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  1. Resistance to humanized monoclonal erbB2/HER2 antibody, trastuzumab (Herceptin), has become a pivotal obstacle for targeted therapy of HER2-positive breast cancers. The activation of alternative growth factor ...

    Authors: Xing-Ming Ye, Hua-Yu Zhu, Wen-Dong Bai, Ting Wang, Lei Wang, Ying Chen, An-Gang Yang and Lin-Tao Jia
    Citation: BMC Cancer 2014 14:134
    Content type: Research article Published on:

  2. To reduce sampling error associated with cancer detection in prostate needle biopsies, we explored the possibility of using fluorescence in situ hybridisation (FISH) to detect chromosomal abnormalities in the ...

    Authors: Ying Zhang, Thomas Perez, Beth Blondin, Jing Du, Ping Liu, Diana Escarzaga, John S Coon, Larry E Morrison and Katerina Pestova
    Citation: BMC Cancer 2014 14:129
    Content type: Research article Published on:

  3. Loss of phosphatase and tensin homologue (PTEN) function evaluated by loss of PTEN protein expression on immunohistochemistry (IHC) has been reported as both prognostic in metastatic colorectal cancer and pred...

    Authors: Christopher Hocking, Jennifer E Hardingham, Vy Broadbridge, Joe Wrin, Amanda R Townsend, Niall Tebbutt, John Cooper, Andrew Ruszkiewicz, Chee Lee and Timothy J Price
    Citation: BMC Cancer 2014 14:128
    Content type: Research article Published on:

  4. Acute leukemia in early age (EAL) is characterized by acquired genetic alterations such as MLL rearrangements (MLL-r). The aim of this case-controlled study was to investigate whether single nucleotide polymorphi...

    Authors: Mariana Emerenciano, Thayana Conceição Barbosa, Bruno Almeida Lopes, Caroline Barbieri Blunck, Alessandra Faro, Camilla Andrade, Claus Meyer, Rolf Marschalek and Maria S Pombo-de-Oliveira
    Citation: BMC Cancer 2014 14:127
    Content type: Research article Published on:

  5. Breast cancer is the second most lethal cancer in women. Understanding biological mechanisms that cause progression of this disease could yield new targets for prevention and treatment. Recent experimental stu...

    Authors: Qi Cao, Jerome Hersl, Hongloan La, Mark Smith, Jason Jenkins, Olga Goloubeva, Vasken Dilsizian, Katherine Tkaczuk, Wengen Chen and Laundette Jones
    Citation: BMC Cancer 2014 14:126
    Content type: Research article Published on:

  6. The wnt/β-catenin signaling pathway is known to affect in cancer oncogenesis and progression by interacting with the tumor microenvironment. However, the roles of wnt3a and wnt5a in colorectal cancer (CRC) hav...

    Authors: Myung Ah Lee, Jin-Hee Park, Si Young Rhyu, Seong-Taek Oh, Won-Kyoung Kang and Hee-Na Kim
    Citation: BMC Cancer 2014 14:125
    Content type: Research article Published on:

  7. Triple negative breast cancer (TNBC) has higher rates of recurrence and distant metastasis, and poorer outcome as compared to non-TNBC. Aberrant activation of WNT signaling has been detected in TNBC, which mig...

    Authors: Lixin Yang, Aldwin Apollo Perez, Sayuri Fujie, Charles Warden, Jie Li, Yafan Wang, Bryan Yung, Yun-Ru Chen, Xiyong Liu, Hang Zhang, Shu Zheng, Zheng Liu, David Ann and Yun Yen
    Citation: BMC Cancer 2014 14:124
    Content type: Research article Published on:

  8. In Germany, about 20% of the total population have a migration background. Differences exist between migrants and non-migrants in terms of health care access and utilisation. Colorectal cancer is the second mo...

    Authors: Anne Dahlhaus, Corina Guethlin, Arthur Schall, Maja Taubenroth, Reyn van Ewijk, Hajo Zeeb, Zeycan Albay, Sylvia Schulz-Rothe, Martin Beyer, Ferdinand M Gerlach, Maria Blettner and Andrea Siebenhofer
    Citation: BMC Cancer 2014 14:123
    Content type: Study protocol Published on:

  9. Bmi1 has been identified as an important regulator in breast cancer, but its relationship with other signaling molecules such as ERα and HER2 is undetermined.

    Authors: Huali Wang, Haijing Liu, Xin Li, Jing Zhao, Hong Zhang, Jingzhuo Mao, Yongxin Zou, Hong Zhang, Shuang Zhang, Wei Hou, Lin Hou, Michael A McNutt and Bo Zhang
    Citation: BMC Cancer 2014 14:122
    Content type: Research article Published on:

  10. It remains presently unclear whether disease progression in colorectal carcinoma (CRC), from early, to invasive and metastatic forms, is associated to a gradual increase in genetic instability and to a scheme ...

    Authors: Béatrice Orsetti, Janick Selves, Caroline Bascoul-Mollevi, Laurence Lasorsa, Karine Gordien, Frédéric Bibeau, Blandine Massemin, François Paraf, Isabelle Soubeyran, Isabelle Hostein, Valérie Dapremont, Rosine Guimbaud, Christophe Cazaux, Michel Longy and Charles Theillet
    Citation: BMC Cancer 2014 14:121
    Content type: Research article Published on:

  11. Ovarian cancer is now recognized as a number of distinct diseases primarily defined by histological subtype. Both clear cell ovarian carcinomas (CCC) and ovarian endometrioid carcinomas (EC) may arise from end...

    Authors: Kimberly C Wiegand, Bryan T Hennessy, Samuel Leung, Yemin Wang, Zhenlin Ju, Mollianne McGahren, Steve E Kalloger, Sarah Finlayson, Katherine Stemke-Hale, Yiling Lu, Fan Zhang, Michael S Anglesio, Blake Gilks, Gordon B Mills, David G Huntsman and Mark S Carey
    Citation: BMC Cancer 2014 14:120
    Content type: Research article Published on:

  12. Yes-associated protein (YAP1) is frequently reported to function as an oncogene in many types of cancer, but in breast cancer results remain controversial. We set out to clarify the role of YAP1 in breast canc...

    Authors: Sophie Lehn, Nicholas P Tobin, Andrew H Sims, Olle Stål, Karin Jirström, Håkan Axelson and Göran Landberg
    Citation: BMC Cancer 2014 14:119
    Content type: Research article Published on:

  13. Chemokines have been implicated in tumor progression and metastasis. In melanoma, chemokine receptors have been implicated in organ selective metastasis by regulating processes such as chemoattraction, adhesio...

    Authors: Sandra Pinto, Alicia Martínez-Romero, José-Enrique O’Connor, Rosario Gil-Benso, Teresa San-Miguel, Liria Terrádez, Carlos Monteagudo and Robert C Callaghan
    Citation: BMC Cancer 2014 14:118
    Content type: Research article Published on:

  14. Neutrophil-lymphocyte ratio (NLR) has recently been reported as a predictor of Hepatocellular carcinoma (HCC). However, its prognostic value in HCC still remains controversial. In this study, we aimed to evalu...

    Authors: Wei-Kai Xiao, Dong Chen, Shao-Qiang Li, Shun-Jun Fu, Bao-Gang Peng and Li-Jian Liang
    Citation: BMC Cancer 2014 14:117
    Content type: Research article Published on:

  15. Cervical cancer ranks second among all cancers reported in Sri Lankan women. This study assessed the prevalence and type-distribution of human papillomavirus (HPV) among Sri Lankan women with invasive cervical...

    Authors: Kanishka Karunaratne, Himali Ihalagama, Saman Rohitha, Anco Molijn, Kusuma Gopala, Johannes E Schmidt, Jing Chen, Sanjoy Datta and Shailesh Mehta
    Citation: BMC Cancer 2014 14:116
    Content type: Research article Published on:

  16. Adult brainstem gliomas are rare primary brain tumors (<2% of gliomas). The goal of this study was to analyze clinical, prognostic and therapeutic factors in a large series of histologically proven brainstem g...

    Authors: Thomas Reithmeier, Aanyo Kuzeawu, Bettina Hentschel, Markus Loeffler, Michael Trippel and Guido Nikkhah
    Citation: BMC Cancer 2014 14:115
    Content type: Research article Published on:

  17. Hepatocellular carcinoma (HCC) is a primary liver tumor and is the most difficult human malignancy to treat. In this study, we sought to develop an integrative approach in which real-time tumor monitoring, gen...

    Authors: Jing Chen, Shu Zhu, Liangqian Tong, Jiansha Li, Fei Chen, Yunfeng Han, Ming Zhao and Wei Xiong
    Citation: BMC Cancer 2014 14:114
    Content type: Research article Published on:

  18. CD248 is a cell surface glycoprotein, highly expressed by stromal cells and fibroblasts of tumors and inflammatory lesions, but virtually undetectable in healthy adult tissues. CD248 promotes tumorigenesis, wh...

    Authors: Sahana Suresh Babu, Yanet Valdez, Andrea Xu, Alice M O’Byrne, Fernando Calvo, Victor Lei and Edward M Conway
    Citation: BMC Cancer 2014 14:113
    Content type: Research article Published on:

  19. Resistin, adipocyte-secreting adipokine, may play critical role in modulating cancer pathogenesis. The aim of this study was to investigate the effects of resistin on HCC adhesion to the endothelium, and the m...

    Authors: Chen-Chieh Yang, Shun-Fu Chang, Jian-Kang Chao, Yi-Liang Lai, Wei-En Chang, Wen-Hsiu Hsu and Wu-Hsien Kuo
    Citation: BMC Cancer 2014 14:112
    Content type: Research article Published on:

  20. Bevacizumab, an antibody neutralizing Vascular Endothelial Growth Factor (VEGF), is licensed for the management of patients with advanced colon cancer. However, tumor biomarkers identifying the molecular tumor...

    Authors: George Pentheroudakis, Vassiliki Kotoula, Elena Fountzilas, George Kouvatseas, George Basdanis, Ioannis Xanthakis, Thomas Makatsoris, Elpida Charalambous, Demetris Papamichael, Epaminontas Samantas, Pavlos Papakostas, Dimitrios Bafaloukos, Evangelia Razis, Christos Christodoulou, Ioannis Varthalitis, Nicholas Pavlidis…
    Citation: BMC Cancer 2014 14:111
    Content type: Research article Published on:

  21. In many tumour types serumlactate dehydrogenase (LDH) levels proved to represent an indirect marker of tumour hypoxia, neo-angiogenesis and worse prognosis. As we previously reported LDH is an important predic...

    Authors: Luca Faloppi, Mario Scartozzi, Maristella Bianconi, Gianluca Svegliati Baroni, Pierluigi Toniutto, Riccardo Giampieri, Michela Del Prete, Samuele De Minicis, Davide Bitetto, Cristian Loretelli, Marco D’Anzeo, Antonio Benedetti and Stefano Cascinu
    Citation: BMC Cancer 2014 14:110
    Content type: Research article Published on:

  22. MicroRNAs(miRNAs) are small non-coding RNAs that participate in a variety of biologic processes, and dysregulation of miRNA is always associated with cancer development and progression. Aberrant expression of ...

    Authors: Guang-jun Zhang, He Zhou, Hua-xu Xiao, Yu Li and Tong Zhou
    Citation: BMC Cancer 2014 14:109
    Content type: Research article Published on:

  23. Hepatocellular carcinoma (HCC) is one of the major causes of cancer-related death especially among Asian and African populations. It is urgent that we identify carcinogenesis-related genes to establish an inno...

    Authors: Masamichi Hayashi, Shuji Nomoto, Mitsuhiro Hishida, Yoshikuni Inokawa, Mitsuro Kanda, Yukiyasu Okamura, Yoko Nishikawa, Chie Tanaka, Daisuke Kobayashi, Suguru Yamada, Goro Nakayama, Tsutomu Fujii, Hiroyuki Sugimoto, Masahiko Koike, Michitaka Fujiwara, Shin Takeda…
    Citation: BMC Cancer 2014 14:108
    Content type: Research article Published on:

  24. ATAD2 is associated with many cellular processes, such as cell growth, migration and invasion. However, no studies have been conducted on the molecular biological function of the ATAD2 gene in hepatocellular c...

    Authors: Gang Wu, Haiyang Liu, Hui He, Yawei Wang, Xiaojun Lu, Yanqiu Yu, Shuguan Xia, Xiangyu Meng and Yongfeng Liu
    Citation: BMC Cancer 2014 14:107
    Content type: Research article Published on:

  25. Prostate cancer is the most common cancer in male in most Western countries, including France. Despite a significant morbidity and mortality to a lesser extent, the etiology of prostate cancer remains largely ...

    Authors: Florence Menegaux, Antoinette Anger, Hasina Randrianasolo, Claire Mulot, Pierre Laurent-Puig, François Iborra, Jean-Pierre Bringer, Benoit Leizour, Rodolphe Thuret, Pierre-Jean Lamy, Xavier Rébillard and Brigitte Trétarre
    Citation: BMC Cancer 2014 14:106
    Content type: Study protocol Published on:

  26. Increased ratio of n-3/n-6 polyunsaturated fatty acids (PUFAs) in diet or serum may have a protective effect on the risk of breast cancer (BC); however, the conclusions from prospective studies are still contr...

    Authors: Bo Yang, Xiao-Li Ren, Yuan-Qin Fu, Jin-Long Gao and Duo Li
    Citation: BMC Cancer 2014 14:105
    Content type: Research article Published on:

  27. Glypican-3(GPC3) has been implicated in tumor development and progression for several years. However, the prognostic significance of GPC3 expression in patients with hepatocellular carcinoma (HCC) is controver...

    Authors: Wei-Kai Xiao, Chao-Ying Qi, Dong Chen, Shao-Qiang Li, Shun-Jun Fu, Bao-Gang Peng and Li-Jian Liang
    Citation: BMC Cancer 2014 14:104
    Content type: Research article Published on:

  28. Obesity is associated with an increased risk of esophageal adenocarcinoma (EAC) and a decreased risk of esophageal squamous cell carcinoma (ESCC). However, little is known about the risk of EAC and ESCC relate...

    Authors: Björn Lindkvist, Dorthe Johansen, Tanja Stocks, Hans Concin, Tone Bjørge, Martin Almquist, Christel Häggström, Anders Engeland, Göran Hallmans, Gabriele Nagel, Håkan Jonsson, Randi Selmer, Hanno Ulmer, Steinar Tretli, Pär Stattin and Jonas Manjer
    Citation: BMC Cancer 2014 14:103
    Content type: Research article Published on:

  30. GATA-5, a zinc-finger transcription factor and member of the GATA family proteins 1–6, is known to be involved in cellular differentiation. We recently found that tumor-specific hypermethylation of the GATA5 CpG ...

    Authors: Inga Peters, Natalia Dubrowinskaja, Michael Kogosov, Mahmoud Abbas, Jörg Hennenlotter, Christoph von Klot, Axel S Merseburger, Arnulf Stenzl, Ralph Scherer, Markus A Kuczyk and Jürgen Serth
    Citation: BMC Cancer 2014 14:101
    Content type: Research article Published on:

  31. At the present time, there is a lack of data about the involvement of flotillins and stomatin in the development of non-small cell lung cancer (NSCLC) and soft tissue sarcomas (STS). Moreover, changes in expre...

    Authors: Ksenia A Arkhipova, Anastasia N Sheyderman, Konstantin K Laktionov, Valeria V Mochalnikova and Irina B Zborovskaya
    Citation: BMC Cancer 2014 14:100
    Content type: Research article Published on:

  32. Endothelial cells play a complex role in the pathobiology of cancer. This role is not limited to the making of blood vessels to allow for influx of oxygen and nutrients required for the high metabolic demands ...

    Authors: Kathleen G Neiva, Kristy A Warner, Marcia S Campos, Zhaocheng Zhang, Juliana Moren, Theodora E Danciu and Jacques E Nör
    Citation: BMC Cancer 2014 14:99
    Content type: Research article Published on:

  33. Esophageal squamous cell carcinoma (ESCC) is one of the most lethal malignancies with a 5-year survival rate less than 15%. Understanding of the molecular mechanisms involved in the pathogenesis of ESCC become...

    Authors: Haidan Liu, Jinfu Yang, Yunchang Yuan, Zhenkun Xia, Mingjiu Chen, Li Xie, Xiaolong Ma, Jian Wang, Sufeng Ouyang, Qin Wu, Fenglei Yu, Xinmin Zhou, Yifeng Yang, Ya Cao, Jianguo Hu and Bangliang Yin
    Citation: BMC Cancer 2014 14:98
    Content type: Research article Published on:

  34. Accumulating evidence showed that microRNAs are involved in development and progression of multiple tumors. Recent studies have found that miR-181a were dysregulated in several types of cancers, however, the f...

    Authors: Chengcheng Zou, Yongguo Li, Yiyi Cao, Jinnan Zhang, Jingrong Jiang, Yanrui Sheng, Sen Wang, Ailong Huang and Hua Tang
    Citation: BMC Cancer 2014 14:97
    Content type: Research article Published on:

  35. There are a lot of unmet needs in patients with triple-negative breast cancer (TNBC). Fenofibrate, a peroxisome proliferator-activated receptor alpha (PPAR-α) agonist, has been used for decades to treat hypert...

    Authors: Ting Li, Qunling Zhang, Jian Zhang, Gong Yang, Zhimin Shao, Jianmin Luo, Minhao Fan, Chen Ni, Zhenhua Wu and Xichun Hu
    Citation: BMC Cancer 2014 14:96
    Content type: Research article Published on:

  36. Accurate indication classification is critical for obtaining unbiased estimates of colonoscopy effectiveness and quality improvement efforts, but there is a dearth of published systematic classification approa...

    Authors: Hirut Fassil, Kenneth F Adams, Sheila Weinmann, V Paul Doria-Rose, Eric Johnson, Andrew E Williams, Douglas A Corley and Chyke A Doubeni
    Citation: BMC Cancer 2014 14:95
    Content type: Research article Published on:

  37. Although cancer survivors are known to be at greater risk of developing second primary cancer (SPC), SPC incidence estimates in France are thus far lacking. We used a multivariate approach to compute these est...

    Authors: Jérémie Jégu, Marc Colonna, Laetitia Daubisse-Marliac, Brigitte Trétarre, Olivier Ganry, Anne-Valérie Guizard, Simona Bara, Xavier Troussard, Véronique Bouvier, Anne-Sophie Woronoff and Michel Velten
    Citation: BMC Cancer 2014 14:94
    Content type: Research article Published on:

  39. Cancer patients with primary tumors showing extensive hypoxia and highly elevated interstitial fluid pressure (IFP) have poor prognosis. The potential of diffusion-weighted magnetic resonance imaging (DW-MRI) ...

    Authors: Tord Hompland, Christine Ellingsen, Kanthi Galappathi and Einar K Rofstad
    Citation: BMC Cancer 2014 14:92
    Content type: Research article Published on:

  41. A subpopulation of tumor cells with distinct stem-like properties (cancer stem-like cells, CSCs) may be responsible for tumor initiation, invasive growth, and possibly dissemination to distant organ sites. CSC...

    Authors: Zhihong Chen, Lora W Forman, Robert M Williams and Douglas V Faller
    Citation: BMC Cancer 2014 14:90
    Content type: Research article Published on:

  42. Retinoblastoma (Rb) is the most common intraocular tumor in childhood worldwide. It is a deadly pediatric eye cancer. The main cause of death in Rb patients is intracranial and systemic metastasis. ROCK is the...

    Authors: Jing Wang, Xiao-Hong Liu, Zi-Jian Yang, Bing Xie and Yi-Sheng Zhong
    Citation: BMC Cancer 2014 14:89
    Content type: Research article Published on:

  43. Effective chemotherapy rapidly reduces the spin–lattice relaxation of water protons (T1) in solid tumours and this change (ΔT1) often precedes and strongly correlates with the eventual change in tumour volume (TV...

    Authors: Claudia Weidensteiner, Peter R Allegrini, Melanie Sticker-Jantscheff, Vincent Romanet, Stephane Ferretti and Paul MJ McSheehy
    Citation: BMC Cancer 2014 14:88
    Content type: Research article Published on:

  44. The struggle against social inequalities is a priority for many international organizations. The objective of the study was to quantify the cancer burden related to social deprivation by identifying the cancer...

    Authors: Josephine Bryere, Olivier Dejardin, Veronique Bouvier, Marc Colonna, Anne-Valérie Guizard, Xavier Troussard, Carole Pornet, Françoise Galateau-Salle, Simona Bara, Ludivine Launay, Lydia Guittet and Guy Launoy
    Citation: BMC Cancer 2014 14:87
    Content type: Research article Published on:

  45. To determine the diagnostic and prognostic capability of urinary and tumoral syndecan-1 (SDC-1) levels in patients with cancer of the urinary bladder.

    Authors: Makito Miyake, Adrienne Lawton, Yunfeng Dai, Myron Chang, Lourdes Mengual, Antonio Alcaraz, Steve Goodison and Charles J Rosser
    Citation: BMC Cancer 2014 14:86
    Content type: Research article Published on:

  46. Pancreatic cancer is one of the most aggressive cancers, and the aggressiveness of pancreatic cancer is in part due to its intrinsic and extrinsic drug resistance characteristics, which are also associated wit...

    Authors: Yuhua Lu, Jingjing Lu, Xiaohong Li, Hui Zhu, Xiangjun Fan, Shajun Zhu, Yao Wang, Qingsong Guo, Lei Wang, Yan Huang, Mingyan Zhu and Zhiwei Wang
    Citation: BMC Cancer 2014 14:85
    Content type: Research article Published on:

  47. Recent evidence suggests that the prostate cancer (PCa)-specific up-regulation of certain genes such as AMACR, EZH2, PSGR, PSMA and TRPM8 could be associated with an aberrant expression of non-coding microRNAs...

    Authors: Kati Erdmann, Knut Kaulke, Cathleen Thomae, Doreen Huebner, Mildred Sergon, Michael Froehner, Manfred P Wirth and Susanne Fuessel
    Citation: BMC Cancer 2014 14:82
    Content type: Research article Published on:

  48. Improved insight into the molecular characteristics of the different ovarian cancer subgroups is needed for developing a more individualized and optimized treatment regimen. The aim of this study was to a) ide...

    Authors: Bente Vilming Elgaaen, Ole Kristoffer Olstad, Kari Bente Foss Haug, Berit Brusletto, Leiv Sandvik, Anne Cathrine Staff, Kaare M Gautvik and Ben Davidson
    Citation: BMC Cancer 2014 14:80
    Content type: Research article Published on:

  49. Quickly and accurately localizing small peripheral pulmonary lesions can avoid prolonged operative time and unplanned open thoracotomy. In this study, we aimed to introduce and evaluate a new technique combini...

    Authors: Yang Shentu, Liang Zhang, Hengle Gu, Feng Mao, Minghui Cai, Zhengping Ding and Zhiqiang Wang
    Citation: BMC Cancer 2014 14:79
    Content type: Research article Published on:

  50. Increasing evidence suggests that forkhead box A1 (FOXA1) is frequently dysregulated in many types of human cancers. However, the exact function and mechanism of FOXA1 in human endometrial cancer (EC) remains ...

    Authors: Meiting Qiu, Wei Bao, Jingyun Wang, Tingting Yang, Xiaoying He, Yun Liao and Xiaoping Wan
    Citation: BMC Cancer 2014 14:78
    Content type: Research article Published on:

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