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  1. Despite extensive research, the five-year survival rate of oral squamous cell carcinoma (OSCC) patients has not improved. Effective treatment of OSCC requires the identification of molecular targets and signal...

    Authors: Sanjukta Chakraborty, SM Azeem Mohiyuddin, KS Gopinath and Arun Kumar
    Citation: BMC Cancer 2008 8:163
  2. p53 is an important tumour suppressor with a known role in the later stages of colorectal cancer, but its relevance to the early stages of neoplastic initiation remains somewhat unclear. Although p53-dependent...

    Authors: Karen R Reed, Valerie S Meniel, Victoria Marsh, Alicia Cole, Owen J Sansom and Alan R Clarke
    Citation: BMC Cancer 2008 8:162
  3. Viscum album (VA) preparations have been used as a complimentary therapy in cancer. In addition to their cytotoxic properties, they have also been shown to have immunostimulatory properties. In the present study...

    Authors: Sri Ramulu Elluru, Jean-Paul Duong van Huyen, Sandrine Delignat, Michel D Kazatchkine, Alain Friboulet, Srini V Kaveri and Jagadeesh Bayry
    Citation: BMC Cancer 2008 8:161
  4. Adenine nucleotide translocase (ANT) is located in the inner mitochondrial membrane and catalyzes the exchange of mitochondrial ATP for cytosolic ADP. ANT has been known to be a major component of the permeabi...

    Authors: Ji-Young Jang, Yun Choi, Yoon-Kyung Jeon, Khin Chaw aYu Aung and Chul-Woo Kim
    Citation: BMC Cancer 2008 8:160
  5. Antisense oligonucleotides against hTR (As-ODN-hTR) have shown promising results as treatment strategies for various human malignancies. All-trans retinoic acid (ATRA) is a signalling molecule with important r...

    Authors: Qin Xu, Zhiyuan Zhang, Ping Zhang and Wantao Chen
    Citation: BMC Cancer 2008 8:159
  6. Our previous study revealed that Vav3 oncogene is overexpressed in human prostate cancer, activates androgen receptor, and stimulates growth in prostate cancer cells. The current study is to determine a potent...

    Authors: Kiwon Lee, Yin Liu, Jun Qin Mo, Jinsong Zhang, Zhongyun Dong and Shan Lu
    Citation: BMC Cancer 2008 8:158
  7. Progress in lung cancer is hampered by the lack of clinically useful diagnostic markers. The goal of this study was to provide a detailed evaluation of lung cancer tumor markers indicative of molecular abnorma...

    Authors: Min Cheng, Yongyan Chen, Xiaoqing Yu, Zhigang Tian and Haiming Wei
    Citation: BMC Cancer 2008 8:156
  8. The identification of a BRCA1 or BRCA2 mutation in familial breast cancer kindreds allows genetic testing of at risk relatives. However, considerable controversy exists regarding the cancer risks in women who tes...

    Authors: D Gareth Evans, Andrew Shenton, Emma Woodward, Fiona Lalloo, Anthony Howell and Eamonn R Maher
    Citation: BMC Cancer 2008 8:155
  9. Inhibitor of DNA binding/Inhibitor of differentiation 4 (ID4) is a critical factor for cell proliferation and differentiation in normal vertebrate development. ID4 has regulative functions for differentiation and...

    Authors: Erik Noetzel, Jürgen Veeck, Dieter Niederacher, Oliver Galm, Felicitas Horn, Arndt Hartmann, Ruth Knüchel and Edgar Dahl
    Citation: BMC Cancer 2008 8:154
  10. Cell lines constitute a powerful model to study cancer, and here we describe three new epithelial ovarian cancer (EOC) cell lines derived from poorly differentiated serous solid tumors (TOV-1946, and TOV-2223G...

    Authors: Véronique Ouellet, Magdalena Zietarska, Lise Portelance, Julie Lafontaine, Jason Madore, Marie-Line Puiffe, Suzanna L Arcand, Zhen Shen, Josée Hébert, Patricia N Tonin, Diane M Provencher and Anne-Marie Mes-Masson
    Citation: BMC Cancer 2008 8:152
  11. Tumour hypoxia is known to be a poor prognostic indicator, predictive of increased risk of metastatic disease and reduced survival. Genomic instability has been proposed as one of the potential mechanisms for ...

    Authors: Tuula M Kalliomäki, Gordon McCallum, Sarah Jane Lunt, Peter G Wells and Richard P Hill
    Citation: BMC Cancer 2008 8:151
  12. In the present study we analyze, in patients with breast cancer, the tumor expression of androgen receptors (AR), its relationship with clinicopathological characteristics and with the expression of several ma...

    Authors: Luis O Gonzalez, Maria D Corte, Julio Vazquez, Sara Junquera, Rosario Sanchez, Ana C Alvarez, Juan C Rodriguez, Maria L Lamelas and Francisco J Vizoso
    Citation: BMC Cancer 2008 8:149
  13. The objective of this study was to evaluate the efficacy and toxicity of infusional 5-fluorouracil (5-FU), folinic acid and oxaliplatin (modified FOLFOX-6) in patients with advanced gastric cancer (AGC), as fi...

    Authors: Bhumsuk Keam, Seock-Ah Im, Sae-Won Han, Hye Seon Ham, Min A Kim, Do-Youn Oh, Se-Hoon Lee, Jee Hyun Kim, Dong-Wan Kim, Tae-You Kim, Dae Seog Heo, Woo Ho Kim and Yung-Jue Bang
    Citation: BMC Cancer 2008 8:148
  14. The 21-kDa Vaccinia virus VH1-related (VHR) dual-specific protein phosphatase (encoded by the DUSP3 gene) plays a critical role in cell cycle progression and is itself regulated during the cell cycle. We have pre...

    Authors: Rachel Henkens, Philippe Delvenne, Mohammad Arafa, Michel Moutschen, Mustapha Zeddou, Lutz Tautz, Jacques Boniver, Tomas Mustelin and Souad Rahmouni
    Citation: BMC Cancer 2008 8:147
  15. BRCA1 and BRCA2 are the two most important genes associated with familial breast and ovarian cancer susceptibility. In addition, PALB2 has recently been identified as a breast cancer susceptibility gene in sever...

    Authors: Katri Pylkäs, Hannele Erkko, Jenni Nikkilä, Szilvia Sólyom and Robert Winqvist
    Citation: BMC Cancer 2008 8:146
  16. The human gene ERH (Enhancer of the Rudimentary gene Homologue) has previously been identified by in silico analysis of four million ESTs as a gene differentially expressed in breast cancer. The biological functi...

    Authors: Menelaos Zafrakas, Inge Losen, Ruth Knüchel and Edgar Dahl
    Citation: BMC Cancer 2008 8:145
  17. RET/PTC (rearranged in transformation/papillary thyroid carcinomas) gene rearrangements are the most frequent genetic alterations identified in papillary thyroid carcinoma. Although it has been established tha...

    Authors: Young-Rae Kim, Hee Sun Byun, Minho Won, Kyeong Ah Park, Jin Man Kim, Byung Lyul Choi, Hyunji Lee, Jang Hee Hong, Jongsun Park, Jeong Ho Seok, Dong Wook Kim, Minho Shong, Seung-Kiel Park and Gang Min Hur
    Citation: BMC Cancer 2008 8:144
  18. IGF binding protein-3 (IGFBP-3) regulates the bioavailability of insulin-like growth factors I and II, and has both anti-proliferative and pro-apoptotic properties. Elevated plasma IGFBP-3 has been associated ...

    Authors: Temitope O Keku, Robert S Sandler, James G Simmons, Joseph Galanko, John T Woosley, Michelle Proffitt, Oluwaseun Omofoye, Maya McDoom and Pauline K Lund
    Citation: BMC Cancer 2008 8:143
  19. Epithelial growth factor receptor (EGFR) and KRAS mutation status have been reported as predictive markers of tumour response to EGFR inhibitors. High resolution melting (HRM) analysis is an attractive screening ...

    Authors: Hongdo Do, Michael Krypuy, Paul L Mitchell, Stephen B Fox and Alexander Dobrovic
    Citation: BMC Cancer 2008 8:142
  20. With improved childhood cancer cure rate, long term sequelae are becoming an important factor of quality of life. Signs of cardiovascular disease are frequently found in long term survivors of cancer. Cardiac ...

    Authors: Veronika Velensek, Uros Mazic, Ciril Krzisnik, Damjan Demšar, Janez Jazbec and Berta Jereb
    Citation: BMC Cancer 2008 8:141
  21. The incidence of breast cancer has doubled over the past 20 years in the Czech Republic. Hereditary factors may be a cause of young onset, bilateral breast or ovarian cancer, and familial accumulation of the d...

    Authors: Eva Machackova, Lenka Foretova, Mirka Lukesova, Petra Vasickova, Marie Navratilova, Ilse Coene, Hana Pavlu, Veronika Kosinova, Jitka Kuklova and Kathleen Claes
    Citation: BMC Cancer 2008 8:140
  22. Previous studies have found differences in the histological subtypes of lung cancers affecting males and females. Our objective was to investigate trends in the incidence of histological subtypes of lung cance...

    Authors: Victoria A Bennett, Elizabeth A Davies, Ruth H Jack, Vivian Mak and Henrik Møller
    Citation: BMC Cancer 2008 8:139
  23. Inherited genetic factors such as E-cadherin (CDH1) promoter variants are believed to influence the risk towards sporadic diffuse gastric cancer (DGC). Recently, a new regulatory region essential for CDH1 transcr...

    Authors: Soroush Nasri, Helen More, Francesco Graziano, Annamaria Ruzzo, Emily Wilson, Anita Dunbier, Cushla McKinney, Tony Merriman, Parry Guilford, Mauro Magnani and Bostjan Humar
    Citation: BMC Cancer 2008 8:138
  24. High incidence rates of gastrointestinal tract cancers have been reported in the Caspian region of Iran. This study aimed to: 1) describe the geographical spatial patterns of gastrointestinal tract cancer inci...

    Authors: Mohammadreza Mohebbi, Mahmood Mahmoodi, Rory Wolfe, Keramat Nourijelyani, Kazem Mohammad, Hojjat Zeraati and Akbar Fotouhi
    Citation: BMC Cancer 2008 8:137
  25. The number of breast cancer patients diagnosed with ductal carcinoma in situ (DCIS) continues to grow. Laboratory and clinical data indicate that DCIS can progress to invasive disease. Carbohydrate-mediated cell-...

    Authors: Soheila Korourian, Eric Siegel, Thomas Kieber-Emmons and Behjatolah Monzavi-Karbassi
    Citation: BMC Cancer 2008 8:136
  26. Gastrointestinal stromal tumors (GIST) exhibit an unpredictable clinical course and can rapidly progress to lethality. Predictions about the biological behavior of GIST are based on a number of canonical clini...

    Authors: Dolores Di Vizio, Francesca Demichelis, Sara Simonetti, Guido Pettinato, Luigi Terracciano, Luigi Tornillo, Michael R Freeman and Luigi Insabato
    Citation: BMC Cancer 2008 8:134
  27. Data exist that demonstrate isoflavones' potent antiproliferative effects on prostate cancer cells. We evaluated the efficacy of isoflavone in patients with PSA recurrent prostate cancer after prior therapy. W...

    Authors: John M Pendleton, Winston W Tan, Satoshi Anai, Myron Chang, Wei Hou, Kathleen T Shiverick and Charles J Rosser
    Citation: BMC Cancer 2008 8:132
  28. Previous studies and biological mechanisms of carcinogenesis suggest that the steroid receptor content of benign breast epithelium may be related to breast cancer risk. The objective in this study was to compa...

    Authors: Christy G Woolcott, Sandip K SenGupta, Wedad M Hanna and Kristan J Aronson
    Citation: BMC Cancer 2008 8:130
  29. The oncoprotein HER-2 is over-expressed and/or has undergone gene amplification in between 20 to 30% of breast and ovarian cancers. HER-2 amplified breast cancer is associated with a poor prognosis and increas...

    Authors: Aisha Siddiqa, Linda M Long, Liuxia Li, Robert A Marciniak and Irene Kazhdan
    Citation: BMC Cancer 2008 8:129
  30. The inactivation of tumor suppressor genes (TSGs) by aberrant DNA methylation plays an important role in the development of malignancy. Since this epigenetic change is reversible, it is a potential target for ...

    Authors: Maryse Lemaire, Guy G Chabot, Noël JM Raynal, Louise F Momparler, Annie Hurtubise, Mark L Bernstein and Richard L Momparler
    Citation: BMC Cancer 2008 8:128
  31. Breast cancer (BC) mortality is declining such that the number of survivors of BC in the community is increasing. BC survivors report a range of sequelae from their cancer and its management beyond the period ...

    Authors: Marijana Lijovic, Susan R Davis, Pam Fradkin, Maria La China, Helen Farrugia, Rory Wolfe and Robin J Bell
    Citation: BMC Cancer 2008 8:126
  32. TRP channels have been shown to be involved in tumour generation and malignant growth. However, the expression of these channels in breast cancer remains unclear. Here we studied the expression and function of...

    Authors: Arnaud Guilbert, Isabelle Dhennin-Duthille, Yassine EL Hiani, Nathalie Haren, Hafida Khorsi, Henri Sevestre, Ahmed Ahidouch and Halima Ouadid-Ahidouch
    Citation: BMC Cancer 2008 8:125
  33. Methotrexate (MTX) uptake is mediated by the reduced folate carrier (RFC). Defective drug uptake in association with decreased RFC expression is a common mechanism of MTX resistance in many tumor types. Heavy ...

    Authors: Rui Yang, Wei-Wei Li, Bang H Hoang, Hansoo Kim, Debabrata Banerjee, Albert Kheradpour, John H Healey, Paul A Meyers, Joseph R Bertino and Richard Gorlick
    Citation: BMC Cancer 2008 8:124
  34. Hypoxia influences tumor growth by inducing angiogenesis and genetic alterations. Hypoxia-inducible factor 1α (HIF-1α), p53, and vascular endothelial growth factor (VEGF) are all important factors in the mecha...

    Authors: Sung Yong Oh, Hyuk-Chan Kwon, Sung-Hyun Kim, Jin Seok Jang, Min Chan Kim, Kyeong Hee Kim, Jin-Yeong Han, Chung Ock Kim, Su-Jin Kim, Jin-sook Jeong and Hyo-Jin Kim
    Citation: BMC Cancer 2008 8:123
  35. Among the most prominent metabolic alterations in cancer cells are the increase in glucose consumption and the conversion of glucose to lactic acid via the reduction of pyruvate even in the presence of oxygen....

    Authors: Christoph Otto, Ulrike Kaemmerer, Bertram Illert, Bettina Muehling, Nadja Pfetzer, Rainer Wittig, Hans Ullrich Voelker, Arnulf Thiede and Johannes F Coy
    Citation: BMC Cancer 2008 8:122
  36. Methyl-CpG binding domain protein 1 (MBD1), a suppressor of gene transcription, may be involved in inactivation of tumor suppressor genes during tumorigenesis. Over-expression of MBD1 has been reported in huma...

    Authors: Chen Liu, Yaohui Chen, Xianjun Yu, Chen Jin, Jin Xu, Jiang Long, Quanxing Ni, Deliang Fu, Hong Jin and Chen Bai
    Citation: BMC Cancer 2008 8:121
  37. Surgical resection of liver metastases arising from colorectal cancer is considered the only curative treatment option. However, many patients subsequently experience disease recurrence. We prospectively inves...

    Authors: Birgit Gruenberger, Werner Scheithauer, Robert Punzengruber, Christoph Zielinski, Dietmar Tamandl and Thomas Gruenberger
    Citation: BMC Cancer 2008 8:120
  38. To gain a better understanding of the effects of therapeutic agents on the tumor microenvironment in invasive cancers, we developed a co-culture model from an invasive lobular carcinoma. Tumor cells expressing...

    Authors: Marie P Piechocki
    Citation: BMC Cancer 2008 8:119
  39. The biological effects of CD24 (FL-80) cross-linking on breast cancer cells have not yet been established. We examined the impact of CD24 cross-linking on human breast cancer cell line MCF-7.

    Authors: Jong Bin Kim, Eunyoung Ko, Wonshik Han, Jeong Eon Lee, Kyung-Min Lee, Incheol Shin, Sangmin Kim, Jong Won Lee, Jihyoung Cho, Ji-Yeon Bae, Hyeon-Gun Jee and Dong-Young Noh
    Citation: BMC Cancer 2008 8:118
  40. The ATM gene has been frequently involved in hereditary breast cancer as a low-penetrance susceptibility gene but evidence regarding the role of ATM as a breast cancer susceptibility gene has been contradictory.

    Authors: Patricio González-Hormazábal, Teresa Bravo, Rafael Blanco, Carlos Y Valenzuela, Fernando Gómez, Enrique Waugh, Octavio Peralta, Waldo Ortuzar, Jose M Reyes and Lilian Jara
    Citation: BMC Cancer 2008 8:117
  41. SNP309 T/G (rs2279744) causes higher levels of MDM2, the most important negative regulator of the p53 tumor suppressor. SNP72 G/C (rs1042522) gives rise to a p53 protein with a greatly reduced capacity to indu...

    Authors: Joerg Bittenbring, Frédérique Parisot, Alain Wabo, Monika Mueller, Lynn Kerschenmeyer, Markus Kreuz, Lorenz Truemper, Olfert Landt, Alain Menzel, Michael Pfreundschuh and Klaus Roemer
    Citation: BMC Cancer 2008 8:116
  42. The polymorphism SNP309 (rs2279744) in the promoter region of the MDM2 gene has been shown to alter protein expression and may play a role in the susceptibility to lung cancer. The MDM2 protein is a key inhibitor...

    Authors: Kirstin Mittelstrass, Wiebke Sauter, Albert Rosenberger, Thomas Illig, Maria Timofeeva, Norman Klopp, Hendrik Dienemann, Eckart Meese, Gerhard Sybrecht, Gabi Woelke, Mathias Cebulla, Maria Degen, Harald Morr, Peter Drings, Andreas Groeschel, Karsten Grosse Kreymborg…
    Citation: BMC Cancer 2008 8:113
  43. Patients with chronic inflammatory bowel disease (IBD) are at an increased risk of colorectal cancer (CRC) and it is estimated that one in six persons diagnosed with IBD will develop CRC. This fact suggests th...

    Authors: Janina Suchy, Ewa Kłujszo-Grabowska, Józef Kładny, Cezary Cybulski, Dominika Wokołorczyk, Jolanta Szymańska-Pasternak, Grzegorz Kurzawski, Rodney J Scott and Jan Lubiński
    Citation: BMC Cancer 2008 8:112

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