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  1. Metastatic breast cancer (MBC) prognosis is highly variable, depending on various factors such as the biological subtype, the performance status, disease extension…. A better evaluation of a patient’s prognost...

    Authors: Amélie Darlix, Pierre-Jean Lamy, Evelyne Lopez-Crapez, Antoine Laurent Braccini, Nelly Firmin, Gilles Romieu, Simon Thezenas and William Jacot
    Citation: BMC Cancer 2016 16:428
    Content type: Research article Published on:

  2. Radiofrequency radiation in the frequency range 30 kHz–300 GHz was evaluated to be Group 2B, i.e. ‘possibly’ carcinogenic to humans, by the International Agency for Research on Cancer (IARC) at WHO in May 2011...

    Authors: Michael Carlberg, Lena Hedendahl, Mikko Ahonen, Tarmo Koppel and Lennart Hardell
    Citation: BMC Cancer 2016 16:426
    Content type: Research article Published on:

  3. Colorectal cancer is one of the most common types of cancers worldwide. Recent studies have identified cancer-initiating cells (CICs) as a subgroup of replication-competent cells in the development of colorect...

    Authors: Kishan Bellamkonda, Naveen Kumar Chandrashekar, Janina Osman, Benson Chellakkan Selvanesan, Sayeh Savari and Anita Sjölander
    Citation: BMC Cancer 2016 16:425
    Content type: Research article Published on:

  4. Metastatic progression of breast cancer involves phenotypic plasticity of the carcinoma cells moving between epithelial and mesenchymal behaviors. During metastatic seeding and dormancy, even highly aggressive...

    Authors: Min Yang, Bo Ma, Hanshuang Shao, Amanda M. Clark and Alan Wells
    Citation: BMC Cancer 2016 16:419
    Content type: Research article Published on:

  5. Whether excess body weight influences colorectal cancer (CRC) survival is unclear. We studied pre-diagnostic body mass index (BMI) and weight change in relation to CRC-specific mortality among incident CRC cas...

    Authors: Ida Laake, Inger K. Larsen, Randi Selmer, Inger Thune and Marit B. Veierød
    Citation: BMC Cancer 2016 16:402
    Content type: Research article Published on:

  6. MammaTyper is a novel CE-marked in vitro diagnostic RT-qPCR assay which assigns routinely processed breast cancer specimens into the molecular subtypes Luminal A-like, Luminal B-like (HER2 positive or negative),

    Authors: Mark Laible, Kornelia Schlombs, Katharina Kaiser, Elke Veltrup, Stefanie Herlein, Sotiris Lakis, Robert Stöhr, Sebastian Eidt, Arndt Hartmann, Ralph M. Wirtz and Ugur Sahin
    Citation: BMC Cancer 2016 16:398
    Content type: Technical advance Published on:

  8. Multiple new targeted agents have been developed for patients with human epidermal growth factor receptor type 2 (HER2) – positive breast cancer. Patients with HER2– positive breast cancer will develop brain m...

    Authors: Koichi Mitsuya, Junichiro Watanabe, Yoko Nakasu, Nakamasa Hayashi, Hideyuki Harada and Ichiro Ito
    Citation: BMC Cancer 2016 16:391
    Content type: Case report Published on:

  9. Lymphangioleiomyomatosis (LAM) is a rare idiopathic disorder that occurs in women of childbearing age, and consists of a diffuse proliferation of abnormal smooth muscle cells along the thoracic and abdominal l...

    Authors: Kensuke Suzuki, Kazunori Nagasaka, Katsutoshi Oda, Hiroyuki Abe, Daichi Maeda, Yoko Matsumoto, Takahide Arimoto, Kei Kawana, Masashi Fukayama, Yutaka Osuga and Tomoyuki Fujii
    Citation: BMC Cancer 2016 16:390
    Content type: Case report Published on:

  10. The incidence of lung cancer in many parts of the country as shown in cancer registry statistics is not decreasing. The incidence of adenocarcinoma (ADCA) in Songkhla is now higher than that of squamous cell c...

    Authors: Hutcha Sriplung, Seesai Yeesoonsang, Edward McNeil and Surichai Bilheem
    Citation: BMC Cancer 2016 16:389
    Content type: Research article Published on:

  11. The lack of positive costimulatory molecules represents one of the mechanisms by which tumor cells evade immune surveillance. Promoter hypermethylation plays a major role in cancer development through transcri...

    Authors: Marco Scarpa, Melania Scarpa, Ignazio Castagliuolo, Francesca Erroi, Silvia Basato, Paola Brun, Imerio Angriman and Carlo Castoro
    Citation: BMC Cancer 2016 16:388
    Content type: Research article Published on:

  12. Deterioration in bone health is one of the presenting symptoms of Multiple Myeloma (MM), a cancer of plasma cells. As a consequence of this condition, patients suffer bone pain and bone damage and report cance...

    Authors: M. Heinrich, A. Fisher, B. Paton, O. McCourt, R. J. Beeken, A. Hackshaw, J. Wardle and K. Yong
    Citation: BMC Cancer 2016 16:387
    Content type: Study protocol Published on:

  14. Bone metastasis is relatively uncommon in gastric cancer patients, but its incidence has been rising. Early detection of bone metastasis is important in preventing complications related to bone metastasis such...

    Authors: Sun Min Lim, Youn Nam Kim, Ki Hyun Park, Beodeul Kang, Hong Jae Chon, Chan Kim, Joo Hoon Kim and Sun Young Rha
    Citation: BMC Cancer 2016 16:385
    Content type: Research article Published on:

  15. Cetuximab is a commonly used antibody agent in the treatment of colorectal or head and neck cancer. Although it is generally well tolerated in most patients, cetuximab has been associated with some rare but se...

    Authors: Christophe Maritaz, Carole Metz, Nabil Baba-Hamed, Méryam Jardin-Szucs and Gaël Deplanque
    Citation: BMC Cancer 2016 16:384
    Content type: Case report Published on:

  16. Meprin displays multiple functions in both health and disease, due in part to its broad proteolytic activity. In this report, we explored the clinical significance and functional relevance of the expression of...

    Authors: Xiao Wang, Jian Chen, Jingtao Wang, Fudong Yu, Senlin Zhao, Yu Zhang, Huamei Tang and Zhihai Peng
    Citation: BMC Cancer 2016 16:383
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2018 18:70

  17. Better insights into the molecular changes involved in virus-associated and -independent head and neck cancer may advance our knowledge of HNC carcinogenesis and identify critical disease biomarkers. Here we a...

    Authors: Zuzana Vojtechova, Ivan Sabol, Martina Salakova, Jana Smahelova, Jiri Zavadil, Lubomir Turek, Marek Grega, Jan Klozar, Bohumir Prochazka and Ruth Tachezy
    Citation: BMC Cancer 2016 16:382
    Content type: Research article Published on:

  19. Transanal total mesorectal excision (taTME) is an emerging surgical technique for rectal cancer. However, the oncological and perioperative outcomes are controversial when compared with conventional laparoscop...

    Authors: Bin Ma, Peng Gao, Yongxi Song, Cong Zhang, Changwang Zhang, Longyi Wang, Hongpeng Liu and Zhenning Wang
    Citation: BMC Cancer 2016 16:380
    Content type: Research article Published on:

  20. Aberrant expression of microRNAs has been associated with migration of tumor cells. In this study, we aimed to investigate the biological significance of miR-944 whose function is unknown in breast cancer.

    Authors: Ali Flores-Pérez, Laurence A. Marchat, Sergio Rodríguez-Cuevas, Verónica Piña Bautista, Lizeth Fuentes-Mera, Diana Romero-Zamora, Anabel Maciel-Dominguez, Olga Hernández de la Cruz, Miguel Fonseca-Sánchez, Erika Ruíz-García, Horacio Astudillo-de la Vega and César López-Camarillo
    Citation: BMC Cancer 2016 16:379
    Content type: Research article Published on:

  21. The estrogen receptor (ER) inhibitor tamoxifen reduces breast cancer mortality by 31 % and has served as the standard treatment for ER-positive breast cancers for decades. However, 50 % of advanced ER-positive...

    Authors: Sara Kangaspeska, Susanne Hultsch, Alok Jaiswal, Henrik Edgren, John-Patrick Mpindi, Samuli Eldfors, Oscar Brück, Tero Aittokallio and Olli Kallioniemi
    Citation: BMC Cancer 2016 16:378
    Content type: Research article Published on:

  22. Expression of the androgen receptor (AR) is associated with androgen-dependent proliferation arrest and terminal differentiation of normal prostate epithelial cells. Additionally, activation of the AR is requi...

    Authors: Jan Roger Olsen, Waqas Azeem, Margrete Reime Hellem, Kristo Marvyin, Yaping Hua, Yi Qu, Lisha Li, Biaoyang Lin, XI-Song Ke, Anne Margrete Øyan and Karl-Henning Kalland
    Citation: BMC Cancer 2016 16:377
    Content type: Research article Published on:

  23. Male breast cancer (MBC) is rare. Given the paucity of randomized trials, treatment is generally extrapolated from female breast cancer guidelines.

    Authors: Piera Gargiulo, Matilde Pensabene, Monica Milano, Grazia Arpino, Mario Giuliano, Valeria Forestieri, Caterina Condello, Rossella Lauria and Sabino De Placido
    Citation: BMC Cancer 2016 16:375
    Content type: Research article Published on:

  26. Every year 170,000 patients are diagnosed with brain metastases (BMs) in the United States. Traditionally, adjuvant whole brain radiotherapy (AWBRT) has been offered following local therapy with neurosurgery (...

    Authors: Gerald B. Fogarty, Angela Hong, Vinai Gondi, Bryan Burmeister, Kari Jacobsen, Serigne Lo, Elizabeth Paton, Brindha Shivalingam and John F. Thompson
    Citation: BMC Cancer 2016 16:372
    Content type: Debate Published on:

  27. Gastric cancer is the fourth most common cancer and the second most deadly cancer worldwide. Study on molecular mechanisms of carcinogenesis will play a significant role in diagnosing and treating gastric canc...

    Authors: Huijuan Wang, Hailong Zhang, Pengchi Deng, Chunqi Liu, Dandan Li, Hui Jie, Hu Zhang, Zongguang Zhou and Ying-Lan Zhao
    Citation: BMC Cancer 2016 16:371
    Content type: Research article Published on:

  30. African American (AA) colon cancer patients have a worse prognosis than Caucasian (CA) colon cancer patients, however, reasons for this disparity are not well understood. To determine if tumor biology might co...

    Authors: Rangaswamy Govindarajan, James Posey, Calvin Y. Chao, Ruixiao Lu, Trafina Jadhav, Ahmed Y. Javed, Awais Javed, Fade A. Mahmoud, Raymond U. Osarogiagbon and Upender Manne
    Citation: BMC Cancer 2016 16:368
    Content type: Research article Published on:

  31. Human papillomavirus DNA detection in head and neck squamous cell carcinoma has been linked to improved patient prognosis. The main aims of the study was to test the hypotheses that HPV16 E6/E7 oncogene and p5...

    Authors: Liam Masterson, David M. Winder, Siolian L. R. Ball, Katie Vaughan, Martin Lehmann, Lars-Uwe Scholtz, Jane C. Sterling, Holger H. Sudhoff and Peter K. C. Goon
    Citation: BMC Cancer 2016 16:367
    Content type: Research article Published on:

  32. Several recent studies have reported that patients with metastatic colorectal cancer (CRC) whose primary tumor is located in left side of the colon have more favorable responses to anti-epidermal growth factor...

    Authors: Hidekazu Kuramochi, Ayako Nakamura, Go Nakajima, Yuka Kaneko, Tatsuo Araida, Masakazu Yamamoto and Kazuhiko Hayashi
    Citation: BMC Cancer 2016 16:366
    Content type: Research article Published on:

  33. Cornelia de Lange syndrome is the prototype for cohesinopathy disorders, which are characterized by defects in chromosome segregation. Kidney malformations, including nephrogenic rests, are common in Cornelia ...

    Authors: Claudia Santoro, Andrea Apicella, Fiorina Casale, Angela La Manna, Martina Di Martino, Daniela Di Pinto, Cristiana Indolfi and Silverio Perrotta
    Citation: BMC Cancer 2016 16:365
    Content type: Case report Published on:

  34. For patients with metastatic renal cell carcinoma (mRCC), targeted therapies have entered the market since 2006. The aims of this study were to evaluate the uptake and use of targeted therapies for mRCC in The...

    Authors: S. De Groot, S. Sleijfer, W. K. Redekop, E. Oosterwijk, J. B. A. G. Haanen, L. A. L. M. Kiemeney and C. A. Uyl-de Groot
    Citation: BMC Cancer 2016 16:364
    Content type: Research article Published on:

  35. Primary diffuse large B-cell lymphoma of the central nervous system (PCNS-DLBCL) is a distinct clinicopathological entity with a poor prognosis. Concurrent MYC and BCL2 overexpression predicts inferior prognos...

    Authors: Sehui Kim, Soo Jeong Nam, Dohee Kwon, Hannah Kim, Eunyoung Lee, Tae Min Kim, Dae Seog Heo, Sung Hye Park, Chul Woo Kim and Yoon Kyung Jeon
    Citation: BMC Cancer 2016 16:363
    Content type: Research article Published on:

  36. To assess the impact of volumetric-modulated arc therapy (VMAT) compared with 3D-conformal radiotherapy (3DCRT) in patients with newly diagnosed high grade glioma in terms of toxicity, progression free surviva...

    Authors: Pierina Navarria, Federico Pessina, Luca Cozzi, Anna Maria Ascolese, Francesca Lobefalo, Antonella Stravato, Giuseppe D’Agostino, Ciro Franzese, Manuela Caroli, Lorenzo Bello and Marta Scorsetti
    Citation: BMC Cancer 2016 16:362
    Content type: Research article Published on:

  37. Some triple negative breast cancer (TNBC) patients are at higher risk of recurrence in the first three years after treatment. This rapid relapse has been suggested to be associated with inflammatory mediators ...

    Authors: Gina Bouchard, Hélène Therriault, Sameh Geha, Yves Bérubé-Lauzière, Rachel Bujold, Caroline Saucier and Benoit Paquette
    Citation: BMC Cancer 2016 16:361
    Content type: Research article Published on:

  38. Short-term starvation prior to chemotherapy administration protects mice against toxicity. We undertook dose-escalation of fasting prior to platinum-based chemotherapy to determine safety and feasibility in ca...

    Authors: Tanya B. Dorff, Susan Groshen, Agustin Garcia, Manali Shah, Denice Tsao-Wei, Huyen Pham, Chia-Wei Cheng, Sebastian Brandhorst, Pinchas Cohen, Min Wei, Valter Longo and David I. Quinn
    Citation: BMC Cancer 2016 16:360
    Content type: Research article Published on:

  39. Osteopontin is a secreted phosphoglycoprotein that is expressed by a number of normal cells as well as a variety of tumor cells. With respect to breast cancer, osteopontin has been implicated in regulating tum...

    Authors: S. Saleh, D. E. Thompson, J. McConkey, P. Murray and R. A. Moorehead
    Citation: BMC Cancer 2016 16:359
    Content type: Research article Published on:

  40. Serine/arginine-rich splicing factors (SRSFs) and HNRNPA1 have oncogenic properties. However, their proteomic expressions and practical priority in gastric cancer (GC) and colorectal cancer (CRC) are mostly un...

    Authors: Won Cheol Park, Hak-Ryul Kim, Dong Baek Kang, Jae-Suk Ryu, Keum-Ha Choi, Gyeong-Ok Lee, Ki Jung Yun, Keun Young Kim, Raekil Park, Kwon-Ha Yoon, Ji-Hyun Cho, Young-Jin Lee, Soo-Cheon Chae, Min-Cheol Park and Do-Sim Park
    Citation: BMC Cancer 2016 16:358
    Content type: Research article Published on:

  41. Patients with primary and metastatic liver malignancies represent a highly heterogeneous patient pool characterised by some of the shortest life expectancies amongst oncology patients. Investigation and better...

    Authors: Olga Golubnitschaja, Kristina Yeghiazaryan, Helena Stricker, Daniela Trog, Hans H. Schild and Leonard Berliner
    Citation: BMC Cancer 2016 16:357
    Content type: Research article Published on:

  42. Delay in the diagnosis of breast cancer in symptomatic women of 3 months or more is associated with advanced stage and low survival. We conducted this study to learn more about the extent and reasons behind di...

    Authors: A. Maghous, F. Rais, S. Ahid, N. Benhmidou, K. Bellahamou, H. Loughlimi, E. Marnouche, S. Elmajjaoui, H. Elkacemi, T. Kebdani and N. Benjaafar
    Citation: BMC Cancer 2016 16:356
    Content type: Research article Published on:

  43. TFEB (transcription factor EB) regulates metabolic homeostasis through its activation of lysosomal biogenesis following its nuclear translocation. TFEB activity is inhibited by mTOR phosphorylation, which sign...

    Authors: Paula Andrea Marin Zapata, Carsten Jörn Beese, Anja Jünger, Giovanni Dalmasso, Nathan Ryan Brady and Anne Hamacher-Brady
    Citation: BMC Cancer 2016 16:355
    Content type: Research article Published on:

  44. It has been shown that epidermal growth factor receptor (EGFR) mutation status is associated with 5-fluorouracil (5-FU) sensitivity in non-small-cell lung cancer (NSCLC). However, the relationship between EGFR...

    Authors: Tetsuro Tominaga, Tomoshi Tsuchiya, Koji Mochinaga, Junichi Arai, Naoya Yamasaki, Keitaro Matsumoto, Takuro Miyazaki, Toshiya Nagasaki, Atsushi Nanashima, Kazuhiro Tsukamoto and Takeshi Nagayasu
    Citation: BMC Cancer 2016 16:354
    Content type: Research article Published on:

  45. Cholangiocarcinoma is characterized by late diagnosis and a poor survival rate. MicroRNAs have been involved in the pathogenesis of different cancer types, including cholangiocarcinoma. Our aim was to identify...

    Authors: Tiziana Palumbo, George A. Poultsides, Grigorios Kouraklis, Theodore Liakakos, Alexandra Drakaki, George Peros, Maria Hatziapostolou and Dimitrios Iliopoulos
    Citation: BMC Cancer 2016 16:353
    Content type: Research article Published on:

  46. Human epidermal growth factor receptor 2 (HER2)-positive breast cancer is a particularly aggressive form of the disease, and ultimately progresses in patients with metastases on standard therapies. Anthracycli...

    Authors: Kathy Miller, Javier Cortes, Sara A. Hurvitz, Ian E. Krop, Debu Tripathy, Sunil Verma, Kaveh Riahi, Joseph G. Reynolds, Thomas J. Wickham, Istvan Molnar and Denise A. Yardley
    Citation: BMC Cancer 2016 16:352
    Content type: Study protocol Published on:

  47. We adapted Bayesian statistical learning strategies to the prognosis field to investigate if genome-wide common SNP improve the prediction ability of clinico-pathological prognosticators and applied it to non-...

    Authors: E. López de Maturana, A. Picornell, A. Masson-Lecomte, M. Kogevinas, M. Márquez, A. Carrato, A. Tardón, J. Lloreta, M. García-Closas, D. Silverman, N. Rothman, S. Chanock, F. X. Real, M. E. Goddard and N. Malats
    Citation: BMC Cancer 2016 16:351
    Content type: Research article Published on:

  48. Early detection of oral squamous cell carcinomas (OSCCs) is urgently needed to improve the prognosis and quality of life (QOL) of patients. Oral leukoplakias (OLs), known as the most common premalignant lesion...

    Authors: Masanobu Abe, Satoshi Yamashita, Yoshiyuki Mori, Takahiro Abe, Hideto Saijo, Kazuto Hoshi, Toshikazu Ushijima and Tsuyoshi Takato
    Citation: BMC Cancer 2016 16:350
    Content type: Research article Published on:

  49. Dietary methionine restriction (MR) improves healthspan in part by reducing adiposity and by increasing insulin sensitivity in rodent models. The purpose of this study was to determine whether MR inhibits tumo...

    Authors: J. R. Hens, I. Sinha, F. Perodin, T. Cooper, R. Sinha, J. Plummer, C. E. Perrone and D. Orentreich
    Citation: BMC Cancer 2016 16:349
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Cancer 2016 16:474

  50. The objective of our study was to investigate the clinical characteristics and prognosis of postterm choriocarcinoma patients at Peking Union Medical College Hospital within the past 30 years.

    Authors: Jie Li, Junjun Yang, Pengfei Liu, Tong Ren, Jun Zhao, Fengzhi Feng, Xirun Wan and Yang Xiang
    Citation: BMC Cancer 2016 16:347
    Content type: Research article Published on:

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