Figure 4From: E7080, a multi-targeted tyrosine kinase inhibitor suppresses tumor cell migration and invasion Inhibition of DX3 cell invasion by E7080. (A) Invasion of DX3 cells into Matrigel in the presence or absence of E7080 was measured: DX3 cells were stained with calcien AM and images taken every 15 μm. (B) Quantification of invasion is shown for a representative experiment in a series of three. Values are mean + s.e.m. of two transwells with 4 fields per transwell. p values comparing treated cells with controls were calculated using Paired t-test. (C) The fluorescent intensity of DX3 cells on the upper side of the Transwell was measured in untreated and E7080 treated cells following staining with calcein AM. Results are mean + s.e.m from a representative experiment in a series of three.Back to article page