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  1. Cancer-related self-tests are currently available to buy in pharmacies or over the internet, including tests for faecal occult blood, PSA and haematuria. Self-tests have potential benefits (e.g. convenience) b...

    Authors: Sue Wilson, Angela V Ryan, Sheila M Greenfield, Sue C Clifford, Roger L Holder, Helen M Pattison, David A Fitzmaurice and Richard J McManus
    Citation: BMC Cancer 2008 8:102
  2. Women with BRCA1 or BRCA2 mutations have a substantially increased risk of breast and ovarian cancer compared with the general population. Therefore, prophylactic mastectomy (PM) and bilateral salpingo-oophorecto...

    Authors: Larissa I Batista, Karen H Lu, Elisabeth K Beahm, Banu K Arun, Diane C Bodurka and Funda Meric-Bernstam
    Citation: BMC Cancer 2008 8:101
  3. Breast cancers (BC) in women carrying mutations in BRCA1 gene are more frequently estrogen receptor negative than the nonhereditary BC. Nevertheless, tamoxifen has been found to have a protective effect in pre...

    Authors: Maria M Litwiniuk, Krzysztof Rożnowski, Violetta Filas, Dariusz D Godlewski, Małgorzata Stawicka, Remigiusz Kaleta and Jan Bręborowicz
    Citation: BMC Cancer 2008 8:100
  4. Currently, there is clear evidence that apoptosis plays an important role in the development and progression of tumors. One of the best characterized apoptosis triggering systems is the CD95/Fas/APO-1 pathway;...

    Authors: Adriana Aguilar-Lemarroy, Jose E Romero-Ramos, Vicente Olimon-Andalon, Georgina Hernandez-Flores, Jose M Lerma-Diaz, Pablo C Ortiz-Lazareno, Gilberto Morgan-Villela, Susana del Toro-Arreola, Alejandro Bravo-Cuellar and Luis F Jave-Suarez
    Citation: BMC Cancer 2008 8:99
  5. Esophageal squamous cell carcinoma (ESCC) is a genetically complex tumor type and a major cause of cancer related mortality. Although distinct genetic alterations have been linked to ESCC development and progn...

    Authors: Ana Carneiro, Anna Isinger, Anna Karlsson, Jan Johansson, Göran Jönsson, Pär-Ola Bendahl, Dan Falkenback, Britta Halvarsson and Mef Nilbert
    Citation: BMC Cancer 2008 8:98
  6. One of the major challenges in currently chemotherapeutic theme is lacking effective biomarkers for drug response and sensitivity. Our current study focus on two promising biomarkers, ERCC1 (excision repair cr...

    Authors: Lifeng Wang, Jia Wei, Xiaoping Qian, Haitao Yin, Yang Zhao, Lixia Yu, Tingting Wang and Baorui Liu
    Citation: BMC Cancer 2008 8:97
  7. The TP53 polymorphisms Arg72Pro (Ex4+199 G>C) and Ins16 (IVS3+24 ins16) have been proposed to modify risk of breast cancer associated with germline BRCA1 and BRCA2 mutations. Allele frequencies of these polymo...

    Authors: Luca Cavallone, Suzanna L Arcand, Christine Maugard, Parviz Ghadirian, Anne-Marie Mes-Masson, Diane Provencher and Patricia N Tonin
    Citation: BMC Cancer 2008 8:96
  8. Mutations in the mitochondrial genome (mtgenome) have been associated with many disorders, including breast cancer. Nipple aspirate fluid (NAF) from symptomatic women could potentially serve as a minimally inv...

    Authors: John P Jakupciak, Andrea Maggrah, Samantha Maragh, Jennifer Maki, Brian Reguly, Katrina Maki, Roy Wittock, Kerry Robinson, Paul D Wagner, Robert E Thayer, Ken Gehman, Teresa Gehman, Sudhir Srivastava, Alioune Ngom, Gabriel D Dakubo and Ryan L Parr
    Citation: BMC Cancer 2008 8:95
  9. Listeria monocytogenes is a highly versatile bacterial carrier system for introducing protein, DNA and RNA into mammalian cells. The delivery of tumor antigens with the help of this carrier into tumor-bearing an...

    Authors: Jochen Stritzker, Sabine Pilgrim, Aladar A Szalay and Werner Goebel
    Citation: BMC Cancer 2008 8:94
  10. The process of diagnosis and management of solitary pulmonary nodules (SPNs) between 1 and 3 cm is not standardized. This multicentre study investigated how diagnosis of newly discovered SPNs is managed in rou...

    Authors: Kazem Alzahouri, Michel Velten, Patrick Arveux, Marie-Christine Woronoff-Lemsi, Damien Jolly and Francis Guillemin
    Citation: BMC Cancer 2008 8:93
  11. Prospero-related homeobox 1 (Prox1) transcription factor was described as a tumor-suppressor gene in liver tumors. In contrast, Prox1 knock out in murine embryos drastically reduces proliferation of hepatoblasts.

    Authors: Jozsef Dudas, Tümen Mansuroglu, Federico Moriconi, Florian Haller, Joerg Wilting, Thomas Lorf, Laszlo Füzesi and Giuliano Ramadori
    Citation: BMC Cancer 2008 8:92
  12. Recent advances in genomics, proteomics, and the increasing demands for biomarker validation studies have catalyzed changes in the landscape of cancer research, fueling the development of tissue banks for tran...

    Authors: Sambit K Mohanty, Amita T Mistry, Waqas Amin, Anil V Parwani, Andrew K Pople, Linda Schmandt, Sharon B Winters, Erin Milliken, Paula Kim, Nancy B Whelan, Ghada Farhat, Jonathan Melamed, Emanuela Taioli, Rajiv Dhir, Harvey I Pass and Michael J Becich
    Citation: BMC Cancer 2008 8:91
  13. The variable penetrance of ovarian cancer in BRCA1 mutation carriers suggests that other genetic or environmental factors modify disease risk. The C to T transition in the 3' untranslated region of the prohibitin...

    Authors: Anna Jakubowska, Jacek Gronwald, Janusz Menkiszak, Bohdan Górski, Tomasz Huzarski, Tomasz Byrski, Axel Benner, Jan Lubiński, Rodney J Scott and Ute Hamann
    Citation: BMC Cancer 2008 8:90
  14. This study examined sex-specific patterns and temporal trends in the incidence of solid tumours in the Northern Region of England from 1968 to 2005. This updates earlier analyses from the region where sex was ...

    Authors: Brooke L Magnanti, M Tevfik Dorak, Louise Parker, Alan W Craft, Peter W James and Richard JQ McNally
    Citation: BMC Cancer 2008 8:89
  15. To investigate the changes of the neoplastic microenvironment during the different morphological alterations of hyperplastic and pre-invasive breast lesions.

    Authors: Kitty Pavlakis, Irene Messini, Thomas Vrekoussis, Petros Yiannou, Dimitrios Keramopoullos, Niki Louvrou, Theodoros Liakakos and Efstathios N Stathopoulos
    Citation: BMC Cancer 2008 8:88
  16. Colorectal cancer is one of the most common causes of cancer-related mortality. The disease is clinically and genetically heterogeneous though a strong hereditary component has been identified. However, only a...

    Authors: Simone Picelli, Jana Vandrovcova, Siân Jones, Tatjana Djureinovic, Johanna Skoglund, Xiao-Lei Zhou, Victor E Velculescu, Bert Vogelstein and Annika Lindblom
    Citation: BMC Cancer 2008 8:87
  17. To asses the clinical profile, treatment outcome and prognostic factors in primary breast lymphoma (PBL).

    Authors: Wendy Jeanneret-Sozzi, Alphonse Taghian, Ron Epelbaum, Philip Poortmans, Daniel Zwahlen, Beat Amsler, Sylviane Villette, Yazid Belkacémi, Tan Nguyen, Pierre Scalliet, Philippe Maingon, Cristina Gutiérrez, Pauline Gastelblum, Marco Krengli, Rita Abi Raad, Mahmut Ozsahin…
    Citation: BMC Cancer 2008 8:86
  18. At present pathogenic mechanisms of cancer cachexia are poorly understood. Previous evidence in animal models implicates the melanocortin-4 receptor gene (MC4R) in the development of cancer cachexia. In humans, M...

    Authors: Susanne Knoll, Sabiene Zimmer, Anke Hinney, André Scherag, Andreas Neubauer and Johannes Hebebrand
    Citation: BMC Cancer 2008 8:85
  19. Experimental evidence suggests that matrix metalloproteinase-13 (MMP-13) protein may promote breast tumor progression, however, its role is yet to be fully established. Furthermore, it is not clear whether MMP...

    Authors: Bin Zhang, Xuchen Cao, Yanxue Liu, Wenfeng Cao, Fei Zhang, Shiwu Zhang, Hongtao Li, Liansheng Ning, Li Fu, Yun Niu, Ruifang Niu, Baocun Sun and Xishan Hao
    Citation: BMC Cancer 2008 8:83
  20. Single-agent gemcitabine (GEM) is a standard treatment for advanced and metastatic pancreatic cancer. This study examines the question whether GEM-based combination chemotherapy can further improve treatment e...

    Authors: Volker Heinemann, Stefan Boeck, Axel Hinke, Roberto Labianca and Christophe Louvet
    Citation: BMC Cancer 2008 8:82
  21. Metastatic prostate cancer is associated with a high morbidity and mortality but the spreading mechanisms are still poorly understood. The aminobisphosphonate alendronate, used to reduce bone loss, has also be...

    Authors: Johanna M Tuomela, Maija P Valta, Kalervo Väänänen and Pirkko L Härkönen
    Citation: BMC Cancer 2008 8:81
  22. Aim of this longitudinal study was to investigate the sensitivity to change of the Swedish Self Evaluation of Communication Experiences after Laryngeal Cancer questionnaire (the S-SECEL), addressing communicat...

    Authors: Mia Johansson, Anna Rydén and Caterina Finizia
    Citation: BMC Cancer 2008 8:80
  23. Malignant gliomas are lethal cancers, highly dependent on angiogenesis and treatment options and prognosis still remain poor for patients with recurrent glioblastoma multiforme (GBM). Ephs and ephrins have man...

    Authors: Lin-Fang Wang, Emmanouil Fokas, Janko Juricko, An You, Frank Rose, Axel Pagenstecher, Rita Engenhart-Cabillic and Han-Xiang An
    Citation: BMC Cancer 2008 8:79
  24. Protein-bound polysaccharide (PSK) is derived from the CM-101 strain of the fungus Coriolus versicolor and has shown anticancer activity in vitro and in in vivo experimental models and human cancers. Several rand...

    Authors: Eva Jiménez-Medina, Enrique Berruguilla, Irene Romero, Ignacio Algarra, Antonia Collado, Federico Garrido and Angel Garcia-Lora
    Citation: BMC Cancer 2008 8:78
  25. Elevated levels of matrix metalloproteinases have been found to associate with poor prognosis in various carcinomas. This study aimed at evaluating plasma levels of MMP1, MMP8 and MMP13 as diagnostic and progn...

    Authors: Julie Decock, Wouter Hendrickx, Ulla Vanleeuw, Vanya Van Belle, Sabine Van Huffel, Marie-Rose Christiaens, Shu Ye and Robert Paridaens
    Citation: BMC Cancer 2008 8:77
  26. Recent studies suggest an association between chronic inflammation, modulating the tissue microenvironment, and tumor biology. Tumor environment consists of tumor, stromal and endothelial cells and infiltratin...

    Authors: Vassiliki Pelekanou, Marilena Kampa, Maria Kafousi, Katerina Darivianaki, Elias Sanidas, Dimitrios D Tsiftsis, Efstathios N Stathopoulos, Andreas Tsapis and Elias Castanas
    Citation: BMC Cancer 2008 8:76
  27. Past studies have shown that women with abnormal cytology or epithelial cells in nipple aspirate fluid (NAF) have an increased relative risk (RR) of breast cancer when compared to women from whom NAF was attem...

    Authors: Kimberly A Baltzell, Michelle Moghadassi, Terri Rice, Jennette D Sison and Margaret Wrensch
    Citation: BMC Cancer 2008 8:75
  28. Radiotherapy can be used to treat all stages of cervical cancer. For improving local control via radiotherapy, it is important to use additional antitumor agents. Aminopeptidase N (APN)/CD13, a 150-kDa metallo...

    Authors: Hirohisa Tsukamoto, Kiyosumi Shibata, Hiroaki Kajiyama, Mikio Terauchi, Akihiro Nawa and Fumitaka Kikkawa
    Citation: BMC Cancer 2008 8:74
  29. Thymostimulin is a thymic peptide fraction with immune-mediated cytotoxicity against hepatocellular carcinoma in vitro. In a phase II trial, we investigated safety and efficacy including selection criteria for be...

    Authors: Matthias M Dollinger, Christa M Behrens, Joachim Lesske, Susanne Behl, Curd Behrmann and Wolfgang E Fleig
    Citation: BMC Cancer 2008 8:72
  30. A recent genome wide case-control association study identified NuMA region on 11q13 as a candidate locus for breast cancer susceptibility. Specifically, the variant Ala794Gly was suggested to be associated with i...

    Authors: Outi Kilpivaara, Matias Rantanen, Anitta Tamminen, Kristiina Aittomäki, Carl Blomqvist and Heli Nevanlinna
    Citation: BMC Cancer 2008 8:71
  31. Glucose regulated proteins (GRPs) are main regulators of cellular homeostasis due to their role as molecular chaperones. Moreover, the functions of GRPs suggest that they also may play important roles in cance...

    Authors: Rupert Langer, Marcus Feith, Joerg Rüdiger Siewert, Hans-Juergen Wester and Heinz Hoefler
    Citation: BMC Cancer 2008 8:70
  32. Tissue factor (TF) is a transmembrane protein that acts as a receptor for activated coagulation factor VII (FVIIa), initiating the coagulation cascade. Recent studies demonstrate that expression of tumor-deriv...

    Authors: Jun Fang, Lubing Gu, Ningxi Zhu, Hao Tang, Carlos S Alvarado and Muxiang Zhou
    Citation: BMC Cancer 2008 8:69
  33. CDKN1C (also known as p57KIP2) is a cyclin-dependent kinase inhibitor previously implicated in several types of human cancer. Its family members (CDKN1A/p21CIP1 and B/p27KIP1) have been implicated in breast cance...

    Authors: Pamela S Larson, Benjamin L Schlechter, Chia-Lin King, Qiong Yang, Chelsea N Glass, Charline Mack, Robert Pistey, Antonio de las Morenas and Carol L Rosenberg
    Citation: BMC Cancer 2008 8:68
  34. Sewage workers provide an essential service in the protection of public and environmental health. However, they are exposed to varied mixtures of chemicals; some are known or suspected to be genotoxics or carc...

    Authors: Hamzeh Al Zabadi, Luc Ferrari, Anne-Marie Laurent, Aziz Tiberguent, Christophe Paris and Denis Zmirou-Navier
    Citation: BMC Cancer 2008 8:67
  35. Current practice is to perform a completion axillary lymph node dissection (ALND) for breast cancer patients with tumor-involved sentinel lymph nodes (SLNs), although fewer than half will have non-sentinel nod...

    Authors: Holbrook E Kohrt, Richard A Olshen, Honnie R Bermas, William H Goodson, Douglas J Wood, Solomon Henry, Robert V Rouse, Lisa Bailey, Vicki J Philben, Frederick M Dirbas, Jocelyn J Dunn, Denise L Johnson, Irene L Wapnir, Robert W Carlson, Frank E Stockdale, Nora M Hansen…
    Citation: BMC Cancer 2008 8:66
  36. Vinca alkaloids are an important class of anticancer agents and semisynthetic vinca alkaloids are developed to improve the therapeutic index of this class of drugs. In the present study, a direct comparison wa...

    Authors: Cindy Simoens, Filip Lardon, Bea Pauwels, Christel MJ De Pooter, Hilde AJ Lambrechts, Greet GO Pattyn, Fabienne Breillout and Jan B Vermorken
    Citation: BMC Cancer 2008 8:65
  37. Immunohistochemical studies of lymphatic vessels have been limited by a lack of specific markers. Recently, the novel D2-40 antibody, which selectively marks endothelium of lymphatic vessels, was released. The...

    Authors: Vanessa FZ Marinho, Konradin Metze, Fernanda SF Sanches, Gislene FS Rocha and Helenice Gobbi
    Citation: BMC Cancer 2008 8:64
  38. Several epidemiologic studies have examined the association between physical activity and pancreatic cancer risk; however, the results of these studies are not consistent.

    Authors: Brook A Calton, Rachael Z Stolzenberg-Solomon, Steven C Moore, Arthur Schatzkin, Catherine Schairer, Demetrius Albanes and Michael F Leitzmann
    Citation: BMC Cancer 2008 8:63
  39. In recent years, preoperative volume reduction of locally advanced breast cancers, resulting in higher rates of breast-conserving surgery (BCS), has become increasingly important also in postmenopausal women. ...

    Authors: Ute E Krainick-Strobel, Werner Lichtenegger, Diethelm Wallwiener, Augustinus H Tulusan, Fritz Jänicke, Gunther Bastert, Ludwig Kiesel, Birgit Wackwitz and Stefan Paepke
    Citation: BMC Cancer 2008 8:62
  40. We present two melting curve analysis (MCA)-based semiquantitative real time PCR techniques to detect the promoter methylation status of genes. The first, MCA-MSP, follows the same principle as standard MSP bu...

    Authors: Aiala Lorente, Wolf Mueller, Edurne Urdangarín, Paula Lázcoz, Andreas von Deimling and Javier S Castresana
    Citation: BMC Cancer 2008 8:61
  41. Early onset lung cancer shows some familial aggregation, pointing to a genetic predisposition. This study was set up to investigate the role of candidate genes in the susceptibility to lung cancer patients you...

    Authors: Albert Rosenberger, Thomas Illig, Katrin Korb, Norman Klopp, Vera Zietemann, Gabi Wölke, Eckart Meese, Gerhard Sybrecht, Florian Kronenberg, Matthias Cebulla, Maria Degen, Peter Drings, Andreas Gröschel, Nikolaus Konietzko, Karsten grosse Kreymborg, Karl Häußinger…
    Citation: BMC Cancer 2008 8:60
  42. Germline inactivating mutations in BRCA1 and BRCA2 underlie a major proportion of the inherited predisposition to breast and ovarian cancer. These mutations are usually detected by DNA sequencing. Cost-effective ...

    Authors: Elena A Takano, Gillian Mitchell, Stephen B Fox and Alexander Dobrovic
    Citation: BMC Cancer 2008 8:59
  43. Arsenic trioxide (As2O3) exhibits promising anticarcinogenic activity in acute promyelocytic leukemic patients and induces apoptosis in various tumor cells in vitro. Here, we investigated the effect of the natura...

    Authors: Tseng-Hsi Lin, Hsing-Chun Kuo, Fen-Pi Chou and Fung-Jou Lu
    Citation: BMC Cancer 2008 8:58
  44. Recent studies have demonstrated a direct involvement of B7-H1, PD-1 and FOXP3 molecules in the immune escape of cancer. B7-H1 is an inhibitory molecule that binds to PD-1 on T lymphocytes, while FOXP3 is a ma...

    Authors: Hazem Ghebeh, Eman Barhoush, Asma Tulbah, Naser Elkum, Taher Al-Tweigeri and Said Dermime
    Citation: BMC Cancer 2008 8:57
  45. To determine the incidence of reversible amenorrhea in women with breast cancer undergoing adjuvant anthracycline-based chemotherapy with or without docetaxel.

    Authors: Martine Berliere, Florence Dalenc, Nathalie Malingret, Anita Vindevogel, Philippe Piette, Henry Roche, Jacques Donnez, Michel Symann, Joseph Kerger and Jean-Pascal Machiels
    Citation: BMC Cancer 2008 8:56
  46. We sought to examine the detection rate of cancer cells in peripheral blood (PBL) and in bone marrow (BM) using an established 7-gene marker panel and evaluated whether there were any definable associations of...

    Authors: Kaidi Mikhitarian, Renee Hebert Martin, Megan Baker Ruppel, William E Gillanders, Rana Hoda, Del H Schutte, Kathi Callahan, Michael Mitas and David J Cole
    Citation: BMC Cancer 2008 8:55
  47. Single nucleotide polymorphisms (SNPs) are the most frequent type of genetic variation in the human genome, and are of interest for the study of susceptibility to and protection from diseases. The haplotype at...

    Authors: Rikke D Hansen, Mette Sørensen, Anne Tjønneland, Kim Overvad, Håkan Wallin, Ole Raaschou-Nielsen and Ulla Vogel
    Citation: BMC Cancer 2008 8:54
  48. Cancer in the sinonasal tract is rare, but persons who have been occupationally exposed to wood dust have a substantially increased risk. It has been estimated that approximately 3.6 million workers are expose...

    Authors: Jette Bornholdt, Johnni Hansen, Torben Steiniche, Michael Dictor, Annemarie Antonsen, Henrik Wolff, Vivi Schlünssen, Reetta Holmila, Danièle Luce, Ulla Vogel, Kirsti Husgafvel-Pursiainen and Håkan Wallin
    Citation: BMC Cancer 2008 8:53

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