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  1. Angiogenesis, among other signaling pathways, plays a key-role in sarcoma biology. Regorafenib (RE) has recently been shown to be effective in imatinib and sunitinib-refractory GIST in a phase III trial.

    Authors: Thomas Brodowicz, Bernadette Liegl-Atzwager, Emmanuelle Tresch, Sophie Taieb, Andrew Kramar, Viktor Gruenwald, Marie Vanseymortier, Stéphanie Clisant, Jean-Yves Blay, Axel Le Cesne and Nicolas Penel
    Citation: BMC Cancer 2015 15:127
    Content type: Study protocol Published on:

  2. Inflammatory cytokines in the colonic microenvironment have been shown to increase with advance colorectal cancer disease state. However, the contribution of inflammatory cytokines to pre-malignant disease, su...

    Authors: Curtis J Henry, Rebecca L Sedjo, Andrii Rozhok, Jennifer Salstrom, Dennis Ahnen, Theodore R Levin, Ralph D’Agostino Jr, Steven Haffner, James DeGregori and Tim Byers
    Citation: BMC Cancer 2015 15:123
    Content type: Research article Published on:

  3. We performed a multicenter, double-blind, placebo-controlled, phase II clinical trial of human dsDNA-based preparation Panagen in a tablet form. In total, 80 female patients with stage II-IV breast cancer were...

    Authors: Anastasia S Proskurina, Tatiana S Gvozdeva, Ekaterina A Alyamkina, Evgenia V Dolgova, Konstantin E Orishchenko, Valeriy P Nikolin, Nelly A Popova, Sergey V Sidorov, Elena R Chernykh, Alexandr A Ostanin, Olga Y Leplina, Victoria V Dvornichenko, Dmitriy M Ponomarenko, Galina S Soldatova, Nikolay A Varaksin, Tatiana G Ryabicheva…
    Citation: BMC Cancer 2015 15:122
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Cancer 2016 16:117

  4. Despite multimodal therapy esophageal cancer often presents with poor prognosis. To improve outcome, tumor angiogenesis and anti-angiogenic therapeutic agents have recently gained importance. However, patient ...

    Authors: Lena Dreikhausen, Susanne Blank, Leila Sisic, Ulrike Heger, Wilko Weichert, Dirk Jäger, Thomas Bruckner, Natalia Giese, Lars Grenacher, Christine Falk, Katja Ott and Thomas Schmidt
    Citation: BMC Cancer 2015 15:121
    Content type: Research article Published on:

  5. This study aimed to evaluate the behavior of non-muscle-invasive bladder cancer (NMIBC) in patients submitted to transurethral bladder resection (TURB) comparing subjects in chronic therapy with aspirin, stati...

    Authors: Antonio Luigi Pastore, Giovanni Palleschi, Andrea Fuschi, Luigi Silvestri, Yazan Al Salhi, Elisabetta Costantini, Alessandro Zucchi, Vincenzo Petrozza, Cosimo de Nunzio and Antonio Carbone
    Citation: BMC Cancer 2015 15:120
    Content type: Research article Published on:

  6. Everolimus (RAD001) is an orally administered mTOR inhibitor that is well known for its antitumor efficacy and that has been approved for the treatment of several solid tumors, including renal cell carcinoma. ...

    Authors: Ji Hyun Park, Min-Hee Ryu, Young Soo Park, Sook Ryun Park, Young-Soon Na, Baek-Yeol Rhoo and Yoon-Koo Kang
    Citation: BMC Cancer 2015 15:119
    Content type: Case report Published on:

  7. Malignant glioma is one of the most devastating tumors in adults with poor patient prognosis. Notably, glioma often exhibits resistance to conventional chemotherapeutic approaches, complicating patient treatme...

    Authors: Sangeetha Sukumari-Ramesh, Niyathi Prasad, Cargill H Alleyne Jr, John R Vender and Krishnan M Dhandapani
    Citation: BMC Cancer 2015 15:118
    Content type: Research article Published on:

  9. Tumor suppression of Transforming Growth Factor (TGF-β) signaling pathway requires an adaptor protein, Embryonic Liver Fodrin (ELF). Disruption of ELF expression resulted in miscolocalization of Smad3 and Smad...

    Authors: Fei Ji, Shun-Jun Fu, Shun-Li Shen, Long-Juan Zhang, Qing-Hua Cao, Shao-Qiang Li, Bao-Gang Peng, Li-Jian Liang and Yun-Peng Hua
    Citation: BMC Cancer 2015 15:116
    Content type: Research article Published on:

  10. Capecitabine has activity against several types of cancer. In 10-15% of patients treated with capecitabine, treatment is discontinued because of serious adverse reactions, mostly within the first weeks of trea...

    Authors: Melanie JM van Pelt-Sprangers, Eric CT Geijteman, Jelmer Alsma, Ingrid A Boere, Ron HJ Mathijssen and Stephanie CE Schuit
    Citation: BMC Cancer 2015 15:115
    Content type: Case report Published on:

  11. The relationship between the clinicopathological features and molecular changes associated with standardized uptake value (SUV) determined by Positron emission tomography (PET) with [18F] fluorodeoxyglucose (1...

    Authors: Tomoya Mizuno, Takao Kamai, Hideyuki Abe, Setsu Sakamoto, Kazuhiro Kitajima, Daisaku Nishihara, Hideo Yuki, Tsunehito Kambara, Hironori Betsunoh, Masahiro Yashi, Yoshitatsu Fukabori, Yasushi Kaji and Ken-Ichiro Yoshida
    Citation: BMC Cancer 2015 15:114
    Content type: Research article Published on:

  13. The growth of solid tumors and their regrowth after treatment is dependent upon functional tumor vasculature. Some chemotherapeutic agents have shown anti-angiogenic properties but there are limited studies of...

    Authors: Andrea S Fung, Carol Lee, Man Yu and Ian F Tannock
    Citation: BMC Cancer 2015 15:112
    Content type: Research article Published on:

  14. Chronic comorbidities and some of the commonly-used medications are thought to affect cancer patients’ outcomes, but their relative impact on esophageal carcinoma (EC) has not been well studied. The purpose of...

    Authors: Li-Ru He, Wei Qiao, Zhong-Xing Liao, Ritsuko Komaki, Linus Ho, Wayne L Hofstetter and Steven H Lin
    Citation: BMC Cancer 2015 15:111
    Content type: Research article Published on:

  15. Conditional deletion of the tumour suppressor gene Apc within the murine intestine results in acute Wnt signalling activation. The associated over-expression of a myriad of Wnt signalling target genes yields phen...

    Authors: Karen R Reed, Igor V Korobko, Natalia Ninkina, Elena V Korobko, Ben R Hopkins, James L Platt, Vladimir Buchman and Alan R Clarke
    Citation: BMC Cancer 2015 15:110
    Content type: Research article Published on:

  16. The Src homology phosphotyrosyl phosphatase 2 (SHP2) is a positive effector of cell growth and survival signaling as well transformation induced by multiple tyrosine kinase oncogenes. Since the basal-like and ...

    Authors: Hua Zhao and Yehenew M Agazie
    Citation: BMC Cancer 2015 15:109
    Content type: Research article Published on:

  18. Non-small cell lung cancer (NSCLC) is a highly metastatic cancer with limited therapeutic options, so development of novel therapies that target NSCLC is needed. During the early stage of metastasis, the cance...

    Authors: Weiling He, Shanyang He, Zuo Wang, Hongwei Shen, Wenfeng Fang, Yang Zhang, Wei Qian, Millicent Lin, Jinglun Yuan, Jinyang Wang, Wenhua Huang, Liantang Wang and Zunfu Ke
    Citation: BMC Cancer 2015 15:107
    Content type: Research article Published on:

  19. There is increasing evidence that vitamin D deficiency is a risk factor for cancer, however it remains uncertain whether vitamin D deficiency also predisposes to death from cancer. The aim of the study was to ...

    Authors: Germaine Wong, Wai Hon Lim, Joshua Lewis, Jonathan C Craig, Robin Turner, Kathy Zhu, Ee Mun Lim and Richard Prince
    Citation: BMC Cancer 2015 15:106
    Content type: Research article Published on:

  20. Ovarian cancer is a common gynaecological malignancy still remaining a challenge to treat. The objective of this study was to evaluate the impact of platinum dose reduction and chemotherapy delays on progressi...

    Authors: Sigita Liutkauskiene, Rasa Janciauskiene, Kristina Jureniene, Saulius Grizas, Rasa Malonyte and Elona Juozaityte
    Citation: BMC Cancer 2015 15:105
    Content type: Research article Published on:

  21. Detailed knowledge of the essential pro-angiogenic biomolecules, the vascular endothelial growth factor (VEGF) family and its receptors, in the characteristically heterogeneous tumor tissue is a pre-requisite ...

    Authors: Caren Jayasinghe, Nektaria Simiantonaki and Charles James Kirkpatrick
    Citation: BMC Cancer 2015 15:104
    Content type: Research article Published on:

  22. Lymphangiogenesis plays a significant role in metastasis and recurrence of gastric cancer. There is no report yet focusing on the modulation of VEGF pathway and lymphangiogenesis of gastric cancer by targeting...

    Authors: Hongxia Chen, Runnian Guan, Yupeng Lei, Jianyong Chen, Qi Ge, Xiaoshen Zhang, Ruoxu Dou, Hongyuan Chen, Hao Liu, Xiaolong Qi, Xiaodong Zhou and Changyan Chen
    Citation: BMC Cancer 2015 15:103
    Content type: Research article Published on:

  23. This study investigated the prognostic role of nuclear expression of p65 in patients with locally advanced squamous cell carcinoma of the head and neck (SCCHN) receiving post-operative radio(chemo)therapy.

    Authors: Dirk Rades, Stefan Huttenlocher, Nina D Seibold, Maximilian P Gebhard, Christoph Thorns, Katrin Hasselbacher, Barbara Wollenberg and Steven E Schild
    Citation: BMC Cancer 2015 15:102
    Content type: Research article Published on:

  24. Tertiary lymphoid structures (TLS) are highly organized immune cell aggregates that develop at sites of inflammation or infection in non-lymphoid organs. Despite the described role of inflammation in tumor pro...

    Authors: Stine L Figenschau, Silje Fismen, Kristin A Fenton, Christopher Fenton and Elin S Mortensen
    Citation: BMC Cancer 2015 15:101
    Content type: Research article Published on:

  25. Analysing human papillomavirus (HPV) viral load is important in determining the risk of developing cervical cancer (CC); most knowledge to date regarding HPV viral load and cervical lesions has been related to...

    Authors: Luisa Del Río-Ospina, Sara Cecilia Soto-De León, Milena Camargo, Darwin Andrés Moreno-Pérez, Ricardo Sánchez, Antonio Pérez-Prados, Manuel Elkin Patarroyo and Manuel Alfonso Patarroyo
    Citation: BMC Cancer 2015 15:100
    Content type: Research article Published on:

  26. The role of human papillomavirus (HPV) in the development of esophageal cancer remains controversial. Our study aims to test the association between HPV 16 infection and esophageal cancer in China, providing u...

    Authors: Shao-Kai Zhang, Lan-Wei Guo, Qiong Chen, Meng Zhang, Shu-Zheng Liu, Pei-Liang Quan, Jian-Bang Lu and Xi-Bin Sun
    Citation: BMC Cancer 2015 15:99
    Content type: Research article Published on:

  27. A low muscle mass is prevalent in patients with metastatic colorectal cancer (mCRC) and has been associated with poor treatment outcome. Chemotherapeutic treatment has an additional unfavorable effect on muscl...

    Authors: Anne van der Werf, Susanne Blauwhoff-Buskermolen, Jacqueline AE Langius, Johannes Berkhof, Henk MW Verheul and Marian AE de van der Schueren
    Citation: BMC Cancer 2015 15:98
    Content type: Study protocol Published on:

  28. Resveratrol extracted from grape has been an ideal alternative drug in the therapy of different cancers including colorectal cancer (CRC). Since the underlying mechanisms of resveratrol on the invasion and met...

    Authors: Qing Ji, Xuan Liu, Zhifen Han, Lihong Zhou, Hua Sui, Linlin Yan, Haili Jiang, Jianlin Ren, Jianfeng Cai and Qi Li
    Citation: BMC Cancer 2015 15:97
    Content type: Research article Published on:

  30. Because of the high likelihood of multiple brain metastases (BM) from small cell lung cancer (SCLC), the role of focal treatment using stereotactic radiosurgery (SRS) has yet to be determined. We aimed to eval...

    Authors: Shoji Yomo and Motohiro Hayashi
    Citation: BMC Cancer 2015 15:95
    Content type: Research article Published on:

  31. Primary liver cancer (PLC) is a common cancer worldwide, especially in developing countries. Several previous studies using different datasets have summarized PLC incidence rates and trends in different popula...

    Authors: Yue Zhang, Jian-Song Ren, Ju-Fang Shi, Ni Li, Yu-Ting Wang, Chunfeng Qu, Yawei Zhang and Min Dai
    Citation: BMC Cancer 2015 15:94
    Content type: Research article Published on:

  33. MicroRNAs (miRNAs) are small non-coding RNAs that silence their cognate target genes by specifically binding and cleaving messenger RNAs or inhibiting their translation. In this study, we explored whether miRN...

    Authors: Wentao Liu, Lin Qi, Hui Lv, Xiongbing Zu, Minfeng Chen, Jun Wang, Longfei Liu, Feng Zeng and Yuan Li
    Citation: BMC Cancer 2015 15:92
    Content type: Research article Published on:

  34. Fibulin-4, a member of the fibulin family of extracellular glycoproteins, is implicated in the progressions of some cancers. However, no information has been available to date regarding the function of fibulin...

    Authors: Jie Chen, Zhao Liu, Shuang Fang, Rui Fang, Xi Liu, Yueran Zhao, XiangXin Li, Lei Huang and Jie Zhang
    Citation: BMC Cancer 2015 15:91
    Content type: Research article Published on:

  35. Structural maintenance of chromosomes 1A (SMC1A) is a member of the cohesion family of proteins that plays crucial roles in cell cycle control. Recent studies have concluded that SMC1A is involved in the patho...

    Authors: Jianwei Wang, Shaojun Yu, Liming Cui, Wenhui Wang, Jun Li, Ke Wang and Xinyuan Lao
    Citation: BMC Cancer 2015 15:90
    Content type: Research article Published on:

  36. Triple-negative breast cancer (TNBC) shows aggressive clinical behavior, but the treatment options are limited due to lack of a specific target. TNBC shares many clinical and pathological similarities with BRC...

    Authors: Na Young Jang, Dan Hyo Kim, Bong Jun Cho, Eun Jung Choi, Jong-Soo Lee, Hong-Gyun Wu, Eui Kyu Chie and In Ah Kim
    Citation: BMC Cancer 2015 15:89
    Content type: Research article Published on:

  38. Ipilimumab is a fully human monoclonal antibody directed against cytotoxic T-lymphocyte antigen-4 , a key negative regulator of T-cell activation approved by the Food and Drug Administration as of March 2011 f...

    Authors: Olga Venditti, Delia De Lisi, Marco Caricato, Damiano Caputo, Gabriella Teresa Capolupo, Chiara Taffon, Elisa Pagliara, Sofia Battisi, Anna Maria Frezza, Andrea Onetti Muda, Giuseppe Tonini and Daniele Santini
    Citation: BMC Cancer 2015 15:87
    Content type: Case report Published on:

  39. Estrogen receptor alpha (ERa/ESR1) expression is regulated by alternative splicing. Its most frequently detectable exon7 skipping isoform (ERaD7) is a dominant negative variant. Elevated expression of ERaD7 was a...

    Authors: Marc Hirschfeld, Yi Qin Ouyang, Markus Jaeger, Thalia Erbes, Marzenna Orlowska-Volk, Axel zur Hausen and Elmar Stickeler
    Citation: BMC Cancer 2015 15:86
    Content type: Research article Published on:

  40. The extent to which metastatic tumors further evolve by accumulating additional mutations is unclear and has yet to be addressed extensively using next-generation sequencing of high-grade serous ovarian cancer.

    Authors: Jung-Yun Lee, Jung-Ki Yoon, Boyun Kim, Soochi Kim, Min A Kim, Hyeonseob Lim, Duhee Bang and Yong-Sang Song
    Citation: BMC Cancer 2015 15:85
    Content type: Research article Published on:

  41. Perioperatory chemoradiotherapy (CRT) improves local control and survival in patients with locally advanced rectal cancer (LARC). The objective of the current study was to evaluate the addition of bevacizumab ...

    Authors: Ramon Salazar, Jaume Capdevila, Berta Laquente, Jose Luis Manzano, Carles Pericay, Mercedes Martínez Villacampa, Carlos López, Ferran Losa, Maria Jose Safont, Auxiliadora Gómez, Vicente Alonso, Pilar Escudero, Javier Gallego, Javier Sastre, Cristina Grávalos, Sebastiano Biondo…
    Citation: BMC Cancer 2015 15:60
    Content type: Research article Published on:

  42. To evaluate whether the addition of bevacizumab (BVZ) to capecitabine-based chemoradiotherapy in the preoperative treatment of locally advanced rectal cancer (LARC) improves efficacy measured by the pathologic...

    Authors: Margarita García, Mercedes Martinez-Villacampa, Cristina Santos, Valentin Navarro, Alex Teule, Ferran Losa, Aleydis Pisa, Maria Cambray, Gemma Soler, Laura Lema, Esther Kreisler, Agnes Figueras, Xavier San Juan, Francesc Viñals, Sebastiano Biondo and Ramon Salazar
    Citation: BMC Cancer 2015 15:59
    Content type: Research article Published on:

  43. Despite significant advances in staging and therapies, lung cancer remains a major cause of cancer-related lethality due to its high incidence and recurrence. Clearly, a novel approach is required to develop n...

    Authors: Norashikin Zakaria, Narazah Mohd Yusoff, Zubaidah Zakaria, Moon Nian Lim, Puteri J Noor Baharuddin, Kamal Shaik Fakiruddin and Badrul Yahaya
    Citation: BMC Cancer 2015 15:84
    Content type: Research article Published on:

  45. Although advanced esophageal squamous-cell carcinoma (ESCC) is treated using a multidisciplinary approach, outcomes remain unsatisfactory. The microenvironment of cancer cells has recently been shown to strong...

    Authors: Shin Saito, Kazue Morishima, Takashi Ui, Hiroko Hoshino, Daisuke Matsubara, Shumpei Ishikawa, Hiroyuki Aburatani, Masashi Fukayama, Yoshinori Hosoya, Naohiro Sata, Alan K Lefor, Yoshikazu Yasuda and Toshiro Niki
    Citation: BMC Cancer 2015 15:82
    Content type: Research article Published on:

  46. Identification of specific mutations in cancer patients may lead to the discovery of genes, which can affect susceptibility and/or prognosis. It has previously been reported that mutations in BRCA1 and BRCA2 gene...

    Authors: Meryam El Khachibi, Brehima Diakite, Khalil Hamzi, Abdallah Badou, Mohamed Amine Senhaji, Amina Bakhchane, Hassan Jouhadi, Abdelhamid Barakat, Abdellatif Benider and Sellama Nadifi
    Citation: BMC Cancer 2015 15:81
    Content type: Technical advance Published on:

  47. Local control is always considered in metastatic neuroblastoma (NBL). The aim of this study is to evaluate the impact of radical surgery on survival in children over 1 year of age.

    Authors: Maria Antonietta De Ioris, Alessandro Crocoli, Benedetta Contoli, Maria Carmen Garganese, Gianluigi Natali, Paolo Tomà, Alessandro Jenkner, Renata Boldrini, Maria Debora De Pasquale, Giuseppe Maria Milano, Silvia Madafferi, Aurora Castellano, Franco Locatelli and Alessandro Inserra
    Citation: BMC Cancer 2015 15:79
    Content type: Research article Published on:

  48. About 20% of patients with primary breast cancer develop metastatic disease during the course of the disease. At this point the disease is considered incurable and thus treatment is aimed at palliation and lif...

    Authors: Iben Kümler, Eva Balslev, Jan Stenvang, Nils Brünner and Dorte Nielsen
    Citation: BMC Cancer 2015 15:78
    Content type: Study protocol Published on:

  49. Cancer-related fatigue (CRF) is the most common and distressing symptom in breast cancer survivors. Approximately 40% to 80% of cancer patients undergoing active treatment suffer from CRF. Exercise improves ov...

    Authors: José Francisco Meneses-Echávez, Emilio González-Jiménez and Robinson Ramírez-Vélez
    Citation: BMC Cancer 2015 15:77
    Content type: Research article Published on:

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