Table 4 Interaction of the MTHFR A1298C polymorphism and cigarette smoking or alcohol drinking

1.0 (reference)

-

1.0 (reference)

-

291/161

2.56 (1.92 - 3.42)

<0.01

3.40 (2.42 - 4.78)

<0.01

1.89 (0.78 - 4.61)

0.16

2.82 (1.02 - 7.83)

0.05**

18/9

2.83 (1.23 - 6.50)

0.01

3.15 (1.24 - 7.98)

0.02

Crude P_interaction = 0.39 and adjusted P_interaction = 0.11

Appropriate drinkers

Excessive drinkers

OR (95% CI)

Cases/

OR (95% CI)

Crude

P

Adjusted*

P

Controls

Crude

P

Adjusted*

P

1.0 (reference)

-

1.0 (reference)

-

265/171

1.76 (1.33 - 2.34)

<0.01

1.64 (1.18 - 2.29)

<0.01

11/14

0.89 (0.40 - 2.02)

0.79

0.86 (0.35 - 2.16)

0.76

19/4

5.40 (1.80 - 16.2)

<0.01

7.24 (1.89 - 27.7)

<0.01

Crude P_interaction = 0.08 and adjusted P_interaction = 0.05†