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Figure 3 | BMC Cancer

Figure 3

From: Characterization of AKT independent effects of the synthetic AKT inhibitors SH-5 and SH-6 using an integrated approach combining transcriptomic profiling and signaling pathway perturbations

Figure 3

Distinct alterations of gene expression caused by the PIAs. (A) Graphical display of up- and down-regulated genes (fold change > = 2) after 48 hours of treatment with either the PI3kinase inhibitors or the PIAs. (B) Heatmap of probe sets which are associated with the mitotic cell cycle (GO-annotation GO:0000278) and down regulated in the SW480 cells by SH-5 and SH-6, respectively. (C) Verification of down regulated genes in SW480 cells using RT-PCR.

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BMC Cancer

ISSN: 1471-2407

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