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  1. We aimed to investigate the prevalence and predictors of Complementary and Alternative Medicine (CAM) use among cancer patients and non-cancer volunteers, and to assess the knowledge of and attitudes toward CA...

    Authors: Kah Hoong Chang, Rachel Brodie, Mei Ann Choong, Karl J Sweeney and Michael J Kerin
    Citation: BMC Cancer 2011 11:196
    Content type: Research article Published on:

  2. Earlier studies have reported the production of histamine in colorectal cancers (CRCs). The effect of histamine is largely determined locally by the histamine receptor expression pattern. Recent evidence sugge...

    Authors: Zhengyu Fang, Wantong Yao, Yi Xiong, Jiana Li, Li Liu, Lei Shi, Wei Zhang, Chao Zhang, Liping Nie and Jun Wan
    Citation: BMC Cancer 2011 11:195
    Content type: Research article Published on:

  3. Major histocompatibility complex class I-related chain A and B (MICA/B) are two stress-inducible ligands that bind the immunoreceptor NKG2D and play an important role in mediating the cyotoxicity of NK and T c...

    Authors: Xiulong Xu, Geetha S Rao, Veronika Groh, Thomas Spies, Paolo Gattuso, Howard L Kaufman, Janet Plate and Richard A Prinz
    Citation: BMC Cancer 2011 11:194
    Content type: Research article Published on:

  4. Cancer patients routinely develop symptoms consistent with profound circadian disruption, which causes circadian disruption diminished quality of life. This study was initiated to determine the relationship be...

    Authors: James F Grutsch, Carol Ferrans, Patricia A Wood, Jovelyn Du-Quiton, Dinah Faith T Quiton, Justin L Reynolds, Christine M Ansell, Eun Young Oh, Mary Ann Daehler, Robert D Levin, Donald P Braun, Digant Gupta, Christopher G Lis and William JM Hrushesky
    Citation: BMC Cancer 2011 11:193
    Content type: Research article Published on:

  5. Breast cancer (BC) causes more deaths than any other cancer among women in Catalonia. Early detection has contributed to the observed decline in BC mortality. However, there is debate on the optimal screening ...

    Authors: Misericordia Carles, Ester Vilaprinyo, Francesc Cots, Aleix Gregori, Roger Pla, Rubén Román, Maria Sala, Francesc Macià, Xavier Castells and Montserrat Rue
    Citation: BMC Cancer 2011 11:192
    Content type: Research article Published on:

  6. Treatment of invasive breast cancer has an alarmingly high rate of failure because effective targets have not been identified. One potential target is mitochondrial generated reactive oxygen species (ROS) beca...

    Authors: Jorming Goh, Linda Enns, Soroosh Fatemie, Heather Hopkins, John Morton, Christina Pettan-Brewer and Warren Ladiges
    Citation: BMC Cancer 2011 11:191
    Content type: Research article Published on:

  7. Most patients with cancers of the nasal cavity or paranasal sinuses are candidates of radiation therapy either due incomplete resection or technical inoperability. Local control in this disease is dose depende...

    Authors: Alexandra D Jensen, Anna V Nikoghosyan, Christine Windemuth-Kieselbach, Jürgen Debus and Marc W Münter
    Citation: BMC Cancer 2011 11:190
    Content type: Study protocol Published on:

  8. L1 cell adhesion molecule (CD171) is expressed in many malignant tumors and its expression correlates with unfavourable outcome. It thus represents a target for tumor diagnosis and therapy. An earlier study co...

    Authors: Hilke Zander, Tamina Rawnaq, Max von Wedemeyer, Michael Tachezy, Miriam Kunkel, Gerrit Wolters, Maximilian Bockhorn, Melitta Schachner, Jakob R Izbicki and Jussuf Kaifi
    Citation: BMC Cancer 2011 11:189
    Content type: Research article Published on:

  9. Because of the late clinical presentation of biliary tract cancer (BTC), only 10% of patients are eligible for curative surgery. Even among those patients who have undergone curative surgery, most patients dev...

    Authors: Yun-Gyoo Lee, Sae-Won Han, Do-Youn Oh, Eui Kyu Chie, Jin-Young Jang, Seock-Ah Im, Tae-You Kim, Sun-Whe Kim, Sung Whan Ha and Yung-Jue Bang
    Citation: BMC Cancer 2011 11:188
    Content type: Research article Published on:

  10. Although gangliocytic paraganglioma (GP) has generally been regarded as a neuroendocrine tumor, its origin remains unclear. We therefore aimed to investigate the details of this disease by carefully analyzing ...

    Authors: Yoichiro Okubo, Megumi Wakayama, Tetsuo Nemoto, Kanako Kitahara, Haruo Nakayama, Kazutoshi Shibuya, Tomoyuki Yokose, Manabu Yamada, Kayoko Shimodaira, Daisuke Sasai, Takao Ishiwatari, Masaru Tsuchiya and Nobuyuki Hiruta
    Citation: BMC Cancer 2011 11:187
    Content type: Research article Published on:

  11. As a negative modulator of the canonical Wnt signaling pathway, Naked1 (NKD1) is widely expressed in many normal tissues. However, the expression pattern and clinicopathological significance of NKD1 in patient...

    Authors: Sheng Zhang, Yan Wang, Shun-Dong Dai and En-Hua Wang
    Citation: BMC Cancer 2011 11:186
    Content type: Research article Published on:

  12. Immunohistochemical detection of cold shock proteins is predictive for deleterious outcome in various malignant diseases. We recently described active secretion of a family member, denoted Y-box (YB) protein-1...

    Authors: Frank Tacke, Nicolas Kanig, Abdelaziz En-Nia, Thilo Kaehne, Christiane S Eberhardt, Victoria Shpacovitch, Christian Trautwein and Peter R Mertens
    Citation: BMC Cancer 2011 11:185
    Content type: Research article Published on:

  13. Glioblastoma (GBM) is a highly aggressive malignant primary brain tumor, characterized by rapid growth, diffuse infiltration of cells into both adjacent and remote brain regions, and a generalized resistance t...

    Authors: Barbara C Merk, Jennifer L Owens, Maria-Beatriz S Lopes, Corinne M Silva and Isa M Hussaini
    Citation: BMC Cancer 2011 11:184
    Content type: Research article Published on:

  14. β-Elemene, a compound found in an herb used in traditional Chinese medicine, has shown promising anti-cancer effects against a broad spectrum of tumors. The mechanism by which β-elemene kills cells remains unc...

    Authors: Jing Liu, Ye Zhang, Jinglei Qu, Ling Xu, Kezuo Hou, Jingdong Zhang, Xiujuan Qu and Yunpeng Liu
    Citation: BMC Cancer 2011 11:183
    Content type: Research article Published on:

  15. Long-term locoregional control in locally advanced squamous cell carcinoma of the head and neck (SCCHN) remains challenging. While recent years have seen various approaches to improve outcome by intensificatio...

    Authors: Alexandra D Jensen, Jürgen Krauss, Karin Potthoff, Almaz Desta, Gregor Habl, Athanasios Mavtratzas, Christine Windemuth-Kiesselbach, Jürgen Debus and Marc W Münter
    Citation: BMC Cancer 2011 11:182
    Content type: Study protocol Published on:

  16. This is a randomized, controlled trial of preoperative chemotherapy in patients undergoing surgery for oesophageal squamous cell carcinoma (OSCC). Patients were allocated to chemotherapy, consisting of 2-4 cyc...

    Authors: Jurjen J Boonstra, Tjebbe C Kok, Bas PL Wijnhoven, Mark van Heijl, Mark I van Berge Henegouwen, Fiebo JW ten Kate, Peter D Siersema, Winand NM Dinjens, Jan JB van Lanschot, Hugo W Tilanus and Ate van der Gaast
    Citation: BMC Cancer 2011 11:181
    Content type: Research article Published on:

  17. Stat3 is a cytokine- and growth factor-inducible transcription factor that regulates cell motility, migration, and invasion under normal and pathological situations, making it a promising target for cancer the...

    Authors: Zanobia A Syed, Weihong Yin, Kendall Hughes, Jennifer N Gill, Runhua Shi and John L Clifford
    Citation: BMC Cancer 2011 11:180
    Content type: Research article Published on:

  18. Weekly docetaxel has occasionally been used in the neoadjuvant to downstage breast cancer to reduce toxicity and possibly enhance quality of life. However, no studies have compared the standard three weekly re...

    Authors: Leslie G Walker, Jennifer M Eremin, Mark M Aloysius, Wichai Vassanasiri, Mary B Walker, Mohamed El-Sheemy, Ged Cowley, Jeanette Beer, Srila Samphao, Janice Wiseman, Jibril A Jibril, David Valerio, David J Clarke, Mujahid Kamal, Gerald W Thorpe, Karin Baria…
    Citation: BMC Cancer 2011 11:179
    Content type: Research article Published on:

  20. To assess the role of Thymidine Phosphorylase and β-tubulin III in clinical outcome of Chinese advanced gastric cancer patients receiving first-line capecitabine plus paclitaxel.

    Authors: Jing Gao, Ming Lu, Jing-wei Yu, Yan-yan Li and Lin Shen
    Citation: BMC Cancer 2011 11:177
    Content type: Research article Published on:

  21. Recent data in esophageal cancer suggests the variant allele of a single-nucleotide polymorphism (SNP) in XRCC1 may be associated with resistance to radiochemotherapy. However, this SNP has not been assessed in a...

    Authors: Harry H Yoon, Paul J Catalano, Kathleen M Murphy, Todd C Skaar, Santosh Philips, Mark Powell, Elizabeth A Montgomery, Michael J Hafez, Steven M Offer, Geoffrey Liu, Stephen J Meltzer, Xifeng Wu, Arlene A Forastiere, Al B Benson, Lawrence R Kleinberg and Michael K Gibson
    Citation: BMC Cancer 2011 11:176
    Content type: Research article Published on:

  22. Tazarotene-induced gene 1 (TIG1) is a retinoid-inducible type II tumour suppressor gene. The B isoform of TIG1 (TIG1B) inhibits growth and invasion of cancer cells. Expression of TIG1B is frequently downregula...

    Authors: Chang-Chieh Wu, Fu-Ming Tsai, Rong-Yaun Shyu, Ya-Ming Tsai, Chun-Hua Wang and Shun-Yuan Jiang
    Citation: BMC Cancer 2011 11:175
    Content type: Research article Published on:

  23. The DNA repair gene Ku70, an important member of non-homologous end-joining repair system, is thought to play an important role in the repairing of DNA double strand breaks. It is known that defects in double str...

    Authors: Mei-Due Yang, Hwei-Chung Wang, Wen-Shin Chang, Chia-Wen Tsai and Da-Tian Bau
    Citation: BMC Cancer 2011 11:174
    Content type: Research article Published on:

  24. MAP2K4 is a putative tumor and metastasis suppressor gene frequently found to be deleted in various cancer types. We aimed to conduct a comprehensive analysis of this gene to assess its involvement in ovarian ca...

    Authors: Sally J Davis, David YH Choong, Manasa Ramakrishna, Georgina L Ryland, Ian G Campbell and Kylie L Gorringe
    Citation: BMC Cancer 2011 11:173
    Content type: Research article Published on:

  25. A subset of lung cancer patients harbour EGFR somatic mutations in their tumours and are candidates for treatment with EGFR tyrosine kinase inhibitors. In a few cases EGFR mutations have also been found in the ge...

    Authors: Irene Centeno, Pilar Blay, Iñigo Santamaría, Aurora Astudillo, Ana S Pitiot, Fernando G Osorio, Patricia González-Arriaga, Fernando Iglesias, Primitiva Menéndez, Adonina Tardón, Jose M Freije and Milagros Balbín
    Citation: BMC Cancer 2011 11:172
    Content type: Research article Published on:

  26. Of all female genital tract tumors, 1-3% are stromal malignancies. In 8-10% of cases, these are represented by Müllerian adenosarcoma an extremely rare tumor characterized by a stromal component of usually low...

    Authors: Tito S Patrelli, Enrico M Silini, Salvatore Gizzo, Roberto Berretta, Laura Franchi, Elena Thai, Adolf Lukanovic, Giovanni B Nardelli and Alberto Bacchi Modena
    Citation: BMC Cancer 2011 11:171
    Content type: Case report Published on:

  27. Celastrol is an active ingredient of the traditional Chinese medicinal plant Tripterygium Wilfordii, which exhibits significant antitumor activity in different cancer models in vitro and in vivo; however, the lac...

    Authors: Guozhu Chen, Xuhui Zhang, Ming Zhao, Yan Wang, Xiang Cheng, Di Wang, Yuanji Xu, Zhiyan Du and Xiaodan Yu
    Citation: BMC Cancer 2011 11:170
    Content type: Research article Published on:

  28. Mesothelioma is an aggressive neoplasm with few effective treatments, one being cytoreductive surgery. We previously described a test, based on differential expression levels of four genes, to predict clinical...

    Authors: Gavin J Gordon, Raphael Bueno and David J Sugarbaker
    Citation: BMC Cancer 2011 11:169
    Content type: Research article Published on:

  29. Bladder cancer, the 5th most common malignancy in the USA, is often detected as a result of incidental findings or by presenting hematuria. Once diagnosed the disease is one of the costliest cancers to treat due ...

    Authors: Anuradha Murali, Laura Kasman and Christina Voelkel-Johnson
    Citation: BMC Cancer 2011 11:168
    Content type: Research article Published on:

  30. The cellular response of malignant tumors to hypoxia is diverse. Several important endogenous metabolic markers are upregulated under hypoxic conditions. We examined the staining patterns and co-expression of ...

    Authors: Saskia E Rademakers, Jasper Lok, Albert J van der Kogel, Johan Bussink and Johannes HAM Kaanders
    Citation: BMC Cancer 2011 11:167
    Content type: Research article Published on:

  31. Rhabdomyosarcoma is a solid tumor, resulting from dysregulation of the skeletal myogenesis program. For rhabdomyosarcomas (RMS) with a predilection for the head and neck, genitourinary tract, extremities, trun...

    Authors: Wojciech Kukwa, Piotr Wojtowicz, Beata Jagielska, Grzegorz Sobczyk, Andrzej Kukwa and Anna M Czarnecka
    Citation: BMC Cancer 2011 11:166
    Content type: Case report Published on:

  32. Partnership for Health-2 (PFH-2) is a web-based version of Partnership for Health, an evidence-based smoking cessation intervention for childhood cancer survivors. This paper describes the PFH-2 intervention a...

    Authors: Janet S de Moor, Elaine Puleo, Jennifer S Ford, Mark Greenberg, David C Hodgson, Vida L Tyc, Jamie Ostroff, Lisa R Diller, Andrea Gurmankin Levy, Kim Sprunck-Harrild and Karen M Emmons
    Citation: BMC Cancer 2011 11:165
    Content type: Research article Published on:

  33. Gastric and esophageal cancers are among the most lethal human malignancies. Their epidemiology is geographically diverse. This study compares the survival of gastric and esophageal cancer patients among sever...

    Authors: Morteza Bashash, T Greg Hislop, Amil M Shah, Nhu Le, Angela Brooks-Wilson and Chris D Bajdik
    Citation: BMC Cancer 2011 11:164
    Content type: Research article Published on:

  34. Family size and birth order are known to influence the risk of some cancers. However, it is still unknown whether these effects change from early to later adulthood. We used the data of the Swedish Family-Canc...

    Authors: Melanie Bevier, Marianne Weires, Hauke Thomsen, Jan Sundquist and Kari Hemminki
    Citation: BMC Cancer 2011 11:163
    Content type: Research article Published on:

  35. Stromal fibroblasts participate in the development of a permissive environment for tumor growth, yet molecular pathways to therapeutically target fibroblasts are poorly defined. CD248, also known as endosialin...

    Authors: Margarida Maia, Astrid DeVriese, Tom Janssens, Michaël Moons, Rik J Lories, Jan Tavernier and Edward M Conway
    Citation: BMC Cancer 2011 11:162
    Content type: Research article Published on:

  36. Aquaporins (AQPs) have been recognized to promote tumor progression, invasion, and metastasis and are therefore recognized as promising targets for novel anti-cancer therapies. Potentially relevant AQPs in dis...

    Authors: Arne Warth, Thomas Muley, Michael Meister, Esther Herpel, Anita Pathil, Hans Hoffmann, Philipp A Schnabel, Christian Bender, Andreas Buness, Peter Schirmacher and Ruprecht Kuner
    Citation: BMC Cancer 2011 11:161
    Content type: Research article Published on:

  37. Childhood cancer differs from most common adult cancers, suggesting a distinct aetiology for some types of childhood cancer. Our objective in this study was to test the difference in incidence rates of 4 non-C...

    Authors: Beatriz de Camargo, Juliana Moreira de Oliveira Ferreira, Rejane de Souza Reis, Sima Ferman, Marceli de Oliveira Santos and Maria S Pombo-de-Oliveira
    Citation: BMC Cancer 2011 11:160
    Content type: Research article Published on:

  38. Criteria for admitting patients with incurable diseases to the medical intensive care unit (MICU) remain unclear and have ethical implications.

    Authors: Claire Andréjak, Nicolas Terzi, Stéphanie Thielen, Emmanuel Bergot, Gérard Zalcman, Pierre Charbonneau and Vincent Jounieaux
    Citation: BMC Cancer 2011 11:159
    Content type: Research article Published on:

  39. Some breast cancer patients receiving anti-angiogenic treatment show increased metastases, possibly as a result of induced hypoxia. The effect of hypoxia on tumor cell migration was assessed in selected lumina...

    Authors: Melanie J Voss, Mischa F Möller, Desmond G Powe, Bernd Niggemann, Kurt S Zänker and Frank Entschladen
    Citation: BMC Cancer 2011 11:158
    Content type: Research article Published on:

  40. The purpose of this study was to assess the feasibility and accuracy of sentinel lymph nodes (SLNs) detection using 99mTc phytate in predicting pelvic lymph nodes status for radical abdominal trachelectomy (RA...

    Authors: Xue-lian Du, Xiu-gui Sheng, Tao Jiang, Qing-shui Li, Hao Yu, Chun-xia Pan, Chun-hua Lu, Cong Wang and Qu-qing Song
    Citation: BMC Cancer 2011 11:157
    Content type: Research article Published on:

  41. The use of radiotherapy in osteosarcoma (OS) is controversial due to its radioresistance. OS patients currently treated with radiotherapy generally are inoperable, have painful skeletal metastases, refuse surg...

    Authors: Jantine PosthumaDeBoer, Thomas Würdinger, Harm CA Graat, Victor W van Beusechem, Marco N Helder, Barend J van Royen and Gertjan JL Kaspers
    Citation: BMC Cancer 2011 11:156
    Content type: Research article Published on:

  42. Women with a personal history of breast cancer have a high risk of developing an ipsi- or contralateral recurrence. We aimed to compare the growth rate of primary breast cancer and recurrences in women who had...

    Authors: Ingrid Millet, Emmanuelle Bouic-Pages, Denis Hoa, David Azria and Patrice Taourel
    Citation: BMC Cancer 2011 11:155
    Content type: Research article Published on:

  43. Maslinic acid, a pentacyclic triterpene found in the protective wax-like coating of the leaves and fruit of Olea europaea L., is a promising agent for the prevention of colon cancer. We have shown elsewhere that ...

    Authors: Fernando J Reyes-Zurita, Gisela Pachón-Peña, Daneida Lizárraga, Eva E Rufino-Palomares, Marta Cascante and José A Lupiáñez
    Citation: BMC Cancer 2011 11:154
    Content type: Research article Published on:

  44. NSAIDs exhibit protective properties towards some cancers, especially colon cancer. Yet, it is not clear how they play their protective role. PGE2 is generally shown as the only target of the NSAIDs anticancerous...

    Authors: Lisenn Lalier, François Pedelaborde, Christophe Braud, Jean Menanteau, François M Vallette and Christophe Olivier
    Citation: BMC Cancer 2011 11:153
    Content type: Research article Published on:

  45. Authors: Juliana G Assumpção, Ana Luíza Seidinger, Maria José Mastellato, Raul C Ribeiro, Gerard P Zambetti, Ramapriya Ganti, Kumar Srivastava, Sheila Shurtleff, Deqing Pei, Luiz Carlos Zeferino, Rozany M Dufloth, Silvia Regina Brandalise and José Andres Yunes
    Citation: BMC Cancer 2011 11:152
    Content type: Erratum Published on:

    The original article was published in BMC Cancer 2008 8:357

  47. Hepatocellular carcinoma (HCC) usually has a dismal prognosis because of its limited response to current pharmacotherapy and high metastatic rate. Sulfated oligosaccharide has been confirmed as having potent a...

    Authors: Chun-Li Xiao, Zhong-Hua Tao, Lin Guo, Wei-Wei Li, Jin-Liang Wan, Hui-Chuan Sun, Lu Wang, Zhao-You Tang, Jia Fan and Wei-Zhong Wu
    Citation: BMC Cancer 2011 11:150
    Content type: Research article Published on:

  48. Breast cancer is a collection of diseases in which molecular phenotypes can act as both indicators and mediators of therapeutic strategy. Therefore, candidate therapeutics must be assessed in the context of mu...

    Authors: Jeffrey D Altenburg, Andrew A Bieberich, Colin Terry, Kevin A Harvey, Justin F VanHorn, Zhidong Xu, V Jo Davisson and Rafat A Siddiqui
    Citation: BMC Cancer 2011 11:149
    Content type: Research article Published on:

  49. Despite the recent publication of results from two randomized clinical trials, prostate specific antigen (PSA) screening for prostate cancer remains a controversial issue. There is lack of agreement across stu...

    Authors: David C Wheeler, Konrad M Szymanski, Amanda Black and David E Nelson
    Citation: BMC Cancer 2011 11:148
    Content type: Debate Published on:

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