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  1. Human homeobox genes encode nuclear proteins that act as transcription factors involved in the control of differentiation and proliferation. Currently, the role of these genes in development and tumor progress...

    Authors: Thais Chile, Maria Angela Henriques Zanella Fortes, Maria Lúcia Cardillo Corrêa-Giannella, Helena Paula Brentani, Durvanei Augusto Maria, Renato David Puga, Vanessa de Jesus R de Paula, Marcia Saldanha Kubrusly, Estela Maria Novak, Telésforo Bacchella and Ricardo Rodrigues Giorgi
    Citation: BMC Cancer 2013 13:451
    Content type: Research article Published on:

  2. Several lines of evidence indicate that Sirt1, a class III histone deacetylase (HDAC) is implicated in the initiation and progression of malignancies and thus gained attraction as druggable target. Since data ...

    Authors: Albrecht Stenzinger, Volker Endris, Frederick Klauschen, Bruno Sinn, Katja Lorenz, Arne Warth, Benjamin Goeppert, Volker Ehemann, Alexander Muckenhuber, Carsten Kamphues, Marcus Bahra, Peter Neuhaus and Wilko Weichert
    Citation: BMC Cancer 2013 13:450
    Content type: Research article Published on:

  3. Racial disparities in breast cancer survival have been well documented. This study examines the association of race/ethnicity and socioeconomic status (SES) on breast cancer-specific mortality in a large popul...

    Authors: Carol A Parise and Vincent Caggiano
    Citation: BMC Cancer 2013 13:449
    Content type: Research article Published on:

  4. MicroRNAs are regulators that can play an essential role in tumorigenesis. Although miR-302 families have been suggested to be tumor repressors in human cancer, the mechanism by which they suppress tumor devel...

    Authors: Lumin Wang, Jiayi Yao, Xin Shi, Lili Hu, Zongfang Li, Tusheng Song and Chen Huang
    Citation: BMC Cancer 2013 13:448
    Content type: Research article Published on:

  5. Although the percentage of patients with renal cell carcinoma (RCC) extending into venous systems is unexpectedly high, the prognostic impact and independency of venous tumor thrombus-related factors on overal...

    Authors: Masanori Hirono, Mikio Kobayashi, Tomoyasu Tsushima, Wataru Obara, Nobuo Shinohara, Keiichi Ito, Masatoshi Eto, Tatsuya Takayama, Yasuhisa Fujii, Masaharu Nishikido, Go Kimura, Takeshi Kishida, Masayuki Takahashi, Noriomi Miyao, Yukio Naya, Takashige Abe…
    Citation: BMC Cancer 2013 13:447
    Content type: Research article Published on:

  6. Patients with acute leukemia experience a substantial symptom burden and are at risk of developing infections throughout the course of repeated cycles of intensive chemotherapy. Physical activity in recent yea...

    Authors: Mary Jarden, Tom Møller, Lars Kjeldsen, Henrik Birgens, Jesper Frank Christensen, Karl Bang Christensen, Finn Diderichsen, Carsten Hendriksen and Lis Adamsen
    Citation: BMC Cancer 2013 13:446
    Content type: Study protocol Published on:

  7. Metaplastic carcinoma, an uncommon subtype of breast cancer, is part of the spectrum of basal-like, triple receptor-negative breast carcinomas. The present study examined 20 surgical specimens of metaplastic b...

    Authors: Roberto Herrera-Goepfert, Teresa Vela-Chávez, Adela Carrillo-García, Marcela Lizano-Soberón, Alfredo Amador-Molina, Luis F Oñate-Ocaña and Rita Sotelo-Regil Hallmann
    Citation: BMC Cancer 2013 13:445
    Content type: Research article Published on:

  8. Trastuzumab is an antibody widely used in the treatment of breast cancer cases that test positive for the human epidermal growth factor receptor 2 (HER2). Many patients, however, become resistant to this antib...

    Authors: Eloah Rabello Suarez, Edgar Julian Paredes-Gamero, Auro Del Giglio, Ivarne Luis dos Santos Tersariol, Helena Bonciani Nader and Maria Aparecida Silva Pinhal
    Citation: BMC Cancer 2013 13:444
    Content type: Research article Published on:

  10. The preoperative ratio of neutrophils to lymphocytes (NLR) has been proposed as a marker of poor outcome in patients having a resection for colorectal cancer (CRC). This study investigated the association betw...

    Authors: Lucy Jankova, Owen F Dent, Charles Chan, Pierre Chapuis and Stephen J Clarke
    Citation: BMC Cancer 2013 13:442
    Content type: Research article Published on:

  11. The activator protein-1 (AP-1) transcription factor is believed to be important in tumorigenesis and altered AP-1 activity was associated with cell transformation. We aimed to assess the potential role of AP-1...

    Authors: Amirhossein Kharman-Biz, Hui Gao, Reza Ghiasvand, Chunyan Zhao, Kazem Zendehdel and Karin Dahlman-Wright
    Citation: BMC Cancer 2013 13:441
    Content type: Research article Published on:

  12. The t(6;9)(p23;q34) chromosomal translocation is found in 1% of acute myeloid leukemia and encodes the fusion protein DEK-NUP214 (formerly DEK-CAN) with largely uncharacterized functions.

    Authors: Carl Sandén, Malin Ageberg, Jessica Petersson, Andreas Lennartsson and Urban Gullberg
    Citation: BMC Cancer 2013 13:440
    Content type: Research article Published on:

  13. The mutation status of the BRAF and KRAS genes has been proposed as prognostic biomarker in colorectal cancer. Of them, only the BRAF V600E mutation has been validated independently as prognostic for overall s...

    Authors: Vlad Popovici, Eva Budinska, Fred T Bosman, Sabine Tejpar, Arnaud D Roth and Mauro Delorenzi
    Citation: BMC Cancer 2013 13:439
    Content type: Research article Published on:

  14. Tumor microenviroment is characteristic of inflammation, ischemia and starvation of nutrient. TNF-α, which is an extraordinarily pleiotropic cytokine, could be an endogenous tumor promoter in some tumor types....

    Authors: Xingrui Kou, Yingying Jing, Weijie Deng, Kai Sun, Zhipeng Han, Fei Ye, Guofeng Yu, Qingmin Fan, Lu Gao, Qiudong Zhao, Xue Zhao, Rong Li, Lixin Wei and Mengchao Wu
    Citation: BMC Cancer 2013 13:438
    Content type: Research article Published on:

  15. Not only four but rather seven different human epidermal growth factor receptor related (Her) receptor tyrosine kinases (RTKs) have been described to be expressed in a variety of normal and neoplastic tissues: He...

    Authors: Anna Machleidt, Stefan Buchholz, Simone Diermeier-Daucher, Florian Zeman, Olaf Ortmann and Gero Brockhoff
    Citation: BMC Cancer 2013 13:437
    Content type: Research article Published on:

  16. Tumour-associated lymphocytes (TALs) have been linked with good prognosis in several solid tumours. This study aimed to evaluate the prognostic significance of CD3, CD8 and CD20 positive lymphocytes in pancrea...

    Authors: Nilanjana Tewari, Abed M Zaitoun, Arvind Arora, Srinivasan Madhusudan, Mohammad Ilyas and Dileep N Lobo
    Citation: BMC Cancer 2013 13:436
    Content type: Research article Published on:

  17. The optimal choice of cytotoxic drugs for intraperitoneal chemotherapy (IPC) in conjunction with cytoreductive surgery (CRS) for treatment of peritoneal carcinomatosis (PC) is poorly defined. We investigated d...

    Authors: Peter H Cashin, Haile Mahteme, Wilhelm Graf, Henning Karlsson, Rolf Larsson and Peter Nygren
    Citation: BMC Cancer 2013 13:435
    Content type: Research article Published on:

  18. Breast cancer incidence is increasing. The survival rate varies and is longer in high-income countries. In Brazil, lower-income populations rely on the Unified Public Health System (Sistema Único de Saude, SUS...

    Authors: Débora Balabram, Cassio M Turra and Helenice Gobbi
    Citation: BMC Cancer 2013 13:434
    Content type: Research article Published on:

  19. DNA damage response has been clearly described as an anti-cancer barrier in early human tumorigenesis. Moreover, interestingly, testicular germ cell tumors (TGCTs) have been reported to lack the DNA Damage Res...

    Authors: Stefania Staibano, Gennaro Ilardi, Vincenza Leone, Chiara Luise, Francesco Merolla, Francesco Esposito, Francesco Morra, Maria Siano, Renato Franco, Alfredo Fusco, Paolo Chieffi and Angela Celetti
    Citation: BMC Cancer 2013 13:433
    Content type: Research article Published on:

    The Retraction Note to this article has been published in BMC Cancer 2021 21:100

  20. Mesenchymal–epithelial transition (MET) is now suggested to participate in the process of metastatic tumor formation. However, in hepatocellular carcinoma (HCC) the process is still not well revealed.

    Authors: Dianbo Yao, Songlin Peng and Chaoliu Dai
    Citation: BMC Cancer 2013 13:432
    Content type: Research article Published on:

  21. Class III β-tubulin (TUBB3) is a prognostic marker in various tumors, but the role of TUBB3 in advanced gastric cancer is not clearly defined. We analyzed the significance of TUBB3 expression, along with that ...

    Authors: Jun-Eul Hwang, Ji-Yun Hong, Karham Kim, Seung-Hun Kim, Won-Young Choi, Min-Jee Kim, Sung-Hoon Jung, Hyun-Jeong Shim, Woo-Kyun Bae, Eu-Chang Hwang, Kyung-Hwa Lee, Jae-Hyuk Lee, Sang-Hee Cho and Ik-Joo Chung
    Citation: BMC Cancer 2013 13:431
    Content type: Research article Published on:

  22. Thymosin β10 (Tβ10) expression is associated with malignant phenotypes in many cancers. However, the role and mechanisms of Tβ10 in liver fluke-associated cholangiocarcinoma (CCA) are not fully understood. In ...

    Authors: Sirinapa Sribenja, Kanlayanee Sawanyawisuth, Ratthaphol Kraiklang, Chaisiri Wongkham, Kulthida Vaeteewoottacharn, Sumalee Obchoei, Qizhi Yao, Sopit Wongkham and Changyi Chen
    Citation: BMC Cancer 2013 13:430
    Content type: Research article Published on:

  23. Bone morphogenetic protein 4 (BMP4) belongs to the transforming growth factor β (TGF-β) family of proteins. BMPs regulate cell proliferation, differentiation and motility, and have also been reported to be inv...

    Authors: Minna Ampuja, Riikka Jokimäki, Kati Juuti-Uusitalo, Alejandra Rodriguez-Martinez, Emma-Leena Alarmo and Anne Kallioniemi
    Citation: BMC Cancer 2013 13:429
    Content type: Research article Published on:

  24. Periampullary adenocarcinomas comprise pancreatic, distal bile duct, ampullary and duodenal adenocarcinoma. The epithelia of these anatomical structures share a common embryologic origin from the foregut. With...

    Authors: Peter Bronsert, Ilona Kohler, Martin Werner, Frank Makowiec, Simon Kuesters, Jens Hoeppner, Ulrich Theodor Hopt, Tobias Keck, Dirk Bausch and Ulrich Friedrich Wellner
    Citation: BMC Cancer 2013 13:428
    Content type: Research article Published on:

  25. Somatostatin analogues (SSAs) are indicated to relieve carcinoid syndrome but seem to have antiproliferative effects on neuroendocrine tumours (NETs). This is the first prospective study investigating tumour s...

    Authors: Marta Martín-Richard, Bartomeu Massutí, Eva Pineda, Vicente Alonso, Maribel Marmol, Daniel Castellano, Emilio Fonseca, Antonio Galán, Marta Llanos, Maria Angeles Sala, Carlos Pericay, Fernando Rivera, Javier Sastre, Ángel Segura, Maria Quindós and Pascal Maisonobe
    Citation: BMC Cancer 2013 13:427
    Content type: Research article Published on:

  26. Adjuvant endocrine therapy can improve disease-free survival and time before recurrence in breast cancer patients. However, it is associated with considerable side effects that negatively affect patients’ quality...

    Authors: Pia von Blanckenburg, Franziska Schuricht, Ute-Susann Albert, Winfried Rief and Yvonne Nestoriuc
    Citation: BMC Cancer 2013 13:426
    Content type: Study protocol Published on:

  27. The role of estrogen receptor beta (ER-β) in breast cancer (BC) remains unclear. Some studies have suggested that ER-β may oppose the actions of estrogen receptor alpha (ER-α), and clinical evidence has indica...

    Authors: Marcelo Madeira, André Mattar, Ângela Flávia Logullo, Fernando Augusto Soares and Luiz Henrique Gebrim
    Citation: BMC Cancer 2013 13:425
    Content type: Research article Published on:

  28. Disruption of the transforming growth factor-beta (TGF-β) signaling pathway is observed in many cancers, including cervical cancer, resulting in TGF-β resistance. While normal human keratinocytes (HKc) and hum...

    Authors: Diego Altomare, Rupa Velidandla, Lucia Pirisi and Kim E Creek
    Citation: BMC Cancer 2013 13:424
    Content type: Research article Published on:

  29. This manuscript evaluates whether specific symptoms, a symptom index (SI), CA125 and HE4 can help identify women with malignant tumors in the group of women with adnexal masses previously diagnosed with ultras...

    Authors: Denise da Rocha Pitta, Luis Otávio Sarian, Amilcar Barreta, Elisabete Aparecida Campos, Liliana Lucci de Angelo Andrade, Ana Maria Dias Fachini, Leonardo Martins Campbell and Sophie Derchain
    Citation: BMC Cancer 2013 13:423
    Content type: Research article Published on:

  30. Epithelial ovarian cancer is one of the most lethal gynecologic malignancies. Clinicopathological factors do not permit precise prognosis and cannot provide guidance to specific treatments. In this study we as...

    Authors: Anna Bachmayr-Heyda, Stefanie Aust, Georg Heinze, Stephan Polterauer, Christoph Grimm, Elena Ioana Braicu, Jalid Sehouli, Sandrina Lambrechts, Ignace Vergote, Sven Mahner, Dietmar Pils, Eva Schuster, Theresia Thalhammer, Reinhard Horvat, Carsten Denkert, Robert Zeillinger…
    Citation: BMC Cancer 2013 13:422
    Content type: Research article Published on:

  31. Tumor-associated macrophages (TAM) play an important role in tumor microenvironment. Particularly, M2 macrophages contribute to tumor progression, depending on the expression of NF-κB. Tumor-derived exosomes c...

    Authors: Ji-Young Jang, Jong-Kuen Lee, Yoon-Kyung Jeon and Chul-Woo Kim
    Citation: BMC Cancer 2013 13:421
    Content type: Research article Published on:

  33. Treatment options for patients with locally advanced pancreatic cancer include surgery, chemotherapy as well as radiotherapy. In many cases, surgical resection is not possible, and therefore treatment alternat...

    Authors: Stephanie E Combs, Daniel Habermehl, Meinhard Kieser, Constantin Dreher, Jens Werner, Renate Haselmann, Oliver Jäkel, Dirk Jäger, Markus W Büchler and Jürgen Debus
    Citation: BMC Cancer 2013 13:419
    Content type: Study protocol Published on:

  34. The major obstacles to the successful use of individual nutritional compounds as preventive or therapeutic agents are their efficacy and bioavailability. One approach to overcoming this problem is to use combi...

    Authors: Rafat A Siddiqui, Kevin A Harvey, Candace Walker, Jeffrey Altenburg, Zhidong Xu, Colin Terry, Ignacio Camarillo, Yava Jones-Hall and Cary Mariash
    Citation: BMC Cancer 2013 13:418
    Content type: Research article Published on:

  35. Neoadjuvant radiochemotherapy (RCT) is now part of the armamentarium of cancer of the lower and middle rectum. It is recommended in current clinical practice prior to surgical excision if the lesion is classif...

    Authors: Jérémie H Lefevre, Alexandra Rousseau, Magali Svrcek, Yann Parc, Tabassome Simon and Emmanuel Tiret
    Citation: BMC Cancer 2013 13:417
    Content type: Study protocol Published on:

  36. The prognosis of pancreatic cancer (PC) is one of the poorest among all cancers, due largely to the lack of methods for screening and early detection. New biomarkers for identifying high-risk or early-stage su...

    Authors: Shawn A Ritchie, Hirofumi Akita, Ichiro Takemasa, Hidetoshi Eguchi, Elodie Pastural, Hiroaki Nagano, Morito Monden, Yuichiro Doki, Masaki Mori, Wei Jin, Tolulope T Sajobi, Dushmanthi Jayasinghe, Bassirou Chitou, Yasuyo Yamazaki, Thayer White and Dayan B Goodenowe
    Citation: BMC Cancer 2013 13:416
    Content type: Research article Published on:

  37. Circulating tumour cells (CTC) are receiving increasing attention as prognostic, predictive and pharmacodynamic biomarkers in cancer patients. However, their clinical significance can be dependent on an accura...

    Authors: Jeffrey Cummings, Karen Morris, Cong Zhou, Robert Sloane, Matt Lancashire, Daniel Morris, Stephen Bramley, Matt Krebs, Leila Khoja and Caroline Dive
    Citation: BMC Cancer 2013 13:415
    Content type: Technical advance Published on:

  38. Approximately 20–30% of patients with cancer experience a clinically relevant level of emotional distress in response to disease and treatment. This in itself is alarming but it is even more problematic becaus...

    Authors: Susanne Mattsson, Sven Alfonsson, Maria Carlsson, Peter Nygren, Erik Olsson and Birgitta Johansson
    Citation: BMC Cancer 2013 13:414
    Content type: Study protocol Published on:

  39. Malignant mesotheliomas (MMs) are chemoresistant tumors related to exposure to asbestos fibers. The long latency period of MM (30-40 yrs) and heterogeneity of tumor presentation make MM difficult to diagnose a...

    Authors: Sherrill L Macura, Jeremy L Steinbacher, Maximilian B MacPherson, Melissa J Lathrop, Mutlay Sayan, Jedd M Hillegass, Stacie L Beuschel, Timothy N Perkins, Page C Spiess, Albert van der Vliet, Kelly J Butnor, Arti Shukla, Marilyn Wadsworth, Christopher C Landry and Brooke T Mossman
    Citation: BMC Cancer 2013 13:400
    Content type: Research article Published on:

  40. To identify predictors of long-term outcome for patients with clinical complete response (cCR) after definite chemoradiotherapy (CRT) or radiation therapy (RT) for oesophageal cancer (EC).

    Authors: Antoine Adenis, Emmanuelle Tresch, Sylvain Dewas, Olivier Romano, Mathieu Messager, Eric Amela, Stéphanie Clisant, Andrew Kramar, Christophe Mariette and Xavier Mirabel
    Citation: BMC Cancer 2013 13:413
    Content type: Research article Published on:

  41. Colorectal cancer (CRC) is one of the most common cancers worldwide and a leading cause of cancer related death. Although the mortality rate of CRC is decreasing, finding novel targets for its therapy remains ...

    Authors: Xing-Hua Liang, Ling-ling Li, Geng-Gang Wu, Yi-Cheng Xie, Guang-Xian Zhang, Wei Chen, Hai-Feng Yang, Qi-Long Liu, Wen-Hong Li, Wen-guang He, Yan-Nian Huang and Xian-Cheng Zeng
    Citation: BMC Cancer 2013 13:412
    Content type: Research article Published on:

  42. Matrix metalloproteases and collagen are key participants in breast cancer, but their precise roles in cancer etiology and progression remain unclear. MMP13 helps regulate collagen structure and has been ascri...

    Authors: Seth W Perry, Jill M Schueckler, Kathleen Burke, Giuseppe L Arcuri and Edward B Brown
    Citation: BMC Cancer 2013 13:411
    Content type: Research article Published on:

  43. Molecular biomarkers are essential for monitoring treatment effects, predicting prognosis, and improving survival rate in oral squamous cell carcinoma. This study sought to verify the effectiveness of two inte...

    Authors: Masaki Nagata, Arhab A Noman, Kenji Suzuki, Hiroshi Kurita, Makoto Ohnishi, Tokio Ohyama, Nobutaka Kitamura, Takanori Kobayashi, Kohya Uematsu, Katsu Takahashi, Naoki Kodama, Tomoyuki Kawase, Hideyuki Hoshina, Nobuyuki Ikeda, Susumu Shingaki and Ritsuo Takagi
    Citation: BMC Cancer 2013 13:410
    Content type: Research article Published on:

  44. Breast cancer is the leading malignant disease among western women with incidence increasing over time. High mammographic density is a well-established risk factor for breast cancer. We explored trends in mamm...

    Authors: Sophie Sell Hellmann, Elsebeth Lynge, Walter Schwartz, Ilse Vejborg and Sisse Helle Njor
    Citation: BMC Cancer 2013 13:409
    Content type: Research article Published on:

  45. Prostate cancer is one of the leading causes of cancer related deaths. For diagnosis, predicting the outcome of the disease, and for assessing potential new biomarkers, pathologists and researchers routinely a...

    Authors: Giuseppe Lippolis, Anders Edsjö, Leszek Helczynski, Anders Bjartell and Niels Chr Overgaard
    Citation: BMC Cancer 2013 13:408
    Content type: Technical advance Published on:

  46. It is known that suboptimal adherence rates may affect endocrine treatments for breast cancer, but little information has been reported whether any efforts to improve treatment adherence have been successful. ...

    Authors: Volker Ziller, Ioannis Kyvernitakis, Dana Knöll, Astrid Storch, Olaf Hars and Peyman Hadji
    Citation: BMC Cancer 2013 13:407
    Content type: Research article Published on:

  47. Melanocortin-1 receptor (MC1R) gene variants are very common and are associated with melanoma risk, but their contribution to melanoma risk prediction compared with traditional risk factors is unknown. We aimed t...

    Authors: Anne E Cust, Chris Goumas, Kylie Vuong, John R Davies, Jennifer H Barrett, Elizabeth A Holland, Helen Schmid, Chantelle Agha-Hamilton, Bruce K Armstrong, Richard F Kefford, Joanne F Aitken, Graham G Giles, D Timothy Bishop, Julia A Newton-Bishop, John L Hopper, Graham J Mann…
    Citation: BMC Cancer 2013 13:406
    Content type: Research article Published on:

  48. Retrospective analyses in the West suggest that mutations in KRAS codons 61 and 146, BRAF, NRAS, and PIK3CA are negative predictive factors for cetuximab treatment in colorectal cancer patients. We developed a no...

    Authors: Hideaki Bando, Takayuki Yoshino, Eiji Shinozaki, Tomohiro Nishina, Kentaro Yamazaki, Kensei Yamaguchi, Satoshi Yuki, Shinya Kajiura, Satoshi Fujii, Takeharu Yamanaka, Katsuya Tsuchihara and Atsushi Ohtsu
    Citation: BMC Cancer 2013 13:405
    Content type: Technical advance Published on:

  49. Breast cancer is one of the leading causes of cancer deaths. Triple-negative breast cancer (TNBC), an immunophenotype defined by the absence of immunolabeling for estrogen receptor (ER), progesterone receptor ...

    Authors: David A Wiese, Tuddow Thaiwong, Vilma Yuzbasiyan-Gurkan and Matti Kiupel
    Citation: BMC Cancer 2013 13:403
    Content type: Research article Published on:

  50. Premature discontinuation of aromatase inhibitors (AIs) in breast cancer survivors compromises treatment outcomes. We aimed to evaluate whether patient-reported joint pain predicts premature discontinuation of...

    Authors: Kannie Chim, Sharon X Xie, Carrie T Stricker, Qing S Li, Robert Gross, John T Farrar, Angela DeMichele and Jun J Mao
    Citation: BMC Cancer 2013 13:401
    Content type: Research article Published on:

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