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  1. Comprehensive evidence on the incidence, time course and independent risk factors of metachronous peritoneal carcinomatosis (metaPC) in gastric cancer patients treated with curative intent in the context of av...

    Authors: Florian Seyfried, Burkhard H von Rahden, Alexander D Miras, Martin Gasser, Uwe Maeder, Volker Kunzmann, Christoph-Thomas Germer, Jörg OW Pelz and Alexander G Kerscher
    Citation: BMC Cancer 2015 15:73
    Content type: Research article Published on:

  3. Expression and activation of the cMET receptor have been implicated in tumor progression and resistance to chemotherapy in human pancreatic cancer. In this regard we assessed the effects of targeting cMET in p...

    Authors: Franziska Brandes, Katharina Schmidt, Christine Wagner, Julia Redekopf, Hans Jürgen Schlitt, Edward Kenneth Geissler and Sven Arke Lang
    Citation: BMC Cancer 2015 15:71
    Content type: Research article Published on:

  4. We previously identified dermicidin (DCD), which encodes a growth and survival factor, as a gene amplified and overexpressed in a subset of breast tumors. Patients with DCD-positive breast cancer have worse pr...

    Authors: Jasna Bancovik, Dayson F Moreira, Daniel Carrasco, Jun Yao, Dale Porter, Ricardo Moura, Anamaria Camargo, Cibely C Fontes-Oliveira, Miguel G Malpartida, Silvia Carambula, Edouard Vannier, Bryan E Strauss, Alda Wakamatsu, Venancio AF Alves, Angela F Logullo, Fernando A Soares…
    Citation: BMC Cancer 2015 15:70
    Content type: Research article Published on:

  5. Glioblastoma multiforme (GBM) is the most common primary central nervous system neoplasm in adults. Radioactive 125I seed implantation has been widely applied in the treatment of cancers. Moreover, previous clini...

    Authors: Yunhong Tian, Qiang Xie, Jie He, Xiaojun Luo, Tao Zhou, Ying Liu, Zuoping Huang, Yunming Tian, Dan Sun and Kaitai Yao
    Citation: BMC Cancer 2015 15:1
    Content type: Research article Published on:

  6. Varying the rate of continuous intravenous infusions of 5-fluorouracil (5FU) chemotherapy over a 24-hour period has been reported to improve patient outcomes. It has been hypothesized that circadian variation ...

    Authors: Gini F Fleming, Philip Schumm, Greg Friberg, Mark J Ratain, Uchenna O Njiaju and Richard L Schilsky
    Citation: BMC Cancer 2015 15:69
    Content type: Research article Published on:

  7. Alterations and senescence in bone marrow mesenchymal stromal cells of multiple myeloma patients (MM-BMMSCs) have become an important research focus. However the role of senescence in the pathophysiology of MM...

    Authors: Rimma Berenstein, Olga Blau, Axel Nogai, Marlies Waechter, Ekaterina Slonova, Martin Schmidt-Hieber, Annegret Kunitz, Antonio Pezzutto, Bernd Doerken and Igor Wolfgang Blau
    Citation: BMC Cancer 2015 15:68
    Content type: Research article Published on:

  8. This study aims to evaluate the impact of colony stimulating factor-1 (CSF-1) expression on recurrence and survival of patients with clear-cell renal cell carcinoma (ccRCC) following surgery.

    Authors: Liu Yang, Qian Wu, Le Xu, Weijuan Zhang, Yu Zhu, Haiou Liu, Jiejie Xu and Jianxin Gu
    Citation: BMC Cancer 2015 15:67
    Content type: Research article Published on:

  9. Thymidine kinase 1 (TK1) is a cellular enzyme involved in DNA precursor synthesis, and its activity has been used as a proliferation marker for monitoring malignant diseases. Here, for the first time, we evalu...

    Authors: Kiran Kumar Jagarlamudi, Lars Olof Hansson and Staffan Eriksson
    Citation: BMC Cancer 2015 15:66
    Content type: Research article Published on:

  10. To select optimal candidates for limited lung resection, it is necessary to accurately differentiate the non-invasive tumors from other small-sized lung cancer. Urinary N1, N12-diacetylspermine (DiAcSpm) has been...

    Authors: Yusuke Takahashi, Hirotoshi Horio, Koji Sakaguchi, Kyoko Hiramatsu and Masao Kawakita
    Citation: BMC Cancer 2015 15:65
    Content type: Research article Published on:

  11. The clinical significance of microRNAs (miRNAs) in intrahepatic cholangiocarcinoma (ICC) is unclear. The objective of this study is to examine the miRNA expression profiles and identify a miRNA signature for t...

    Authors: Mei-Yin Zhang, Shu-Hong Li, Guo-Liang Huang, Guo-He Lin, Ze-Yu Shuang, Xiang-Ming Lao, Li Xu, Xiao-Jun Lin, Hui-Yun Wang and Sheng-Ping Li
    Citation: BMC Cancer 2015 15:64
    Content type: Research article Published on:

  12. Despite long-term or permanent health problems, cancer survivors are often motivated to return to work. For cancer survivors who have lost their job, return to work can be more challenging compared to employed...

    Authors: Martine P van Egmond, Saskia FA Duijts, Sylvia J Vermeulen, Allard J van der Beek and Johannes R Anema
    Citation: BMC Cancer 2015 15:63
    Content type: Study protocol Published on:

  13. Given the paucity of information on dose intensity, the objective of this study is to describe the use of adjuvant chemotherapy for stage III colon cancer, focusing on relative dose intensity (RDI), overall su...

    Authors: Sherrie L Aspinall, Chester B Good, Xinhua Zhao, Francesca E Cunningham, Bernadette B Heron, Mark Geraci, Vida Passero, Roslyn A Stone, Kenneth J Smith, Renee Rogers, Jenna Shields, Megan Sartore, D Patrick Boyle, Sherry Giberti, John Szymanski, Doug Smith…
    Citation: BMC Cancer 2015 15:62
    Content type: Research article Published on:

  14. Patients with BRAF mutation-positive advanced melanoma respond well to matched therapy with BRAF or MEK inhibitors, but often quickly develop resistance.

    Authors: Jennifer Wheler, Roman Yelensky, Gerald Falchook, Kevin B Kim, Patrick Hwu, Apostolia M Tsimberidou, Philip J Stephens, David Hong, Maureen T Cronin and Razelle Kurzrock
    Citation: BMC Cancer 2015 15:61
    Content type: Research article Published on:

  15. Clear cell sarcoma (CCS), initially named malignant melanoma of soft parts, is an aggressive soft tissue sarcoma (STS) that, due to MITF activation, shares with melanoma the expression of melanocyte differenti...

    Authors: Marcella Tazzari, Elena Palassini, Barbara Vergani, Antonello Villa, Francesca Rini, Tiziana Negri, Chiara Colombo, Flavio Crippa, Carlo Morosi, Paolo G Casali, Silvana Pilotti, Silvia Stacchiotti, Licia Rivoltini and Chiara Castelli
    Citation: BMC Cancer 2015 15:58
    Content type: Case report Published on:

  16. Risk classification and prediction of prognosis in GIST is still a matter of debate. Data on the impact of age and gender as potential confounding factors are limited. Therefore we comprehensively investigated...

    Authors: Klaus Kramer, Uwe Knippschild, Benjamin Mayer, Kira Bögelspacher, Hanno Spatz, Doris Henne-Bruns, Abbas Agaimy, Matthias Schwab and Michael Schmieder
    Citation: BMC Cancer 2015 15:57
    Content type: Research article Published on:

  17. Colorectal cancer is one of the major causes of cancer mortality world-wide. Prevention would improve if at-risk subjects could be identified. The aim of this study was to characterise plasma protein biomarker...

    Authors: Michela Bertuzzi, Cristina Marelli, Renzo Bagnati, Alessandro Colombi, Roberto Fanelli, Calogero Saieva, Marco Ceroti, Benedetta Bendinelli, Saverio Caini, Luisa Airoldi and Domenico Palli
    Citation: BMC Cancer 2015 15:56
    Content type: Research article Published on:

  18. Neo-adjuvant breast cancer clinical trials of zoledronic acid (ZOL) have shown that patients with oestrogen negative (ER-ve) tumours have improved disease outcomes. We investigated the molecular mechanism behi...

    Authors: Caroline Wilson, Penelope Ottewell, Robert E Coleman and Ingunn Holen
    Citation: BMC Cancer 2015 15:55
    Content type: Research article Published on:

  19. Gamma knife radiosurgery (GKRS) has been increasingly employed for the treatment of elderly patients with brain metastases, mainly due to its demonstrated effectiveness and low complication rate. However, only...

    Authors: Jae-Young Park, Kyung-Sub Moon, Kyung-Hwa Lee, Sa-Hoe Lim, Woo-Youl Jang, Hyeseon Lee, Tae-Young Jung, In-Young Kim and Shin Jung
    Citation: BMC Cancer 2015 15:54
    Content type: Research article Published on:

  20. S100 family proteins have recently been identified as biomarkers in various cancers. Of this protein family, S100A14 and S100A16 are also believed to play an important role in tumor progression. The aim of the...

    Authors: Mizuko Tanaka, Naoki Ichikawa-Tomikawa, Namiko Shishito, Keisuke Nishiura, Tomiko Miura, Ayumi Hozumi, Hideki Chiba, Sayaka Yoshida, Tohru Ohtake and Takashi Sugino
    Citation: BMC Cancer 2015 15:53
    Content type: Research article Published on:

  21. Transformation of B-cell chronic lymphocytic leukaemia (B-CLL) to diffuse large B cell lymphoma (DLBCL) (Richter’s syndrome (RS)) is a rare (2-15% of patients) but catastrophic complication of B-CLL. Dose-inte...

    Authors: Toby A Eyre, Ruth Clifford, Corran Roberts, Lucy Boyle, Anne Francis, Anna Schuh and Susan J Dutton
    Citation: BMC Cancer 2015 15:52
    Content type: Study protocol Published on:

  22. We explored if known risk factors for pancreatic cancer such as type II diabetes and chronic inflammation, influence the pathophysiology of an established primary tumor in the pancreas and if administration of...

    Authors: Dietmar Zechner, Tobias Radecke, Jonas Amme, Florian Bürtin, Ann-Christin Albert, Lars Ivo Partecke and Brigitte Vollmar
    Citation: BMC Cancer 2015 15:51
    Content type: Research article Published on:

  23. Drug resistance is a major challenge in cancer therapeutics. Abundant evidence indicates that DNA repair systems are enhanced after repetitive chemotherapeutic treatments, rendering cancers cells drug-resistan...

    Authors: Jianwei Wang, Lina Zhou, Zhi Li, Ting Zhang, Wenpeng Liu, Zheng Liu, Yate-Ching Yuan, Fan Su, Lu Xu, Yan Wang, Xiaotong Zhou, Hong Xu, Yuejin Hua, Ying-Jie Wang, Li Zheng, Yue-E Teng…
    Citation: BMC Cancer 2015 15:50
    Content type: Research article Published on:

  25. Both oxaliplatin/capecitabine-based chemoradiation (OXCAP-RT) and carboplatin-paclitaxel based radiation (CarPac-RT) are active regimens in oesophageal adenocarcinoma, but no randomised study has compared thei...

    Authors: Somnath Mukherjee, Christopher N Hurt, Sarah Gwynne, Andrew Bateman, Simon Gollins, Ganesh Radhakrishna, Maria Hawkins, Jo Canham, Wyn Lewis, Heike I Grabsch, Ricky A Sharma, Wendy Wade, Rhydian Maggs, Bethan Tranter, Ashley Roberts, David Sebag-Montefiore…
    Citation: BMC Cancer 2015 15:48
    Content type: Study protocol Published on:

  26. A majority of patients with rectal cancer and metastasis are not eligible to curative treatment because of an extensive and unresectable metastatic disease. Primary tumor resection is still debated in this sit...

    Authors: Eddy Cotte, Laurent Villeneuve, Guillaume Passot, Gilles Boschetti, Sylvie Bin-Dorel, Yves Francois and Olivier Glehen
    Citation: BMC Cancer 2015 15:47
    Content type: Study protocol Published on:

  27. Renal cell cancer (RCC) is one of the most frequent primary sites for metastatic pancreatic tumors although metastatic tumors are rare among pancreatic malignant tumors. The purpose of this study is to disclos...

    Authors: Takeshi Yuasa, Naoko Inoshita, Akio Saiura, Shinya Yamamoto, Shinji Urakami, Hitoshi Masuda, Yasuhisa Fujii, Iwao Fukui, Yuichi Ishikawa and Junji Yonese
    Citation: BMC Cancer 2015 15:46
    Content type: Research article Published on:

  28. The evolution of mutations in the BCR-ABL1 fusion gene transcript renders CML patients resistant to tyrosine kinase inhibitor (TKI) based therapy. Thus screening for BCR-ABL1 mutations is recommended particularly...

    Authors: Lucia Cavelier, Adam Ameur, Susana Häggqvist, Ida Höijer, Nicola Cahill, Ulla Olsson-Strömberg and Monica Hermanson
    Citation: BMC Cancer 2015 15:45
    Content type: Research article Published on:

  29. The tumor microenvironment plays a determinative role in stimulating tumor progression and metastasis. Notably, tumor-stroma signals affect the pattern of infiltrated immune cells and the profile of tumor-rele...

    Authors: Birgitte Grum-Schwensen, Jörg Klingelhöfer, Mette Beck, Charlotte Menné Bonefeld, Petra Hamerlik, Per Guldberg, Mariam Grigorian, Eugene Lukanidin and Noona Ambartsumian
    Citation: BMC Cancer 2015 15:44
    Content type: Research article Published on:

  33. The optimal form of exercise for individuals with cancer has yet to be identified, but there is evidence that exercise improves their quality of life. The aim of this study is to assess the efficacy and effici...

    Authors: Aintzane Sancho, Sergio Carrera, Marisol Arietaleanizbeascoa, Veronica Arce, Nere Mendizabal Gallastegui, Anna Giné March, Aitor Sanz-Guinea, Araceli Eskisabel, Ana Lopez Rodriguez, Rosa A Martín, Guillermo Lopez-Vivanco and Gonzalo Grandes
    Citation: BMC Cancer 2015 15:40
    Content type: Study protocol Published on:

  34. Trogocytosis is defined as the transfer of cell-surface membrane proteins and membrane patches from one cell to another through contact. It is reported that human epidermal growth factor receptor 2 (HER2) coul...

    Authors: Eiji Suzuki, Tatsuki R Kataoka, Masahiro Hirata, Kosuke Kawaguchi, Mariko Nishie, Hironori Haga and Masakazu Toi
    Citation: BMC Cancer 2015 15:39
    Content type: Research article Published on:

  35. To describe the Gd-EOB-DTPA-enhanced MRI appearances of cholangiocarcinoma, and evaluate the relative signal intensities (RSIs) changes of major abdominal organs, and investigate the effect of total bilirubin ...

    Authors: Shi-Ting Feng, Ling Wu, Huasong Cai, Tao Chan, Yanji Luo, Zhi Dong, Keguo Zheng and Zi-Ping Li
    Citation: BMC Cancer 2015 15:38
    Content type: Research article Published on:

  36. Epidemiologic data indicates that Asian diets, which are high in soy protein, reduce a women’s risk of developing breast cancer. However, it has been difficult to dissociate the benefits of soy from other vari...

    Authors: Katrina L Watson, Leanne Stalker, Robert A Jones and Roger A Moorehead
    Citation: BMC Cancer 2015 15:37
    Content type: Research article Published on:

  37. The microscopic residual tumor at the bronchial margin after radical surgery (R1 resection) affects prognosis negatively in non-small-cell lung cancer (NSCLC) patients. For patients with good performance statu...

    Authors: Meixiang Zhou, Tao Li, Yongmei Liu, Changjin Sun, Na Li, Yong Xu, Jiang Zhu, Zhenyu Ding, Yongsheng Wang, Meijuan Huang, Feng Peng, Jin Wang, Li Ren, You Lu and Youling Gong
    Citation: BMC Cancer 2015 15:36
    Content type: Research article Published on:

  38. Human epidermal growth factor receptor-2 (HER2) overexpression and gene amplification are currently established by immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH), respectively. This stud...

    Authors: Thomas v O Hansen, Jonas Vikesaa, Sine S Buhl, Henrik H Rossing, Vera Timmermans-Wielenga and Finn C Nielsen
    Citation: BMC Cancer 2015 15:35
    Content type: Research article Published on:

  39. Toll-like receptors (TLRs) are effector molecules expressed on the surface of ovarian cancer (OC) cells, but the functions of the TLR2/TLR4 signaling pathways in these cells remain unclear. Melatonin (mel) act...

    Authors: Luiz Gustavo A Chuffa, Beatriz A Fioruci-Fontanelli, Leonardo O Mendes, Fábio R Ferreira Seiva, Marcelo Martinez, Wagner J Fávaro, Raquel F Domeniconi, Patrícia FF Pinheiro, Lucilene Delazari dos Santos and Francisco Eduardo Martinez
    Citation: BMC Cancer 2015 15:34
    Content type: Research article Published on:

  40. The purpose of this study was to evaluate serum HE4 as a biomarker to detect recurrent disease during follow-up of patients with endometrial adenocarcinoma (EAC).

    Authors: Donal J Brennan, Andreas Hackethal, Kristy P Mann, Irene Mutz-Dehbalaie, Heidi Fiegl, Christian Marth and Andreas Obermair
    Citation: BMC Cancer 2015 15:33
    Content type: Research article Published on:

  41. Adenocarcinomas of both the gastroesophageal junction and stomach are molecularly complex, but differ with respect to epidemiology, etiology and survival. There are few data directly comparing the frequencies ...

    Authors: Hector H Li-Chang, Katayoon Kasaian, Ying Ng, Amy Lum, Esther Kong, Howard Lim, Steven JM Jones, David G Huntsman, David F Schaeffer and Stephen Yip
    Citation: BMC Cancer 2015 15:32
    Content type: Research article Published on:

  42. Lung adenocarcinoma patients with EGFR gene mutations have shown a dramatic response to gefitinib. However, drug resistance eventually emerges which limits the mean duration of response. With that in view, we exa...

    Authors: Rintaro Noro, Masahiro Seike, Fenfei Zou, Chie Soeno, Kuniko Matsuda, Teppei Sugano, Nobuhiko Nishijima, Masaru Matsumoto, Kazuhiro Kitamura, Seiji Kosaihira, Yuji Minegishi, Akinobu Yoshimura, Kaoru Kubota and Akihiko Gemma
    Citation: BMC Cancer 2015 15:31
    Content type: Research article Published on:

  43. Germline mutations in PALB2 have been identified in approximately 1% of familial breast cancer (BC) in several populations. Nevertheless its contribution in the South-American population is unknown. The goal of t...

    Authors: Yessica Leyton, Patricio Gonzalez-Hormazabal, Rafael Blanco, Teresa Bravo, Ricardo Fernandez-Ramires, Sebastian Morales, Natalia Landeros, Jose M Reyes, Octavio Peralta, Julio C Tapia, Fernando Gomez, Enrique Waugh, Gladys Ibañez, Janara Pakomio, Gilberto Grau and Lilian Jara
    Citation: BMC Cancer 2015 15:30
    Content type: Research article Published on:

  44. Esophageal carcinoma is one of the most common malignancies with high cancer-related morbidity and mortality worldwide. MicroRNAs (miRNAs) are a class of small non-coding RNAs that regulate a wide variety of c...

    Authors: Tingting Yu, Risheng Cao, Shuo Li, Mingen Fu, Lihua Ren, Weixu Chen, Hong Zhu, Qiang Zhan and Ruihua Shi
    Citation: BMC Cancer 2015 15:29
    Content type: Research article Published on:

  45. While weight gain following breast cancer is considered common, results supporting these findings are dated. This work describes changes in body weight following breast cancer over 72 months, compares weight w...

    Authors: Dimitrios Vagenas, Tracey DiSipio, Diana Battistutta, Wendy Demark-Wahnefried, Sheree Rye, John Bashford, Chris Pyke, Christobel Saunders and Sandra C Hayes
    Citation: BMC Cancer 2015 15:28
    Content type: Research article Published on:

  46. The ability of medical practitioners to communicate risk estimates effectively to patients diagnosed with melanoma relies on accurate information about prognostic factors and their impact on survival. This stu...

    Authors: Peter D Baade, Patrick Royston, Philipa H Youl, Martin A Weinstock, Alan Geller and Joanne F Aitken
    Citation: BMC Cancer 2015 15:27
    Content type: Research article Published on:

  47. The number of predictive biomarkers that will be necessary to assess in clinical practice will increase with the availability of drugs that target specific molecular alterations. Therefore, diagnostic laborato...

    Authors: Bastiaan BJ Tops, Nicola Normanno, Henriette Kurth, Eliana Amato, Andrea Mafficini, Nora Rieber, Delphine Le Corre, Anna Maria Rachiglio, Anne Reiman, Orla Sheils, Christoph Noppen, Ludovic Lacroix, Ian A Cree, Aldo Scarpa, Marjolijn JL Ligtenberg and Pierre Laurent-Puig
    Citation: BMC Cancer 2015 15:26
    Content type: Research article Published on:

  48. The discovery of cancer stem cells and tumor heterogeneity prompted the exploration of additional mechanisms aside from genetic mutations for carcinogenesis and cancer progression. The aim of the present study...

    Authors: Xianghui He, Baosong Li, Yang Shao, Na Zhao, Yiling Hsu, Zhixiang Zhang and Liwei Zhu
    Citation: BMC Cancer 2015 15:24
    Content type: Research article Published on:

  49. Bilateral diffuse uveal melanocytic proliferation (BDUMP) is a paraneoplastic ocular syndrome occurring in patients with systemic, often occult but advanced carcinoma and is the hallmark of poor prognosis. Ocu...

    Authors: Maria Pefkianaki, Rupesh Agrawal, Parul Desai, Carlos Pavesio and Mandeep S Sagoo
    Citation: BMC Cancer 2015 15:23
    Content type: Case report Published on:

  50. A breast cancer susceptibility locus has been mapped to the gene encoding TOX3. Little is known regarding the expression pattern or biological role of TOX3 in breast cancer or in the mammary gland. Here we ana...

    Authors: Akop Seksenyan, Asha Kadavallore, Ann E Walts, Brian de la Torre, Dror Berel, Samuel P Strom, Parinaz Aliahmad, Vincent A Funari and Jonathan Kaye
    Citation: BMC Cancer 2015 15:22
    Content type: Research article Published on:

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