Figure 4

Correlation of Mre11 and Rad50 protein levels with sensitivity to NSC 734406. Relative protein levels (open bars) are compared to NSC 734406 sensitivity (red lines) in each cell line. The sensitivity data was obtained from http://dtp.nci.nih.gov. The center line in each data set reflects the mean for that parameter across the entire panel, and then the results for each cell line are represented to the left (low protein level or drug resistance) or to the right (high protein or drug sensitivity) of the mean. The observation that the red lines and boxes have an inverse correlation reflect the fact that low protein level correlates with drug sensitivity.