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  1. Ovarian carcinoma is a common, and often deadly, gynecological cancer. Mutations in BRCA1 and BRCA2 genes are present in at least a fifth of patients. Uncovering other genes that become mutated subsequent to BRCA...

    Authors: Jian Zhang, Yuhao Shi, Emilie Lalonde, Lili Li, Luca Cavallone, Alex Ferenczy, Walter H Gotlieb, William D Foulkes and Jacek Majewski
    Citation: BMC Cancer 2013 13:146
    Content type: Research article Published on:

  2. The Cancer/Testis Antigens (CTAs) are a heterogeneous group of proteins whose expression is typically restricted to the testis. However, they are aberrantly expressed in most cancers that have been examined to...

    Authors: Robert Kim, Prakash Kulkarni and Sridhar Hannenhalli
    Citation: BMC Cancer 2013 13:144
    Content type: Research article Published on:

  3. NR4A orphan nuclear receptors are involved in multiple biological processes which are important in tumorigenesis such as cell proliferation, apoptosis, differentiation, and glucose utilization. The significanc...

    Authors: Shawn Llopis, Brittany Singleton, Tamika Duplessis, Latonya Carrier, Brian Rowan and Christopher Williams
    Citation: BMC Cancer 2013 13:139
    Content type: Research article Published on:

  4. Breast cancer is the most common female cancer worldwide. The lifetime risk of a woman being diagnosed with breast cancer is approximately 12.5%. For women who carry the deleterious mutation in either of the BRCA

    Authors: Emer M Guinan, Juliette Hussey, Sarah A McGarrigle, Laura A Healy, Jacintha N O’Sullivan, Kathleen Bennett and Elizabeth M Connolly
    Citation: BMC Cancer 2013 13:138
    Content type: Study protocol Published on:

  5. We attempted to identify novel biomarkers and therapeutic targets for esophageal squamous cell carcinoma by gene expression profiling of frozen esophageal squamous carcinoma specimens and examined the function...

    Authors: Qing Wang, Chenming Ma and Wolfgang Kemmner
    Citation: BMC Cancer 2013 13:137
    Content type: Research article Published on:

  6. In China, there are currently no approved therapies for the treatment of metastatic renal cell carcinoma (mRCC) following progression with vascular endothelial growth factor (VEGF)-targeted agents. In the phas...

    Authors: Jun Guo, Yiran Huang, Xu Zhang, Fangjian Zhou, Yinghao Sun, Shukui Qin, Zhangqun Ye, Hui Wang, Annette Jappe, Patrick Straub, Nicoletta Pirotta and Sven Gogov
    Citation: BMC Cancer 2013 13:136
    Content type: Research article Published on:

  7. The measurement properties of instruments used to assess functional capacity, physical activity and muscle strength in participants with non-small cell lung cancer (NSCLC) have not been systematically reviewed.

    Authors: Catherine L Granger, Christine F McDonald, Selina M Parry, Cristino C Oliveira and Linda Denehy
    Citation: BMC Cancer 2013 13:135
    Content type: Research article Published on:

  8. The p53 protein is expressed as multiple isoforms that differ in their N- and C-terminus due to alternative splicing, promoter or codon initiation usage. Δ40p53 lacks the first 39 residues containing the main ...

    Authors: Hind Hafsi, Daniela Santos-Silva, Stéphanie Courtois-Cox and Pierre Hainaut
    Citation: BMC Cancer 2013 13:134
    Content type: Research article Published on:

  9. The incidence of oropharyngeal squamous cell carcinoma (OPSCC) has markedly increased over the last three decades due to newly found associations with human papillomavirus (HPV) infection. Primary radiotherapy...

    Authors: Anthony C Nichols, John Yoo, J Alex Hammond, Kevin Fung, Eric Winquist, Nancy Read, Varagur Venkatesan, S Danielle MacNeil, D Scott Ernst, Sara Kuruvilla, Jeff Chen, Martin Corsten, Michael Odell, Libni Eapen, Julie Theurer, Philip C Doyle…
    Citation: BMC Cancer 2013 13:133
    Content type: Study protocol Published on:

  11. There is currently no consensus regarding the optimal timing for androgen suppression therapy in patients with prostate cancer that have undergone local therapy with curative intent but are proven to have node...

    Authors: Frank Kunath, Bastian Keck, Gerta Rücker, Edith Motschall, Bernd Wullich, Gerd Antes and Joerg J Meerpohl
    Citation: BMC Cancer 2013 13:131
    Content type: Research article Published on:

  12. Lung cancer diagnosis is usually achieved through a set of bronchoscopic techniques or computed tomography guided-transthoracic needle aspiration (CT-TTNA). However these procedures have a variable diagnostic ...

    Authors: Antonio Bugalho, Dalila Ferreira, Ralf Eberhardt, Sara S Dias, Paula A Videira, Felix J Herth and Luis Carreiro
    Citation: BMC Cancer 2013 13:130
    Content type: Research article Published on:

  14. αB-crystallin is able to modulate vascular endothelial growth factor (VEGF) secretion. In many solid tumors VEGF is associated with angiogenesis, metastasis formation and poor prognosis. We set out to assess w...

    Authors: Chantal van de Schootbrugge, Johan Bussink, Paul N Span, Fred CGJ Sweep, Reidar Grénman, Hanneke Stegeman, Ger JM Pruijn, Johannes HAM Kaanders and Wilbert C Boelens
    Citation: BMC Cancer 2013 13:128
    Content type: Research article Published on:

  15. A long-term prospective assessment of QoL in cervical cancer patients is still lacking. Here, we provide the first 2-years prospective, longitudinal study evaluating emotional distress and QoL in early stage (...

    Authors: Giovanna Mantegna, Marco Petrillo, Gilda Fuoco, Laura Venditti, Serena Terzano, Luigi Pedone Anchora, Giovanni Scambia and Gabriella Ferrandina
    Citation: BMC Cancer 2013 13:127
    Content type: Research article Published on:

  16. Studies on the association between MDM2 SNP309 (T > G) and gastric cancer have reported conflicting results. Thus, the aim of this study was to investigate whether MDM2 SNP309 is associated with susceptibility an...

    Authors: Xiaolin Pan, Yuqin Li, Jin Feng, Xiaoyong Wang, Bo Hao, Ruihua Shi and Guoxin Zhang
    Citation: BMC Cancer 2013 13:126
    Content type: Research article Published on:

  17. The malignant potential of tumour cells may be influenced by the molecular nature of KRAS mutations being codon 13 mutations less aggressive than codon 12 ones. Their metabolic profile is also different, with an ...

    Authors: Agnès Figueras, Maria Antonia Arbos, Maria Teresa Quiles, Francesc Viñals, Josep Ramón Germà and Gabriel Capellà
    Citation: BMC Cancer 2013 13:125
    Content type: Research article Published on:

  18. Increased histone H3 phosphorylation is an essential regulatory mechanism for neoplastic cell transformation. We aimed to explore the role of histone H3 phosphorylation at serine10 (p-H3Ser10) in Epstein-Barr ...

    Authors: Binbin Li, Guoliang Huang, Xiangning Zhang, Rong Li, Jian Wang, Ziming Dong and Zhiwei He
    Citation: BMC Cancer 2013 13:124
    Content type: Research article Published on:

  19. Whether the 7th edition of American Joint Committee on Cancer (AJCC) TNM staging system (AJCC-7) is a successful revision remains debatable. We aimed to compare the predictive capacity of the AJCC-7 for colore...

    Authors: Peng Gao, Yong-xi Song, Zhen-ning Wang, Ying-ying Xu, Lin-lin Tong, Jing-xu Sun, Miao Yu and Hui-mian Xu
    Citation: BMC Cancer 2013 13:123
    Content type: Research article Published on:

  20. Supporting health care sector decisions using time-dependent endpoints (TDEs) such as time to progression (TTP), progression-free survival (PFS), and event-free survival (EFS) remains controversial. This study...

    Authors: Jorge Félix, Filipa Aragão, João M Almeida, Frederico JM Calado, Diana Ferreira, António BS Parreira, Ricardo Rodrigues and João FR Rijo
    Citation: BMC Cancer 2013 13:122
    Content type: Research article Published on:

  21. The objective of this Phase I dose escalation study was to explore the safety and tolerability of eltrombopag, an oral, nonpeptide, thrombopoietin receptor agonist, in patients with advanced soft tissue sarcom...

    Authors: Sant P Chawla, Arthur Staddon, Andrew Hendifar, Conrad A Messam, Rita Patwardhan and Yasser Yasser Mostafa Kamel
    Citation: BMC Cancer 2013 13:121
    Content type: Research article Published on:

  22. The use of bevacizumab in combination with fluoropyrimidine-containing chemotherapy is a well-established first-line and second-line treatment for patients with metastatic colorectal cancer (mCRC). However, th...

    Authors: Stephen Clarke, Matt Burge, Cassandra Cordwell, Peter Gibbs, William Reece and Niall Tebbutt
    Citation: BMC Cancer 2013 13:120
    Content type: Study protocol Published on:

  23. Vitamin D transcriptional effects were linked to tumor growth control, however, the hormone targets were determined in cell cultures exposed to supra physiological concentrations of 1,25(OH)2D3 (50-100nM). Our ai...

    Authors: Cintia Milani, Maria Lucia Hirata Katayama, Eduardo Carneiro de Lyra, JoEllen Welsh, Laura Tojeiro Campos, M Mitzi Brentani, Maria do Socorro Maciel, Rosimeire Aparecida Roela, Paulo Roberto del Valle, João Carlos Guedes Sampaio Góes, Suely Nonogaki, Rodrigo Esaki Tamura and Maria Aparecida Azevedo Koike Folgueira
    Citation: BMC Cancer 2013 13:119
    Content type: Research article Published on:

  24. The purpose of this study is to evaluate the prognostic value of TFPI-2 expression in breast cancer patients through examining the correlation between TFPI-2 expression and breast cancer clinicopathologic feat...

    Authors: Cheng Xu, Huijun Wang, Hongyu He, Fengyun Zheng, Yating Chen, Jin Zhang, Xiaoyan Lin, Duan Ma and Hongwei Zhang
    Citation: BMC Cancer 2013 13:118
    Content type: Research article Published on:

  26. Cytogenetic and gene expression analyses in head and neck squamous cell carcinomas (HNSCC) have allowed identification of genomic aberrations that may contribute to cancer pathophysiology. Nevertheless, the mo...

    Authors: Sandra Bernaldo de Quirós, Anna Merlo, Pablo Secades, Iriana Zambrano, Ines Saenz de Santa María, Nerea Ugidos, Eloisa Jantus-Lewintre, Rafael Sirera, Carlos Suarez and María-Dolores Chiara
    Citation: BMC Cancer 2013 13:116
    Content type: Research article Published on:

  27. Proline-, glutamic acid-, and leucine-rich protein 1 (PELP1), a coregulator of the estrogen receptors (ERs) alpha and beta, is a potential proto-oncogene in hormone dependent gynecological malignancies. To bet...

    Authors: Stefanie Aust, Peter Horak, Dietmar Pils, Sophie Pils, Christoph Grimm, Reinhard Horvat, Dan Tong, Bernd Schmid, Paul Speiser, Alexander Reinthaller and Stephan Polterauer
    Citation: BMC Cancer 2013 13:115
    Content type: Research article Published on:

  28. The management of advanced stage non-small cell lung cancer is increasingly based on diagnostic and predictive analyses performed mostly on limited amounts of tumor tissue. The evaluation of Epidermal Growth F...

    Authors: Luisella Righi, Alessandra Cuccurullo, Simona Vatrano, Susanna Cappia, Daniela Giachino, Paolo De Giuli, Mara Ardine, Silvia Novello, Marco Volante, Giorgio V Scagliotti and Mauro Papotti
    Citation: BMC Cancer 2013 13:114
    Content type: Technical advance Published on:

  29. Despite the potential of improving the delivery of epigenetic drugs, the subsequent assessment of changes in their epigenetic activity is largely dependent on the availability of a suitable and rapid screening...

    Authors: Sue Ping Lim, Raman Kumar, Yamini Akkamsetty, Wen Wang, Kristen Ho, Paul M Neilsen, Diego J Walther, Rachel J Suetani, Clive Prestidge and David F Callen
    Citation: BMC Cancer 2013 13:113
    Content type: Technical advance Published on:

  30. The use of computerized systems to support evidence-based practice is commonplace in contemporary medicine. Despite the prolific use of electronic support systems there has been relatively little research on t...

    Authors: Julia M Langton, Nicole Pesa, Shelley Rushton, Robyn L Ward and Sallie-Anne Pearson
    Citation: BMC Cancer 2013 13:112
    Content type: Research article Published on:

  31. We sought to identify high-risk areas of pancreatic cancer incidence, and determine if clusters of persons diagnosed with pancreatic cancer were more likely to be located near arsenic-contaminated drinking wat...

    Authors: Wen Liu-Mares, Jill A MacKinnon, Recinda Sherman, Lora E Fleming, Caio Rocha-Lima, Jennifer J Hu and David J Lee
    Citation: BMC Cancer 2013 13:111
    Content type: Research article Published on:

  32. Experimental data suggest that mitochondria is involved in tumorigenesis. However, little is known about the qualitative and quantitative changes of mtDNA in colorectal cancer tissues. We therefore conducted p...

    Authors: HaiHong Cui, Ping Huang, ZhiJing Wang, YunXin Zhang, ZhenHua Zhang, Wei Xu, XiaoPeng Wang, Ying Han and XiaoMing Guo
    Citation: BMC Cancer 2013 13:110
    Content type: Research article Published on:

  33. Solitary Fibrous Tumor is a rare type of soft tissue tumor of intermediate malignant potential which may recur or metastasize in 15-20% of cases. Data on the management of patients with advanced SFT is scarce:...

    Authors: Alice Levard, Olfa Derbel, Pierre Méeus, Dominique Ranchère, Isabelle Ray-Coquard, Jean-Yves Blay and Philippe A Cassier
    Citation: BMC Cancer 2013 13:109
    Content type: Research article Published on:

  34. High invasion and metastasis are the primary factors causing poor prognosis of patients with hepatocellular carcinoma (HCC). However, the molecular mechanisms underlying these biological behaviors have not bee...

    Authors: Lin Zhang, Gang Huang, Xiaowu Li, Yujun Zhang, Yan Jiang, Junjie Shen, Jia Liu, Qingliang Wang, Jin Zhu, Xiaobin Feng, Jiahong Dong and Cheng Qian
    Citation: BMC Cancer 2013 13:108
    Content type: Research article Published on:

  36. Glioblastoma is one of the intractable cancers and is highly resistant to ionizing radiation. This radioresistance is partly due to the presence of a hypoxic region which is widely found in advanced malignant ...

    Authors: Hironobu Yasui, Taketoshi Asanuma, Junichi Kino, Tohru Yamamori, Shunsuke Meike, Masaki Nagane, Nobuo Kubota, Mikinori Kuwabara and Osamu Inanami
    Citation: BMC Cancer 2013 13:106
    Content type: Research article Published on:

  37. Europe faces an enormous public health challenge with aging populations and rising cancer incidence. Little is known about what concerns the public across European countries regarding cancer care towards the e...

    Authors: Claudia Bausewein, Natalia Calanzani, Barbara A Daveson, Steffen T Simon, Pedro L Ferreira, Irene J Higginson, Dorothee Bechinger-English, Luc Deliens, Marjolein Gysels, Franco Toscani, Lucas Ceulemans, Richard Harding and Barbara Gomes
    Citation: BMC Cancer 2013 13:105
    Content type: Research article Published on:

  38. Aluminum is used in a wide range of applications and is a potential environmental hazard. The known genotoxic effects of aluminum might play a role in the development of breast cancer. However, the data curren...

    Authors: Raquel Mary Rodrigues-Peres, Solange Cadore, Stefanny Febraio, Juliana Karina Heinrich, Katia Piton Serra, Sophie F M Derchain, Jose Vassallo and Luis Otavio Sarian
    Citation: BMC Cancer 2013 13:104
    Content type: Research article Published on:

  39. Although both excision repair cross-complementing group 1 (ERCC1) and breast cancer susceptibility gene 1 (BRCA1) can be effective biomarkers for chemosensitivity in primary malignant tumors, their applicabili...

    Authors: Lu Yuanming, Zhang Lineng, Song Baorong, Peng Junjie and Cai Sanjun
    Citation: BMC Cancer 2013 13:103
    Content type: Research article Published on:

  40. The purpose of this study was to evaluate the efficacy and tolerability of weekly docetaxel, cisplatin, and S-1 (weekly TPS) as induction chemotherapy for patients with locally advanced head and neck squamous ...

    Authors: Woo Kyun Bae, Jun Eul Hwang, Hyun Jeong Shim, Sang Hee Cho, Ki Hyeong Lee, Hye Suk Han, Eun-Kee Song, Hwan Jung Yun, In Sung Cho, Joon Kyoo Lee, Sang-Chul Lim, Woong-Ki Chung and Ik-Joo Chung
    Citation: BMC Cancer 2013 13:102
    Content type: Research article Published on:

  41. To analyse the prognostic significance of preoperative C-reactive protein (CRP) serum level in patients with upper urinary tract urothelial carcinoma (UUT-UC).

    Authors: Barbara Stein, Andres Jan Schrader, Gerd Wegener, Christoph Seidel, Markus A Kuczyk and Sandra Steffens
    Citation: BMC Cancer 2013 13:101
    Content type: Research article Published on:

  42. Atypical teratoid rhabdoid tumor (ATRT) patients display a dismal median overall survival of less than 1 year. A consistent fraction of cases carries de-novo SMARCB1/INI1 constitutional mutations in the setting o...

    Authors: Piergiorgio Modena, Iacopo Sardi, Monica Brenca, Laura Giunti, Anna Maria Buccoliero, Bianca Pollo, Veronica Biassoni, Lorenzo Genitori, Manila Antonelli, Roberta Maestro, Felice Giangaspero and Maura Massimino
    Citation: BMC Cancer 2013 13:100
    Content type: Case report Published on:

  43. Many studies support the hypothesis that specific microRNA (miRNA) expression in various human cancers including hepatocarcinogenesis is closely associated with diagnosis and prognosis. In hepatocellular carci...

    Authors: Yoshiki Murakami, Akihiro Tamori, Saori Itami, Toshihito Tanahashi, Hidenori Toyoda, Masami Tanaka, Weihong Wu, Nariso Brojigin, Yuji Kaneoka, Atsuyuki Maeda, Takashi Kumada, Norifumi Kawada, Shoji Kubo and Masahiko Kuroda
    Citation: BMC Cancer 2013 13:99
    Content type: Research article Published on:

  44. Intraoperative detection of 18F-FDG-avid tissue sites during 18F-FDG-directed surgery can be very challenging when utilizing gamma detection probes that rely on a fixed target-to-background (T/B) ratio (ratiometr...

    Authors: Stephen P Povoski, Gregg J Chapman, Douglas A Murrey, Robert Lee, Edward W Martin and Nathan C Hall
    Citation: BMC Cancer 2013 13:98
    Content type: Research article Published on:

  45. The Michigan Prevention Research Center, the University of Michigan Schools of Nursing, Public Health, and Medicine, and the Michigan Department of Community Health propose a multidisciplinary academic-clinica...

    Authors: Maria C Katapodi, Laurel L Northouse, Ann M Schafenacker, Debra Duquette, Sonia A Duffy, David L Ronis, Beth Anderson, Nancy K Janz, Jennifer McLosky, Kara J Milliron, Sofia D Merajver, Linh M Duong and Glenn Copeland
    Citation: BMC Cancer 2013 13:97
    Content type: Study protocol Published on:

  46. The Bag (Bcl-2 associated athanogene) family of proteins consists of 6 members sharing a common, single-copied Bag domain through which they interact with the molecular chaperone Hsp70. Bag5 represents an exce...

    Authors: Anja Bruchmann, Corinna Roller, Tamara Vanessa Walther, Georg Schäfer, Sara Lehmusvaara, Tapio Visakorpi, Helmut Klocker, Andrew C B Cato and Danilo Maddalo
    Citation: BMC Cancer 2013 13:96
    Content type: Research article Published on:

  47. Pancreatic ductal adenocarcinoma (PDAC) is the fourth most common cause of cancer related death. It is lethal in nearly all patients, due to an almost complete chemoresistance. Most if not all drugs that pass ...

    Authors: Paola Longati, Xiaohui Jia, Johannes Eimer, Annika Wagman, Michael-Robin Witt, Stefan Rehnmark, Caroline Verbeke, Rune Toftgård, Matthias Löhr and Rainer L Heuchel
    Citation: BMC Cancer 2013 13:95
    Content type: Research article Published on:

  48. Ovarian cancer is the deadliest gynecologic cancer in the US. The consumption of refined sugars has increased dramatically over the past few decades, accounting for almost 15% of total energy intake. Yet, ther...

    Authors: Melony G King, Sara H Olson, Lisa Paddock, Urmila Chandran, Kitaw Demissie, Shou-En Lu, Niyati Parekh, Lorna Rodriguez-Rodriguez and Elisa V Bandera
    Citation: BMC Cancer 2013 13:94
    Content type: Research article Published on:

  49. The development of resistance to chemotherapies represents a significant barrier to successful cancer treatment. Resistance mechanisms are complex, can involve diverse and often unexpected cellular processes, ...

    Authors: Li Chen, Lynda Stuart, Toshiro K Ohsumi, Shawn Burgess, Gaurav K Varshney, Anahita Dastur, Mark Borowsky, Cyril Benes, Adam Lacy-Hulbert and Emmett V Schmidt
    Citation: BMC Cancer 2013 13:93
    Content type: Research article Published on:

  50. Poly (ADP-ribose) polymerase 1 (PARP1) overexpression plays a critical role in ovarian cancer progression and the clinical development of PARP1 inhibitors to treat BRCA-mutated ovarian cancer has advanced rapi...

    Authors: Fang-Fang Bi, Da Li and Qing Yang
    Citation: BMC Cancer 2013 13:90
    Content type: Research article Published on:

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