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  1. Most cervical cancer patients with pelvic recurrent or persistent disease are not candidates for exenteration, therefore, they only receive palliative chemotherapy. Here we report the results of a novel treatm...

    Authors: Carlos Lopez-Graniel, Rigoberto Dolores, Lucely Cetina, Aaron Gonzalez, David Cantu, Jose Chanona, Jesus Uribe, Myrna Candelaria, Rocio Brom, Jaime de la Garza and Alfonso Duenas-Gonzalez
    Citation: BMC Cancer 2005 5:118
    Content type: Research article Published on:

  2. New chemotherapy regimens for patients with colorectal cancer have improved survival, but at the cost of clinical toxicity. Oxaliplatin, an agent used in first-line therapy for metastatic colorectal cancer, ca...

    Authors: Gregory D Leonard, Maurice A Wright, Mary G Quinn, Suzanne Fioravanti, Nancy Harold, Barbara Schuler, Rebecca R Thomas and Jean L Grem
    Citation: BMC Cancer 2005 5:116
    Content type: Research article Published on:

  3. Bleomycin is poorly permeant but potent cytotoxic and radiosensitizing drug. The aim of the study was to evaluate whether a physical drug delivery system – electroporation can increase radiosensitising effect ...

    Authors: Simona Kranjc, Maja Cemazar, Alenka Grosel, Marjeta Sentjurc and Gregor Sersa
    Citation: BMC Cancer 2005 5:115
    Content type: Research article Published on:

  4. P-glycoprotein is responsible for the ATP-dependent export of certain structurally unrelated compounds including many chemotherapeutic drugs. Amplification of P-glycoprotein activity can result in multi-drug r...

    Authors: Mirela R Fekete, William H McBride and Frank Pajonk
    Citation: BMC Cancer 2005 5:114
    Content type: Research article Published on:

  5. The tissue-specific translation elongation factor eEF1A2 was recently shown to be a potential oncogene that is overexpressed in ovarian cancer. Although there is no direct evidence for an involvement of eEF1A2...

    Authors: Victoria AL Tomlinson, Helen J Newbery, Naomi R Wray, Juliette Jackson, Alexey Larionov, William R Miller, J Michael Dixon and Catherine M Abbott
    Citation: BMC Cancer 2005 5:113
    Content type: Research article Published on:

  6. Previous reports show a high proportion of young CRC patients in Iran. In this study we aim to look for the clustering of colorectal cancer in families of a series of CRC patients from Iran.

    Authors: Mahboobeh Mahdavinia, Faraz Bishehsari, Reza Ansari, Nasim Norouzbeigi, Ahmad Khaleghinejad, Mahshid Hormazdi, Naser Rakhshani and Reza Malekzadeh
    Citation: BMC Cancer 2005 5:112
    Content type: Research article Published on:

  7. The aim of the study was to investigate whether p503S, p504S and p510S gene expression in peripheral-blood be useful as a diagnostic or prognostic marker of prostatic cancer.

    Authors: Maria Rosaria Cardillo, Vincenzo Gentile, Mauro Ciccariello, Laura Giacomelli, Silvio Messinetti and Franco Di Silverio
    Citation: BMC Cancer 2005 5:111
    Content type: Research article Published on:

  8. Cancer serum protein profiling by mass spectrometry has uncovered mass profiles that are potentially diagnostic for several common types of cancer. However, direct mass spectrometric profiling has a limited dy...

    Authors: Wei-Min Gao, Rork Kuick, Randal P Orchekowski, David E Misek, Ji Qiu, Alissa K Greenberg, William N Rom, Dean E Brenner, Gilbert S Omenn, Brian B Haab and Samir M Hanash
    Citation: BMC Cancer 2005 5:110
    Content type: Research article Published on:

  9. Post-transplant lymphoproliferative disorder (PTLD) is a complication of solid organ and allogeneic hematopoietic stem cell transplantation (HSCT); following autologous HSCT only rare cases of PTLD have been r...

    Authors: Alberto Zambelli, Daniele Lilleri, Fausto Baldanti, Mario Scelsi, Laura Villani and Gian Antonio Da Prada
    Citation: BMC Cancer 2005 5:109
    Content type: Case report Published on:

  10. The Cooperative Prostate Cancer Tissue Resource (CPCTR) is a consortium of four geographically dispersed institutions that are funded by the U.S. National Cancer Institute (NCI) to provide clinically annotated...

    Authors: Ashokkumar A Patel, André Kajdacsy-Balla, Jules J Berman, Maarten Bosland, Milton W Datta, Rajiv Dhir, John Gilbertson, Jonathan Melamed, Jan Orenstein, Kuei-Fang Tai and Michael J Becich
    Citation: BMC Cancer 2005 5:108
    Content type: Research article Published on:

  12. Chronic lymphocytic leukemia (CLL) is a monoclonal disorder, characterized by a progressive proliferation of functionally incompetent B lymphocytes. There is increased evidence of association between CLL and s...

    Authors: KI Papageorgiou and MG Kaniorou-Larai
    Citation: BMC Cancer 2005 5:106
    Content type: Case report Published on:

  13. A common sequence polymorphism at codon 72 of the p53 gene encoding either arginine or proline was recently shown to be functionally relevant for apoptosis induction in vitro. In B-type chronic lymphocytic leu...

    Authors: Isrid Sturm, Andrew G Bosanquet, Michael Hummel, Bernd Dörken and Peter T Daniel
    Citation: BMC Cancer 2005 5:105
    Content type: Research article Published on:

  14. Previous data from our laboratory has indicated that there is a functional link between the β-adrenergic receptor signaling pathway and the G-protein inwardly rectifying potassium channel (GIRK1) in human brea...

    Authors: Howard K Plummer III, Madhu S Dhar, Maria Cekanova and Hildegard M Schuller
    Citation: BMC Cancer 2005 5:104
    Content type: Research article Published on:

  15. Despite exciting new targeted therapeutics against non-Hodgkin's lymphoma (NHL), chemotherapy remains a cornerstone of therapy. While purine nucleoside analogs have significant activity in low grade NHL, the p...

    Authors: Mitchell R Smith, Indira Joshi, Fang Jin and Coleman Obasaju
    Citation: BMC Cancer 2005 5:103
    Content type: Research article Published on:

  17. The mechanisms of chemoresistance in ovarian cancer patients remain largely to be elucidated. Paclitaxel/cisplatin combination is the standard chemotherapeutic treatment for this disease, although some patient...

    Authors: Bárbara Mesquita, Isabel Veiga, Deolinda Pereira, Ana Tavares, Isabel M Pinto, Carla Pinto, Manuel R Teixeira and Sérgio Castedo
    Citation: BMC Cancer 2005 5:101
    Content type: Research article Published on:

  20. The purpose of our study was to investigate the immunohistochemical expression of TGF-β1 and p27 in pancreatic adenocarcinomas and to compare the findings with the clinicopathological features and survival. We...

    Authors: Nil Culhaci, Ozgul Sagol, Sedat Karademir, Huseyin Astarcioglu, Ibrahim Astarcioglu, Mujde Soyturk, Ilhan Oztop and Funda Obuz
    Citation: BMC Cancer 2005 5:98
    Content type: Research article Published on:

  21. Inhibition of the COP9 signalosome (CSN) associated kinases CK2 and PKD by curcumin causes stabilization of the tumor suppressor p53. It has been shown that curcumin induces tumor cell death and apoptosis. Cur...

    Authors: Melanie Füllbeck, Xiaohua Huang, Renate Dumdey, Cornelius Frommel, Wolfgang Dubiel and Robert Preissner
    Citation: BMC Cancer 2005 5:97
    Content type: Research article Published on:

  23. Gene expression data is abundantly available from the Gene Expression Omnibus (GEO) and various websites. Pathway specific analyses of gene-gene correlations across these datasets remain relatively unexplored,...

    Authors: Tomas Radivoyevitch
    Citation: BMC Cancer 2005 5:95
    Content type: Research article Published on:

  24. Cancer patients may harbor micrometastases that remain dormant, clinically undetectable during a variable period of time. A traumatic event or surgery may trigger the balance towards tumor growth as a result o...

    Authors: Nagi S El Saghir, Ihab I Elhajj, Fady B Geara and Mukbil H Hourani
    Citation: BMC Cancer 2005 5:94
    Content type: Case report Published on:

  25. Breast cancer is one of the most frequent causes of death in Mexican women over 35 years of age. At molecular level, changes in many genetic networks have been reported as associated with this neoplasia. To an...

    Authors: Normand García, Fabio Salamanca, Horacio Astudillo-de la Vega, Everardo Curiel-Quesada, Isabel Alvarado, Rosenda Peñaloza and Diego Arenas
    Citation: BMC Cancer 2005 5:93
    Content type: Research article Published on:

  26. Adenomyoepithelial tumours and myoepithelial carcinomas of the breast are primarily defined by the presence of neoplastic cells with a myoepithelial immunophenotype. Current classification schemes are based on...

    Authors: Daniela Hungermann, Horst Buerger, Christian Oehlschlegel, Hermann Herbst and Werner Boecker
    Citation: BMC Cancer 2005 5:92
    Content type: Research article Published on:

  27. The RTOG 94-13 trial has provided evidence that patients with high risk prostate cancer benefit from an additional radiotherapy to the pelvic nodes combined with concomitant hormonal ablation. Since lymphatic ...

    Authors: Ute Ganswindt, Frank Paulsen, Stefan Corvin, Kai Eichhorn, Stefan Glocker, Ilse Hundt, Mattias Birkner, Markus Alber, Aristotelis Anastasiadis, Arnulf Stenzl, Roland Bares, Wilfried Budach, Michael Bamberg and Claus Belka
    Citation: BMC Cancer 2005 5:91
    Content type: Research article Published on:

  28. Esophagus squamous cell cancer (ESCC) is the most common cancer in women with 20.2% and second in men with 10.7% relative frequency among all cancer cases diagnosed in Van Region in the east of Turkey. Ninety ...

    Authors: Mahmut Ilhan, Tugrul Erbaydar, Necmettin Akdeniz and Sevket Arslan
    Citation: BMC Cancer 2005 5:90
    Content type: Research article Published on:

  29. Bisphosphonate therapy has been readily accepted as standard of care for individuals with bone metastases from breast cancer. In this study we determined whether the proportion of patients experiencing a skele...

    Authors: Winston Liauw, Eva Segelov, Anna Lih, Ms Ruth Dunleavy, Matthew Links and Robyn Ward
    Citation: BMC Cancer 2005 5:89
    Content type: Research article Published on:

  31. Published data suggests that docetaxel combined with 5-fluorouracil (5-FU) may have synergistic activity in treating advanced gastric cancer. We performed a phase I study of docetaxel and 5-FU to determine the...

    Authors: Se Hoon Park, Soo-Mee Bang, Eun Kyung Cho, Dong Bok Shin, Jae Hoon Lee, Woon KI Lee and Min Chung
    Citation: BMC Cancer 2005 5:87
    Content type: Research article Published on:

  32. Affymetrix GeneChip Array and Massively Parallel Signature Sequencing (MPSS) are two high throughput methodologies used to profile transcriptomes. Each method has certain strengths and weaknesses; however, no ...

    Authors: Asa J Oudes, Jared C Roach, Laura S Walashek, Lillian J Eichner, Lawrence D True, Robert L Vessella and Alvin Y Liu
    Citation: BMC Cancer 2005 5:86
    Content type: Research article Published on:

  33. Neurofibromatosis type 1 is an autosomal dominant neurocutaneous disorder with characteristic features of skin and central nervous system involvement. Gastrointestinal involvement is rare, but the risk of mali...

    Authors: Wan-Sik Lee, Yang-Seok Koh, Jung-Chul Kim, Chang-Hwan Park, Young-Eun Joo, Hyun-Soo Kim, Chol-Kyoon Cho, Sung-Kyu Choi, Jong-Sun Rew and Sei-Jong Kim
    Citation: BMC Cancer 2005 5:85
    Content type: Case report Published on:

  34. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor, which plays a central role in biologic processes under hypoxic conditions, especially concerning tumour angiogenesis. HIF-1α is the relevant, oxyge...

    Authors: Thomas Fillies, Richard Werkmeister, Paul J van Diest, Burkhard Brandt, Ulrich Joos and Horst Buerger
    Citation: BMC Cancer 2005 5:84
    Content type: Research article Published on:

  35. Currently, no satisfactory biomarkers are available to screen for lung cancer. Surface-Enhanced Laser Desorption/ionization Time-of- Flight Mass Spectrometry ProteinChip system (SELDI-TOF-MS) is one of the cur...

    Authors: Shuan-ying Yang, Xue-yuan Xiao, Wang-gang Zhang, Li-juan Zhang, Wei Zhang, Bin Zhou, Guoan Chen and Da-cheng He
    Citation: BMC Cancer 2005 5:83
    Content type: Research article Published on:

  36. Data concerning incidence and prevalence of cancer in the different regions of Russia have traditionally not been provided on a basis that facilitated comparison with data from countries in western parts of Eu...

    Authors: Arild Vaktskjold, Jelena A Lebedintseva, Dmitrij S Korotov, Anatolij V Tkatsjov, Tatjana S Podjakova and Eiliv Lund
    Citation: BMC Cancer 2005 5:82
    Content type: Research article Published on:

  37. EMSY could be involved in low-level susceptibility to breast and ovarian cancer. Gene amplification is seen in a proportion of breast and ovarian tumours and correlates with poor prognosis in breast cancer patie...

    Authors: Patrick R Benusiglio, Fabienne Lesueur, Craig Luccarini, Joan McIntosh, Robert N Luben, Paula Smith, Alison Dunning, Douglas F Easton, Bruce AJ Ponder and Paul D Pharoah
    Citation: BMC Cancer 2005 5:81
    Content type: Research article Published on:

  38. Recovery of iodide uptake in thyroid cancer cells by means of obtaining the functional expression of the sodium/iodide symporter (NIS) represents an innovative strategy for the treatment of poorly differentiat...

    Authors: Ivan Presta, Franco Arturi, Elisabetta Ferretti, Tiziana Mattei, Daniela Scarpelli, Emanuele Tosi, Angela Scipioni, Marilena Celano, Alberto Gulino, Sebastiano Filetti and Diego Russo
    Citation: BMC Cancer 2005 5:80
    Content type: Research article Published on:

  39. Brachytherapy, interstitial tumor bed irradiation, following conservative surgery has been shown to provide excellent local control and limb preservation in patients with soft tissue sarcomas (STS), whereas li...

    Authors: Tadahiko Kubo, Takashi Sugita, Shoji Shimose, Toshihiro Matsuo, Ken Hirao, Hiroaki Kimura, Masahiro Kenjo and Mitsuo Ochi
    Citation: BMC Cancer 2005 5:79
    Content type: Research article Published on:

  40. Tumor resistance to chemotherapy may be present at the beginning of treatment, develop during treatment, or become apparent on re-treatment of the patient. The mechanisms involved are usually inferred from exp...

    Authors: Federica Di Nicolantonio, Stuart J Mercer, Louise A Knight, Francis G Gabriel, Pauline A Whitehouse, Sanjay Sharma, Augusta Fernando, Sharon Glaysher, Silvana Di Palma, Penny Johnson, Shaw S Somers, Simon Toh, Bernie Higgins, Alan Lamont, Tim Gulliford, Jeremy Hurren…
    Citation: BMC Cancer 2005 5:78
    Content type: Research article Published on:

  41. Chromosomal Comparative Genomic Hybridization (CGH) has been applied to all stages of cervical carcinoma progression, defining a specific pattern of chromosomal imbalances in this tumor. However, given its lim...

    Authors: Alfredo Hidalgo, Michael Baudis, Iver Petersen, Hugo Arreola, Patricia Piña, Guelaguetza Vázquez-Ortiz, Dulce Hernández, José González, Minerva Lazos, Ricardo López, Carlos Pérez, José García, Karla Vázquez, Brenda Alatorre and Mauricio Salcedo
    Citation: BMC Cancer 2005 5:77
    Content type: Research article Published on:

  42. By modulating the expression levels of specific signal transduction molecules, the 26S proteasome plays a central role in determining cell cycle progression or arrest and cell survival or death in response to ...

    Authors: Frank Pajonk, Arndt van Ophoven, Christian Weissenberger and William H McBride
    Citation: BMC Cancer 2005 5:76
    Content type: Research article Published on:

  43. Cancer prevention trials using different types of antioxidant supplements have been carried out at several occasions and one of the investigated compounds has been the antioxidant N-acetyl-L-cysteine (NAC). St...

    Authors: Anna C Gustafsson, Ilya Kupershmidt, Esther Edlundh-Rose, Giulia Greco, Annalucia Serafino, Eva K Krasnowska, Thomas Lundeberg, Luisa Bracci-Laudiero, Maria-Concetta Romano, Tiziana Parasassi and Joakim Lundeberg
    Citation: BMC Cancer 2005 5:75
    Content type: Research article Published on:

  44. Because of the high resistance rate of fibrosarcomas against cytotoxic agents clinical chemotherapy of these tumors is not established. A better understanding of the diverse modes of tumor cell death following...

    Authors: Marcus Lehnhardt, Ludger Klein-Hitpass, Cornelius Kuhnen, Heinz Herbert Homann, Adrien Daigeler, Hans Ulrich Steinau, Sonja Roehrs, Laura Schnoor, Lars Steinstraesser and Oliver Mueller
    Citation: BMC Cancer 2005 5:74
    Content type: Research article Published on:

  46. Medical oncologists continue to use performance status as a proxy for quality of life (QOL) measures, as completion of QOL instruments is perceived as time consuming, may measure aspects of QOL not affected by...

    Authors: Sandro J Martins, Nelson Ho, Sueli O Cavamura, Cecilia M Harada, Crystina A Yamamoto and Teresa Y Takagaki
    Citation: BMC Cancer 2005 5:72
    Content type: Research article Published on:

  47. Combined chemoradiotherapy (CRT) is the treatment of choice for stage III NSCLC. Gemcitabine (G) is a novel deoxycitidine analogue that has been proven to be a potent radiosensitizer. Twenty-two consecutive pa...

    Authors: Ufuk Abacioglu, Perran F Yumuk, Hale Caglar, Meric Sengoz and Nazim S Turhal
    Citation: BMC Cancer 2005 5:71
    Content type: Research article Published on:

  48. The clinical and pathological characteristics and the clinical course of patients with breast cancer and BRCA 1–2 mutation are poorly known.

    Authors: Andrea Veronesi, Clelia de Giacomi, Maria D Magri, Davide Lombardi, Martina Zanetti, Cristina Scuderi, Riccardo Dolcetti, Alessandra Viel, Diana Crivellari, Ettore Bidoli and Mauro Boiocchi
    Citation: BMC Cancer 2005 5:70
    Content type: Research article Published on:

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