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  1. Sporadic colorectal cancers (CRC) are multifactorial diseases resulting from the combined effects of numerous genetic, environmental and behavioral risk factors. Genetic association studies have suggested low-...

    Authors: Sébastien Küry, Bruno Buecher, Sébastien Robiou-du-Pont, Catherine Scoul, Hélène Colman, Tanguy Le Neel, Claire Le Houérou, Roger Faroux, Jean Ollivry, Bernard Lafraise, Louis-Dominique Chupin, Véronique Sébille and Stéphane Bézieau
    Citation: BMC Cancer 2008 8:326
    Content type: Research article Published on:

  2. Estrogen is an established endometrial carcinogen. One of the most important mediators of estrogenic action is the estrogen receptor alpha. We have investigated whether polymorphic variation in the estrogen re...

    Authors: Sara Wedrén, Lovisa Lovmar, Keith Humphreys, Cecilia Magnusson, Håkan Melhus, Ann-Christine Syvänen, Andreas Kindmark, Ulf Landegren, Maria Lagerström Fermér, Fredrik Stiger, Ingemar Persson, John A Baron and Elisabete Weiderpass
    Citation: BMC Cancer 2008 8:322
    Content type: Research article Published on:

  3. The relationship between Helicobacter pylori infection and pancreatic cancer has been investigated in three previous studies with contradictory results. The aim of the present study was to investigate the associa...

    Authors: Björn Lindkvist, Dorthe Johansen, Anders Borgström and Jonas Manjer
    Citation: BMC Cancer 2008 8:321
    Content type: Research article Published on:

  4. Hypoxia-inducible factor 1 alpha (HIF-1α) is involved in processes promoting carcinogenesis of many tumors. However, its role in the development of colorectal cancer is unknown. To investigate the significance...

    Authors: Nektaria Simiantonaki, Marios Taxeidis, Caren Jayasinghe, Ursula Kurzik-Dumke and Charles James Kirkpatrick
    Citation: BMC Cancer 2008 8:320
    Content type: Research article Published on:

  5. Granulosa cell tumours (GCTs) are frequently seen in menopausal women and are relatively indolent. Although the physiological properties of normal granulosa cells have been studied extensively, little is known...

    Authors: Misa Imai, Miho Muraki, Kiyoshi Takamatsu, Hidekazu Saito, Motoharu Seiki and Yuji Takahashi
    Citation: BMC Cancer 2008 8:319
    Content type: Research article Published on:

  6. Anthracyclines and taxanes are commonly used in the treatment of breast cancer. However, tumor resistance to these drugs often develops, possibly due to overexpression of drug transporters. It remains unclear ...

    Authors: Stacey L Hembruff, Monique L Laberge, David J Villeneuve, Baoqing Guo, Zachary Veitch, Melanie Cecchetto and Amadeo M Parissenti
    Citation: BMC Cancer 2008 8:318
    Content type: Research article Published on:

  7. Epidemiological studies suggested the chemopreventive role of higher calcium intake in colorectal carcinogenesis. We examined genetic polymorphisms that might influence calcium metabolism: lactase (LCT) gene 1...

    Authors: Krisztián Bácsi, Erika Hitre, János P Kósa, Henrik Horváth, Áron Lazáry, Péter L Lakatos, Bernadett Balla, Barna Budai, Péter Lakatos and Gábor Speer
    Citation: BMC Cancer 2008 8:317
    Content type: Research article Published on:

  8. Epidemiological studies suggest that physical activity reduces the risk of colon cancer in humans. Results from animal studies, however, are inconclusive. The present study investigated the effects of voluntar...

    Authors: Jihyeung Ju, Bonnie Nolan, Michelle Cheh, Mousumi Bose, Yong Lin, George C Wagner and Chung S Yang
    Citation: BMC Cancer 2008 8:316
    Content type: Research article Published on:

  9. Transcriptional profiling of prostate cancer (PC) has unveiled new markers of neoplasia and allowed insights into mechanisms underlying this disease. Genomewide analyses have also identified new chromosomal ab...

    Authors: Raquel Bermudo, David Abia, Berta Ferrer, Iracema Nayach, Alberto Benguria, Ángel Zaballos, Javier del Rey, Rosa Miró, Elías Campo, Carlos Martínez-A, Ángel R Ortiz, Pedro L Fernández and Timothy M Thomson
    Citation: BMC Cancer 2008 8:315
    Content type: Research article Published on:

  10. Accurate staging of rectal tumors is essential for making the correct treatment choice. In a previous study, we found that loss of 17p, 18q and gain of 8q, 13q and 20q could distinguish adenoma from carcinoma ...

    Authors: Esther H Lips, Ronald van Eijk, Eelco JR de Graaf, Jan Oosting, Noel FCC de Miranda, Tom Karsten, Cornelis J van de Velde, Paul HC Eilers, Rob AEM Tollenaar, Tom van Wezel and Hans Morreau
    Citation: BMC Cancer 2008 8:314
    Content type: Research article Published on:

  11. Doxorubicin is considered one of the most potent established chemotherapeutics in the treatment of liposarcoma; however, the response rates usually below 30%, are still disappointing. This study was performed ...

    Authors: Adrien Daigeler, Ludger Klein-Hitpass, Ansgar Michael Chromik, Oliver Müller, Jörg Hauser, Heinz-Herbert Homann, Hans-Ulrich Steinau and Marcus Lehnhardt
    Citation: BMC Cancer 2008 8:313
    Content type: Research article Published on:

  12. Heat shock protein 90 (Hsp90) overexpression has been implicated in breast carcinogenesis, with putative prognostic and therapeutic implications. The purpose of this study is to evaluate the immunohistochemica...

    Authors: Flora Zagouri, Afrodite Nonni, Theodoros N Sergentanis, Christos A Papadimitriou, Nikolaos V Michalopoulos, Andreas C Lazaris, Efstratios Patsouris and George C Zografos
    Citation: BMC Cancer 2008 8:312
    Content type: Research article Published on:

  13. The ageing of the population is expected to bring an enormous growth in demand for oncological health care. In order to anticipate and respond to future trends, cancer care needs to be critically evaluated. Th...

    Authors: Ron Pritzkuleit, Annika Waldmann, Heiner Raspe and Alexander Katalinic
    Citation: BMC Cancer 2008 8:311
    Content type: Research article Published on:

  14. Lactic acid bacteria (LAB) are beneficial probiotic organisms that contribute to improved nutrition, microbial balance, and immuno-enhancement of the intestinal tract, as well as anti-tumor activity. The aim o...

    Authors: Do Kyung Lee, Seok Jang, Mi Jin Kim, Jung Hyun Kim, Myung Jun Chung, Kyung Jae Kim and Nam Joo Ha
    Citation: BMC Cancer 2008 8:310
    Content type: Research article Published on:

  15. Triple-negative breast cancer (estrogen receptor-, progesterone receptor-, and HER2-negative) (TNBC) is a high risk breast cancer that lacks specific therapy targeting these proteins.

    Authors: Tatsuya Toyama, Hiroko Yamashita, Naoto Kondo, Katsuhiro Okuda, Satoru Takahashi, Hidefumi Sasaki, Hiroshi Sugiura, Hirotaka Iwase and Yoshitaka Fujii
    Citation: BMC Cancer 2008 8:309
    Content type: Research article Published on:

  16. 14-3-3 sigma (σ) promotes G2/M cell cycle arrest by sequestering cyclin B1-CDC2 complex in cytoplasm. Down-regulation of 14-3-3σ, which has been demonstrated in various carcinomas, may contribute to malignant ...

    Authors: Zhihui Wang, Claes G Tropè, Zhenhe Suo, Gunhild Trøen, Guanrui Yang, Jahn M Nesland and Ruth Holm
    Citation: BMC Cancer 2008 8:308
    Content type: Research article Published on:

  17. Triple-negative (TN) breast cancer, which is defined as being negative for the estrogen receptor (ER), the progesterone receptor (PR), and the human epidermal growth factor receptor 2 (HER-2), represents a sub...

    Authors: Jiyoung Rhee, Sae-Won Han, Do-Youn Oh, Jee Hyun Kim, Seock-Ah Im, Wonshik Han, In Ae Park, Dong-Young Noh, Yung-Jue Bang and Tae-You Kim
    Citation: BMC Cancer 2008 8:307
    Content type: Research article Published on:

  18. Bone marrow-derived stromal cells (BMSCs) are important for development, tissue cell replenishment, and wound healing in physiological and pathological conditions. BMSCs were found to preferably reach sites un...

    Authors: M Hu, J-L Yang, H Teng, Y-Q Jia, R Wang, X-W Zhang, Y Wu, Y Luo, X-C Chen, R Zhang, L Tian, X Zhao and Y-Q Wei
    Citation: BMC Cancer 2008 8:306
    Content type: Research article Published on:

  19. Obesity in postmenopausal women is associated with increased breast cancer risk, development of more aggressive tumors and resistance to certain anti-breast cancer treatments. Some of these effects might be me...

    Authors: Elena Fiorio, Anna Mercanti, Marianna Terrasi, Rocco Micciolo, Andrea Remo, Alessandra Auriemma, Annamaria Molino, Veronica Parolin, Bruno Di Stefano, Franco Bonetti, Antonio Giordano, Gian Luigi Cetto and Eva Surmacz
    Citation: BMC Cancer 2008 8:305
    Content type: Research article Published on:

  20. Despite the advances made during decades of research, the mechanisms by which glioma is initiated and established remain elusive. The discovery of glioma stem cells (GSCs) may help to elucidate the processes o...

    Authors: Qiang Huang, Quan-Bin Zhang, Jun Dong, Yin-Yan Wu, Yun-Tian Shen, Yao-Dong Zhao, Yu-De Zhu, Yi Diao, Ai-Dong Wang and Qing Lan
    Citation: BMC Cancer 2008 8:304
    Content type: Research article Published on:

  21. NDRG2 (N-Myc downstream-regulated gene 2) was initially cloned in our laboratory. Previous results have shown that NDRG2 expressed differentially in normal and cancer tissues. Specifically, NDRG2 mRNA was down-r...

    Authors: Huadong Zhao, Jian Zhang, Jianguo Lu, Xianli He, Changsheng Chen, Xiaojun Li, Li Gong, Guoqiang Bao, Qiang Fu, Suning Chen, Wei Lin, Hai Shi, Jianjun Ma, Xinping Liu, Qingjiu Ma and Libo Yao
    Citation: BMC Cancer 2008 8:303
    Content type: Research article Published on:

  22. Many cancers, including breast cancer, have been identified with increased levels of phosphorylated or the active form of Signal Transducers and Activators of Transcription 3 (STAT3) protein. However, whether ...

    Authors: Jacqueline C Lieblein, Sarah Ball, Brian Hutzen, A Kate Sasser, Huey-Jen Lin, Tim HM Huang, Brett M Hall and Jiayuh Lin
    Citation: BMC Cancer 2008 8:302
    Content type: Research article Published on:

  23. Protease activated receptor-2 (PAR-2) has been implicated in cellular proliferation, invasion and metastasis in various tumors. Lymph node metastasis is an important patient prognostic factor for uterine cervi...

    Authors: Israt Jahan, Jiro Fujimoto, Syed Mahfuzul Alam, Eriko Sato and Teruhiko Tamaya
    Citation: BMC Cancer 2008 8:301
    Content type: Research article Published on:

  24. Nestin was originally identified as a class VI intermediate filament protein that is expressed in stem cells and progenitor cells in the mammalian CNS during development. This protein is replaced in the adult ...

    Authors: Renata Veselska, Marketa Hermanova, Tomas Loja, Petr Chlapek, Iva Zambo, Karel Vesely, Karel Zitterbart and Jaroslav Sterba
    Citation: BMC Cancer 2008 8:300
    Content type: Research article Published on:

  25. Chronic myelomonocytic leukemia (CMML) is a hematological disease close to, but separate from both myeloproliferative disorders (MPD) and myelodysplastic syndromes and may show either myeloproliferative (MP-CM...

    Authors: Véronique Gelsi-Boyer, Virginie Trouplin, José Adélaïde, Nicola Aceto, Virginie Remy, Stephane Pinson, Claude Houdayer, Christine Arnoulet, Danielle Sainty, Mohamed Bentires-Alj, Sylviane Olschwang, Norbert Vey, Marie-Joëlle Mozziconacci, Daniel Birnbaum and Max Chaffanet
    Citation: BMC Cancer 2008 8:299
    Content type: Research article Published on:

  26. While increased urokinase-type plasminogen activator (uPA) expression in breast cancer tissue is directly associated with poor prognosis, recent evidence suggests that uPA overexpression may suppress tumor gro...

    Authors: Wenyi Qin, Weizhu Zhu, John E Hewett, George Rottinghaus, Yin-Chieh Chen, John T Flynn, Beth Kliethermes, Ferdinando Mannello and Edward R Sauter
    Citation: BMC Cancer 2008 8:298
    Content type: Research article Published on:

  27. Genomic alterations of the proto-oncogene c-erbB-2 (HER-2/neu) are associated with aggressive behavior and poor prognosis in patients with breast cancer. The variable clinical outcomes seen in patients with si...

    Authors: Rachel E Ellsworth, Darrell L Ellsworth, Heather L Patney, Brenda Deyarmin, Brad Love, Jeffrey A Hooke and Craig D Shriver
    Citation: BMC Cancer 2008 8:297
    Content type: Research article Published on:

  28. Papillary thyroid microcarcinoma (PTMC) is defined as a papillary thyroid carcinoma less than or equal to 1.0 cm in size. Independent prognostic factors for clinical recurrence of PTMC have not been clearly de...

    Authors: Tae Yong Kim, Suck Joon Hong, Jung Min Kim, Won Gu Kim, Gyungyub Gong, Jin Sook Ryu, Won Bae Kim, Sung-Cheol Yun and Young Kee Shong
    Citation: BMC Cancer 2008 8:296
    Content type: Research article Published on:

  29. The prediction of response to treatment would be valuable for managing cervical carcinoma with neoadjuvant chemotherapy.

    Authors: Chel Hun Choi, Sang Yong Song, Jung-Joo Choi, Young Ae Park, Heeseok Kang, Tae-Joong Kim, Jeong-Won Lee, Byoung-Gie Kim, Je-Ho Lee and Duk-Soo Bae
    Citation: BMC Cancer 2008 8:295
    Content type: Research article Published on:

  31. Since the second half of the 1990s, kidney cancer mortality has tended to stabilize and decline in many European countries, due to the decrease in the prevalence of smokers. Nevertheless, incidence of kidney c...

    Authors: Gonzalo López-Abente, Nuria Aragonés, Beatriz Pérez-Gómez, Rebeca Ramis, Enrique Vidal, Javier García-Pérez, Pablo Fernández-Navarro and Marina Pollán
    Citation: BMC Cancer 2008 8:293
    Content type: Research article Published on:

  32. In recent years, numerous studies have investigated somatic mutations in mitochondrial DNA in various tumours. The observed high mutation rates might reflect mitochondrial deregulation; consequently, mutation ...

    Authors: Piotr Bragoszewski, Jolanta Kupryjanczyk, Ewa Bartnik, Andrea Rachinger and Jerzy Ostrowski
    Citation: BMC Cancer 2008 8:292
    Content type: Research article Published on:

  33. In order to elucidate tumoral progression and drug resistance, cultured cell lines are valuable tools applied on tumor related assays provided they are well established and characterized. Our laboratory settle...

    Authors: Camila ML Machado, Rafael Y Ikemori, Tatiana Q Zorzeto, Ana CMA Nogueira, Suse DS Barbosa, Wilson Savino, André A Schenka, José Vassallo, Juliana K Heinrich, Fátima Boetcher-Luiz and Liana Verinaud
    Citation: BMC Cancer 2008 8:291
    Content type: Research article Published on:

  34. Whereas the antimicrobial peptides hBD-2 and -3 are related to inflammation, the constitutively expressed hBD-1 might function as 8p tumour suppressor gene and thus play a key role in control of transcription ...

    Authors: M Wenghoefer, A Pantelis, H Dommisch, W Götz, R Reich, S Bergé, M Martini, JP Allam, S Jepsen, S Merkelbach-Bruse, HP Fischer, N Novak and J Winter
    Citation: BMC Cancer 2008 8:290
    Content type: Research article Published on:

  35. The oncoproteins of human papillomavirus (HPVs) directly effect cell-cycle control. We hypothesize that regulatory and cell cycle protein expression might be additionally modified in the cervix of HIV/HPV co-i...

    Authors: Alcina F Nicol, Andréa Rodrigues Cordovil Pires, Simone R de Souza, Gerard J Nuovo, Beatriz Grinsztejn, Aparecida Tristão, Fabio B Russomano, Luciane Velasque, José R Lapa e Silva and Claude Pirmez
    Citation: BMC Cancer 2008 8:289
    Content type: Research article Published on:

  36. Rearrangement of the short arm of chromosome 8 (8p) is very common in epithelial cancers such as breast cancer. Usually there is an unbalanced translocation breakpoint in 8p12 (29.7 Mb – 38.5 Mb) with loss of ...

    Authors: Susanna L Cooke, Jessica CM Pole, Suet-Feung Chin, Ian O Ellis, Carlos Caldas and Paul AW Edwards
    Citation: BMC Cancer 2008 8:288
    Content type: Research article Published on:

  37. Widespread use of mammography in breast cancer screening has led to the identification of increasing numbers of patients with ductal carcinoma in situ (DCIS). DCIS of the breast with an area of focal invasion 1 m...

    Authors: Yasuhiro Okumura, Yutaka Yamamoto, Zhenhuan Zhang, Tatsuya Toyama, Teru Kawasoe, Mutsuko Ibusuki, Yumi Honda, Ken-ichi Iyama, Hiroko Yamashita and Hirotaka Iwase
    Citation: BMC Cancer 2008 8:287
    Content type: Research article Published on:

  38. Elucidating the molecular mechanisms by which tumors become resistant to Herceptin is critical for the treatment of Her2-overexpressed metastatic breast cancer.

    Authors: Se Hun Kang, Keon Wook Kang, Kyung-Hee Kim, Bumi Kwon, Seok-Ki Kim, Ho-Young Lee, Sun-Young Kong, Eun Sook Lee, Sang-Geun Jang and Byong Chul Yoo
    Citation: BMC Cancer 2008 8:286
    Content type: Research article Published on:

  39. Mutations in the mitochondrial genome (mtgenome) have been associated with cancer and many other disorders. These mutations can be point mutations or deletions, or admixtures (heteroplasmy). The detection of m...

    Authors: John P Jakupciak, Samantha Maragh, Maura E Markowitz, Alissa K Greenberg, Mohammad O Hoque, Anirban Maitra, Peter E Barker, Paul D Wagner, William N Rom, Sudhir Srivastava, David Sidransky and Catherine D O'Connell
    Citation: BMC Cancer 2008 8:285
    Content type: Research article Published on:

  40. Hypermethylation of the TGFBI promoter has been shown to correlate with decreased expression of this gene in human tumor cell lines. In this study, we optimized a methylation-specific polymerase chain reaction (M...

    Authors: Jinesh N Shah, Genze Shao, Tom K Hei and Yongliang Zhao
    Citation: BMC Cancer 2008 8:284
    Content type: Research article Published on:

  41. Understanding risks is considered to be crucial for informed decision-making. Inaccurate risk perception is a common finding in women with a family history of breast cancer attending genetic counseling. As yet...

    Authors: Caroline F Ockhuysen-Vermey, Lidewij Henneman, Christi J van Asperen, Jan C Oosterwijk, Fred H Menko and Daniëlle RM Timmermans
    Citation: BMC Cancer 2008 8:283
    Content type: Study protocol Published on:

  43. A functional polymorphism within MDM2, SNP309 T>G, has been linked to early onset cancer. This study examined clinical associations of breast cancer with SNP309 in a Scottish Caucasian population and investiga...

    Authors: Fiona EM Paulin, Mary O'Neill, Gillian McGregor, Andrew Cassidy, Alison Ashfield, Clinton W Ali, Alastair J Munro, Lee Baker, Colin A Purdie, David P Lane and Alastair M Thompson
    Citation: BMC Cancer 2008 8:281
    Content type: Research article Published on:

  44. Musashi1 (Msi1) is an RNA binding protein with a central role during nervous system development and stem cell maintenance. High levels of Msi1 have been reported in several malignancies including brain tumors ...

    Authors: Patricia C Sanchez-Diaz, Tarea L Burton, Suzanne C Burns, Jaclyn Y Hung and Luiz OF Penalva
    Citation: BMC Cancer 2008 8:280
    Content type: Research article Published on:

  45. Vascular endothelial growth factor (VEGF) is a potent angiogenic cytokine produced physiologically by the uterus. Pathological secretion by tumours promotes growth and metastasis. High circulating VEGF levels ...

    Authors: Aoife J Lowery, Karl J Sweeney, Alan P Molloy, Emer Hennessy, Catherine Curran and Michael J Kerin
    Citation: BMC Cancer 2008 8:279
    Content type: Research article Published on:

  46. Many women in Iran have a relatively high body mass index. To investigate whether the condition contributes to excess breast cancer cases, a case-control study was conducted to assess the relationships between...

    Authors: Ali Montazeri, Jila Sadighi, Faranak Farzadi, Farzaneh Maftoon, Mariam Vahdaninia, Mariam Ansari, Akram Sajadian, Mandana Ebrahimi, Shahpar Haghighat and Iraj Harirchi
    Citation: BMC Cancer 2008 8:278
    Content type: Research article Published on:

  47. DNA microarray analysis has great potential to become an important clinical tool to individualize prognostication and treatment for breast cancer patients. However, with any emerging technology, there are many...

    Authors: Vietty Wong, Dong-Yu Wang, Keisha Warren, Supriya Kulkarni, Scott Boerner, Susan Jane Done and Wey Liang Leong
    Citation: BMC Cancer 2008 8:277
    Content type: Research article Published on:

  48. The molecular mechanisms underlying melanoma tumor development and progression are still not completely understood. One of the new candidates that emerged from a recent gene expression profiling study is fatty ac...

    Authors: Ana Slipicevic, Kjersti Jørgensen, Martina Skrede, Anne Katrine Ree Rosnes, Gunhild Trøen, Ben Davidson and Vivi Ann Flørenes
    Citation: BMC Cancer 2008 8:276
    Content type: Research article Published on:

  49. This retrospective study aims to determine: 1) the sensitivity of preoperative mammography (Mx) and ultrasound (US), and re-reviewed Mx to detect multifocal multicentric breast carcinoma (MMBC), defined by pat...

    Authors: Anna Bozzini, Giuseppe Renne, Lorenza Meneghetti, Giuseppe Bandi, Gabriela Santos, Anna Rita Vento, Simona Menna, Stefania Andrighetto, Giuseppe Viale, Enrico Cassano and Massimo Bellomi
    Citation: BMC Cancer 2008 8:275
    Content type: Research article Published on:

  50. Metastasis to regional lymph nodes is a common step in the progression of cancer. Recent evidence suggests that tumor production of CXCR4 promotes lymph node metastasis. Nitric oxide (NO) may also increase met...

    Authors: Hironao Yasuoka, Rieko Kodama, Mitsuyoshi Hirokawa, Yuuki Takamura, Akira Miyauchi, Tokio Sanke and Yasushi Nakamura
    Citation: BMC Cancer 2008 8:274
    Content type: Research article Published on:

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