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  1. A functional vascular network is essential for the survival, growth and spread of solid tumours, making blood vessels a key target for therapeutic strategies. Combretastatin A-4 phosphate (CA-4-P) is a tubulin...

    Authors: Gabi U Dachs, Andrew J Steele, Claudia Coralli, Chryso Kanthou, Andrew C Brooks, Sarah P Gunningham, Margaret J Currie, Ally I Watson, Bridget A Robinson and Gillian M Tozer
    Citation: BMC Cancer 2006 6:280
  2. Several studies showed that gain-of-function somatic mutations affecting the catalytic domain of EGFR in non-small cell lung carcinomas were associated with response to gefitinib and erlotinib, both EGFR-tyrosine...

    Authors: Tanios Bekaii-Saab, Nita Williams, Christoph Plass, Miguel Villalona Calero and Charis Eng
    Citation: BMC Cancer 2006 6:278
  3. Phase III trials evaluating the efficacy of gefitinib (IRESSA) in non-small cell lung cancer (NSCLC) lend support to the need for improved patient selection in terms of gefitinib use. Mutation of the epidermal...

    Authors: Rintaro Noro, Akihiko Gemma, Seiji Kosaihira, Yutaka Kokubo, Mingwei Chen, Masahiro Seike, Kiyoko Kataoka, Kuniko Matsuda, Tetsuya Okano, Yuji Minegishi, Akinobu Yoshimura and Shoji Kudoh
    Citation: BMC Cancer 2006 6:277
  4. Breast cancer subtypes identified in genomic studies have different underlying genetic defects. Mutations in the tumor suppressor p53 occur more frequently in estrogen receptor (ER) negative, basal-like and HE...

    Authors: Melissa A Troester, Jason I Herschkowitz, Daniel S Oh, Xiaping He, Katherine A Hoadley, Claire S Barbier and Charles M Perou
    Citation: BMC Cancer 2006 6:276
  5. Human breast cancer is a heterogeneous disease, histopathologically, molecularly and phenotypically. The molecular basis of this heterogeneity is not well understood. We have used a mouse model of DCIS that co...

    Authors: Ruria Namba, Jeannie E Maglione, Ryan R Davis, Colin A Baron, Stephenie Liu, Condie E Carmack, Lawrence JT Young, Alexander D Borowsky, Robert D Cardiff and Jeffrey P Gregg
    Citation: BMC Cancer 2006 6:275
  6. Health related quality of life (HRQOL) is an important outcome after treatment for upper gastrointestinal carcinoma. This study aimed to compare HRQOL in patients with advanced gastric cancer (GC) receiving ei...

    Authors: Sanambar Sadighi, Mohammad Ali Mohagheghi, Ali Montazeri and Zahra Sadighi
    Citation: BMC Cancer 2006 6:274
  7. Currently 1 in 11 women over the age of 60 in Australia are diagnosed with breast cancer. Following treatment, most breast cancer patients are left with shoulder and arm impairments which can impact significan...

    Authors: Sharon L Kilbreath, Kathryn M Refshauge, Jane M Beith, Leigh C Ward, Judy M Simpson and Ross D Hansen
    Citation: BMC Cancer 2006 6:273
  8. Androgen-independent prostate adenocarcinomas are responsible for about 6% of overall cancer deaths in men.

    Authors: Elizabeth Devilard, Franck Bladou, Olivier Ramuz, Gilles Karsenty, Jean-Philippe Dalès, Gwenaëlle Gravis, Catherine Nguyen, François Bertucci, Luc Xerri and Daniel Birnbaum
    Citation: BMC Cancer 2006 6:272
  9. Breast cancer is the commonest cancer among women in Nigeria and globally. In Nigeria, late presentations of breast cancer cases have also been consistent for three decades. In an environment where there is no...

    Authors: O Abimbola Oluwatosin and Oladimeji Oladepo
    Citation: BMC Cancer 2006 6:271
  10. Matrix metalloproteinases (MMP) have been shown to play a role in colorectal cancer (CRC). More recently, MMP1, MMP3 and MMP7 functional gene promoter polymorphisms have been found to be associated with CRC occur...

    Authors: Astrid Lièvre, Jacqueline Milet, Jérôme Carayol, Delphine Le Corre, Chantal Milan, Alexandre Pariente, Bernard Nalet, Jacques Lafon, Jean Faivre, Claire Bonithon-Kopp, Sylviane Olschwang, Catherine Bonaiti-Pellié and Pierre Laurent-Puig
    Citation: BMC Cancer 2006 6:270
  11. In breast cancer current guidelines do not recommend the routine use of serum tumour markers. Differently, we observed that CEA-TPA-CA15.3 (carcinoembryonic (CEA) tissue polypeptide (TPA) and cancer associated...

    Authors: Andrea Nicolini, Gianna Tartarelli, Angelo Carpi, Maria Rita Metelli, Paola Ferrari, Loretta Anselmi, Massimo Conte, Piero Berti and Paolo Miccoli
    Citation: BMC Cancer 2006 6:269
  12. The transcription factor 7-like 2 (TCF7L2) is a critical component of the Wnt/β-catenin pathway. Aberrant TCF7L2 expression modifies Wnt signaling and mediates oncogenic effects through the upregulation of c-MYC ...

    Authors: Barbara Burwinkel, Kalai S Shanmugam, Kari Hemminki, Alfons Meindl, Rita K Schmutzler, Christian Sutter, Barbara Wappenschmidt, Marion Kiechle, Claus R Bartram and Bernd Frank
    Citation: BMC Cancer 2006 6:268
  13. In search of a suitable GSH-depleting agent, a novel copper complex viz., copper N-(2-hydroxyacetophenone) glycinate (CuNG) has been synthesized, which was initially found to be a potential resistance modifying a...

    Authors: Ananda Mookerjee, Jayati Mookerjee Basu, Surajit Majumder, Shilpak Chatterjee, Gouri S Panda, Pranabananda Dutta, Smarajit Pal, Pratima Mukherjee, Thomas Efferth, Syamal Roy and Soumitra K Choudhuri
    Citation: BMC Cancer 2006 6:267
  14. Detection of circulating malignant cells (CMCs) through a reverse transcriptase-polymerase chain reaction (RT-PCR) assay seems to be a demonstration of systemic disease. We here evaluated the prognostic role o...

    Authors: Giuseppe Palmieri, Sabrina MR Satriano, Mario Budroni, Antonio Cossu, Francesco Tanda, Sergio Canzanella, Corrado Caracò, Ester Simeone, Antonio Daponte, Nicola Mozzillo, Giuseppe Comella, Giuseppe Castello and Paolo A Ascierto
    Citation: BMC Cancer 2006 6:266
  15. Epstein-Barr virus (EBV) is the causative agent of immunosuppression associated lymphoproliferations such as post-transplant lymphoproliferative disorder (PTLD), AIDS related immunoblastic lymphomas (ARL) and ...

    Authors: Laszlo Markasz, György Stuber, Emilie Flaberg, Åsa Gustafsson Jernberg, Staffan Eksborg, Eva Olah, Henriette Skribek and Laszlo Szekely
    Citation: BMC Cancer 2006 6:265
  16. There is a paucity of literature on the referral outcome of patients seen in phase I trial clinics in academic oncology centres. This study aims to provide information on the accrual rate and to identify obsta...

    Authors: Jeremy Ho, Gregory R Pond, Colin Newman, Martha Maclean, Eric X Chen, Amit M Oza and Lillian L Siu
    Citation: BMC Cancer 2006 6:263
  17. The reciprocal (9;22) translocation fuses the bcr (breakpoint cluster region) gene on chromosome 22 to the abl (Abelson-leukemia-virus) gene on chromosome 9. Depending on the breakpoint on chromosome 22 (the Phil...

    Authors: Xiaomin Zheng, Saskia Güller, Tim Beissert, Elena Puccetti and Martin Ruthardt
    Citation: BMC Cancer 2006 6:262
  18. From 1968 to 2002, Singapore experienced an almost three-fold increase in breast cancer incidence. This increase appeared to be different across the three main ethnic groups: Chinese, Malays and Indians. This ...

    Authors: Xueling Sim, R Ayesha Ali, Sara Wedren, Denise Li-Meng Goh, Chuen-Seng Tan, Marie Reilly, Per Hall and Kee-Seng Chia
    Citation: BMC Cancer 2006 6:261
  19. Anaplastic thyroid cancer (ATC) is one of the most aggressive human malignancies and appears to arise mainly from transformation of pre-existing differentiated thyroid cancer (DTC). However, the carcinogenic m...

    Authors: Junko Akaishi, Masamitsu Onda, Junichi Okamoto, Shizuyo Miyamoto, Mitsuji Nagahama, Kouichi Ito, Akira Yoshida and Kazuo Shimizu
    Citation: BMC Cancer 2006 6:260
  20. Circulating plasma Epstein Barr Virus DNA (EBV-DNA) is a sensitive and specific marker of nasopharyngeal carcinoma (NPC). The mainstay of treatment of metastatic NPC is systemic chemotherapy and resection for ...

    Authors: Stephen L Chan, Edwin P Hui, Sing F Leung, Anthony TC Chan and Brigette BY Ma
    Citation: BMC Cancer 2006 6:259
  21. Bowel cancer is common and is a major cause of death. Meta-analysis of randomised controlled trials estimates that screening for colorectal cancer using faecal occult blood (FOB) test reduces mortality from co...

    Authors: Sue Wilson, Michael JO Wakelam, Richard FD Hobbs, Angela V Ryan, Janet A Dunn, Val D Redman, Fiona Patrick, Lynne Colbourne, Ashley Martin and Tariq Ismail
    Citation: BMC Cancer 2006 6:258
  22. Two functional single nucleotide polymorphisms (SNPs) in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, C677T and A1298C, lead to decreased enzyme activity and affect chemosensitivity of tumor cells. ...

    Authors: Damali N Martin, Brenda J Boersma, Tiffany M Howe, Julie E Goodman, Leah E Mechanic, Stephen J Chanock and Stefan Ambs
    Citation: BMC Cancer 2006 6:257
  23. In a recent pilot report, we showed that Smac/DIABLO mRNA is expressed de novo in a subset of cervical cancer patients. We have now expanded this study and analyzed Smac/DIABLO expression in the primary lesions i...

    Authors: Abril Arellano-Llamas, Francisco J Garcia, Delia Perez, David Cantu, Magali Espinosa, Jaime G De la Garza, Vilma Maldonado and Jorge Melendez-Zajgla
    Citation: BMC Cancer 2006 6:256
  24. Maspin, a member of the serpin family, is a suppressor of tumor growth, an inhibitor of angiogenesis and an inducer of apoptosis. Maspin induces apoptosis by increasing Bax, a member of the Bcl-2 family of apo...

    Authors: Antonello A Romani, Paolo Soliani, Silvia Desenzani, Angelo F Borghetti and Pellegrino Crafa
    Citation: BMC Cancer 2006 6:255
  25. Epigenetic alterations and loss of heterozygosity are mechanisms of tumor suppressor gene inactivation. A new carcinogenic pathway, targeting the RAS effectors has recently been documented. RASSF1A, on 3p21.3,...

    Authors: Paula Lázcoz, Jorge Muñoz, Manuel Nistal, Ángel Pestaña, Ignacio Encío and Javier S Castresana
    Citation: BMC Cancer 2006 6:254
  26. HNSCC progression to adjacent tissue and nodes may be mediated by altered glycoproteins and glycolipids such as MUC1 mucin. This report constitutes a detailed statistical study about MUC1 expression and anti-M...

    Authors: Martín E Rabassa, María V Croce, Adrián Pereyra and Amada Segal-Eiras
    Citation: BMC Cancer 2006 6:253
  27. SnoN is an important regulator of the transforming growth factor beta (TGFβ) signalling pathway and has been shown to exhibit both tumour promotion and suppression activity.

    Authors: June A Chia, Lisa A Simms, Sarah-Jane Cozzi, Joanne Young, Jeremy R Jass, Michael D Walsh, Kevin J Spring, Barbara A Leggett and Vicki LJ Whitehall
    Citation: BMC Cancer 2006 6:252
  28. Bowel cancer is common and is a major cause of death. Most people with bowel symptoms who meet the criteria for urgent referral to secondary care will not be found to have bowel cancer, and some people who are...

    Authors: Angela V Ryan, Sue Wilson, Michael JO Wakelam, Sally A Warmington, Janet A Dunn, Richard FD Hobbs, Ashley Martin and Tariq Ismail
    Citation: BMC Cancer 2006 6:251
  29. The efficacy of screening for colorectal cancer using a simple blood-based assay for the detection of tumor cells disseminated in the circulation at an early stage of the disease is gaining positive feedback f...

    Authors: Rossella Solmi, Giampaolo Ugolini, Giancarlo Rosati, Simone Zanotti, Mattia Lauriola, Isacco Montroni, Marco del Governatore, Antonello Caira, Mario Taffurelli, Donatella Santini, Domenico Coppola, Lia Guidotti, Paolo Carinci and Pierluigi Strippoli
    Citation: BMC Cancer 2006 6:250
  30. It remains unknown whether primary ocular adnexal extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is a homogeneous entity, as there are few reports of the results ...

    Authors: Kazuki Tanimoto, Naohiro Sekiguchi, Yukiko Yokota, Akihiro Kaneko, Takashi Watanabe, Akiko Miyagi Maeshima, Yoshihiro Matsuno, Mine Harada, Kensei Tobinai and Yukio Kobayashi
    Citation: BMC Cancer 2006 6:249
  31. Celecoxib inhibits PGE2 production in cancerous tissue. We previously reported that PGE2 levels in nipple aspirate fluid (NAF) and plasma were not decreased in women at increased breast cancer risk who receive...

    Authors: Edward R Sauter, Wenyi Qin, Lisa Schlatter, John E Hewett and John T Flynn
    Citation: BMC Cancer 2006 6:248
  32. The presence of an oligodendroglial component within a glioblastoma multiforme (GBM) is considered a prognostically favorable factor, but the clinical outcome of patients with glioblastoma multiforme with olig...

    Authors: Dirk Vordermark, Klemens Ruprecht, Peter Rieckmann, Wolfgang Roggendorf, Giles H Vince, Monika Warmuth-Metz, Oliver Kölbl and Michael Flentje
    Citation: BMC Cancer 2006 6:247
  33. Human breast tissue undergoes phases of proliferation, differentiation and regression regulated by changes of the levels of circulating sex hormones during the menstrual cycle or aging. Ovarian hormones also l...

    Authors: Natalija Eigėlienė, Pirkko Härkönen and Risto Erkkola
    Citation: BMC Cancer 2006 6:246
  34. Oncogene amplification and overexpression occur in tumor cells. Amplification status may provide diagnostic and prognostic information and may lead to new treatment strategies. Chromosomal regions 8p12, 8q24, ...

    Authors: Anne Letessier, Fabrice Sircoulomb, Christophe Ginestier, Nathalie Cervera, Florence Monville, Véronique Gelsi-Boyer, Benjamin Esterni, Jeannine Geneix, Pascal Finetti, Christophe Zemmour, Patrice Viens, Emmanuelle Charafe-Jauffret, Jocelyne Jacquemier, Daniel Birnbaum and Max Chaffanet
    Citation: BMC Cancer 2006 6:245
  35. The observation that germline mutations in the oxidative DNA damage repair gene MUTYH cause colorectal cancer (CRC) provides strong evidence that dysregulation of the base excision repair (BER) pathway influences...

    Authors: Peter Broderick, Tina Bagratuni, Jairam Vijayakrishnan, Steven Lubbe, Ian Chandler and Richard S Houlston
    Citation: BMC Cancer 2006 6:243
  36. The proto-oncogene pituitary tumor-transforming gene (PTTG) has been shown to be abundantly overexpressed in a large variety of neoplasms likely promoting neo-vascularization and tumor invasiveness. In this st...

    Authors: Christine Solbach, Marc Roller, Frank Eckerdt, Silke Peters and Rainald Knecht
    Citation: BMC Cancer 2006 6:242
  37. Fascin is an actin bundling protein with roles in the formation of cell protrusions and motility of mesenchymal and neuronal cells. Fascin is normally low or absent from epithelia, but is upregulated in severa...

    Authors: Yosuke Hashimoto, Marek Skacel, Ian C Lavery, Abir L Mukherjee, Graham Casey and Josephine C Adams
    Citation: BMC Cancer 2006 6:241

    The Erratum to this article has been published in BMC Cancer 2011 11:488

  38. Persistent fatigue is recognised as one of the most common, ongoing symptoms reported by patients following cancer treatment and may have profound effects on the quality of life. However, recent cross-sectiona...

    Authors: David Goldstein, Barbara Bennett, Michael Friedlander, Tracey Davenport, Ian Hickie and Andrew Lloyd
    Citation: BMC Cancer 2006 6:240
  39. The CCND1 gene generates two mRNAs (cyclin D1a and D1b) through an alternative splicing at the site of a common A/G polymorphism. Cyclin D1a and b proteins differ in their C-terminus, a region involved in protein...

    Authors: Sophie Krieger, Juliette Gauduchon, Mikel Roussel, Xavier Troussard and Brigitte Sola
    Citation: BMC Cancer 2006 6:238
  40. Osteosarcoma is a very aggressive tumor with a propensity to metastasize and invade surrounding tissue. Identification of the molecular determinants of invasion and metastatic potential may guide the developme...

    Authors: Cristiane A Dalla-Torre, Maisa Yoshimoto, Chung-Hae Lee, Anthony M Joshua, Silvia RC de Toledo, Antônio S Petrilli, Joyce AD Andrade, Susan Chilton-MacNeill, Maria Zielenska and Jeremy A Squire
    Citation: BMC Cancer 2006 6:237
  41. The Wnt signaling pathway is activated by mutations in the APC and β-catenin genes in many types of human cancer. β-catenin is stabilized by these mutations and activates transcription in part by acting as a b...

    Authors: Christophe Fuerer, Krisztian Homicsko, Alexander N Lukashev, Anne-Laure Pittet and Richard D Iggo
    Citation: BMC Cancer 2006 6:236
  42. Oxidative damage to mitochondrial DNA has been implicated as a causative factor in a wide variety of degenerative diseases, aging and cancer. The modified guanine, 7,8-dihydro-8-oxoguanine (also known as 8-hyd...

    Authors: Aditi Chatterjee, Elizabeth Mambo, Yonggang Zhang, Theodore DeWeese and David Sidransky
    Citation: BMC Cancer 2006 6:235
  43. Accumulating data suggest that liver is a major target organ of systemic effects observed in the presence of a cancer. In this study, we investigated the consequences of the presence of chemically induced brai...

    Authors: Daniel Pouliquen, Christophe Olivier, Emilie Debien, Khaled Meflah, François M Vallette and Jean Menanteau
    Citation: BMC Cancer 2006 6:234
  44. Previous studies indicate that alterations in Human Leukocyte Antigen (HLA) class I expression are frequent in colorectal tumors. This would suggest serious limitations for immunotherapy-based strategies invol...

    Authors: Jan Willem F Dierssen, Noel FCC de Miranda, Arend Mulder, Marjo van Puijenbroek, Willem Verduyn, Frans HJ Claas, Cornelis JH van de Velde, Gert Jan Fleuren, Cees J Cornelisse, Willem E Corver and Hans Morreau
    Citation: BMC Cancer 2006 6:233
  45. Hepatocelluar carcinoma (HCC) is one of the most common cancers worldwide and a major cause of cancer-related mortality. HCC is highly resistant to currently available chemotherapeutic drugs. Defects in apopto...

    Authors: Henning Schulze-Bergkamen, Binje Fleischer, Marcus Schuchmann, Achim Weber, Arndt Weinmann, Peter H Krammer and Peter R Galle
    Citation: BMC Cancer 2006 6:232
  46. Ataxia telangiectasia-mutated and Rad3-related (ATR) is a member of the PIK-related family which plays, along with ATM, a central role in cell-cycle regulation. ATR has been shown to phosphorylate several tumo...

    Authors: Francine Durocher, Yvan Labrie, Penny Soucy, Olga Sinilnikova, Damian Labuda, Paul Bessette, Jocelyne Chiquette, Rachel Laframboise, Jean Lépine, Bernard Lespérance, Geneviève Ouellette, Roxane Pichette, Marie Plante, Sean V Tavtigian and Jacques Simard
    Citation: BMC Cancer 2006 6:230

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