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  1. High-dose interferon alfa-2b (IFNalfa-2b), according to the ECOG 1684 schedule, is the only approved adjuvant treatment for stage III melanoma patients by the FDA and EMEA. However, the risk/benefit profile ha...

    Authors: Vanna Chiarion-Sileni, Paola Del Bianco, Antonella Romanini, Michele Guida, Adriano Paccagnella, Maurizio Dalla Palma, Emanuele Naglieri, Ruggero Ridolfi, Barbara Silvestri, Maria Michiara and Gian Luca De Salvo
    Citation: BMC Cancer 2006 6:44
    Content type: Research article Published on:

  2. Breast cancer appears to be a disease of both the developing and developed worlds. Among Turkish women, breast cancer is the second leading cause of cancer-related deaths. The aims of this cross-sectional stud...

    Authors: Pınar Erbay Dündar, Dilek Özmen, Beyhan Öztürk, Gökçe Haspolat, Filiz Akyıldız, Sümeyra Çoban and Gamze Çakıroğlu
    Citation: BMC Cancer 2006 6:43
    Content type: Research article Published on:

  3. The combination of capecitabine and gemcitabine at Fixed Dose Rate (FDR) has been demonstrated to be well tolerated, with apparent efficacy in patients with advanced cancers. FDR gemcitabine infusion leads to ...

    Authors: Daniele Santini, Bruno Vincenzi, Gaia Schiavon, Annalisa La Cesa, Simona Gasparro, Angelo Vincenzi and Giuseppe Tonini
    Citation: BMC Cancer 2006 6:42
    Content type: Research article Published on:

  4. CEA is a tumor-associated antigen abundantly expressed on several cancer types, including those naturally refractory to chemotherapy. The selection and characterization of human anti-CEA single-chain antibody ...

    Authors: Emiliano Pavoni, Michela Flego, Maria Luisa Dupuis, Stefano Barca, Fiorella Petronzelli, Anna Maria Anastasi, Valeria D'Alessio, Angela Pelliccia, Paola Vaccaro, Giorgia Monteriù, Alessandro Ascione, Rita De Santis, Franco Felici, Maurizio Cianfriglia and Olga Minenkova
    Citation: BMC Cancer 2006 6:41
    Content type: Research article Published on:

  5. Accumulating databases in human genome research have enabled integrated genome-wide study on complicated diseases such as cancers. A practical approach is to mine a global transcriptome profile of disease from...

    Authors: Bingjian Lü, Jing Xu, Maode Lai, Hao Zhang and Jian Chen
    Citation: BMC Cancer 2006 6:40
    Content type: Research article Published on:

  6. Complementary and alternative medicine (CAM) use is common among cancer patients. This paper reviews the use of CAM in a series of patients with locally advanced breast cancer (LABC).

    Authors: Lucy K Helyer, Stephen Chin, Betty K Chui, Barbara Fitzgerald, Sunil Verma, Eileen Rakovitch, George Dranitsaris and Mark Clemons
    Citation: BMC Cancer 2006 6:39
    Content type: Research article Published on:

  7. Leptin (LEP) has been consistently associated with angiogenesis and tumor growth. Leptin exerts its physiological action through its specific receptor (LEPR). We have investigated whether genetic variations in LE...

    Authors: Kaouther Snoussi, A Donny Strosberg, Noureddine Bouaouina, Slim Ben Ahmed, A Noureddine Helal and Lotfi Chouchane
    Citation: BMC Cancer 2006 6:38
    Content type: Research article Published on:

  8. The hereditary hemochromatosis gene HFE plays a pivotal role in iron homeostasis. The association between cancer and HFE hetero- or homozygosity has previously been shown including hepatocellular and nonhepatocel...

    Authors: Aysen Gunel-Ozcan, Sibel Alyılmaz-Bekmez, Emine Nilufer Guler and Dicle Guc
    Citation: BMC Cancer 2006 6:37
    Content type: Research article Published on:

  9. Carcinogenesis typically involves multiple somatic mutations in caretaker (DNA repair) and gatekeeper (tumor suppressors and oncogenes) genes. Analysis of mutation spectra of the tumor suppressor that is most ...

    Authors: Vladimir N Babenko, Malay K Basu, Fyodor A Kondrashov, Igor B Rogozin and Eugene V Koonin
    Citation: BMC Cancer 2006 6:36
    Content type: Research article Published on:

  10. Breast cancer survivors often encounter physiological and psychological problems related to their diagnosis and treatment that can influence long-term prognosis. The aim of this research is to investigate the ...

    Authors: John M Saxton, Amanda Daley, Nicola Woodroofe, Robert Coleman, Hilary Powers, Nanette Mutrie, Vanessa Siddall and Helen Crank
    Citation: BMC Cancer 2006 6:35
    Content type: Study protocol Published on:

  11. The optimal cancer treatment for an older population is largely unknown because of the low numbers of elderly patients accrued into clinical trials. This project focuses on the attitudes of the elderly about p...

    Authors: Carol A Townsley, Kelvin K Chan, Gregory R Pond, Christine Marquez, Lillian L Siu and Sharon E Straus
    Citation: BMC Cancer 2006 6:34
    Content type: Research article Published on:

  12. Esophageal squamous cell carcinoma (ESCC) is one of the most malignant tumors and typically presents at an advanced and rapidly fatal stage. To better understand the role of genetics in the etiology and preven...

    Authors: Nan Hu, Luxia Qian, Ying Hu, Jian-Zhong Shou, Chaoyu Wang, Carol Giffen, Quan-Hong Wang, Yuan Wang, Alisa M Goldstein, Michael Emmert-Buck and Philip R Taylor
    Citation: BMC Cancer 2006 6:33
    Content type: Research article Published on:

  13. Nestin is a protein belonging to class VI of intermediate filaments that is produced in stem/progenitor cells in the mammalian CNS during development and is consecutively replaced by other intermediate filamen...

    Authors: Renata Veselska, Petr Kuglik, Pavel Cejpek, Hana Svachova, Jakub Neradil, Tomas Loja and Jirina Relichova
    Citation: BMC Cancer 2006 6:32
    Content type: Research article Published on:

  14. It is important to discriminate between primary and secondary lung cancer. However, often, the discriminating diagnosis of primary lung acinar adenocarcinoma and lung metastasis of colorectal cancer based on m...

    Authors: Satoshi Ikeda, Masahiko Fujimori, Satoshi Shibata, Masazumi Okajima, Yasuyo Ishizaki, Takeshi Kurihara, Yoshihiro Miyata, Masahiko Iseki, Yosuke Shimizu, Noriaki Tokumoto, Shinji Ozaki and Toshimasa Asahara
    Citation: BMC Cancer 2006 6:31
    Content type: Research article Published on:

  15. The application of induction chemotherapy failed to provide a consistent benefit for local control in primary treatment of advanced head and neck (H&N) cancers. The aim of this study was to compare the results...

    Authors: Reinhold Graf, Bert Hildebrandt, Wolfgang Tilly, Hanno Riess, Roland Felix, Volker Budach and Peter Wust
    Citation: BMC Cancer 2006 6:30
    Content type: Research article Published on:

  16. The prognosis of patients suffering from WHO grade 3 and 4 astrocytic glioma remains poor despite surgery, radiation therapy and the use of current chemotherapy regimen. Indeed, the median survival of glioblas...

    Authors: Pierre A Robe, Didier Martin, Adelin Albert, Manuel Deprez, Alain Chariot and Vincent Bours
    Citation: BMC Cancer 2006 6:29
    Content type: Study protocol Published on:

  17. Former meta-analyses have shown a survival benefit for the addition of chemotherapy (CHX) to radiotherapy (RT) and to some extent also for the use of hyperfractionated radiation therapy (HFRT) and accelerated ...

    Authors: W Budach, T Hehr, V Budach, C Belka and K Dietz
    Citation: BMC Cancer 2006 6:28
    Content type: Research article Published on:

  19. Hypoxia-inducible transcription factor-1α (HIF-1α), which plays an important role in controlling the hypoxia-induced glycolysis pathway, is a "master" gene in the tissue hypoxia response during tumor developme...

    Authors: FengMing Luo, XiaoJing Liu, NaiHong Yan, ShuangQing Li, GuiQun Cao, QingYing Cheng, QingJie Xia and HongJing Wang
    Citation: BMC Cancer 2006 6:26
    Content type: Research article Published on:

  20. Although transforming growth factor β (TGF-β) typically inhibits proliferation of epithelial cells, consistent with a tumor suppressor activity, it paradoxically also exhibits pro-metastatic activity in the la...

    Authors: Christina H Stuelten, Miriam B Buck, Juergen Dippon, Anita B Roberts, Peter Fritz and Cornelius Knabbe
    Citation: BMC Cancer 2006 6:25
    Content type: Research article Published on:

  21. Cervical cancer is due to infection with specific high-risk types of human papillomavirus (HPV). Although the incidence of genital HPV infection in various population groups is high, most of these regress with...

    Authors: Vandana A Govan, Debbie Constant, Margaret Hoffman and Anna-Lise Williamson
    Citation: BMC Cancer 2006 6:24
    Content type: Research article Published on:

  22. Human sperm protein 17 (Sp17) is a highly conserved protein that was originally isolated from a rabbit epididymal sperm membrane and testis membrane pellet. It has recently been included in the cancer/testis (...

    Authors: Fabio Grizzi, Paolo Gaetani, Barbara Franceschini, Antonio Di Ieva, Piergiuseppe Colombo, Giorgia Ceva-Grimaldi, Angelo Bollati, Eldo E Frezza, E Cobos, Riccardo Rodriguez y Baena, Nicola Dioguardi and Maurizio Chiriva-Internati
    Citation: BMC Cancer 2006 6:23
    Content type: Research article Published on:

  23. Kinesin spindle proteins (KSP) are motor proteins that play an essential role in mitotic spindle formation. HsEg5, a KSP, is responsible for the formation of the bipolar spindle, which is critical for proper cell...

    Authors: David A Davis, Sarah H Sarkar, Maha Hussain, Yiwei Li and Fazlul H Sarkar
    Citation: BMC Cancer 2006 6:22
    Content type: Research article Published on:

  24. Mutations in the mitochondrial DNA (mtDNA) have been reported in a wide variety of human neoplasms. A polynucleotide tract extending from 303 to 315 nucleotide positions (D310) within the non-coding region of ...

    Authors: Cenk Aral, Handan Kaya, Çiğdem Ataizi-Çelikel, Mustafa Akkiprik, Özgür Sönmez, Bahadır M Güllüoğlu and Ayşe Özer
    Citation: BMC Cancer 2006 6:21
    Content type: Technical advance Published on:

  25. Haematological cancer is characterised by chromosomal translocation (e.g. MLL translocation in acute leukaemia) and two models have been proposed to explain the origins of recurrent reciprocal translocation. T...

    Authors: Michaël Gué, Jian-Sheng Sun and Thomas Boudier
    Citation: BMC Cancer 2006 6:20
    Content type: Research article Published on:

  26. BACH1 (BRCA1-associated C-terminal helicase 1; also known as BRCA1-interacting protein 1, BRIP1) is a helicase protein that interacts in vivo with BRCA1, the protein product of one of the major genes for heredita...

    Authors: Pia Vahteristo, Kristiina Yliannala, Anitta Tamminen, Hannaleena Eerola, Carl Blomqvist and Heli Nevanlinna
    Citation: BMC Cancer 2006 6:19
    Content type: Research article Published on:

  27. Members of the matrix metalloproteinase (MMP) family of proteases are required for the degradation of the basement membrane and extracellular matrix in both normal and pathological conditions. In vitro, MT1-MMP (...

    Authors: Larisa M Haupt, Erik W Thompson, Ann EO Trezise, Rachel E Irving, Michael G Irving and Lyn R Griffiths
    Citation: BMC Cancer 2006 6:18
    Content type: Research article Published on:

  28. The reduced mortality rate from breast carcinoma among women offered screening mammography is demonstrated after 15–20 years of follow-up. However, the assessment of 5-year overall and event-free survival coul...

    Authors: Laura Cortesi, Vincenzo E Chiuri, Silvia Ruscelli, Valeria Bellelli, Rossella Negri, Ivan Rashid, Claudia Cirilli, Antonella Fracca, Ennio Gallo and Massimo Federico
    Citation: BMC Cancer 2006 6:17
    Content type: Research article Published on:

  29. Angiomotin is a newly discovered molecule that regulates the migration and tubule formation of endothelial cells. It therefore has been implicated in the control of angiogenesis under physiological and patholo...

    Authors: Wen G Jiang, Gareth Watkins, Anthony Douglas-Jones, Lars Holmgren and Robert E Mansel
    Citation: BMC Cancer 2006 6:16
    Content type: Research article Published on:

  30. After development of hormone-refractory metastatic disease, prostate cancer is incurable. The recent history of chemotherapy has shown that with difficult disease targets, combinatorial therapy frequently offe...

    Authors: Kristen D Brubaker, Lisha G Brown, Robert L Vessella and Eva Corey
    Citation: BMC Cancer 2006 6:15
    Content type: Research article Published on:

  31. The anticancer drug Ukrain (NSC-631570) which has been specified by the manufacturer as semisynthetic derivative of the Chelidonium majus L. alkaloid chelidonine and the alkylans thiotepa was reported to exert se...

    Authors: Daniel Habermehl, Bernd Kammerer, René Handrick, Therese Eldh, Charlotte Gruber, Nils Cordes, Peter T Daniel, Ludwig Plasswilm, Michael Bamberg, Claus Belka and Verena Jendrossek
    Citation: BMC Cancer 2006 6:14
    Content type: Research article Published on:

  32. Mediterranean societies, with diets rich in vitamin E isoforms, have a lower risk for colon cancer than those of northern Europe and the Americas. Vitamin E rich diets may neutralize free radicals generated by...

    Authors: Sharon E Campbell, William L Stone, Steven Lee, Sarah Whaley, Hongsong Yang, Min Qui, Paige Goforth, Devin Sherman, Derek McHaffie and Koyamangalath Krishnan
    Citation: BMC Cancer 2006 6:13
    Content type: Research article Published on:

  33. The extracellular matrix has a major effect upon the malignant properties of bladder cancer cells both in vitro in 3-dimensional culture and in vivo. Comparing gene expression of several bladder cancer cells line...

    Authors: Mikhail G Dozmorov, Kimberly D Kyker, Ricardo Saban, Nicholas Knowlton, Igor Dozmorov, Michael B Centola and Robert E Hurst
    Citation: BMC Cancer 2006 6:12
    Content type: Research article Published on:

  35. Intermediary filaments are involved in cell motility and cancer progression. In a variety of organs, the expression of distinct intermediary filaments are associated with patient prognosis. In this study, we s...

    Authors: Thomas Fillies, Richard Werkmeister, Jens Packeisen, Burkhard Brandt, Philippe Morin, Dieter Weingart, Ulrich Joos and Horst Buerger
    Citation: BMC Cancer 2006 6:10
    Content type: Research article Published on:

  36. The inhibition of angiogenesis is a promising strategy for the treatment of malignant primary and secondary tumors in addition to established therapies such as surgery, chemotherapy, and radiation. There is st...

    Authors: Frank Michael Klenke, Martha-Maria Gebhard, Volker Ewerbeck, Amir Abdollahi, Peter E Huber and Axel Sckell
    Citation: BMC Cancer 2006 6:9
    Content type: Research article Published on:

  37. Previously we have generated the monoclonal antibody SM5-1 by using a subtractive immunization protocol of human melanoma. This antibody exhibits a high sensitivity for primary melanomas of 99% (248/250 tested...

    Authors: Uwe Trefzer, Yingwen Chen, Gunda Herberth, Maja Ann Hofmann, Felix Kiecker, Yajun Guo and Wolfram Sterry
    Citation: BMC Cancer 2006 6:8
    Content type: Research article Published on:

  38. Since tacrolimus ointment was approved by the U.S. Food and Drug Administration (FDA) as a promising treatment for atopic dermatitis, it has been approved in more than 30 additional countries, including numero...

    Authors: Jürgen C Becker, Roland Houben, Claudia S Vetter and Eva B Bröcker
    Citation: BMC Cancer 2006 6:7
    Content type: Case report Published on:

  39. We have previously reported that p53 mutated radioresistant lymphoma cell lines undergo mitotic catastrophe after irradiation, resulting in metaphase arrest and the generation of endopolyploid cells. A proport...

    Authors: Martins Kalejs, Andrey Ivanov, Gregory Plakhins, Mark S Cragg, Dzintars Emzinsh, Timothy M Illidge and Jekaterina Erenpreisa
    Citation: BMC Cancer 2006 6:6
    Content type: Research article Published on:

  40. Carboplatin/paclitaxel is the chemotherapy of choice for advanced ovarian cancer, both in first line and in platinum-sensitive recurrence. Although a significant proportion of patients have some neurotoxicity ...

    Authors: Sandro Pignata, Sabino De Placido, Rosalbino Biamonte, Giovanni Scambia, Giovanni Di Vagno, Giuseppe Colucci, Antonio Febbraro, Marco Marinaccio, Alessandra Vernaglia Lombardi, Luigi Manzione, Giacomo Cartenì, Mario Nardi, Saverio Danese, Maria Rosaria Valerio, Andrea de Matteis, Bruno Massidda…
    Citation: BMC Cancer 2006 6:5
    Content type: Research article Published on:

  41. Pleuropulmonary blastoma (PPB) is a rare childhood dysontogenetic intrathoracic neoplasm associated with an unfavourable clinical behaviour.

    Authors: Benoit Quilichini, Nicolas Andre, Corinne Bouvier, Marie-Anne Chrestian, Angelique Rome, Dominique Intagliata, Carole Coze, Gabriel Lena and Helene Zattara
    Citation: BMC Cancer 2006 6:4
    Content type: Case report Published on:

  42. Although numerous chemotherapeutic agents have been tested, the role of systemic chemotherapy for hepatocellular carcinoma (HCC) has not been clarified. New therapeutic strategies are thus needed to improve ou...

    Authors: Se Hoon Park, Yuna Lee, Sang Hoon Han, So Young Kwon, Oh Sang Kwon, Sun Suk Kim, Ju Hyun Kim, Yeon Ho Park, Jeong Nam Lee, Soo-Mee Bang, Eun Kyung Cho, Dong Bok Shin and Jae Hoon Lee
    Citation: BMC Cancer 2006 6:3
    Content type: Research article Published on:

  43. Glioblastoma multiforme is the most malignant form of brain tumor. Despite treatment including surgical resection, adjuvant chemotherapy, and radiation, these tumors typically recur. The recurrent tumor is oft...

    Authors: Nicole C Hank, Joan Rankin Shapiro and Adrienne C Scheck
    Citation: BMC Cancer 2006 6:2
    Content type: Research article Published on:

  44. Cisplatin is widely used as an antineoplastic agent since it is effective against a broad spectrum of different tumours. Nevertheless, it has several potential side effects affecting different organ systems an...

    Authors: Guenter Hofmann, Thomas Bauernhofer, Peter Krippl, Doris Lang-Loidolt, Sabine Horn, Walter Goessler, Walter Schippinger, Ferdinand Ploner, Herbert Stoeger and Hellmut Samonigg
    Citation: BMC Cancer 2006 6:1
    Content type: Case report Published on:

  47. Minichromosome maintenance (MCM) proteins are essential for the initiation of DNA replication and have been found to be relevant markers for prognosis in a variety of tumours. The aim of this study was to asse...

    Authors: Ellen C Obermann, Philip Went, Annette Zimpfer, Alexandar Tzankov, Peter J Wild, Robert Stoehr, Stefano A Pileri and Stephan Dirnhofer
    Citation: BMC Cancer 2005 5:162
    Content type: Research article Published on:

  49. The early to intermediate stages of the majority of colorectal tumours are thought to be driven by aberrations in the Wnt (APC, CTNNB1) and Ras (K-ras) pathways. A smaller proportion of cancers shows mismatch rep...

    Authors: Margreet Lüchtenborg, Matty P Weijenberg, Petra A Wark, A Merdan Saritas, Guido MJM Roemen, Goos NP van Muijen, Adriaan P de Bruïne, Piet A van den Brandt and Anton FPM de Goeij
    Citation: BMC Cancer 2005 5:160
    Content type: Research article Published on:

  50. Eighty percent of all breast cancers and almost 90% of breast cancer deaths occur among post-menopausal women. We used a nested case control design to examine the association between nonsteroidal anti-inflamma...

    Authors: Elham Rahme, Joumana Ghosn, Kaberi Dasgupta, Raghu Rajan and Marie Hudson
    Citation: BMC Cancer 2005 5:159
    Content type: Research article Published on:

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