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  1. Ciz1 promotes initiation of mammalian DNA replication and is present within nuclear matrix associated DNA replication factories. Depletion of Ciz1 from normal and cancer cells restrains entry to S phase and in...

    Authors: Faisal A Rahman, Naveed Aziz and Dawn Coverley
    Citation: BMC Cancer 2010 10:482
    Content type: Research article Published on:

  2. 17-Allylamino-17-demethoxygeldanamycin (17-AAG), a benzoquinone ansamycin antibiotic, specifically targets heat shock protein 90 (Hsp90) and interferes with its function as a molecular chaperone that maintains...

    Authors: Panagiotis K Karkoulis, Dimitrios J Stravopodis, Lukas H Margaritis and Gerassimos E Voutsinas
    Citation: BMC Cancer 2010 10:481
    Content type: Research article Published on:

  3. In the era of cytokines, patients with brain metastases (BM) from renal cell carcinoma had a significantly shorter survival than patients without. Targeted agents (TA) have improved the outcome of patients wit...

    Authors: Ursula M Vogl, Marija Bojic, Wolfgang Lamm, Josa M Frischer, Oskar Pichelmayer, Gero Kramer, Andrea Haitel, Klaus Kitz, Kaan Harmankaya, Christoph C Zielinski and Manuela Schmidinger
    Citation: BMC Cancer 2010 10:480
    Content type: Research article Published on:

  5. Treatment standard for patients with primary glioblastoma (GBM) is combined radiochemotherapy with temozolomide (TMZ). Radiation is delivered up to a total dose of 60 Gy using photons. Using this treatment reg...

    Authors: Stephanie E Combs, Meinhard Kieser, Stefan Rieken, Daniel Habermehl, Oliver Jäkel, Thomas Haberer, Anna Nikoghosyan, Renate Haselmann, Andreas Unterberg, Wolfgang Wick and Jürgen Debus
    Citation: BMC Cancer 2010 10:478
    Content type: Study protocol Published on:

  6. The cytokine-induced anti-apoptotic molecule (CIAPIN1) had been found to be a differentially-expressed gene involved in a variety of cancers, and it was also considered as a candidate tumour suppressor gene in...

    Authors: Hai Shi, Yi Zhou, Heliang Liu, Changsheng Chen, Shujun Li, Nanlin Li, Xiaohua Li, Xi Zhang, Hongwei Zhang, Weizhong Wang and Qingchuan Zhao
    Citation: BMC Cancer 2010 10:477
    Content type: Research article Published on:

  7. Attempts to reduce morbidity and mortality in breast cancer is based on efforts to identify novel biomarkers to support prognosis and therapeutic choices. The present study has focussed on S100 proteins as a p...

    Authors: Patrizia Cancemi, Gianluca Di Cara, Nadia Ninfa Albanese, Francesca Costantini, Maria Rita Marabeti, Rosa Musso, Carmelo Lupo, Elena Roz and Ida Pucci-Minafra
    Citation: BMC Cancer 2010 10:476
    Content type: Research article Published on:

  8. We evaluated the long-term effect of stereotactic body radiation therapy (SBRT) for primary small hepatocellular carcinoma (HCC) ineligible for local therapy or surgery.

    Authors: Jung Hyun Kwon, Si Hyun Bae, Ji Yoon Kim, Byung Ock Choi, Hong Seok Jang, Jeong Won Jang, Jong Young Choi, Seung Kew Yoon and Kyu Won Chung
    Citation: BMC Cancer 2010 10:475
    Content type: Research article Published on:

  9. Whether tumor size and stage distribution are correlated remains controversial. The objective is to assess the relationship between tumor size and disease stage distribution in non-small cell lung cancer (NSCLC).

    Authors: Fu Yang, Haiquan Chen, Jiaqing Xiang, Yawei Zhang, Jianhua Zhou, Hong Hu, Jie Zhang and Xiaoyang Luo
    Citation: BMC Cancer 2010 10:474
    Content type: Research article Published on:

  10. Human neuroblastoma (NB) cell lines may present with either one of the so-called S-and N-subtypes. We have previously reported a strong correlation between protein expression levels of vimentin, an S-subtype m...

    Authors: Xénia Mergui, Marie-Line Puiffe, Dominique Valteau-Couanet, Marc Lipinski, Jean Bénard and Mounira Amor-Guéret
    Citation: BMC Cancer 2010 10:473
    Content type: Research article Published on:

  12. Chondrosarcomas are malignant cartilage tumors that do not respond to traditional chemotherapy or radiation. The 5-year survival rate of histologic grade III chondrosarcoma is less than 30%. An animal model of...

    Authors: Christopher A Hamm, Jeff W Stevens, Hehuang Xie, Elio F Vanin, Jose A Morcuende, Hakeem Abdulkawy, Elisabeth A Seftor, Simone T Sredni, Jared M Bischof, Deli Wang, Sergey Malchenko, Maria de Fatima Bonaldo, Thomas L Casavant, Mary JC Hendrix and Marcelo B Soares
    Citation: BMC Cancer 2010 10:471
    Content type: Research article Published on:

  13. Severe toxicity to 5-fluorouracil (5-FU) based chemotherapy in gastrointestinal cancer has been associated with constitutional genetic alterations of the dihydropyrimidine dehydrogenase gene (DPYD).

    Authors: Joana Savva-Bordalo, João Ramalho-Carvalho, Manuela Pinheiro, Vera L Costa, Ângelo Rodrigues, Paula C Dias, Isabel Veiga, Manuela Machado, Manuel R Teixeira, Rui Henrique and Carmen Jerónimo
    Citation: BMC Cancer 2010 10:470
    Content type: Research article Published on:

  14. Mitomycin C is a chemotherapeutic agent used in the treatment of peritoneal surface malignancies, administered as hyperthermic intraperitoneal chemotherapy after cytoreductive surgery. Pharmacokinetic studies ...

    Authors: Olaf Sørensen, Anders Andersen, Harald Olsen, Kristian Alexandr, Per Olaf Ekstrøm, Karl-Erik Giercksky and Kjersti Flatmark
    Citation: BMC Cancer 2010 10:469
    Content type: Research article Published on:

  15. Glioblastoma multiforme (GBM) is refractory to conventional therapies. To overcome the problem of heterogeneity, more brain tumor markers are required for prognosis and targeted therapy. We have identified and...

    Authors: Chien-Tsun Kuan, Kenji Wakiya, James E Herndon II, Eric S Lipp, Charles N Pegram, Gregory J Riggins, Ahmed Rasheed, Scott E Szafranski, Roger E McLendon, Carol J Wikstrand and Darell D Bigner
    Citation: BMC Cancer 2010 10:468
    Content type: Research article Published on:

  16. Overexpression of Bmi-1 has been observed in a variety of cancers, and it has been suggested to be an independent prognostic marker for the patients. The objective of this study was to determine the level of B...

    Authors: Wan-li Liu, Xian-zhi Guo, Lan-jun Zhang, Jun-ye Wang, Ge Zhang, Su Guan, Yu-min Chen, Qing-li Kong, Li-hua Xu, Man-zhi Li, Li-bing Song and Mu-sheng Zeng
    Citation: BMC Cancer 2010 10:467
    Content type: Research article Published on:

  17. BRCA1 and BRCA2 mutations are found in a proportion of families with multiple early-onset breast cancers. There are a large number of different deleterious mutations in both genes, none of which would be detecta...

    Authors: Lidija Turkovic, Lyle C Gurrin, Melanie Bahlo, Gillian S Dite, Melissa C Southey and John L Hopper
    Citation: BMC Cancer 2010 10:466
    Content type: Research article Published on:

  18. Lymphadenectomy is debated in early stages endometrial cancer. Moreover, a new FIGO classification of endometrial cancer, merging stages IA and IB has been recently published. Therefore, the aims of the presen...

    Authors: Marcos Ballester, Martin Koskas, Charles Coutant, Elisabeth Chéreau, Jeremy Seror, Roman Rouzier and Emile Daraï
    Citation: BMC Cancer 2010 10:465
    Content type: Research article Published on:

  19. Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature cells that accumulates in tumour-bearing hosts. These cells are induced by tumour-derived factors (e.g. prostaglandins) and ha...

    Authors: Joris D Veltman, Margaretha EH Lambers, Menno van Nimwegen, Rudi W Hendriks, Henk C Hoogsteden, Joachim GJV Aerts and Joost PJJ Hegmans
    Citation: BMC Cancer 2010 10:464
    Content type: Research article Published on:

  20. A rural region in south-west Spain has one of the highest lung cancer incidence rates of the country, as revealed by a previous epidemiological 10-year follow-up study. The present work was undertaken to ascer...

    Authors: Carmen San Jose, Agustin Cabanillas, Julio Benitez, Juan Antonio Carrillo, Mercedes Jimenez and Guillermo Gervasini
    Citation: BMC Cancer 2010 10:463
    Content type: Research article Published on:

  21. Giant cell tumour of bone (GCTB) is an expansile osteolytic tumour which contains numerous osteoclast-like giant cells. GCTB frequently recurs and can produce metastatic lesions in the lungs. Bisphosphonates a...

    Authors: Maurice Balke, Laura Campanacci, Carsten Gebert, Piero Picci, Max Gibbons, Richard Taylor, Pancras Hogendoorn, Judith Kroep, John Wass and Nicholas Athanasou
    Citation: BMC Cancer 2010 10:462
    Content type: Research article Published on:

  23. A major challenge in the interpretation of genomic profiling data generated from breast cancer samples is the identification of driver genes as distinct from bystander genes which do not impact tumorigenesis. ...

    Authors: Lesleyann Hawthorn, Jesse Luce, Leighton Stein and Jenniffer Rothschild
    Citation: BMC Cancer 2010 10:460
    Content type: Research article Published on:

  24. Endothelial progenitor cells (EPCs) contribute to tumor angiogenesis and growth. We aimed to determine whether inhibitors of differentiation 1 (Id1) were expressed in circulating EPCs of patients with ovarian ...

    Authors: Yajuan Su, Lei Zheng, Qian Wang, Jie Bao, Zhen Cai and Ailan Liu
    Citation: BMC Cancer 2010 10:459
    Content type: Research article Published on:

  25. Prognostic factors in patients who are diagnosed with T4 breast carcinomas are widely awaited. We here evaluated the clinical role of some molecular alterations involved in tumorigenesis in a well-characterize...

    Authors: Bruno Massidda, MariaCristina Sini, Mario Budroni, Francesco Atzori, MariaCristina Deidda, Valeria Pusceddu, MariaTeresa Perra, Paola Sirigu, Antonio Cossu, Grazia Palomba, MariaTeresa Ionta and Giuseppe Palmieri
    Citation: BMC Cancer 2010 10:458
    Content type: Research article Published on:

  26. Thymostimulin is a thymic peptide fraction with immune-mediated cytotoxicity against hepatocellular carcinoma (HCC) in vitro and palliative efficacy in advanced HCC in two independent phase II trials. The aim of ...

    Authors: Matthias M Dollinger, Christine Lautenschlaeger, Joachim Lesske, Andrea Tannapfel, Anna-Dorothea Wagner, Konrad Schoppmeyer, Oliver Nehls, Martin-Walter Welker, Reiner Wiest and Wolfgang E Fleig
    Citation: BMC Cancer 2010 10:457
    Content type: Research article Published on:

  27. Recent studies identified an increased risk of prostate cancer (PCa) in Caucasian men harboring polymorphisms of genes involved in innate immunity and inflammation. This study was designed to assess whether si...

    Authors: Jie Liu, Bao Song, Xueli Bai, Wenjian Liu, Zengjun Li, Jialin Wang, Yan Zheng and Zhehai Wang
    Citation: BMC Cancer 2010 10:456
    Content type: Research article Published on:

  28. Genomic gains and losses are a result of genomic instability in many types of cancers. BRCA1- and BRCA2-mutated breast cancers are associated with increased amounts of chromosomal aberrations, presumably due thei...

    Authors: Henne Holstege, Erik van Beers, Arno Velds, Xiaoling Liu, Simon A Joosse, Sjoerd Klarenbeek, Eva Schut, Ron Kerkhoven, Christiaan N Klijn, Lodewyk FA Wessels, Petra M Nederlof and Jos Jonkers
    Citation: BMC Cancer 2010 10:455
    Content type: Research article Published on:

  29. Gliomas are the most common type of primary brain tumours, and in this group glioblastomas (GBMs) are the higher-grade gliomas with fast progression and unfortunate prognosis. Two major aspects of glioma biolo...

    Authors: Juan L Garcia, Maria Perez-Caro, Juan A Gomez-Moreta, Francisco Gonzalez, Javier Ortiz, Oscar Blanco, Magdalena Sancho, Jesus M Hernandez-Rivas, Rogelio Gonzalez-Sarmiento and Manuel Sanchez-Martin
    Citation: BMC Cancer 2010 10:454
    Content type: Research article Published on:

  30. Fatigue is prevalent in breast cancer survivors and has profound effects on daily life. The interference of fatigue with endocrine therapy may be difficult to separate. This study investigates the prevalence a...

    Authors: Xu Huang, Qingyuan Zhang, Xinmei Kang, Ying Song and Wenhui Zhao
    Citation: BMC Cancer 2010 10:453
    Content type: Research article Published on:

  31. Patterns of diagnosis and management for men diagnosed with prostate cancer in Queensland, Australia, have not yet been systematically documented and so assumptions of equity are untested. This longitudinal st...

    Authors: Peter D Baade, Joanne F Aitken, Megan Ferguson, Robert A Gardiner and Suzanne K Chambers
    Citation: BMC Cancer 2010 10:452
    Content type: Study protocol Published on:

  32. Platinum-based drugs, such as cisplatin and oxaliplatin, are well-known for inducing chronic sensory neuropathies but their acute and motor neurotoxicities are less well characterised. Use was made of nerve co...

    Authors: Andrew Hill, Peter Bergin, Fritha Hanning, Paul Thompson, Michael Findlay, Dragan Damianovich and Mark J McKeage
    Citation: BMC Cancer 2010 10:451
    Content type: Research article Published on:

  33. Desmoplasia in medulloblastoma is often diagnosed in adult patients and was repeatedly associated with improved results. Today, all medulloblastoma patients receive intensive multimodal treatment including sur...

    Authors: Stefan Rieken, Timo Gaiser, Angela Mohr, Thomas Welzel, Olaf Witt, Andreas E Kulozik, Wolfgang Wick, Jürgen Debus and Stephanie E Combs
    Citation: BMC Cancer 2010 10:450
    Content type: Research article Published on:

  34. Transformed phenotypes are common to cell lines derived from various cancers. Proteome profiling is a valuable tool that may reveal uncharacteristic cell phenotypes in transformed cells. Changes in expression ...

    Authors: Jana Mladkova, Miloslav Sanda, Eva Matouskova and Irena Selicharova
    Citation: BMC Cancer 2010 10:449
    Content type: Research article Published on:

  35. Studies about the biology, treatment pattern, and treatment outcome of metastatic/recurrent neuroendocrine tumor (NET) have been few.

    Authors: Su-Jung Kim, Jin Won Kim, Sae-Won Han, Do-Youn Oh, Se-Hoon Lee, Dong-Wan Kim, Seock-Ah Im, Tae-You Kim, Dae Seog Heo and Yung-Jue Bang
    Citation: BMC Cancer 2010 10:448
    Content type: Research article Published on:

  36. Breast cancer is the most common form of malignancy affecting women worldwide. It is also the leading cancer in females in Cyprus, with approximately 400 new cases diagnosed annually. It is well recognized tha...

    Authors: Andreas Hadjisavvas, Maria A Loizidou, Nicos Middleton, Thalia Michael, Rena Papachristoforou, Eleni Kakouri, Maria Daniel, Panayiotis Papadopoulos, Simon Malas, Yiola Marcou and Kyriacos Kyriacou
    Citation: BMC Cancer 2010 10:447
    Content type: Research article Published on:

  37. Nasopharyngeal carcinoma (NPC) is rare in most parts of the world but is a common malignancy in southern China, especially in Guangdong. Dietary habit is regarded as an important modifier of NPC risk in severa...

    Authors: Wei-Hua Jia, Xiang-Yu Luo, Bing-Jian Feng, Hong-Lian Ruan, Jin-Xin Bei, Wen-Sheng Liu, Hai-De Qin, Qi-Sheng Feng, Li-Zhen Chen, Shugart Yin Yao and Yi-Xin Zeng
    Citation: BMC Cancer 2010 10:446
    Content type: Research article Published on:

  38. Resveratrol (RES), a natural phytoalexin found at high levels in grapes and red wine, has been shown to induce anti-proliferation and apoptosis of human cancer cell lines. However, the underlying molecular mec...

    Authors: Ying Yan, Yan-Yan Gao, Bao-Qin Liu, Xiao-Fang Niu, Ying Zhuang and Hua-Qin Wang
    Citation: BMC Cancer 2010 10:445
    Content type: Research article Published on:

  39. Tumour phenotype is regulated in a complex fashion as a result of interactions between malignant cells and the tumour stroma. Fibroblasts are the most abundant and perhaps most active part of the tumour stroma...

    Authors: Charlotta J Olsen, José Moreira, Eugene M Lukanidin and Noona S Ambartsumian
    Citation: BMC Cancer 2010 10:444
    Content type: Research article Published on:

  40. In addition to regulating platelet function, the G protein-coupled sub-family member Proteinase-activated receptor-1 (PAR1) has a proposed role in the development of various cancers, but its exact role and mec...

    Authors: Daisuke Fujimoto, Yasuo Hirono, Takanori Goi, Kanji Katayama, Shigeru Matsukawa and Akio Yamaguchi
    Citation: BMC Cancer 2010 10:443
    Content type: Research article Published on:

  41. Numerous epidemiological studies have documented that obesity is associated with hepatocellular carcinoma (HCC). The aim of this study was to investigate the biological actions regulated by leptin, the obesity...

    Authors: Nikolaos Stefanou, Vassilis Papanikolaou, Yoichi Furukawa, Yusuke Nakamura and Aspasia Tsezou
    Citation: BMC Cancer 2010 10:442
    Content type: Research article Published on:

  42. Based on their different mechanisms of action, non-overlapping side effects and radiosensitising potential, combining the antimetabolites pemetrexed (multitargeted antifolate, MTA) and gemcitabine (2',2'-diflu...

    Authors: An Wouters, Bea Pauwels, Filip Lardon, Greet GO Pattyn, Hilde AJ Lambrechts, Marc Baay, Paul Meijnders and Jan B Vermorken
    Citation: BMC Cancer 2010 10:441
    Content type: Research article Published on:

  43. Pancreatic cancer is a complex genetic disorder that is characterized by rapid progression, invasiveness, resistance to treatment and high molecular heterogeneity. Various agents have been used in clinical tri...

    Authors: Jan N Kreutzer, Maria Ruzzene and Barbara Guerra
    Citation: BMC Cancer 2010 10:440
    Content type: Research article Published on:

  44. DNA repair capacity is an important determinant of susceptibility to cancer. The hOGG1 enzyme is crucial for repairing the 8-oxoguanine lesion that occurs either as a byproduct of oxidative metabolism or as a ...

    Authors: Randa A El-Zein, Claudia M Monroy, Andrea Cortes, Margaret R Spitz, Anthony Greisinger and Carol J Etzel
    Citation: BMC Cancer 2010 10:439
    Content type: Research article Published on:

  45. Imatinib mesylate has been used for the treatment of unresectable or metastatic gastrointestinal stromal tumors (GIST). The current recommended dose of imatinib is 400 mg/day that is increased to 800 mg/day in...

    Authors: Jun-Eul Hwang, Ju-Young Yoon, Woo-Kyun Bae, Hyun-Jeong Shim, Sang-Hee Cho and Ik-Joo Chung
    Citation: BMC Cancer 2010 10:438
    Content type: Case report Published on:

  46. Nuclear factor-kappa B (NF-κB) signaling constitutes a key event in the multistep process of carcinogenesis, progression and treatment in many cancer types. However, the significance of NF-κB pathway for compl...

    Authors: Ming Yan, Qin Xu, Ping Zhang, Xiao-jian Zhou, Zhi-yuan Zhang and Wan-tao Chen
    Citation: BMC Cancer 2010 10:437
    Content type: Research article Published on:

  48. We investigated the distribution and clinical significance of mobilized endothelial progenitor cells (EPCs) in hepatocellular carcinoma (HCC). We found that many more EPCs were recruited to nonmalignant liver ...

    Authors: De-cai Yu, Jun Chen, Xi-tai Sun, Lin-yuan Zhuang, Chun-ping Jiang and Yi-tao Ding
    Citation: BMC Cancer 2010 10:435
    Content type: Research article Published on:

  49. Heterogeneous nuclear ribonucleoproteins (hnRNPs) of the A/B type (hnRNP A1, A2/B1, A3) are highly related multifunctional proteins participating in alternative splicing by antagonising other splicing factors,...

    Authors: Georgios Boukakis, Meropi Patrinou-Georgoula, Maria Lekarakou, Christos Valavanis and Apostolia Guialis
    Citation: BMC Cancer 2010 10:434
    Content type: Research article Published on:

  50. Increased concentrations of choline-containing compounds are frequently observed in breast carcinomas, and may serve as biomarkers for both diagnostic and treatment monitoring purposes. However, underlying mec...

    Authors: Siver A Moestue, Eldrid Borgan, Else M Huuse, Evita M Lindholm, Beathe Sitter, Anne-Lise Børresen-Dale, Olav Engebraaten, Gunhild M Mælandsmo and Ingrid S Gribbestad
    Citation: BMC Cancer 2010 10:433
    Content type: Research article Published on:

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