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  1. New therapeutic principles in clinical oncology require the adjustment of response criteria to govern therapy decisions. For advanced hepatocellular carcinoma (HCC) a new era has recently begun by the approval...

    Authors: Marius Horger, Ulrich M Lauer, Christina Schraml, Christoph P Berg, Ursula Koppenhöfer, Claus D Claussen, Michael Gregor and Michael Bitzer
    Citation: BMC Cancer 2009 9:208
    Content type: Research article Published on:

  2. Prostaglandin E2 (PGE2) is the major product of Cyclooxygenase-2 (COX-2) in colorectal cancer (CRC). We aimed to assess PGE2 cell surface receptors (EP 1–4) to examine the mechanisms by which PGE2 regulates tumou...

    Authors: Glen A Doherty, Sinead M Byrne, Eamonn S Molloy, Vikrum Malhotra, Sandra C Austin, Elaine W Kay, Frank E Murray and Desmond J Fitzgerald
    Citation: BMC Cancer 2009 9:207
    Content type: Research article Published on:

  3. Glioblastoma are highly aggressive tumors with an average survival time of 12 months with currently available treatment. We have previously shown that specific embryonic neural progenitor cells (NPC) have the ...

    Authors: Karin Staflin, Thole Zuchner, Gabriella Honeth, Anna Darabi and Cecilia Lundberg
    Citation: BMC Cancer 2009 9:206
    Content type: Research article Published on:

  4. Prognosis and optimal treatment strategies of liposarcoma have not been fully defined. The purpose of this study is to define the distinctive clinical features of liposarcomas by assessing prognostic factors.

    Authors: Hyo Song Kim, Jeeyun Lee, Seong Yoon Yi, Hyun Jung Jun, Yoon-La Choi, Geung Hwan Ahn, Sung Wook Seo, Do Hoon Lim, Yong Chan Ahn, Joon Oh Park and Sung Joo Kim
    Citation: BMC Cancer 2009 9:205
    Content type: Research article Published on:

  5. Ser-249 TP53 mutation (249Ser) is a molecular evidence for aflatoxin-related carcinogenesis in Hepatocellular Carcinoma (HCC) and it is frequent in some African and Asian regions, but it is unusual in Western cou...

    Authors: Jeronimo A Nogueira, Suzane K Ono-Nita, Marcelo E Nita, Marcelo MT de Souza, Eliane P do Carmo, Evandro S Mello, Cristovan Scapulatempo, Denise C Paranaguá-Vezozzo, Flair J Carrilho and Venancio AF Alves
    Citation: BMC Cancer 2009 9:204
    Content type: Research article Published on:

  7. There is increasing evidence for the "cancer stem cell (CSC) hypothesis", which holds that cancers are driven by a cellular component that has stem cell properties, including self-renewal, tumorigenicity and m...

    Authors: Emmanuelle Charafe-Jauffret, Christophe Ginestier and Daniel Birnbaum
    Citation: BMC Cancer 2009 9:202
    Content type: Review Published on:

  8. Clinical trials where cancer patients were treated with protease inhibitors have suggested that the serine protease, prostasin, may act as a tumour suppressor. Prostasin is proteolytically activated by the ser...

    Authors: Joanna Selzer-Plon, Jette Bornholdt, Stine Friis, Hanne C Bisgaard, Inger MB Lothe, Kjell M Tveit, Elin H Kure, Ulla Vogel and Lotte K Vogel
    Citation: BMC Cancer 2009 9:201
    Content type: Research article Published on:

  9. RAI3 is an orphan G-protein coupled receptor (GPCR) that has been associated with malignancy and may play a role in the proliferation of breast cancer cells. Although its exact function in normal and malignant...

    Authors: Hannah Jörißen, Nuran Bektas, Edgar Dahl, Arndt Hartmann, Anette ten Haaf, Stefano Di Fiore, Hans Kiefer, Andreas Thess, Stefan Barth and Torsten Klockenbring
    Citation: BMC Cancer 2009 9:200
    Content type: Technical advance Published on:

  10. AVE9633 is a new immunoconjugate comprising a humanized monoclonal antibody, anti-CD33 antigen, linked through a disulfide bond to the maytansine derivative DM4, a cytotoxic agent and potent tubulin inhibitor....

    Authors: Ruoping Tang, Simy Cohen, Jean-Yves Perrot, Anne-Marie Faussat, Claudia Zuany-Amorim, Zora Marjanovic, Hamid Morjani, Fanny Fava, Elise Corre, Ollivier Legrand and Jean-Pierre Marie
    Citation: BMC Cancer 2009 9:199
    Content type: Research article Published on:

  11. Gastric cancer is the third most common malignancy affecting the general population worldwide. Aberrant activation of KRAS is a key factor in the development of many types of tumor, however, oncogenic mutation...

    Authors: Hiroaki Mita, Minoru Toyota, Fumio Aoki, Hirofumi Akashi, Reo Maruyama, Yasushi Sasaki, Hiromu Suzuki, Masashi Idogawa, Lisa Kashima, Kazuyoshi Yanagihara, Masahiro Fujita, Masao Hosokawa, Masanobu Kusano, Sorin Vasile Sabau, Haruyuki Tatsumi, Kohzoh Imai…
    Citation: BMC Cancer 2009 9:198
    Content type: Research article Published on:

  13. Glioblastomas (GBM) are typically comprised of morphologically diverse cells. Despite current advances in therapy, including surgical resection followed by radiation and chemotherapy, the prognosis for patient...

    Authors: Silvia Valensin, Chiara Ghiron, Claudia Lamanna, Andreas Kremer, Marco Rossi, Pietro Ferruzzi, Marco Nievo and Annette Bakker
    Citation: BMC Cancer 2009 9:196
    Content type: Research article Published on:

  14. Teratomas are the commonest germ cell tumours and are most frequently found in the testes and ovary. Extragonadal teratomas are rare and mainly occur in midline structures. Uterine teratomas are extremely rare...

    Authors: Thomas Newsom-Davis, Daniel Poulter, Rebecca Gray, Mohammed Ameen, Iain Lindsay, Kyriakos Papanikolaou, Simon Butler-Manuel, Timothy Christmas, Peter Townsend and Michael Seckl
    Citation: BMC Cancer 2009 9:195
    Content type: Case report Published on:

  15. MicroRNAs are the endogenous small non-coding RNA molecules capable of silencing protein coding genes at the posttranscriptional level. Based on computer-aided predictions, a single microRNA could have over a ...

    Authors: Qiong Jiang, Ming-Guang Feng and Yin-Yuan Mo
    Citation: BMC Cancer 2009 9:194
    Content type: Research article Published on:

  16. TGF-β receptor type I is a mediator of growth inhibitory signals. TGFBR1*6A (rs11466445) is a common polymorphic variant of the TGF-β receptor I gene and has been associated with tumour susceptibility. Neverthele...

    Authors: Adela Castillejo, Trinidad Mata-Balaguer, Paola Montenegro, Enrique Ochoa, Rafael Lázaro, Ana Martínez-Cantó, María-Isabel Castillejo, Carla Guarinos, Víctor-Manuel Barberá, Carmen Guillén-Ponce, Alfredo Carrato and José-Luís Soto
    Citation: BMC Cancer 2009 9:193
    Content type: Research article Published on:

  18. Pancreatic cancer is a common, highly lethal disease with a rising incidence. MUC1 is a tumor-associated antigen that is over-expressed in pancreatic adenocarcinoma. Active immunotherapy that targets MUC1 coul...

    Authors: Yefei Rong, Dayong Jin, Wenchuan Wu, Wenhui Lou, Danshong Wang, Tiantao Kuang, Xiaoling Ni and Xinyu Qin
    Citation: BMC Cancer 2009 9:191
    Content type: Research article Published on:

  19. The progression from Barrett's metaplasia to adenocarcinoma is associated with the acquirement of an apoptosis-resistant phenotype. The bile acid deoxycholate (DCA) has been proposed to play an important role ...

    Authors: Eileen Looby, Mohamed MM Abdel-Latif, Veronica Athié-Morales, Shane Duggan, Aideen Long and Dermot Kelleher
    Citation: BMC Cancer 2009 9:190
    Content type: Research article Published on:

  20. The diagnosis and treatment of cancer is a major life stress such that approximately 35% of patients experience persistent clinically significant distress and carers often experience even higher distress than ...

    Authors: Suzanne K Chambers, Afaf Girgis, Stefano Occhipinti, Sandy Hutchison, Jane Turner, Rob Carter and Jeff Dunn
    Citation: BMC Cancer 2009 9:189
    Content type: Study protocol Published on:

  21. Matrix metalloproteinases (MMPs) are a family of structural and functional related endopeptidases. They play a crucial role in tumor invasion and building of metastatic formations because of their ability to d...

    Authors: Andrea Köhrmann, Ulrike Kammerer, Michaela Kapp, Johannes Dietl and Jelena Anacker
    Citation: BMC Cancer 2009 9:188
    Content type: Research article Published on:

  23. Persistent high risk HPV infection can lead to cervical cancer, the second most common malignant tumor in women worldwide. NK cells play a crucial role against tumors and virus-infected cells through a fine ba...

    Authors: Trinidad Garcia-Iglesias, Alicia del Toro-Arreola, Benibelks Albarran-Somoza, Susana del Toro-Arreola, Pedro E Sanchez-Hernandez, Maria Guadalupe Ramirez-Dueñas, Luz Ma. Adriana Balderas-Peña, Alejandro Bravo-Cuellar, Pablo C Ortiz-Lazareno and Adrian Daneri-Navarro
    Citation: BMC Cancer 2009 9:186
    Content type: Research article Published on:

  24. New, third-generation aromatase inhibitors (AIs) have proven comparable or superior to the anti-estrogen tamoxifen for treatment of estrogen receptor (ER) and/or progesterone receptor (PR) positive breast canc...

    Authors: Anne E Lykkesfeldt, Katrine L Henriksen, Birgitte B Rasmussen, Hironobu Sasano, Dean B Evans, Susanne Møller, Bent Ejlertsen and Henning T Mouridsen
    Citation: BMC Cancer 2009 9:185
    Content type: Research article Published on:

  25. MUTYH-associated polyposis (MAP) is a recessively inherited disorder which predisposes biallelic carriers for a high risk of polyposis and colorectal carcinoma (CRC). Since about one third of the biallelic MAP...

    Authors: Maartje Nielsen, Noel FCC de Miranda, Marjo van Puijenbroek, Ekaterina S Jordanova, Anneke Middeldorp, Tom van Wezel, Ronald van Eijk, Carli MJ Tops, Hans FA Vasen, Frederik J Hes and Hans Morreau
    Citation: BMC Cancer 2009 9:184
    Content type: Research article Published on:

  27. We explored the association of mammographic density, a breast cancer risk factor, with hormonal and proliferation markers in benign tissue from tumor blocks of pre-and postmenopausal breast cancer cases.

    Authors: Martijn Verheus, Gertraud Maskarinec, Eva Erber, Jana S Steude, Jeffrey Killeen, Brenda Y Hernandez and J Mark Cline
    Citation: BMC Cancer 2009 9:182
    Content type: Research article Published on:

  28. The Nijmegen Breakage Syndrome is a chromosomal instability disorder characterized by microcephaly, growth retardation, immunodeficiency, and increased frequency of cancers. Familial studies on relatives of th...

    Authors: Sylvie Desjardins, Joly Charles Beauparlant, Yvan Labrie, Geneviève Ouellette and Francine Durocher
    Citation: BMC Cancer 2009 9:181
    Content type: Research article Published on:

  29. Tumor immune escape and angiogenesis contribute to tumor progression, and gangliosides and activation of signal transducer and activator of transcription (STAT)-3 are implicated in these processes. As both are...

    Authors: Hester van Cruijsen, Mariëlle Gallegos Ruiz, Paul van der Valk, Tanja D de Gruijl and Giuseppe Giaccone
    Citation: BMC Cancer 2009 9:180
    Content type: Research article Published on:

  30. RAS genes acquire the most common somatic gain-of-function mutations in human cancer, and almost all of these mutations are located at codons 12, 13, 61, and 146.

    Authors: Ya-Sian Chang, Kun-Tu Yeh, Tien-Jye Chang, Connie Chai, Hsiu-Chin Lu, Nicholas C Hsu and Jan-Gowth Chang
    Citation: BMC Cancer 2009 9:179
    Content type: Technical advance Published on:

  31. Kaiso has been identified as a new member of the POZ-zinc finger family of transcription factors that are implicated in development and cancer. Although controversy still exists, Kaiso is supposed to be involv...

    Authors: Shun-Dong Dai, Yan Wang, Yuan Miao, Yue Zhao, Yong Zhang, Gui-Yang Jiang, Peng-Xin Zhang, Zhi-Qiang Yang and En-Hua Wang
    Citation: BMC Cancer 2009 9:178
    Content type: Research article Published on:

  32. The Screening Inventory of Psychosocial Problems (SIPP) is a short, validated self-reported questionnaire to identify psychosocial problems in Dutch cancer patients. The one-page 24-item questionnaire assesses...

    Authors: Anna PBM Braeken, Lilian Lechner, Francis CJM van Gils, Ruud MA Houben, Daniëlle Eekers, Ton Ambergen and Gertrudis IJM Kempen
    Citation: BMC Cancer 2009 9:177
    Content type: Study protocol Published on:

  33. The chemokine and bone marrow-homing receptor CXCR4 is implicated in metastases of various cancers. This study was conducted to analyze the association of CXCR4 expression with hepatocellular carcinoma (HCC) b...

    Authors: Zuo-lin Xiang, Zhao-chong Zeng, Zhao-you Tang, Jia Fan, Peng-yuan Zhuang, Ying Liang, Yun-shan Tan and Jian He
    Citation: BMC Cancer 2009 9:176
    Content type: Research article Published on:

  34. Bcl-2/adenovirus E1B 19 kDa-interacting protein 3 (BNIP3) is a pro-apoptotic member of the Bcl-2 family induced under hypoxia. Low or absent expression has recently been described in human tumors, including ga...

    Authors: Esther A Koop, Theo van Laar, Dick F van Wichen, Roel A de Weger, Elsken van der Wall and Paul J van Diest
    Citation: BMC Cancer 2009 9:175
    Content type: Research article Published on:

  35. Lung cancer is one of the most malignant tumors, representing a significant threat to human health. Lung cancer patients often exhibit tumor cell invasion and metastasis before diagnosis which often render cur...

    Authors: Yanyan Wang, Hongfa Yang, Hongbin Liu, Ji Huang and Xingfu Song
    Citation: BMC Cancer 2009 9:174
    Content type: Research article Published on:

  36. Inhibitor of differentiation 4 (Id4), a member of the Id gene family is also a dominant negative regulator of basic helix loop helix (bHLH) transcription factors. Some of the functions of Id4 appear to be uniq...

    Authors: Jason PW Carey, Ananthi J Asirvatham, Oliver Galm, Tandeih A Ghogomu and Jaideep Chaudhary
    Citation: BMC Cancer 2009 9:173
    Content type: Research article Published on:

  38. The aims of this retrospective study were to evaluate laparoscopic triage of patients with advanced ovarian cancer towards primary surgery or neoadjuvant chemotherapy, and to analyze outcome according to the t...

    Authors: Jean-Luc Brun, Roman Rouzier, Frédéric Selle, Sidney Houry, Serge Uzan and Emile Daraï
    Citation: BMC Cancer 2009 9:171
    Content type: Research article Published on:

  39. The nuclear factor-κB (NF-κB) family is a set of transcription factors with key roles in the induction of the inflammatory response and may be the link between inflammation and cancer development. This pathway...

    Authors: Kristin L White, Robert A Vierkant, Catherine M Phelan, Brooke L Fridley, Stephanie Anderson, Keith L Knutson, Joellen M Schildkraut, Julie M Cunningham, Linda E Kelemen, V Shane Pankratz, David N Rider, Mark Liebow, Lynn C Hartmann, Thomas A Sellers and Ellen L Goode
    Citation: BMC Cancer 2009 9:170
    Content type: Research article Published on:

  40. Understanding of immunobiology of bone marrow metastases (designated BM-NPC) versus primary tumors (P-NPC) of the nasopharynx is far from complete. The aim of this study was to determine if there would be differe...

    Authors: Andy Shau-Bin Chou, Hsin-Yi Wang, Hung-Chang Chen, Ming-Hsiu Tsai, Cheng-Keng Chuang and Shuen-Kuei Liao
    Citation: BMC Cancer 2009 9:169
    Content type: Research article Published on:

  41. While there has been much research regarding risk factors and prognostic factors for breast cancer in general, research specific to Iran is sparse. Further, the association between breast cancer survival and s...

    Authors: Abbas Rezaianzadeh, Janet Peacock, Daniel Reidpath, Abdolrasoul Talei, Seyed Vahid Hosseini and Davood Mehrabani
    Citation: BMC Cancer 2009 9:168
    Content type: Research article Published on:

  42. Recent proteomic studies identified Hsp27 as a highly over-expressed protein in oral squamous cell carcinoma (OSCC). Clinical studies that attempted to evaluate the prognostic values of Hsp27 yielded inconsist...

    Authors: Anxun Wang, Xiqiang Liu, Shihu Sheng, Hui Ye, Tingsheng Peng, Fei Shi, David L Crowe and Xiaofeng Zhou
    Citation: BMC Cancer 2009 9:167
    Content type: Research article Published on:

  43. Chondromodulin-1 (ChM1), an endogenous anti-angiogenic factor expressed in cartilage, has been suggested to inhibit invasion of endothelial cells into cartilage. In addition, the ectopic administration of ChM1...

    Authors: Hisashi Mera, Hiroyuki Kawashima, Tatsuya Yoshizawa, Osamu Ishibashi, Md Moksed Ali, Tadashi Hayami, Hiroshi Kitahara, Hiroshi Yamagiwa, Naoki Kondo, Akira Ogose, Naoto Endo and Hiroyuki Kawashima
    Citation: BMC Cancer 2009 9:166
    Content type: Research article Published on:

  44. In breast cancer patients, HER2 overexpression is routinely assessed by immunohistochemistry (IHC) and equivocal cases are subject to fluorescent in situ hybridization (FISH). Our study compares HER2 scoring by h...

    Authors: Gulisa Turashvili, Samuel Leung, Dmitry Turbin, Kelli Montgomery, Blake Gilks, Rob West, Melinda Carrier, David Huntsman and Samuel Aparicio
    Citation: BMC Cancer 2009 9:165
    Content type: Research article Published on:

  45. Because screening mammography for breast cancer is less effective for premenopausal women, we investigated the feasibility of a diagnostic blood test using serum proteins.

    Authors: Jonathan L Jesneck, Sayan Mukherjee, Zoya Yurkovetsky, Merlise Clyde, Jeffrey R Marks, Anna E Lokshin and Joseph Y Lo
    Citation: BMC Cancer 2009 9:164
    Content type: Research article Published on:

  46. Flat epithelial atypia (FEA) of the breast is characterised by a few layers of mildly atypical luminal epithelial cells. Genetic changes found in ductal carcinoma in situ (DCIS) and invasive ductal breast canc...

    Authors: Liqiang Qi, Joost Bart, Lu Ping Tan, Inge Platteel, Tineke van der Sluis, Sippie Huitema, Geert Harms, Li Fu, Harry Hollema and Anke van den Berg
    Citation: BMC Cancer 2009 9:163
    Content type: Research article Published on:

  48. Treatment options for metastatic renal cell carcinoma (RCC) are limited due to resistance to chemo- and radiotherapy. The development of small-molecule multikinase inhibitors has now opened novel treatment opt...

    Authors: Eva Juengel, Johanna Engler, Iyad Natsheh, Jon Jones, Ausra Mickuckyte, Lukasz Hudak, Dietger Jonas and Roman A Blaheta
    Citation: BMC Cancer 2009 9:161
    Content type: Research article Published on:

  49. The 5-year survival of patients with resected pancreatic adenocarcinoma is still unsatisfying. The ESPAC-1 and the CONKO 001 trial proofed that adjuvant chemotherapy improves 5-year survival significantly from...

    Authors: Angela Märten, Jan Schmidt, Jennifer Ose, Sabine Harig, Ulrich Abel, Marc W Münter, Dirk Jäger, Helmut Friess, Julia Mayerle, Guido Adler, Thomas Seufferlein, Thomas Gress, Roland Schmid and Markus W Büchler
    Citation: BMC Cancer 2009 9:160
    Content type: Study protocol Published on:

  50. Colorectal cancer is the third most common cancer in the western world. Chemotherapy is often ineffective to treat the advanced colorectal cancers due to the chemo-resistance. A major contributor to chemo-resi...

    Authors: Shi Yu Yang, Capucine Bolvin, Kevin M Sales, Barry Fuller, Alexander M Seifalian and Marc C Winslet
    Citation: BMC Cancer 2009 9:158
    Content type: Research article Published on:

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