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Table 4 Interaction of the MTHFR A1298C polymorphism and cigarette smoking or alcohol drinking

From: Methylenetetrahydrofolate reductase polymorphisms and interaction with smoking and alcohol consumption in lung cancer risk: a case-control study in a Japanese population

  Non-smokers Ever-smokers
Genotype Cases/ OR (95% CI) Cases/ OR (95% CI)
  Controls Crude P Adjusted* P Controls Crude P Adjusted* P
AA + AC 141/200 1.0 (reference) - 1.0 (reference) - 291/161 2.56 (1.92 - 3.42) <0.01 3.40 (2.42 - 4.78) <0.01
CC 12/9 1.89 (0.78 - 4.61) 0.16 2.82 (1.02 - 7.83) 0.05** 18/9 2.83 (1.23 - 6.50) 0.01 3.15 (1.24 - 7.98) 0.02
Crude Pinteraction = 0.39 and adjusted Pinteraction = 0.11
  Appropriate drinkers Excessive drinkers
Genotype Cases/ OR (95% CI) Cases/ OR (95% CI)
  Controls Crude P Adjusted* P Controls Crude P Adjusted* P
AA + AC 167/190 1.0 (reference) - 1.0 (reference) - 265/171 1.76 (1.33 - 2.34) <0.01 1.64 (1.18 - 2.29) <0.01
CC 11/14 0.89 (0.40 - 2.02) 0.79 0.86 (0.35 - 2.16) 0.76 19/4 5.40 (1.80 - 16.2) <0.01 7.24 (1.89 - 27.7) <0.01
Crude Pinteraction = 0.08 and adjusted Pinteraction = 0.05†
  1. * Adjusted for age, sex, education and smoking or drinking.
  2. **Exact P = 0.046 †Exact P = 0.049