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  1. Prostate cancer cells in primary tumors have been typed CD10-/CD13-/CD24hi/CD26+/CD38lo/CD44-/CD104-. This CD phenotype suggests a lineage relationship between cancer cells and luminal cells. The Gleason grade of...

    Authors: Laura E Pascal, Ricardo ZN Vêncio, Laura S Page, Emily S Liebeskind, Christina P Shadle, Pamela Troisch, Bruz Marzolf, Lawrence D True, Leroy E Hood and Alvin Y Liu
    Citation: BMC Cancer 2009 9:452
  2. Compound K [20-O-β-(D-glucopyranosyl)-20(S)-protopanaxadiol], a metabolite of the protopanaxadiol-type saponins of Panax ginseng C.A. Meyer, has been reported to possess anti-tumor properties to inhibit angiogene...

    Authors: Sung-Hee Cho, Kyung-Sook Chung, Jung-Hye Choi, Dong-Hyun Kim and Kyung-Tae Lee
    Citation: BMC Cancer 2009 9:449
  3. Cancer cells display widespread changes in DNA methylation that may lead to genetic instability by global hypomethylation and aberrant silencing of tumor suppressor genes by focal hypermethylation. In turn, al...

    Authors: Silke Götze, Valeska Feldhaus, Thilo Traska, Marietta Wolter, Guido Reifenberger, Andrea Tannapfel, Cornelius Kuhnen, Dirk Martin, Oliver Müller and Sonja Sievers
    Citation: BMC Cancer 2009 9:447
  4. Hypoxia is associated with increased resistance to chemo- and radiation-therapy. Hyperoxic treatment (hyperbaric oxygen) has previously been shown to potentiate the effect of some forms of chemotherapy, and th...

    Authors: Ingrid Moen, Karl J Tronstad, Odd Kolmannskog, Gerd S Salvesen, Rolf K Reed and Linda EB Stuhr
    Citation: BMC Cancer 2009 9:446
  5. The MYCN gene is transcribed into two major mRNAs: one full-length (MYCN) and one exon 1b-spliced (MYCN Δ1b ) mRNA. But nothing is known about their respective ability to translate the MYCN protein.

    Authors: Roger Besançon, Sandrine Valsesia-Wittmann, Clara Locher, Céline Delloye-Bourgeois, Lydie Furhman, Giovani Tutrone, Christophe Bertrand, Anne-Catherine Jallas, Elisabeth Garin and Alain Puisieux
    Citation: BMC Cancer 2009 9:445
  6. The relevance of angiogenesis inhibition in the treatment of glioblastoma multiforme (GBM) should be considered in the unique context of malignant brain tumours. Although patients benefit greatly from reduced ...

    Authors: Joost JC Verhoeff, Olaf van Tellingen, An Claes, Lukas JA Stalpers, Myra E van Linde, Dirk J Richel, William PJ Leenders and Wouter R van Furth
    Citation: BMC Cancer 2009 9:444
  7. Neuroblastoma is the most common, pediatric, extra-cranial, malignant solid tumor. Despite multimodal therapeutic protocols, outcome for children with a high-risk clinical phenotype remains poor, with long-ter...

    Authors: Paola Scaruffi, Sara Stigliani, Stefano Moretti, Simona Coco, Carla De Vecchi, Francesca Valdora, Alberto Garaventa, Stefano Bonassi and Gian Paolo Tonini
    Citation: BMC Cancer 2009 9:441
  8. Human papillomaviruses (HPV) are the aetiological agents of certain benign and malignant tumours of skin and mucosae; the most important of which is cervical cancer. Also, the incidence of ano-genital warts, H...

    Authors: David M Winder, Siolian LR Ball, Katie Vaughan, Nashat Hanna, Yin Ling Woo, Jürgen-Theodor Fränzer, Jane C Sterling, Margaret A Stanley, Holger Sudhoff and Peter KC Goon
    Citation: BMC Cancer 2009 9:440
  9. Excision repair cross-complementing group 1 (ERCC1) and group 2 (ERCC2), and X-ray repair cross-complementing group 1 (XRCC1) proteins play important roles in the repair of DNA damage and adducts. Single nucle...

    Authors: Zhihua Yin, Baosen Zhou, Qincheng He, Mingchuan Li, Peng Guan, Xuelian Li, Zeshi Cui, Xiaoxia Xue, Meng Su, Rui Ma, Weijun Bai, Shuyue Xia, Yanduo Jiang, Shun Xu, Yi Lv and Xun Li
    Citation: BMC Cancer 2009 9:439
  10. Coregulator proteins are "master regulators", directing transcriptional and posttranscriptional regulation of many target genes, and are critical in many normal physiological processes, but also in hormone dri...

    Authors: Ryan J Hartmaier, Sandrine Tchatchou, Alexandra S Richter, Jay Wang, Sean E McGuire, Todd C Skaar, Jimmy M Rae, Kari Hemminki, Christian Sutter, Nina Ditsch, Peter Bugert, Bernhard HF Weber, Dieter Niederacher, Norbert Arnold, Raymonda Varon-Mateeva, Barbara Wappenschmidt…
    Citation: BMC Cancer 2009 9:438
  11. TrkA (encoded by NTRK1 gene), the high-affinity tyrosine kinase receptor for neurotrophins, is involved in neural crest cell differentiation. Its expression has been reported to be associated with a favourable pr...

    Authors: Beata S Lipska, Elżbieta Drożynska, Paola Scaruffi, Gian Paolo Tonini, Ewa Iżycka-Świeszewska, Szymon Ziętkiewicz, Anna Balcerska, Danuta Perek, Alicja Chybicka, Wojciech Biernat and Janusz Limon
    Citation: BMC Cancer 2009 9:436
  12. Overexpression of Aurora-A and mutant Ras (RasV12) together has been detected in human bladder cancer tissue. However, it is not clear whether this phenomenon is a general event or not. Although crosstalk between...

    Authors: Ya-Shih Tseng, Jenq-Chang Lee, Chi-Ying F Huang and Hsiao-Sheng Liu
    Citation: BMC Cancer 2009 9:435
  13. 5-Fluorouracil(5FU) and oral analogues, such as capecitabine, remain one of the most useful agents for the treatment of colorectal adenocarcinoma. Low toxicity and convenience of administration facilitate use,...

    Authors: Russell D Petty, Leslie M Samuel, Graeme I Murray, Graham MacDonald, Terrence O'Kelly, Malcolm Loudon, Norman Binnie, Emad Aly, Aileen McKinlay, Weiguang Wang, Fiona Gilbert, Scot Semple and Elaina SR Collie-Duguid
    Citation: BMC Cancer 2009 9:434
  14. The response rate of ovarian mucinous carcinomas to paclitaxel/carboplatin is low, prompting interest in targeted molecular therapies. We investigated HER2 expression and amplification, and the potential for t...

    Authors: Jessica N McAlpine, Kimberly C Wiegand, Russell Vang, Brigitte M Ronnett, Anna Adamiak, Martin Köbel, Steve E Kalloger, Kenneth D Swenerton, David G Huntsman, C Blake Gilks and Dianne M Miller
    Citation: BMC Cancer 2009 9:433
  15. Hypoxia-inducible factor 1 alpha (HIF-1α) and vascular endothelial growth factor (VEGF) are frequently overexpressed in numerous types of cancers and are known to be important regulators of angiogenesis. Until...

    Authors: Dan Cao, Mei Hou, Yong-song Guan, Ming Jiang, Yu Yang and Hong-feng Gou
    Citation: BMC Cancer 2009 9:432
  16. Increased ST6Gal I activity has been associated with the α(2,6)sialylation enhancement of membrane glycoconjugates observed in metastatic colorectal carcinomas (CRC). Siaα(2,6)Galβ(1,4)GlcNAc sequence, known a...

    Authors: Clotilde Costa-Nogueira, Susana Villar-Portela, Elisa Cuevas, Emilio Gil-Martín and Almudena Fernández-Briera
    Citation: BMC Cancer 2009 9:431
  17. Studies on the association between prostate cancer and cadmium exposure have yielded conflicting results. This study explored cadmium burden on the risk and phenotype of prostate cancer in men with no evident ...

    Authors: Yi-Chun Chen, Yeong S Pu, Hsi-Chin Wu, Tony T Wu, Ming Kuen Lai, Chun Y Yang and Fung-Chang Sung
    Citation: BMC Cancer 2009 9:429
  18. Ameloblastoma is a frequent odontogenic benign tumor characterized by local invasiveness, high risk of recurrence and occasional metastasis and malignant transformation. Matrix metalloproteinase-2 (MMP-2) prom...

    Authors: Bin Zhang, Jin Zhang, Zhi-Ying Xu and Hong-Liang Xie
    Citation: BMC Cancer 2009 9:427
  19. HIWI, the human homologue of Piwi family, is present in CD34+ hematopoietic stem cells and germ cells, but not in well-differentiated cell populations, indicating that HIWI may play an impotent role in determinin...

    Authors: Wei He, Zhihui Wang, Qi Wang, Qingxia Fan, Chengcao Shou, Junsheng Wang, Karl-Erik Giercksky, Jahn M Nesland and Zhenhe Suo
    Citation: BMC Cancer 2009 9:426
  20. Members of the PDGF family have been suggested as potential biomarkers for papillary thyroid carcinomas (PTC). However, it is known that both expression and stimulatory effect of PDGF ligands can be affected b...

    Authors: Ove Bruland, Øystein Fluge, Lars A Akslen, Hans G Eiken, Johan R Lillehaug, Jan E Varhaug and Per M Knappskog
    Citation: BMC Cancer 2009 9:425
  21. Techniques for detecting circulating tumor cells in the peripheral blood of patients with head and neck cancers may identify individuals likely to benefit from early systemic treatment.

    Authors: Stuart C Winter, Sally-Anne Stephenson, Selva K Subramaniam, Vinidh Paleri, Kien Ha, Conor Marnane, Suren Krishnan and Guy Rees
    Citation: BMC Cancer 2009 9:424
  22. Retinoid Receptors are involved in development and cell homeostasis. Alterations of their expressions have been observed in lung cancer. However, retinoid chemoprevention trials in populations at risk to devel...

    Authors: Stéphane Poulain, Stéphanie Lacomme, Shyue-Fang Battaglia-Hsu, Stanislas du Manoir, Lydia Brochin, Jean-Michel Vignaud and Nadine Martinet
    Citation: BMC Cancer 2009 9:423
  23. Neuroblastoma is a pediatric tumor of neural crest cells that is clinically characterized by its variable evolution, from spontaneous regression to malignancy. Despite many advances in neuroblastoma research, ...

    Authors: Carine Nyalendo, Hervé Sartelet, Stéphane Barrette, Shigeru Ohta, Denis Gingras and Richard Béliveau
    Citation: BMC Cancer 2009 9:422
  24. Along with the development of new cancer therapeutics, more effective tools for the estimation of response to therapy and prediction of disease progression are required for the better management of inoperable ...

    Authors: Sachin Kumar, Randeep Guleria, Vikas Singh, Alok C Bharti, Anant Mohan and Bhudev C Das
    Citation: BMC Cancer 2009 9:421
  25. Although postoperative chemotherapy is widely accepted as the standard modality for Dukes' stage C or earlier stage colorectal cancer (CRC) patients, biomarkers to predict those who may benefit from the therap...

    Authors: Ten-i Godai, Tetsuji Suda, Nobuhiro Sugano, Kazuhito Tsuchida, Manabu Shiozawa, Hironobu Sekiguchi, Akiko Sekiyama, Mitsuyo Yoshihara, Shoichi Matsukuma, Yuji Sakuma, Eiju Tsuchiya, Yoichi Kameda, Makoto Akaike and Yohei Miyagi
    Citation: BMC Cancer 2009 9:420
  26. Androgen deprivation therapy leads to a number of adverse effects including deterioration of the musculoskeletal system and increased risk factors for cardiovascular and metabolic complications. The purpose of...

    Authors: Daniel A Galvão, Nigel Spry, Dennis R Taaffe, James Denham, David Joseph, David S Lamb, Greg Levin, Gillian Duchesne and Robert U Newton
    Citation: BMC Cancer 2009 9:419
  27. Despite well-studied tumor hypoxia in laboratory, little is known about the association with other pathophysiological events in the clinical view. We investigated the prognostic value of hypoxia-inducible fact...

    Authors: Chen-Xin Dai, Qiang Gao, Shuang-Jian Qiu, Min-Jie Ju, Ming-Yan Cai, Yong-Feng Xu, Jian Zhou, Bo-Heng Zhang and Jia Fan
    Citation: BMC Cancer 2009 9:418
  28. TEM1/endosialin is an emerging microvascular marker of tumor angiogenesis. We characterized the expression pattern of TEM1/endosialin in astrocytic and metastatic brain tumors and investigated its role as a ther...

    Authors: Eleanor B Carson-Walter, Bethany N Winans, Melissa C Whiteman, Yang Liu, Sally Jarvela, Hannu Haapasalo, Betty M Tyler, David L Huso, Mahlon D Johnson and Kevin A Walter
    Citation: BMC Cancer 2009 9:417
  29. Tumor-specific cytotoxic T cells and infiltrating lymphocytes are frequently found in tumor tissues in patients with nasopharyngeal carcinoma (NPC). Most patients with NPC, however, especially those with advan...

    Authors: Peng Liu, Bai-Lu Xie, Shao-Hui Cai, Yun-Wen He, Ge Zhang, Yan-Mei Yi and Jun Du
    Citation: BMC Cancer 2009 9:416
  30. Broccoli is a Brassica vegetable that is believed to possess chemopreventive properties. Selenium also shows promise as an anticancer agent. Thus, selenium enrichment of broccoli has the potential to enhance t...

    Authors: Rizky Abdulah, Ahmad Faried, Kenji Kobayashi, Chiho Yamazaki, Eka W Suradji, Kazuto Ito, Kazuhiro Suzuki, Masami Murakami, Hiroyuki Kuwano and Hiroshi Koyama
    Citation: BMC Cancer 2009 9:414
  31. Gastrointestinal stromal tumours (GISTs) represent a heterogeneous group of tumours of mesenchymal origin characterized by gain-of-function mutations in KIT or PDGFRA of the type III receptor tyrosine kinase fami...

    Authors: Jerzy Ostrowski, Marcin Polkowski, Agnieszka Paziewska, Magdalena Skrzypczak, Krzysztof Goryca, Tymon Rubel, Katarzyna Kokoszyñska, Piotr Rutkowski, Zbigniew I Nowecki, Anna Jerzak Vel Dobosz, Dorota Jarosz, Wlodzimierz Ruka and Lucjan S Wyrwicz
    Citation: BMC Cancer 2009 9:413
  32. Pancreatic cancer is an extremely aggressive malignancy. Subjects are afflicted with a variety of disconcerting symptoms, including profound cachexia. Recent data indicate that the outcome of oncological patie...

    Authors: Angela Märten, Moritz N Wente, Jennifer Ose, Markus W Büchler, Ingeborg Rötzer, Christiane Decker-Baumann, Irini Karapanagiotou-Schenkel, Sabine Harig, Jan Schmidt and Dirk Jäger
    Citation: BMC Cancer 2009 9:412
  33. c-Met is a tyrosine kinase receptor for hepatocyte growth factor/scatter factor (HGF/SF), and both c-Met and its ligand are expressed in a variety of tissues. C-Met/HGF/SF signaling is essential for normal emb...

    Authors: Hal E Crosswell, Anindya Dasgupta, Carlos S Alvarado, Tanya Watt, James G Christensen, Pradip De, Donald L Durden and Harry W Findley
    Citation: BMC Cancer 2009 9:411
  34. Y-box binding protein-1 (YB-1) is the prototypic member of the cold shock protein family that fulfills numerous cellular functions. In the nucleus YB-1 protein orchestrates transcription of proliferation-relat...

    Authors: Edgar Dahl, Abdelaziz En-Nia, Frank Wiesmann, Renate Krings, Sonja Djudjaj, Elisabeth Breuer, Thomas Fuchs, Peter J Wild, Arndt Hartmann, Sandra E Dunn and Peter R Mertens
    Citation: BMC Cancer 2009 9:410
  35. Protracted low-dose concurrent chemotherapy combined with radiation has been proposed for enhanced treatment results for esophageal cancer. We evaluated the efficacy and the toxicity of a novel regimen of dail...

    Authors: Satoshi Osawa, Takahisa Furuta, Ken Sugimoto, Takashi Kosugi, Tomohiro Terai, Mihoko Yamade, Yasuhiro Takayanagi, Masafumi Nishino, Yasushi Hamaya, Chise Kodaira, Takanori Yamada, Moriya Iwaizumi, Kosuke Takagaki, Ken-ichi Yoshida, Shigeru Kanaoka and Mutsuhiro Ikuma
    Citation: BMC Cancer 2009 9:408
  36. The xenobiotic transporters, Multidrug Resistance 1 (MDR1/ABCB1) and Breast Cancer Resistance Protein (BCRP/ABCG2) may restrict intestinal absorption of various carcinogens, including heterocyclic amines (HCA) an...

    Authors: Vibeke Andersen, Mette Østergaard, Jane Christensen, Kim Overvad, Anne Tjønneland and Ulla Vogel
    Citation: BMC Cancer 2009 9:407
  37. The Int7G24A variant of transforming growth factor-beta receptor type I (TGFBR1) has been shown to increase the risk for kidney, ovarian, bladder, lung and breast cancers. Its role in colorectal cancer (CRC) has ...

    Authors: Adela Castillejo, Trinidad Mata-Balaguer, Carla Guarinos, María-Isabel Castillejo, Ana Martínez-Cantó, Víctor-Manuel Barberá, Paola Montenegro, Enrique Ochoa, Rafael Lázaro, Carmen Guillén-Ponce, Alfredo Carrato and José-Luís Soto
    Citation: BMC Cancer 2009 9:406
  38. Depending on the population studied, large genomic rearrangements (LGRs) of the mismatch repair (MMR) genes constitute various proportions of the germline mutations that predispose to hereditary non-polyposis col...

    Authors: Katarina Zavodna, Tomas Krivulcik, Maria Gerykova Bujalkova, Tomas Slamka, David Martinicky, Denisa Ilencikova and Zdena Bartosova
    Citation: BMC Cancer 2009 9:405
  39. It has been speculated that the biostimulatory effect of Low Level Laser Therapy could cause undesirable enhancement of tumor growth in neoplastic diseases. The aim of the present study is to analyze the behav...

    Authors: Lúcio Frigo, Juliana SS Luppi, Giovani M Favero, Durnavei A Maria, Sócrates C Penna, Jan M Bjordal, Rene J Bensadoun and Rodrigo AB Lopes-Martins
    Citation: BMC Cancer 2009 9:404
  40. The seroprevalence of IgG antibodies of Streptococcus gallolyticus subspecies gallolyticus, CIP 105428, was evaluated to investigate the controversial association of S. gallolyticus with colorectal carcinoma and ...

    Authors: Ahmed S Abdulamir, Rand R Hafidh, Layla K Mahdi, Tarik Al-jeboori and Fatimah Abubaker
    Citation: BMC Cancer 2009 9:403
  41. Epithelial cell adhesion molecule EpCAM is a transmembrane glycoprotein, which is frequently over-expressed in simple epithelia, progenitors, embryonic and tissue stem cells, carcinoma and cancer-initiating ce...

    Authors: Sabine Denzel, Dorothea Maetzel, Brigitte Mack, Carola Eggert, Gabriele Bärr and Olivier Gires
    Citation: BMC Cancer 2009 9:402
  42. Colon cancer arises from the accumulation of multiple genetic and epigenetic alterations to normal colonic tissue. microRNAs (miRNAs) are small, non-coding regulatory RNAs that post-transcriptionally regulate ...

    Authors: Aaron L Sarver, Amy J French, Pedro M Borralho, Venugopal Thayanithy, Ann L Oberg, Kevin AT Silverstein, Bruce W Morlan, Shaun M Riska, Lisa A Boardman, Julie M Cunningham, Subbaya Subramanian, Liang Wang, Tom C Smyrk, Cecilia MP Rodrigues, Stephen N Thibodeau and Clifford J Steer
    Citation: BMC Cancer 2009 9:401

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