

1.1

1.5

1.2

EPHB4

HTK/MYK1

EPH receptor B4

1.2

1.0

1.5

1.3

EREG

ER

Epiregulin

1.2

1.1

1.2

−1.9

FGFR3

ACH/CEK2

Fibroblast growth factor receptor 3

1.4

1.5

1.2

1.4

FLT1

FLT/VEGFR1

Fms-related tyrosine kinase 1

3.1

2.8

1.4

2.6

HIF1A

HIF-1alpha

Hypoxia-inducible factor 1, alpha

−1.5

1.0

1.0

1.0

HPSE

HPA/HPR1

Heparanase

1.7

1.9

1.1

1.8

ID1

ID

Inhibitor of DNA binding 1, dominant negative helix-loop-helix protein

−1.3

1.6

1.7

1.9

ID3

HEIR-1

Inhibitor of DNA binding 3, dominant negative helix-loop-helix protein

1.5

−1.0

1.4

2.5

IGF1

IGFI

Insulin-like growth factor 1

1.9

1.4

1.2

1.6

IL6

BSF2/HGF

Interleukin 6 (interferon, beta 2)

1.9

1.3

1.5

1.7

IL-8

3-10C/AMCF-I

Interleukin 8

1.9

−1.1

1.2

2.4

ITGAV

CD51/MSK8

Integrin, alpha V (CD51)

−1.1

1.4

1.9

1.9

ITGB3

CD61/GP3A

Integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)

1.3

−1.1

−1.2

2.4

JAG1

AGS/AHD

Jagged 1 (Alagille syndrome)

1.1

1.6

1.6

2.7

KDR

FLK1/VEGFR

Kinase insert domain receptor

1.7

−1.2

−1.2

2.3

LAMA5

KIAA1907

Laminin, alpha 5

1.6

1.2

1.0

1.0

MMP2

CLG4/CLG4A

Matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)

1.7

1.5

−1.3

1.6

MMP9

CLG4B/GELB

Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)

2.6

2.6

1.7

2.4

NOTCH4

INT3/NOTCH3

Notch homolog 4 (Drosophila)

1.5

−1.3

1.0

2.0

NRP1

DKFZp686A03134/DKFZp781F1414

Neuropilin 1

−1.6

−1.3

−1.5

−1.1

NRP2

NP2/NPN2

Neuropilin 2

−1.0

1.0

1.1

1.5

PDGFA

PDGF-A/PDGF1

Platelet-derived growth factor alpha polypeptide

1.2

1.5

1.2

−1.2

PECAM1

CD31/PECAM-1

Platelet/endothelial cell adhesion molecule (CD31 antigen)

1.61

−1.3

1.0

1.7

PLAU

ATF/UPA

Plasminogen activator, urokinase

1.4

1.4

1.4

1.7

PLXDC1

TEM3/TEM7

Plexin domain containing 1

1.9

1.0

1.7

1.8

SERPINF1

EPC-1/PEDF

Serpin peptidase inhibitor, clade F (pigment epithelium derived factor)

1.5

1.1

1.2

1.5

SPHK1

SPHK

Sphingosine kinase 1

1.5

1.0

1.6

2.0

TGFA

TFGA

Transforming growth factor, alpha

1.9

1.4

1.5

2.3

TGFB1

CED/DPD1

Transforming growth factor, beta 1

5.4

4.3

1.4

4.6

TGFB2

TGF-beta2

Transforming growth factor, beta 2

1.7

1.0

1.0

1.8

TGFBR1

ACVRLK4/ALK-5

Transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53 kDa)

1.6

1.5

1.3

1.6

THBS1

THBS/TSP

Thrombospondin 1

1.3

1.2

1.0

1.0

THBS2

TSP2

Thrombospondin 2

1.1

1.0

−1.2

−1.1

TIMP1

CLGI/EPA

TIMP metallopeptidase inhibitor 1

1.3

−1.2

−1.1

1.1

TIMP2

CSC-21K

TIMP metallopeptidase inhibitor 2

1.5

−1.2

−1.3

−1.1

TNFAIP2

B94

Tumour necrosis factor, alpha-induced protein 2

1.7

1.2

−1.1

1.4

VEGF

VEGFA/VPF

Vascular endothelial growth factor

3.1

3.4

1.0

3.1

  1. The Human Angiogenesis RT2 Profiler™ PCR Array was used to screen cDNA from Caco-2 cells exposed for 24 hours to either 1% O2, DMOG (1 mM), EGF (10 ng/ml) or a combination of EGF plus DMOG. Data were compared to HKG: ActB (β-actin), 18S rRNA, HPRT1 (hypoxanthine phosphoribosyltransferase 1) and RPL13A (60S ribosomal protein L13a), and are fold change versus untreated cells. Changes ≥2-fold are shown in bold. Data are from a representative array performed in duplicate using cDNA pooled from 3 different replicate experiments.
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BMC Cancer

ISSN: 1471-2407

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