Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM: GLOBOCAN 2008 v1.2, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 10 [Internet]. 2010, Lyon, France: International Agency for Research on Cancer, http://globocan.iarc.fr, accessed on 31/08/2011
Google Scholar
Vieitez JM, García-Carbonero R, Aparicio J, Feliu J, González-Flores E, Grande E, Pérez-Hoyos T, Salud A, Torres E, Valero M, Valladares-Ayerbes M, Díaz-Rubio E: Recommendations and expert opinion on the adjuvant treatment of colon cáncer in Spain. Clin Transl Oncol. 2011, 13 (11): 798-804. 10.1007/s12094-011-0736-4.
Article
CAS
PubMed
Google Scholar
García-Carbonero R, Gómez España MA, Casado Sáenz E, Alonso Orduña V, Cervantes Ruipérez A, Gallego Plazas J, García Alfonso P, Juez Martel I, González Flores E, Lomas Garrido M, Isla Casado D: SEOM clinical guidelines for the treatment of advanced colorectal cancer. Clin Transl Oncol. 2010, 12 (11): 729-734. 10.1007/s12094-010-0587-4.
Article
PubMed
Google Scholar
Aranda E, Abad A, Carrato A, Cervantes A, García-Foncillas J, García Alfonso P, García Carbonero R, Gómez España A, Tabernero JM, Díaz-Rubio E: Treatment recommendations for metastatic colorectal cancer. Clin Transl Oncol. 2011, 13 (3): 162-178. 10.1007/s12094-011-0636-7.
Article
PubMed
Google Scholar
Hurwitz H, Fehrenbacher L, Novotny W, Cartwright T, Hainsworth J, Heim W, Berlin J, Baron A, Griffing S, Holmgren E, Ferrara N, Fyfe G, Rogers B, Ross R, Kabbinavar F: Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med. 2004, 350 (23): 2335-2342. 10.1056/NEJMoa032691.
Article
CAS
PubMed
Google Scholar
Joulain F, Van Cutsem E, Usman I, Hoyle M, Allegra C: Aflibercept versus placebo in combination with FOLFIRI in previously treated metastatic colorectal cancer (mCRC): Mean overall survival (OS) estimation from a phase III trial (VELOUR). J Clin Oncol. 2012, 30: s3602-
Google Scholar
Van Cutsem E, Sobrero AF, Siena S, Falcone A, Ychou M, Humblet Y, Bouche O, Mineur L, Barone C, Adenis A, Tabernero J, Yoshino T, Lenz HJ, Goldberg RM, Sargent DJ, Cihon F, Wagner A, Laurent D, Grothey A, on behalf of CORRECT Investigators: Phase III CORRECT trial of regorafenib in metastatic colorectal cancer (mCRC). J Clin Oncol. 2012, 30 (suppl; abstr 3502):
Carmeliet P, Jain RK: Angiogenesis in cancer and other diseases. Nature. 2000, 407: 249-257. 10.1038/35025220.
Article
CAS
PubMed
Google Scholar
Weis SM, Cheresh DA: Pathophysiological consequences of VEGF-induced vascular permeability. Nature. 2005, 437: 497-504. 10.1038/nature03987.
Article
CAS
PubMed
Google Scholar
Sakurai T, Kudo M: Signaling pathways governing tumor angiogenesis. Oncology. 2011, 81 (Suppl 1): 24-29.
Article
CAS
PubMed
Google Scholar
Arora A, Scholar EM: Role of tyrosine kinase inhibitors in cancer therapy. J Pharmacol Exp Ther. 2005, 315: 971-979. 10.1124/jpet.105.084145.
Article
CAS
PubMed
Google Scholar
Ivy SP, Wick JY, Kaufman BM: An overview of small-molecule inhibitors of VEGFR signaling. Nature Rev Clin Oncol. 2009, 6: 569-579. 10.1038/nrclinonc.2009.130.
Article
CAS
Google Scholar
Hoch RV, Soriano P: Roles of PDGF in animal development. Development. 2003, 130: 4769-4784. 10.1242/dev.00721.
Article
CAS
PubMed
Google Scholar
Yu J, Ustach C, Kim HR: Platelet-derived growth factor signaling and human cancer. J Biochem Mol Bio. 2003, 36 (1): 49-59. 10.5483/BMBRep.2003.36.1.049.
Article
CAS
Google Scholar
Andrae J, Gallini R, Betsholtz C: Role of platelet-derived growth factors in physiology and medicine. Genes Dev. 2008, 22 (10): 1276-1312. 10.1101/gad.1653708.
Article
CAS
PubMed
PubMed Central
Google Scholar
Carrato A, Swieboda-Sadlej S-S, Lim R, Roman L, Shparyk Y, Bondarenko I, Lin X, Lechuga MJ, Tursi JM, Sun Y, De la Cruz JA, Jonker D, Van Cutsem E: Final results from a randomized, double-blind, phase III study of sunitinib plus FOLFIRI vs placebo plus FOLFIRI in first-line treatment of patients (pts) with metastatic colorectal cancer. Proceedings of the 12th World Cancer on Gastrointestinal Cancer. 2010, Barcelona, Spain, O-0026-30 June-3 July
Google Scholar
Tabernero J, Garcia-Carbonero R, Köhne CH, et al: A phase 2b, double-blind, randomized study evaluating the efficacy and safety of sorafenib (SOR) compared with placebo (PBO) when administered in combination with chemotherapy (modified FOLFOX6) for first-line treatment (tx) of patients (pts) with metastatic colorectal cancer (mCRC), the RESPECT trial. Proceeding of the 2011 European Multidisciplinary Cancer Congress. 2011, Stockholm, Sweden: Abstract LBA19, 23–27 September
Google Scholar
AJCC Cancer Staging Manual. Edited by: Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL, Trotti A. 2010, Springer, 7
Google Scholar
Kaplan EL, Meier P: Non parametric estimation from incomplete observations. J Am Stat Soc A. 1972, 35: 185-206.
Google Scholar
Peto R, Peto J: Asymptotically efficient rank invariant tests procedures. J R Stat Soc A. 1972, 135 (2): 185-207. 10.2307/2344317.
Article
Google Scholar
Cox DR: Regression models and life tables. J R Stat Soc B. 1972, 34: 187-220.
Google Scholar
Schimanski CC, Zimmermann T, Schmidtmann I, Gockel I, Lang H, Galle PR, Moehler M, Berger MR: K-ras mutation status correlates with the expression of VEGFR1, VEGFR2, and PDGFRalpha in colorectal cancer. Int J Colorectal Dis. 2010, 25 (2): 181-186. 10.1007/s00384-009-0843-7.
Article
PubMed
Google Scholar
Wehler TC, Frerichs K, Graf C, Drescher D, Schimanski K, Biesterfeld S, Berger MR, Kanzler S, Junginger T, Galle PR, Moehler M, Gockel I, Schimanski CC: PDGFRalpha/beta expression correlates with the metastatic behavior of human colorectal cancer: a possible rationale for a molecular targeting strategy. Oncol Rep. 2008, 19 (3): 697-704.
CAS
PubMed
Google Scholar
Paulsson J, Sjöblom T, Micke P, Pontén F, Landberg G, Heldin CH, Bergh J, Brennan DJ, Jirström K, Ostman A: Prognostic significance of stromal platelet-derived growth factor beta-receptor expression in human breast cancer. Am J Pathol. 2009, 175 (1): 334-341. 10.2353/ajpath.2009.081030.
Article
PubMed
PubMed Central
Google Scholar
Trojani A, Ripamonti CB, Penco S, Beghini A, Nadali G, Di Bona E, Viola A, Castagnola C, Colapietro P, Grillo G, Pezzetti L, Ravelli E, Patrosso MC, Marocchi A, Cuneo A, Ferrara F, Lazzarino M, Pizzolo G, Cairoli R, Morra E: Molecular analysis of PDGFRA and PDGFRB genes by rapid single-strand conformation polymorphism (SSCP) in patients with core-binding factor leukaemias with KIT or FLT3 mutation. Anticancer Res. 2008, 28 (5A): 2745-2751.
CAS
PubMed
Google Scholar
Longatto-Filho A, Pinheiro C, Martinho O, Moreira MA, Ribeiro LF, Queiroz GS, Schmitt FC, Baltazar F, Reis RM: Molecular characterization of EGFR, PDGFRA and VEGFR2 in cervical adenosquamous carcinoma. BMC Cancer. 2009, 9: 212-10.1186/1471-2407-9-212.
Article
PubMed
PubMed Central
Google Scholar
Martinho O, Longatto-Filho A, Lambros MB, Martins A, Pinheiro C, Silva A, Pardal F, Amorim J, Mackay A, Milanezi F, Tamber N, Fenwick K, Ashworth A, Reis-Filho JS, Lopes JM, Reis RM: Expression, mutation and copy number analysis of platelet-derived growth factor receptor A (PDGFRA) and its ligand PDGFA in gliomas. Br J Cancer. 2009, 101 (6): 973-982. 10.1038/sj.bjc.6605225.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hansen TF, Jakobsen A: Clinical implications of genetic variations in the VEGF system in relation to colorectal cancer. Pharmacogenomics. 2011, 12 (12): 1681-1693. 10.2217/pgs.11.118.
Article
CAS
PubMed
Google Scholar
Jain L, Vargo CA, Danesi R, Sissung TM, Price DK, Venzon D, Venitz J, Figg WD: The role of vascular endothelial growth factor SNPs as predictive and prognostic markers for major solid tumors. Mol Cancer Ther. 2009, 8: 2496-2508. 10.1158/1535-7163.MCT-09-0302.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hansen TF, Christensen RD, Andersen RF, Spindler KL, Johnsson A, Jakobsen A: The predictive value of single nucleotide polymorphisms in the VEGF system to the efficacy of first-line treatment with bevacizumab plus chemotherapy in patients with metastatic colorectal cancer: Results from the Nordic ACT trial. Int J Colorectal Dis. 2012, 27 (6): 715-720. 10.1007/s00384-011-1382-6.
Article
PubMed
Google Scholar
Lambrechts D, Claes B, Delmar P, Reumers J, Mazzone M, Yesilyurt BT, Devlieger R, Verslype C, Tejpar S, Wildiers H, de Haas S, Carmeliet P, Scherer SJ, Van Cutsem E: VEGF pathway genetic variants as biomarkers of treatment outcome with bevacizumab: an analysis of data from the AViTA and AVOREN randomised trials. Lancet Oncol. 2012, 13 (7): 724-733. 10.1016/S1470-2045(12)70231-0.
Article
CAS
PubMed
Google Scholar