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  1. Cervical cancer represents an important global public health problem. It is the 2nd most common cancer among women worldwide. Human Papillomavirus (HPV) infection is now well-established as a necessary cause of i...

    Authors: Luciano Mariani, Núria Monfulleda, Laia Alemany, Enrico Vizza, Ferdinando Marandino, Amina Vocaturo, Maria Benevolo, Beatriz Quirós, Belén Lloveras, Jo Ellen Klaustermeier, Wim Quint, Silvia de Sanjosé and Fs Xavier Bosch
    Citation: BMC Cancer 2010 10:259
  2. Since 1999, patients presenting with brain metastases (BM) from breast cancer (BC) are treated in our institution with a carmustine (BCNU) - methotrexate (MTX) combination. We report here our clinical experien...

    Authors: William Jacot, Marie-Cécile Gerlotto-Borne, Simon Thezenas, Stéphane Pouderoux, Sylvain Poujol, Mahdi About and Gilles Romieu
    Citation: BMC Cancer 2010 10:257
  3. The immune system plays an important role in the multifactorial biologic system during the development of neoplasias. However, the involvement of the inflammatory response in the promotion/control of malignant...

    Authors: Alessandra Estrela-Lima, Márcio SS Araújo, João M Costa-Neto, Andréa Teixeira-Carvalho, Stella M Barrouin-Melo, Sergio V Cardoso, Olindo A Martins-Filho, Rogéria Serakides and Geovanni D Cassali
    Citation: BMC Cancer 2010 10:256
  4. Human Disabled-2 (DAB2), is a multi-function signalling molecule that it is frequently down-regulated in human cancers. We aimed to investigate the possible tumour suppressor effect of DAB2 in nasopharyngeal c...

    Authors: Joanna H Tong, David C Ng, Shuk L Chau, Ken K So, Patrick P Leung, Tin L Lee, Raymond W Lung, Michael W Chan, Anthony W Chan, Kwok W Lo and Ka F To
    Citation: BMC Cancer 2010 10:253
  5. The combination of bevacizumab and irinotecan is a new chemotherapy protocol increasingly used for recurrent malignant glioma. Results from phase II trials suggest this drug combination is beneficial to patien...

    Authors: Tao Xu, Juxiang Chen, Yicheng Lu and Johannes EA Wolff
    Citation: BMC Cancer 2010 10:252
  6. Most individuals who died of trauma were found to harbour microscopic primary cancers at autopsies. Surgical excision of the primary tumour, unfortunately, seems to disturb tumour dormancy in over half of all ...

    Authors: Tibor Bakács and Jitendra N Mehrishi
    Citation: BMC Cancer 2010 10:251
  7. Methotrexate is a chemotherapeutic drug that is used in therapy of a wide variety of cancers. The efficiency of treatment with this drug is compromised by the appearance of resistance. Combination treatments o...

    Authors: Nuria Mencía, Elisabet Selga, Isabel Rico, M Cristina de Almagro, Xenia Villalobos, Sara Ramirez, Jaume Adan, Jose L Hernández, Véronique Noé and Carlos J Ciudad
    Citation: BMC Cancer 2010 10:250
  8. The FUS-DDIT3 fusion oncogene encodes an abnormal transcription factor that has a causative role in the development of myxoid/round-cell liposarcomas (MLS/RCLS). We have previously identified FLT1 (VEGFR1) as a c...

    Authors: Mattias K Andersson, Melker Göransson, Anita Olofsson, Carola Andersson and Pierre Åman
    Citation: BMC Cancer 2010 10:249
  9. Various biomarkers for prediction of distant metastasis in lymph-node negative breast cancer have been described; however, predictive biomarkers for patients with lymph-node positive (LNP) disease in the conte...

    Authors: Dimo Dietrich, Manuel Krispin, Jörn Dietrich, Anne Fassbender, Jörn Lewin, Nadia Harbeck, Manfred Schmitt, Serenella Eppenberger-Castori, Vincent Vuaroqueaux, Frédérique Spyratos, John A Foekens, Ralf Lesche and John WM Martens
    Citation: BMC Cancer 2010 10:247
  10. Angiogenesis plays an important role in the development and progression of tumors. Kallistatin exerts anti-angiogenic and anti-inflammatory activities that may be effective in inhibiting tumor metastasis. We i...

    Authors: Ai-Li Shiau, Min-Li Teo, Shin-Yao Chen, Chrong-Reen Wang, Jeng-Long Hsieh, Meng-Ya Chang, Chih-Jui Chang, Julie Chao, Lee Chao, Chao-Liang Wu and Che-Hsin Lee
    Citation: BMC Cancer 2010 10:245
  11. Estrogens suppress tumor growth in prostate cancer which progresses despite anorchid serum androgen levels, termed castration resistant prostate cancers (CRPC), although the mechanisms are unclear. We hypothes...

    Authors: Bruce Montgomery, Peter S Nelson, Robert Vessella, Tom Kalhorn, David Hess and Eva Corey
    Citation: BMC Cancer 2010 10:244
  12. Human seminoma is classified as classical seminoma (SE) and spermatocytic seminoma (SS). Human SE is known to be more malignant and metastasizing more frequently than SS. Tumor angiogenesis is highly related w...

    Authors: Jong-Hyuk Kim, Chi-Ho Yu, Ji-Young Yhee, Keum-Soon Im, Na-Hyun Kim and Jung-Hyang Sur
    Citation: BMC Cancer 2010 10:243
  13. Calretinin is one of the well-established immunohistochemical markers in the diagnostics of malignant mesothelioma (MM). Its utility as a diagnostic tool in human blood, however, is scarcely investigated. The ...

    Authors: Irina Raiko, Ingrid Sander, Daniel G Weber, Monika Raulf-Heimsoth, Adrian Gillissen, Jens Kollmeier, Arnaud Scherpereel, Thomas Brüning and Georg Johnen
    Citation: BMC Cancer 2010 10:242
  14. Reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR) is a powerful method for the analysis of gene expression. Target gene expression levels are usually normalized to a consistently...

    Authors: Hyun-Wook Rho, Byoung-Chan Lee, Eun-Seok Choi, Il-Ju Choi, Yeon-Su Lee and Sung-Ho Goh
    Citation: BMC Cancer 2010 10:240
  15. Obesity is a global phenomenon and is associated with various types of cancer, including colon cancer. There is a growing interest for safe and effective bioactive compounds that suppress the risk for obesity-...

    Authors: Jairam Vanamala, Lavanya Reddivari, Sridhar Radhakrishnan and Chris Tarver
    Citation: BMC Cancer 2010 10:238
  16. Mutations in the TP53 gene are extremely common and occur very early in the progression of serous ovarian cancers. Gene expression patterns that relate to mutational status may provide insight into the etiology a...

    Authors: Marcus Q Bernardini, Tsukasa Baba, Paula S Lee, Jason C Barnett, Gregory P Sfakianos, Angeles Alvarez Secord, Susan K Murphy, Edwin Iversen, Jeffrey R Marks and Andrew Berchuck
    Citation: BMC Cancer 2010 10:237
  17. This study was designed to investigate an association between the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and the risk of gastric and colorectal cancer in the Korean population.

    Authors: Lian-Hua Cui, Min-Ho Shin, Sun-Seog Kweon, Hee Nam Kim, Hye-Rim Song, Jin-Mei Piao, Jin-Su Choi, Hyun Jeong Shim, Jun Eul Hwang, Hyeong-Rok Kim, Young-Kyu Park and Soo-Hyun Kim
    Citation: BMC Cancer 2010 10:236
  18. The objective of this study was to develop a ligand-targeted photodynamic therapy (tPDT) by conjugating factor VII (fVII) protein with photosensitiser verteporfin in order to overcome the poor selectivity and ...

    Authors: Zhiwei Hu, Benqiang Rao, Shimin Chen and Jinzhong Duanmu
    Citation: BMC Cancer 2010 10:235
  19. Sera from lung cancer patients contain autoantibodies that react with tumor associated antigens (TAAs) that reflect genetic over-expression, mutation, or other anomalies of cell cycle, growth, signaling, and m...

    Authors: William N Rom, Judith D Goldberg, Doreen Addrizzo-Harris, Heather N Watson, Michael Khilkin, Alissa K Greenberg, David P Naidich, Bernard Crawford, Ellen Eylers, Daorong Liu and Eng M Tan
    Citation: BMC Cancer 2010 10:234
  20. CDC25 phosphatases are important regulators of the cell cycle. Their abnormal expression detected in a number of tumors implies that their dysregulation is involved in malignant transformation. However, the ro...

    Authors: Zhihui Wang, Claes G Trope, Vivi Ann Flørenes, Zhenhe Suo, Jahn M Nesland and Ruth Holm
    Citation: BMC Cancer 2010 10:233
  21. Length of hospital stay (LOS) is a surrogate marker for patients' well-being during hospital treatment and is associated with health care costs. Identifying pretreatment factors associated with LOS in surgical...

    Authors: Brenda Laky, Monika Janda, Srinivas Kondalsamy-Chennakesavan, Geoffrey Cleghorn and Andreas Obermair
    Citation: BMC Cancer 2010 10:232
  22. Aberrations of allelic replication timing are epigenetic markers observed in peripheral blood cells of cancer patients. The aberrant markers are non-cancer-type-specific and are accompanied by increased levels...

    Authors: Arnon Nagler, Samuel Cytron, Maya Mashevich, Avital Korenstein-Ilan and Lydia Avivi
    Citation: BMC Cancer 2010 10:230
  23. Exposure of cancer cells to chemotherapeutic agents may result in reduced sensitivity to structurally unrelated agents, a phenomenon known as multidrug resistance, MDR. The purpose of this study is to investig...

    Authors: Rosa S Schneiderman, Esther Shmueli, Eilon D Kirson and Yoram Palti
    Citation: BMC Cancer 2010 10:229
  24. Most previous studies of the CpG island methylator phenotype (CIMP) in colorectal cancer (CRC) have been conducted on a relatively small numbers of CpG sites. In the present study we performed comprehensive DN...

    Authors: Pei Woon Ang, Marie Loh, Natalia Liem, Pei Li Lim, Fabienne Grieu, Aparna Vaithilingam, Cameron Platell, Wei Peng Yong, Barry Iacopetta and Richie Soong
    Citation: BMC Cancer 2010 10:227
  25. Some studies have indicated that reproductive factors affect the risk of histological types of breast cancer differently. The long-term protective effect of a childbirth is preceded by a short-term adverse eff...

    Authors: Grethe Albrektsen, Ivar Heuch and Steinar Ø Thoresen
    Citation: BMC Cancer 2010 10:226
  26. During surgery for endometrial cancer, a pelvic lymphadenectomy with or without para-aortic lymphadenectomy is performed at least in patients with risk factors (stage I, grading 2 and/or histological subtypes ...

    Authors: Nina Bassarak, Thomas Blankenstein, Ansgar Brüning, Darius Dian, Florian Bergauer, Klaus Friese and Ioannis Mylonas
    Citation: BMC Cancer 2010 10:224
  27. Breast cancer is not a single entity but a diverse group of entities. Advances in gene expression profiling and immunohistochemistry as its surrogate marker have led to the unmasking of new breast cancer molec...

    Authors: Dalal M Al Tamimi, Mohamed A Shawarby, Ayesha Ahmed, Ammar K Hassan and Amal A AlOdaini
    Citation: BMC Cancer 2010 10:223
  28. The distinction between primary and secondary ovarian tumors may be challenging for pathologists. The purpose of the present work was to develop genomic and transcriptomic tools to further refine the pathologi...

    Authors: Jean-Philippe Meyniel, Paul H Cottu, Charles Decraene, Marc-Henri Stern, Jérôme Couturier, Ingrid Lebigot, André Nicolas, Nina Weber, Virginie Fourchotte, Séverine Alran, Audrey Rapinat, David Gentien, Sergio Roman-Roman, Laurent Mignot and Xavier Sastre-Garau
    Citation: BMC Cancer 2010 10:222
  29. Epidermal growth factor (EGF) is critical in cancer process. EGF and EGF receptor (EGFR) interaction plays a pivotal role in cell proliferation, differentiation, and tumorigenesis of epithelial tissues. Variat...

    Authors: Shujie Wang, Yao Zhao, Zhenchao Ruan, Hongyan Chen, Weiwei Fan, Juxiang Chen, Qihan Wu, Ji Qian, Tianbao Zhang, Yan Huang and Daru Lu
    Citation: BMC Cancer 2010 10:221
  30. Tumor microenvironment is composed of tumor cells, fibroblasts, endothelial cells, and infiltrating immune cells. Tumor-associated immune cells may inhibit or promote tumor growth and progression. This study w...

    Authors: Fuqiang Dai, Lunxu Liu, Guowei Che, Nanbin Yu, Qiang Pu, Shangfu Zhang, Junliang Ma, Lin Ma and Zongbing You
    Citation: BMC Cancer 2010 10:220
  31. The opposite effects of chemotherapy, which enhance the malignancy of treated cancers such as hepatocellular carcinoma (HCC), are not well understood. We investigated this phenomenon and corresponding mechanis...

    Authors: Wei Xiong, Zheng-Gang Ren, Shuang-Jian Qiu, Hui-Chuan Sun, Lu Wang, Bin-Bin Liu, Qi-Song Li, Wei Zhang, Xiao-Dong Zhu, Liang Liu, Wen-Quan Wang and Zhao-You Tang
    Citation: BMC Cancer 2010 10:219
  32. Numerous hypermethylated genes have been reported in breast cancer, and the silencing of these genes plays an important role in carcinogenesis, tumor progression and diagnosis. These hypermethylated promoters ...

    Authors: Mercedes Zurita, Pedro C Lara, Rosario del Moral, Blanca Torres, José Luis Linares-Fernández, Sandra Ríos Arrabal, Joaquina Martínez-Galán, Francisco Javier Oliver and José Mariano Ruiz de Almodóvar
    Citation: BMC Cancer 2010 10:217
  33. Rapid and effective treatment of cancer-induced bone pain remains a clinical challenge and patients with bone metastasis are more likely to experience severe pain. The voltage-gated sodium channel Nav1.8 plays...

    Authors: Xue-Rong Miao, Xiao-Fei Gao, Jing-Xiang Wu, Zhi-Jie Lu, Zhang-Xiang Huang, Xiao-Qing Li, Cheng He and Wei-Feng Yu
    Citation: BMC Cancer 2010 10:216
  34. Malignant glioma is a rare cancer with poor survival. The influence of diet and antioxidant intake on glioma survival is not well understood. The current study examines the association between antioxidant inta...

    Authors: Gerald N DeLorenze, Lucie McCoy, Ai-Lin Tsai, Charles P Quesenberry Jr, Terri Rice, Dora Il'yasova and Margaret Wrensch
    Citation: BMC Cancer 2010 10:215
  35. Data from the California Health Interview Survey (CHIS) indicate that levels and temporal trends in colorectal cancer (CRC) screening prevalence vary among Asian American groups; however, the reasons for these...

    Authors: Annette E Maxwell, Catherine M Crespi, Cynthia M Antonio and Peiyun Lu
    Citation: BMC Cancer 2010 10:214
  36. Griseofulvin, an antifungal drug, has recently been shown to inhibit proliferation of various types of cancer cells and to inhibit tumor growth in athymic mice. Due to its low toxicity, griseofulvin has drawn ...

    Authors: Krishnan Rathinasamy, Bhavya Jindal, Jayant Asthana, Parminder Singh, Petety V Balaji and Dulal Panda
    Citation: BMC Cancer 2010 10:213
  37. The calcium-permeable cation channel TRPM8 (melastatin-related transient receptor potential member 8) is over-expressed in several cancers. The present study aimed at investigating the expression, function and...

    Authors: Dechen Chodon, Arnaud Guilbert, Isabelle Dhennin-Duthille, Mathieu Gautier, Marie-Sophie Telliez, Henri Sevestre and Halima Ouadid-Ahidouch
    Citation: BMC Cancer 2010 10:212
  38. We have studied the in vitro and in vivo utility of polyethylene glycol (PEG)-hydrogels for the development of an anticancer drug 5-fluorouracil (5-FU) delivery system.

    Authors: Hee Yi, Hee-Jung Cho, Soo-Min Cho, Dong-Goo Lee, AM Abd El-Aty, So-Jeong Yoon, Gun-Won Bae, Kwang Nho, Bokyung Kim, Chi-Ho Lee, Jin-Suk Kim, Michael G Bartlett and Ho-Chul Shin
    Citation: BMC Cancer 2010 10:211
  39. Chemoprevention, which includes the use of synthetic or natural agents (alone or in combination) to block the development of cancer in human beings, is an extremely promising strategy for cancer prevention. Ci...

    Authors: Soumya J Koppikar, Amit S Choudhari, Snehal A Suryavanshi, Shweta Kumari, Samit Chattopadhyay and Ruchika Kaul-Ghanekar
    Citation: BMC Cancer 2010 10:210
  40. Melanoma usually presents as an initial skin lesion without evidence of metastasis. A significant proportion of patients develop subsequent local, regional or distant metastasis, sometimes many years after the...

    Authors: Maxine S Emmett, Kirsty E Symonds, Howard Rigby, Martin G Cook, Rebecca Price, Chris Metcalfe, Antonio Orlando and David O Bates
    Citation: BMC Cancer 2010 10:208

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