- Case report
- Open Access
- Open Peer Review
First case of isolated vaginal metastasis from breast cancer treated by surgery
© Bellati et al.; licensee BioMed Central Ltd. 2012
- Received: 1 March 2012
- Accepted: 23 September 2012
- Published: 17 October 2012
Breast cancer is a leading cause of death in developed countries. This neoplasm frequently relapses at distant sites such as bone, lung, pleura, brain and liver but rarely in the lower female genital tract.
We present the first case of isolated vaginal breast cancer metastasis and its surgical treatment.
This case report focuses on the importance of an accurate genital tract examination as part of regular follow up in breast cancer survivors. Indeed, after this experience we feel that surgery could be considered a valid option for the treatment of an isolated vaginal metastasis.
- Breast cancer
- Radical surgery
- Vaginal metastasis
Breast cancer is the most frequent neoplasm in women and remains the a leading cause of death in developed countries . The neoplasm frequently relapses at distant sites such as bone, lung, pleura, brain and liver . Disease recurrences rarely occur in organs of the lower female genital tract, such as ovary or to the endometrium . The metastasis to the cervix, as an isolated event, is a rare manifestation, with a variable frequency ranging from 0.8% to 1.7% .
Isolated metastasis to the genital tract is explained as a hematogenous spread from the primary site of disease; mostly, it appears as a concomitant involvement of a broadly disseminated disease .
Only two cases of vaginal metastasis from breast cancer have been so far reported in literature [6, 7]; both of them are presented as part of a systemic disease involving also endometrium and ovaries.
We present the first case of isolated vaginal metastasis, secondary to an unilateral lobular breast cancer, recurring four years after complete clinical remission.
In February 2008, a 54-year-old woman, with a history of lobular breast cancer T2N1M0, was referred to our Department for vaginal bleeding. In march 2005 she was submitted to left superior quadrantectomy plus axillary lymphadenectomy followed by adjuvant chemotherapy, radiotherapy, and hormonal treatment for 5 years. After completion of adjuvant chemotherapy and radiotherapy, the patient was followed up regularly every 3–6 months by the mean of clinical examination, imaging and laboratory exams. Gynecological examination was performed every year, with normal findings.
At admission she was in good general condition, only complaining an un-painful vaginal bleeding. She was still under hormonal treatment.
The patient was subjected to adjuvant chemotherapy with Pegilated Liposomal Doxorubicin 40 mg/mq for 6 courses.
After 14 months of negative follow up, we decided to perform an elective completion of surgery with prophylactic aims. A total hysterectomy plus bilateral salpingo-oophorectomy was performed. Surprising, Hystological Examination documented. Again micrometastasis from lobular breast cancer in the contest both of the uterus and ovaries. No adjuvant treatment was proposed.
Twelve months later, the patient is still free from disease.
Metastases to the female genital tract from breast cancer are unusual.
Defining “breast unusual metastasis” as rare systemic failure with a frequency of <1% .
Lobular histotype seems to metastasize to the genital tract more frequently than ductal tumors , probably for an hematogenous propagation.
Few cases are reported in literature describing isolated metastasis to the cervix [4–8, 10]. To our knowledge, this is the first case of an isolated vaginal relapse from breast cancer treated by surgery.
Data regarding vaginal metastasis behavior and treatment are scarce. Most of the cases are treated by radiotherapy [6, 7]. In our opinion, surgery is a valid alternative to radiotherapy , and the absence of relevant side effects or complication and the current status of our patient corroborate this strategy.
Furthermore, this case report suggests that cancer survivors should be subjected to a more thorough gynecologic examination. Although a baseline gynecologic assessment is recommended prior to administration of the cancer risk reduction agents (Tamoxifen), and follow up gynecologic assessment should be performed at each visit, as assess by NCCN Guidelines, currently gynecological counseling is not universally part of breast cancer follow up workup.
Globally our experience highlights that breast cancer survivors deserve a periodic gynecological assessment as part of their regular follow up. Also, we can assume that recurrent disease would have been undetected if deeper evaluations had not be carried out and that when it occurs surgery could be a rationale choice of treatment.
In conclusion, in our opinion, in case of recurrence in female genital tract an expert Gynecologic Oncology Surgeon should be consulted.
Written informed consent was obtained from the patient for publication of this Case report and any accompanying images. A copy of the written consent is available for review by the Series Editor of this journal.
- Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D: Global cancer statistics. CA Cancer J Clin. 2011, 61: 69-90. 10.3322/caac.20107.View ArticlePubMedGoogle Scholar
- Cheng YC, Naoto T, Uemo : Improvement of survival and prospect of cure in patients with metastatic breast cancer. Breast cancer. 2011, [Epub ahead of print]Google Scholar
- Sanuki-Fujimoto N, Takeda A, Amemiya A, Ofuchi T, Ono M, Yamagami R, Hatayama J, Kunieda E, Shigematsu N: Pattern of tumor recurrence in initially nonmetastatic breast cancer patients: distribution and frequency of metastases at unusual sites. Cancer. 2008, 113: 677-82. 10.1002/cncr.23612.View ArticlePubMedGoogle Scholar
- Manci N, Marchetti C, Esposito F, Graziano M, Tomao F, Pastore M, Bellati F, Panici PB: Late breast cancer recurrence to the uterine cervix with a review of the literature. Int J Gynecol Pathol. 2008, 27: 113-7. 10.1097/pgp.0b013e31806add82.View ArticlePubMedGoogle Scholar
- Cohan L, Kaplan AL: Postmenopausal bleeding secondary to metastatic disease in the endocervix from carcinoma of the breast. Gynecol Oncol. 1984, 17: 133-10.1016/0090-8258(84)90067-2.View ArticlePubMedGoogle Scholar
- Pineda A, Sall S: Metastasis of the vagina from carcinoma of the breast. J Reprod Med. 1978, 20: 243-5.PubMedGoogle Scholar
- Giacalone PL, Dumontier C, Roger P, Laffargue F, Baldet P: Metastase vaginale d’un carcinome mammarie. J Gynecol Obstet Reprod. 1998, 27: 714-7.Google Scholar
- Benedetti Panici P, Manci N, Bellati F, Di Donato V, Marchetti C, De Falco C, Di Tucci C, Angioli R: Vaginectomy: a minimally invasive treatment for cervical cancer vaginal recurrence. Int J Gynecol Cancer. 2009, 19: 1625-31. 10.1111/IGC.0b013e3181a80a0a.View ArticlePubMedGoogle Scholar
- Borst MJ, Ingold JA: Metastatic patterns of invasive lobular versus invasive ductal carcinoma of the breast. Surgery. 1993, 114: 637-41.PubMedGoogle Scholar
- Green AE, Biscotti C, Michener C, et al: Isolated cervical metastasis of breast cancer: a case report and review of the literature. Gynecol Oncol. 2004, 95: 267-10.1016/j.ygyno.2004.07.006.View ArticlePubMedGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2407/12/479/prepub
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.