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  1. Angiogenesis is the formation of neovasculature from a pre-existing vascular network. Progression of solid tumors including lung cancer is angiogenesis-dependent. We previously introduced a bioinformatics-base...

    Authors: Jacob E Koskimaki, Emmanouil D Karagiannis, Benjamin C Tang, Hans Hammers, D Neil Watkins, Roberto Pili and Aleksander S Popel
    Citation: BMC Cancer 2010 10:29
    Content type: Research article Published on:

  2. Combinations of trastuzumab with either docetaxel or vinorelbine are considered valuable treatment options for HER2-positive metastatic breast cancer patients. We performed a retrospective comparison of the cl...

    Authors: Stefania Redana, Michela Donadio, Franco Nolè, Maria Elena Jacomuzzi, Alessandra Beano, Rossella Martinello, Anna Sapino, Giuseppe Viale, Massimo Aglietta and Filippo Montemurro
    Citation: BMC Cancer 2010 10:28
    Content type: Research article Published on:

  3. Substantial data indicate that the oncogene microRNA 21 (miR-21) is significantly elevated in glioblastoma multiforme (GBM) and regulates multiple genes associated with cancer cell proliferation, apoptosis, an...

    Authors: Yu Ren, Xuan Zhou, Mei Mei, Xu-Bo Yuan, Lei Han, Guang-Xiu Wang, Zhi-Fan Jia, Peng Xu, Pei-Yu Pu and Chun-Sheng Kang
    Citation: BMC Cancer 2010 10:27
    Content type: Research article Published on:

  4. The objective of this study was to conduct a cost-effectiveness evaluation of pemetrexed compared to docetaxel in the treatment of advanced or metastatic non-small cell lung cancer (NSCLC) for patients with pr...

    Authors: Yumi Asukai, Amparo Valladares, Carlos Camps, Eifiona Wood, Kaisa Taipale, Jorge Arellano, Alejo Cassinello, José Antonio Sacristán and Tatiana Dilla
    Citation: BMC Cancer 2010 10:26
    Content type: Research article Published on:

  5. Currently, the TNM staging system is a widely accepted method for assessing the prognosis of the disease and planning therapeutic strategies for cancer. Of the TNM system, the extent of lymph node involvement ...

    Authors: Do Hyoung Lim, Hyeong Su Kim, Young Suk Park, Jeeyun Lee, Se Hoon Park, Ho Yeong Lim, Sang Hoon Ji, Min Jae Park, Seong Yoon Yi, Ji Yeong An, Tae Sung Sohn, Jae Hyoung Noh, Jae Moon Bae, Sung Kim, Cheol Keun Park and Won Ki Kang
    Citation: BMC Cancer 2010 10:25
    Content type: Research article Published on:

  7. CXCL12 is a chemokine that is constitutively expressed in many organs and tissues. CXCL12 promoter hypermethylation has been detected in primary breast tumours and contributes to their metastatic potential. It ha...

    Authors: Edneia AS Ramos, Anamaria A Camargo, Karin Braun, Renata Slowik, Iglenir J Cavalli, Enilze MSF Ribeiro, Fábio de O Pedrosa, Emanuel M de Souza, Fabrício F Costa and Giseli Klassen
    Citation: BMC Cancer 2010 10:23
    Content type: Research article Published on:

  8. Adequate surgery still remains the only curative treatment of chordoma. Interesting clinical data on advanced disease with molecularly targeted therapies were reported.

    Authors: Virginia Ferraresi, Carmen Nuzzo, Carmine Zoccali, Ferdinando Marandino, Antonello Vidiri, Nicola Salducca, Massimo Zeuli, Diana Giannarelli, Francesco Cognetti and Roberto Biagini
    Citation: BMC Cancer 2010 10:22
    Content type: Research article Published on:

  9. S100 calcium binding protein A8 (S100A8) has been implicated as a prognostic indicator in several types of cancer. However, previous studies are limited in their ability to predict the clinical behavior of the c...

    Authors: Seon-Kyu Kim, Eun-Jung Kim, Sun-Hee Leem, Yun-Sok Ha, Yong-June Kim and Wun-Jae Kim
    Citation: BMC Cancer 2010 10:21
    Content type: Research article Published on:

  10. Glucose regulated protein 78 (Grp78) is involved in the invasion and metastasis in many human cancers including gastric cancer, breast cancer, prostate cancer. But the role of Grp78 in the invasion of human he...

    Authors: Rongjian Su, Zhen Li, Hongdan Li, Huijuan Song, Cuifen Bao, Jia Wei and Liufang Cheng
    Citation: BMC Cancer 2010 10:20
    Content type: Research article Published on:

  11. HPV has been found repeatedly in esophageal carcinoma tissues. However, reported detection rates of HPV DNA in these tumors have varied markedly. Differences in detection methods, sample types, and geographic ...

    Authors: Xueqian Wang, Xiuyun Tian, Fangfang Liu, Yiqiang Zhao, Min Sun, Dafang Chen, Changdong Lu, Zhong Wang, Xiaotian Shi, Qingying Zhang, Donghong Zhang, Zhongying Shen, Feng Li, Curtis C Harris, Hong Cai and Yang Ke
    Citation: BMC Cancer 2010 10:19
    Content type: Research article Published on:

  12. In this study was investigate IAPs in normal human prostate (NP), benign prostatic hyperplasia (BPH), prostatic intraepithelial neoplasia (PIN) and prostatic carcinoma (PC), and their involvement in apoptosis/...

    Authors: Gonzalo Rodríguez-Berriguete, Benito Fraile, Fermín R de Bethencourt, Angela Prieto-Folgado, Nahikari Bartolome, Claudia Nuñez, Bruna Prati, Pilar Martínez-Onsurbe, Gabriel Olmedilla, Ricardo Paniagua and Mar Royuela
    Citation: BMC Cancer 2010 10:18
    Content type: Research article Published on:

  13. High activity of cysteine proteases such as legumain and the cathepsins have been shown to facilitate growth and invasion of a variety of tumor types. In breast cancer, several recent studies have indicated th...

    Authors: Jon J Briggs, Mads H Haugen, Harald T Johansen, Adam I Riker, Magnus Abrahamson, Øystein Fodstad, Gunhild M Mælandsmo and Rigmor Solberg
    Citation: BMC Cancer 2010 10:17
    Content type: Research article Published on:

  14. Dysregulated CD44 expression characterizes most human cancers, including prostate cancer (PCa). PCa loses expression of CD44 standard (CD44s) that is present in benign epithelium, and overexpresses the novel s...

    Authors: Kui Yang, Yaqiong Tang, Gabriel K Habermehl and Kenneth A Iczkowski
    Citation: BMC Cancer 2010 10:16
    Content type: Research article Published on:

  15. Cell lines are commonly used in various kinds of biomedical research in the world. However, it remains uncertain whether genomic alterations existing in primary tumor tissues are represented in cell lines and ...

    Authors: Katumi Tsuji, Shigeto Kawauchi, Soichiro Saito, Tomoko Furuya, Kenzo Ikemoto, Motonao Nakao, Shigeru Yamamoto, Masaaki Oka, Takashi Hirano and Kohsuke Sasaki
    Citation: BMC Cancer 2010 10:15
    Content type: Research article Published on:

  16. Up to one-third of people affected by cancer experience ongoing psychological distress and would benefit from screening followed by an appropriate level of psychological intervention. This rarely occurs in rou...

    Authors: Anna L Hawkes, Karen L Hughes, Sandy D Hutchison and Suzanne K Chambers
    Citation: BMC Cancer 2010 10:14
    Content type: Research article Published on:

  17. The activities of Rac1 and Cdc42 are essential for HRas-induced transformation of rodent fibroblasts. What is more, expression of constitutively activated mutants of Rac1 and/or Cdc42 is sufficient for their m...

    Authors: Daniel M Appledorn, Kim-Hien T Dao, Sandra O'Reilly, Veronica M Maher and J Justin McCormick
    Citation: BMC Cancer 2010 10:13
    Content type: Research article Published on:

  18. Bone metastases are a common and dismal consequence of lung cancer that is a leading cause of death. The role of IL-7 in promoting bone metastases has been previously investigated in NSCLC, but many aspects re...

    Authors: Ilaria Roato, Davide Caldo, Laura Godio, Lucia D'Amico, Paolo Giannoni, Emanuela Morello, Rodolfo Quarto, Luigi Molfetta, Paolo Buracco, Antonio Mussa and Riccardo Ferracini
    Citation: BMC Cancer 2010 10:12
    Content type: Research article Published on:

  19. The X-linked Inhibitor of Apoptosis (XIAP) has attracted much attention as a cancer drug target. It is the only member of the IAP family that can directly inhibit caspase activity in vitro, and it can regulate ap...

    Authors: John Sensintaffar, Fiona L Scott, Robert Peach and Jeffrey H Hager
    Citation: BMC Cancer 2010 10:11
    Content type: Research article Published on:

  20. Chemoresistance is a major obstacle in cancer treatment. Targeted therapies that enhance cancer cell sensitivity to chemotherapeutic agents have the potential to increase drug efficacy while reducing toxic eff...

    Authors: Erin B Dickerson, William H Blackburn, Michael H Smith, Laura B Kapa, L Andrew Lyon and John F McDonald
    Citation: BMC Cancer 2010 10:10
    Content type: Research article Published on:

  21. During the course of normal cellular metabolism, oxygen is consumed and reactive oxygen species (ROS) are produced. If not effectively dissipated, ROS can accumulate and damage resident proteins, lipids, and D...

    Authors: Carol D Curtis, Daniel L Thorngren and Ann M Nardulli
    Citation: BMC Cancer 2010 10:9
    Content type: Research article Published on:

  22. To investigate the relationship between the magnetic resonance imaging (MRI) features of breast cancer and its clinicopathological and biological factors.

    Authors: Oscar Fernández-Guinea, Alejandro Andicoechea, Luis O González, Salomé González-Reyes, Antonio M Merino, Luis C Hernández, Alfonso López-Muñiz, Paz García-Pravia and Francisco J Vizoso
    Citation: BMC Cancer 2010 10:8
    Content type: Research article Published on:

  23. T-cell protein tyrosine phosphatase (TCPTP/TC45) is a ubiquitously expressed intra-cellular non-receptor protein tyrosine phosphatase involved in the negative regulation of several cancer relevant cellular sig...

    Authors: Elina Mattila, Heidi Marttila, Niko Sahlberg, Pekka Kohonen, Siri Tähtinen, Pasi Halonen, Merja Perälä and Johanna Ivaska
    Citation: BMC Cancer 2010 10:7
    Content type: Research article Published on:

  24. Carcinoid heart disease, a known complication of neuroendocrine tumors, is characterized by right heart fibrotic lesions. Carcinoid heart disease has traditionally been defined by the degree of valvular involv...

    Authors: Deidi Strickland Bergestuen, Jørgen Gravning, Kristina Hermann Haugaa, Laura G Sahakyan, Svend Aakhus, Espen Thiis-Evensen, Erik Øie, Pål Aukrust, Håvard Attramadal and Thor Edvardsen
    Citation: BMC Cancer 2010 10:6
    Content type: Research article Published on:

  25. Dendritic cells (DCs) have the potential for cancer immunotherapy due to their ability to process and present antigens to T-cells and also in stimulating immune responses. However, DC-based vaccines have only ...

    Authors: Sitti Rahma Abdul Hafid, Ammu Kutty Radhakrishnan and Kalanithi Nesaretnam
    Citation: BMC Cancer 2010 10:5
    Content type: Research article Published on:

  26. Evidence suggests that tumor cells exposed to some DNA damaging agents are more likely to die if they retain microscopically visible γH2AX foci that are known to mark sites of double-strand breaks. This appear...

    Authors: Judit P Banáth, Dmitry Klokov, Susan H MacPhail, C Adriana Banuelos and Peggy L Olive
    Citation: BMC Cancer 2010 10:4
    Content type: Research article Published on:

  28. Pegylated liposomal doxorubicin (PLD) is active in metastatic breast cancer. This observational study evaluated the efficacy and safety of PLD in patients treated during routine clinical practice.

    Authors: Jens Huober, Werner Fett, Arnd Nusch, Michael Neise, Marcus Schmidt, Arthur Wischnik, Steffen Gerhardt, Thomas Goehler, Hans-Joachim Lück and Andreas Rost
    Citation: BMC Cancer 2010 10:2
    Content type: Research article Published on:

  29. A common treatment option for men with prostate cancer is androgen deprivation therapy (ADT). However, men undergoing ADT may experience physical side effects, changes in quality of life and sometimes psychiat...

    Authors: Monique M Cherrier, Paul R Borghesani, Amy L Shelton and Celestia S Higano
    Citation: BMC Cancer 2010 10:1
    Content type: Research article Published on:

  30. Establishing clinically relevant animal models of glioblastoma multiforme (GBM) remains a challenge, and many commonly used cell line-based models do not recapitulate the invasive growth patterns of patient GB...

    Authors: Jian Wang, Hrvoje Miletic, Per Ø Sakariassen, Peter C Huszthy, Hege Jacobsen, Narve Brekkå, Xingang Li, Peng Zhao, Sverre Mørk, Martha Chekenya, Rolf Bjerkvig and Per Ø Enger
    Citation: BMC Cancer 2009 9:465
    Content type: Research article Published on:

  31. Studies of the role of the cytokine macrophage-migration-inhibitory-factor (MIF) in malignant tumors have revealed its stimulating influence on cell-cycle progression, angiogenesis and anti-apoptosis.

    Authors: Jörg Schrader, Oliver Deuster, Birgit Rinn, Martina Schulz, Andreas Kautz, Richard Dodel, Bernhard Meyer, Yousef Al-Abed, Karthikeyan Balakrishnan, Jens P Reese and Michael Bacher
    Citation: BMC Cancer 2009 9:464
    Content type: Research article Published on:

  32. Costimulatory signaling has been implicated as a potential regulator of antitumor immunity in various human cancers. In contrast to the negative prognostic value of aberrant B7-H1 expression by pancreatic canc...

    Authors: Martin Loos, Dennis M Hedderich, Malte Ottenhausen, Nathalia A Giese, Melanie Laschinger, Irene Esposito, Jörg Kleeff and Helmut Friess
    Citation: BMC Cancer 2009 9:463
    Content type: Research article Published on:

  34. Trimethylation of lysine 27 on histone H3 (H3K27me3) by enhancer of zeste homolog 2 (EZH2) is an epigenetic mark that mediates gene silencing. EZH2 is overexpressed and correlates with poor prognosis in many c...

    Authors: Li-Ru He, Meng-Zhong Liu, Bin-Kui Li, Hui-Lan Rao, Yi-Ji Liao, Xin-Yuan Guan, Yi-Xin Zeng and Dan Xie
    Citation: BMC Cancer 2009 9:461
    Content type: Research article Published on:

  35. To date, there is no consensus on the utility of screening procedures for the early detection of endometrial cancer. The value of transvaginal ultrasound for screening of asymptomatic endometrial cancer has be...

    Authors: Veronika Seebacher, Maximilian Schmid, Stephan Polterauer, Katrin Hefler-Frischmuth, Heinz Leipold, Nicole Concin, Alexander Reinthaller and Lukas Hefler
    Citation: BMC Cancer 2009 9:460
    Content type: Research article Published on:

  37. The purpose of this study was to compare plasma levels of antioxidants and oxidative stress biomarkers in head and neck squamous cell carcinoma (HNSCC) patients with healthy controls. Furthermore, the effect o...

    Authors: Amrit K Sakhi, Kjell M Russnes, Magne Thoresen, Nasser E Bastani, Anette Karlsen, Sigbjørn Smeland and Rune Blomhoff
    Citation: BMC Cancer 2009 9:458
    Content type: Research article Published on:

  38. About 5-10% of breast cancer is due to inherited disease predisposition. Many previously identified susceptibility factors are involved in the maintenance of genomic integrity. AATF plays an important role in ...

    Authors: Maria Haanpää, Mervi Reiman, Jenni Nikkilä, Hannele Erkko, Katri Pylkäs and Robert Winqvist
    Citation: BMC Cancer 2009 9:457
    Content type: Research article Published on:

  39. Salivary adenoid cystic carcinoma (SACC) is one of the most common malignancies of salivary gland. Recurrence or/and early metastasis is its biological properties. In SACC, neoplastic myoepithelial cells secre...

    Authors: Hong Shi, Jie Wang, Fusheng Dong, Xu Wang, Hexiang Li and Yali Hou
    Citation: BMC Cancer 2009 9:456
    Content type: Research article Published on:

  40. Although primary lymphomas of the central nervous system (PCNSL) and extracerebral diffuse large B-cell lymphoma (DLBCL) cannot be distinguished histologically, it is still a matter of debate whether PCNSL dif...

    Authors: Julia Richter, Ole Ammerpohl, José I Martín-Subero, Manuel Montesinos-Rongen, Marina Bibikova, Eliza Wickham-Garcia, Otmar D Wiestler, Martina Deckert and Reiner Siebert
    Citation: BMC Cancer 2009 9:455
    Content type: Research article Published on:

  41. Alterations of mitochondrial DNA (mtDNA) have been implicated in carcinogenesis. We developed an accurate multiplex quantitative real-time PCR for synchronized determination of mtDNA and nuclear DNA (nDNA). We...

    Authors: Peng Xia, Han-Xiang An, Cheng-Xue Dang, Ramin Radpour, Corina Kohler, Emmanouil Fokas, Rita Engenhart-Cabillic, Wolfgang Holzgreve and Xiao Yan Zhong
    Citation: BMC Cancer 2009 9:454
    Content type: Research article Published on:

  42. The High Resolution Melting (HRM) technology has recently been introduced as a rapid and robust analysis tool for the detection of DNA methylation. The methylation status of multiple tumor suppressor genes may...

    Authors: Lasse S Kristensen, Tomasz K Wojdacz, Britta B Thestrup, Carsten Wiuf, Henrik Hager and Lise Lotte Hansen
    Citation: BMC Cancer 2009 9:453
    Content type: Research article Published on:

  43. Prostate cancer cells in primary tumors have been typed CD10-/CD13-/CD24hi/CD26+/CD38lo/CD44-/CD104-. This CD phenotype suggests a lineage relationship between cancer cells and luminal cells. The Gleason grade of...

    Authors: Laura E Pascal, Ricardo ZN Vêncio, Laura S Page, Emily S Liebeskind, Christina P Shadle, Pamela Troisch, Bruz Marzolf, Lawrence D True, Leroy E Hood and Alvin Y Liu
    Citation: BMC Cancer 2009 9:452
    Content type: Research article Published on:

  45. We evaluated the hierarchical risk groups for the estimated survival of WHO grade III glioma patients using recursive partitioning analysis (RPA). To our knowledge, this is the first study to address the resul...

    Authors: Chul-Kee Park, Se-Hoon Lee, Jung Ho Han, Chae-Yong Kim, Dong-Wan Kim, Sun Ha Paek, Dong Gyu Kim, Dae Seog Heo, Il Han Kim and Hee-Won Jung
    Citation: BMC Cancer 2009 9:450
    Content type: Research article Published on:

  46. Compound K [20-O-β-(D-glucopyranosyl)-20(S)-protopanaxadiol], a metabolite of the protopanaxadiol-type saponins of Panax ginseng C.A. Meyer, has been reported to possess anti-tumor properties to inhibit angiogene...

    Authors: Sung-Hee Cho, Kyung-Sook Chung, Jung-Hye Choi, Dong-Hyun Kim and Kyung-Tae Lee
    Citation: BMC Cancer 2009 9:449
    Content type: Research article Published on:

  48. Cancer cells display widespread changes in DNA methylation that may lead to genetic instability by global hypomethylation and aberrant silencing of tumor suppressor genes by focal hypermethylation. In turn, al...

    Authors: Silke Götze, Valeska Feldhaus, Thilo Traska, Marietta Wolter, Guido Reifenberger, Andrea Tannapfel, Cornelius Kuhnen, Dirk Martin, Oliver Müller and Sonja Sievers
    Citation: BMC Cancer 2009 9:447
    Content type: Research article Published on:

  49. Hypoxia is associated with increased resistance to chemo- and radiation-therapy. Hyperoxic treatment (hyperbaric oxygen) has previously been shown to potentiate the effect of some forms of chemotherapy, and th...

    Authors: Ingrid Moen, Karl J Tronstad, Odd Kolmannskog, Gerd S Salvesen, Rolf K Reed and Linda EB Stuhr
    Citation: BMC Cancer 2009 9:446
    Content type: Research article Published on:

  50. The MYCN gene is transcribed into two major mRNAs: one full-length (MYCN) and one exon 1b-spliced (MYCN Δ1b ) mRNA. But nothing is known about their respective ability to translate the MYCN protein.

    Authors: Roger Besançon, Sandrine Valsesia-Wittmann, Clara Locher, Céline Delloye-Bourgeois, Lydie Furhman, Giovani Tutrone, Christophe Bertrand, Anne-Catherine Jallas, Elisabeth Garin and Alain Puisieux
    Citation: BMC Cancer 2009 9:445
    Content type: Research article Published on:

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