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  1. Oropharyngeal cancer (OPC) associated with human papilloma virus (HPV OPC) shows better treatment outcomes than non-HPV OPC. We investigated the expression of p53, β-tubulin, bcl-2 and ERCC 1, which are well-k...

    Authors: Min-Jee Kim, Myung-Seo Ki, Karham Kim, Hyun-Jeong Shim, Jun-Eul Hwang, Woo-Kyun Bae, Ik-Joo Chung, Dong-Hoon Lee, Joon-Kyoo Lee, Tae-Mi Yoon, Sang-Chul Lim, Woong-Ki Chung, Jae-Uk Jeong, Hoi-Soon Lim, Yoo-Duk Choi and Sang-Hee Cho
    Citation: BMC Cancer 2014 14:824
    Content type: Research article Published on:

  2. Vulvar carcinoma is an infrequent tumour, accounting for fewer than 3% of all malignant tumours that affect women, but its incidence is rising in the past few decades. In young women, the manifestation of the ...

    Authors: Erica M Akagi, André M Lavorato-Rocha, Beatriz de Melo Maia, Iara S Rodrigues, Kátia C Carvalho, Monica M Stiepcich, Glauco Baiocchi, Yukie Sato-Kuwabara, Silvia R Rogatto, Fernando A Soares and Rafael M Rocha
    Citation: BMC Cancer 2014 14:822
    Content type: Research article Published on:

  3. Comorbidity has an adverse impact on cancer survival partly through its negative impact on receipt of curative treatment. Comorbidity is unevenly distributed within populations, with some ethnic and socioecono...

    Authors: Diana Sarfati, Jason Gurney, James Stanley and Jonathan Koea
    Citation: BMC Cancer 2014 14:821
    Content type: Research article Published on:

  4. MicroRNA-21 (miR-21) has been suggested to play a significant role in the prognosis of carcinoma. The recognition of novel biomarkers for the prediction of cancer outcomes is urgently required. However, the po...

    Authors: Wenjia Wang, Jinhui Li, Wei Zhu, Chen Gao, RuiJingfang Jiang, Wenxue Li, Qiansheng Hu and Bo Zhang
    Citation: BMC Cancer 2014 14:819
    Content type: Research article Published on:

  5. The management of liver metastases from nasopharyngeal carcinoma (NPC) has not been extensively investigated. This study aimed to compare the long-term outcome of patients with liver metastases from NPC who we...

    Authors: Jun Huang, Qijiong Li, Yun Zheng, Jingxian Shen, Binkui Li, Ruhai Zou, Jianping Wang and Yunfei Yuan
    Citation: BMC Cancer 2014 14:818
    Content type: Research article Published on:

  6. Evidence has accumulated which suggests that sex steroids influence colorectal cancer development and progression. We therefore assessed the association of repeat polymorphisms in the estrogen receptor β gene (ES...

    Authors: Anja Rudolph, Hong Shi, Asta Försti, Michael Hoffmeister, Juan Sainz, Lina Jansen, Kari Hemminki, Hermann Brenner and Jenny Chang-Claude
    Citation: BMC Cancer 2014 14:817
    Content type: Research article Published on:

  7. The management of rectal cancer (RC) has substantially changed over the last decades with the implementation of neoadjuvant chemoradiotherapy, adjuvant therapy and improved surgery such as total mesorectal exc...

    Authors: Armin Wiegering, Christoph Isbert, Ulrich A Dietz, Volker Kunzmann, Sabine Ackermann, Alexander Kerscher, Uwe Maeder, Michael Flentje, Nicolas Schlegel, Joachim Reibetanz, Christoph-Thomas Germer and Ingo Klein
    Citation: BMC Cancer 2014 14:816
    Content type: Research article Published on:

  8. Hepatocellular carcinoma (HCC) is a malignancy with poor survival outcome. New treatment options for the disease are needed. In this study, we identified and evaluated tumor vascular PLVAP as a therapeutic tar...

    Authors: Yun-Hsin Wang, Tsung-Yen Cheng, Ta-Yuan Chen, Kai-Ming Chang, Vincent P Chuang and Kuo-Jang Kao
    Citation: BMC Cancer 2014 14:815
    Content type: Research article Published on:

  9. Pancreatic adenocarcinoma is one of the most lethal cancers, yet it remains understudied and poorly understood. Hyperinsulinemia has been reported to be a risk factor of pancreatic cancer, and the rapid rise o...

    Authors: Michelle T Chan, Gareth E Lim, Søs Skovsø, Yu Hsuan Carol Yang, Tobias Albrecht, Emilyn U Alejandro, Corinne A Hoesli, James M Piret, Garth L Warnock and James D Johnson
    Citation: BMC Cancer 2014 14:814
    Content type: Research article Published on:

  10. Preclinical studies have documented antitumor activity of PARP inhibition both in vitro and in vivo, against Ewing sarcoma cells. This study aimed to translate that observation into a clinical trial to assess the...

    Authors: Edwin Choy, James E Butrynski, David C Harmon, Jeffrey A Morgan, Suzanne George, Andrew J Wagner, David D’Adamo, Gregory M Cote, Yael Flamand, Cyril H Benes, Daniel A Haber, Jose M Baselga and George D Demetri
    Citation: BMC Cancer 2014 14:813
    Content type: Research article Published on:

  11. Prostate cancer (PC) incidence and progression may be influenced by dietary factors, but little is known about the acceptability of dietary modification to men at increased risk of PC. Qualitative interviews w...

    Authors: Jeremy P Horwood, Kerry NL Avery, Chris Metcalfe, Jenny L Donovan, Freddie C Hamdy, David E Neal and J Athene Lane
    Citation: BMC Cancer 2014 14:812
    Content type: Research article Published on:

  12. Although altered levels of adiponectin have been reported as a potential risk factor in colorectal cancer (CRC), the importance of the role played by adiponectin in colorectal carcinogenesis has not been estab...

    Authors: Chung Hyun Tae, Seong-Eun Kim, Sung-Ae Jung, Yang-Hee Joo, Ki-Nam Shim, Hye-Kyung Jung, Tae Hun Kim, Min-Sun Cho, Kwang Ho Kim and Joung Sook Kim
    Citation: BMC Cancer 2014 14:811
    Content type: Research article Published on:

  13. Purpose of this study was to analyse the surgical management and long-term clinical outcome of patients diagnosed with colorectal liver metastases (CLM) over a period of 10 years using data from a German tumou...

    Authors: Christina Hackl, Peter Neumann, Michael Gerken, Martin Loss, Monika Klinkhammer-Schalke and Hans J Schlitt
    Citation: BMC Cancer 2014 14:810
    Content type: Research article Published on:

  14. The pathogenesis of multiple myeloma involves complex genetic and epigenetic events. This study aimed to investigate the role and clinical relevance of the long non-coding RNA (lncRNA), metastasis-associated l...

    Authors: Shih-Feng Cho, Yuli Christine Chang, Chao-Sung Chang, Sheng-Fung Lin, Yi-Chang Liu, Hui-Hua Hsiao, Jan-Gowth Chang and Ta-Chih Liu
    Citation: BMC Cancer 2014 14:809
    Content type: Research article Published on:

  15. Radiotherapy is a chosen treatment option for prostate cancer patients and while some tumours respond well, up to 50% of patients may experience tumour recurrence. Identification of functionally relevant predi...

    Authors: Arabella Young, Rachael Berry, Adele F Holloway, Nicholas B Blackburn, Joanne L Dickinson, Marketa Skala, Jessica L Phillips and Kate H Brettingham-Moore
    Citation: BMC Cancer 2014 14:808
    Content type: Research article Published on:

  16. Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) provide an effective treatment option for selected patients with colorectal peritoneal metastasis with encouraging survival res...

    Authors: Gabriel Glockzin, Michael Gerken, Sven A Lang, Monika Klinkhammer-Schalke, Pompiliu Piso and Hans J Schlitt
    Citation: BMC Cancer 2014 14:807
    Content type: Research article Published on:

  17. In this study, we examined patients who had non-progressive disease for at least 2 years after diagnosis of inoperable locoregional recurrent or metastatic breast cancer under continuous trastuzumab treatment....

    Authors: Isabell Witzel, Volkmar Müller, Wolfgang Abenhardt, Manfred Kaufmann, Winfried Schoenegg, Andreas Schneeweis and Fritz Jänicke
    Citation: BMC Cancer 2014 14:806
    Content type: Research article Published on:

  18. Cancer is the leading cause of disease-related death in adolescents and young adults (AYA). Annual improvements in AYA cancer survival have been inferior to those observed in children and older adults. Prior s...

    Authors: Nancy N Baxter, Corinne Daly, Sumit Gupta, Jason D Pole, Rinku Sutradhar, Mark L Greenberg and Paul C Nathan
    Citation: BMC Cancer 2014 14:805
    Content type: Study protocol Published on:

  19. Anterior gradient 2 (AGR2) has been implicated in tumor-associated phenotypes such as cell viability, invasion and metastasis in various human cancers. However, the tumor promoting activity of AGR2 has not yet...

    Authors: Su Jin Kim, Suyeon Jun, Hee-Yeon Cho, Dong Chul Lee, Young Il Yeom, Jong Hyeok Kim and Dongchul Kang
    Citation: BMC Cancer 2014 14:804
    Content type: Research article Published on:

  20. Persistent infection with one or more high-risk human papillomavirus [HR-HPV] types increases the risk of intraepithelial neoplasia and cervical cancer. A nested case–control study was conducted to investigate...

    Authors: Janet E Flatley, Alexandra Sargent, Henry C Kitchener, Jean M Russell and Hilary J Powers
    Citation: BMC Cancer 2014 14:803
    Content type: Research article Published on:

  21. Mutations in KRAS, BRAF and PIK3CA are the most common somatic alterations found in the colorectal cancer (CRC) patients from Western countries; but their prevalence and prognostic value have not been adequately ...

    Authors: Jing Chen, Fang Guo, Xin Shi, Lihua Zhang, Aifeng Zhang, Hui Jin and Youji He
    Citation: BMC Cancer 2014 14:802
    Content type: Research article Published on:

  22. Resistance to apoptosis induced by anti-cancer drugs is a major obstacle for the treatment of aggressive forms of breast cancer. Galectin-7 (gal-7) was recently shown to be specifically expressed in basal-like...

    Authors: Andrée-Anne Grosset, Marilyne Labrie, Donald Gagné, Maria-Claudia Vladoiu, Louis Gaboury, Nicolas Doucet and Yves St-Pierre
    Citation: BMC Cancer 2014 14:801
    Content type: Research article Published on:

  23. Superparamagnetic poly (lactic-co-glycolic acid) (PLGA)-coated Fe3O4 microcapsules are receiving increased attention as potential diagnostic and therapeutic modalities in the field of oncology. In this study, PLG...

    Authors: Yang Sun, Yuanyi Zheng, Pan Li, Dong Wang, Chengcheng Niu, Yuping Gong, Rongzhong Huang, Zhibiao Wang, Zhigang Wang and Haitao Ran
    Citation: BMC Cancer 2014 14:800
    Content type: Research article Published on:

  24. Epithelial ovarian cancer (EOC) is the most common cause of gynecological malignancy-related mortality. Ovarian clear cell carcinoma (CCC) has unique clinical characteristics and behaviors that differ from oth...

    Authors: Yukihiro Hirata, Noriyuki Murai, Nozomu Yanaihara, Misato Saito, Motoaki Saito, Mitsuyoshi Urashima, Yasuko Murakami, Senya Matsufuji and Aikou Okamoto
    Citation: BMC Cancer 2014 14:799
    Content type: Research article Published on:

  25. Automated breast volume scanner (ABVS) and US elastography (UE) have been useful for the differentiation of benign and malignant lesions. However, combining these two methods applied in diagnosis of breast les...

    Authors: Chaoli Xu, Shuping Wei, Yingdong Xie, Xiaoxiang Guan, Ninghua Fu, Pengfei Huang and Bin Yang
    Citation: BMC Cancer 2014 14:798
    Content type: Research article Published on:

  26. Recurrent T1-2 Nasopharyngeal Carcinoma (rT1-2) may be salvaged by 3D – CRT (3D-Conformal Radiotherapy), IMRT (Intensity Modulated Radiotherapy), Brachytherapy (BT), BT with external radiotherapy. The purpose ...

    Authors: Sufang Qiu, Jun Lu, Wei Zheng, Luying Xu, Shaojun Lin, Chaobin Huang, Yuanji Xu, Lingling Huang and Jianji Pan
    Citation: BMC Cancer 2014 14:797
    Content type: Research article Published on:

  27. As cancer-testis MAGE-A antigens are targets for tumor immunotherapy, it is important to study the regulation of their expression in cancers. This regulation appears to be rather complex and at the moment cont...

    Authors: Heidi Schwarzenbach, Corinna Eichelser, Bettina Steinbach, Josefine Tadewaldt, Klaus Pantel, Victor Lobanenkov and Dmitri Loukinov
    Citation: BMC Cancer 2014 14:796
    Content type: Research article Published on:

  28. The aim of this study was to examine the efficacy and safety of everolimus in patients with progressive unresectable adenoid cystic carcinoma (ACC).

    Authors: Dong-Wan Kim, Do-Youn Oh, Seong Hoon Shin, Jin Hyoung Kang, Byoung Chul Cho, Joo-Seop Chung, HyeJin Kim, Keon Uk Park, Jung Hye Kwon, Ji-Youn Han, Mi-Jung Kim and Yung-Jue Bang
    Citation: BMC Cancer 2014 14:795
    Content type: Research article Published on:

  29. Resistance towards endocrine therapy is a great concern in breast cancer treatment and may partly be explained by the activation of compensatory signaling pathways. The aim of the present study was to investig...

    Authors: Kristina E Aaltonen, Ann H Rosendahl, Hans Olsson, Per Malmström, Linda Hartman and Mårten Fernö
    Citation: BMC Cancer 2014 14:794
    Content type: Research article Published on:

  30. Small cell lung cancer (SCLC) accounts for about 13% of all lung cancer cases. Small cell lung cancer (SCLC) accounts for about 13% of all lung cancer cases. The purpose of the present article is to assess the...

    Authors: Wenwen Zhang, Wenjing Jiang, Linlin Luan, Lili Wang, Xiangrong Zheng and Gongchao Wang
    Citation: BMC Cancer 2014 14:793
    Content type: Research article Published on:

  31. Cancer patients undergo routine computed-tomography (CT) scans and, therefore, iodinated contrast media (ICM) administration. It is not known whether a time-dependent correlation exists between chemotherapy ad...

    Authors: Alberto Farolfi, Elisa Carretta, Corradina Della Luna, Angela Ragazzini, Nicola Gentili, Carla Casadei, Domenico Barone, Martina Minguzzi, Dino Amadori, Oriana Nanni and Giampaolo Gavelli
    Citation: BMC Cancer 2014 14:792
    Content type: Research article Published on:

  33. All the children registered at the National Council for the Prevention and Treatment of Childhood Cancer were analyzed. The rationale for this Federal Government Council is to financially support the treatment...

    Authors: Roberto Rivera-Luna, Jaime Shalkow-Klincovstein, Liliana Velasco-Hidalgo, Rocio Cárdenas-Cardós, Marta Zapata-Tarrés, Alberto Olaya-Vargas, Marco R Aguilar-Ortiz, Eduardo Altamirano-Alvarez, Cecilia Correa-Gonzalez, Fernando Sánchez-Zubieta and Francisco Pantoja-Guillen
    Citation: BMC Cancer 2014 14:790
    Content type: Research article Published on:

  34. The small bowel is one of the critical organs involved in gastrointestinal complications in cervical cancer treated with postoperative intensity modulated radiotherapy. Even with modest doses of radiation ther...

    Authors: Zhongjie Chen, Li Zhu, Bailin Zhang, Maobin Meng, Zhiyong Yuan and Ping Wang
    Citation: BMC Cancer 2014 14:789
    Content type: Research article Published on:

  35. Breast cancer (BC) is the most common malignancy and the leading cause of cancer-related death amongst women worldwide. The risk factors of this disease are numerous, and their prevalence varies between racial...

    Authors: Naser Elkum, Taher Al-Tweigeri, Dahish Ajarim, Ali Al-Zahrani, Suad M Bin Amer and Abdelilah Aboussekhra
    Citation: BMC Cancer 2014 14:788
    Content type: Research article Published on:

  36. Combined radiotherapy and chemotherapy is considered the standard of care for locally advanced nasopharyngeal carcinoma (LA-NPC) in Epstein-Barr virus infection endemic area. This study compared the long-term ...

    Authors: Shang-Yin Wu, Yuan-Hua Wu, Ming-Wei Yang, Wei-Ting Hsueh, Jenn-Ren Hsiao, Sen-Tien Tsai, Kwang-Yu Chang, Jeffrey S Chang and Chia-Jui Yen
    Citation: BMC Cancer 2014 14:787
    Content type: Research article Published on:

  37. Despite considerable recent progress in the treatment of lung adenocarcinoma, there has been little progress in the development of efficacious molecular targeted therapies for squamous cell lung cancer. In add...

    Authors: Hirotsugu Kenmotsu, Masakuni Serizawa, Yasuhiro Koh, Mitsuhiro Isaka, Toshiaki Takahashi, Tetsuhiko Taira, Akira Ono, Tomohiro Maniwa, Shoji Takahashi, Keita Mori, Masahiro Endo, Masato Abe, Isamu Hayashi, Takashi Nakajima, Yasuhisa Ohde and Nobuyuki Yamamoto
    Citation: BMC Cancer 2014 14:786
    Content type: Research article Published on:

  38. The Bmi1 polycomb ring finger oncogene, a transcriptional repressor belonging to the Polycomb group of proteins plays an important role in the regulation of stem cell self-renewal and is elevated in several ca...

    Authors: Anurag N Paranjape, Sai A Balaji, Tamoghna Mandal, Esthelin Vittal Krushik, Pradeep Nagaraj, Geetashree Mukherjee and Annapoorni Rangarajan
    Citation: BMC Cancer 2014 14:785
    Content type: Research article Published on:

  39. Papillary squamous cell carcinoma (PSCC) of the uterine cervix is difficult to diagnose due to its rarity and limited data regarding its clinical behavior. We attempted to assess the degree of stromal invasion...

    Authors: Michikazu Nagura, Masafumi Koshiyama, Noriomi Matsumura, Aki Kido, Tsukasa Baba, Kaoru Abiko, Junzo Hamanishi, Ken Yamaguchi, Yoshiki Mikami and Ikuo Konishi
    Citation: BMC Cancer 2014 14:784
    Content type: Research article Published on:

  40. Interleukin 6 (IL-6)-mediated signal transducers and activators of transcription 3 (STAT-3) phosphorylation (activation) is aberrantly sustained in cholangiocarcinoma cells resulting in enhanced myeloid cell l...

    Authors: Zhaoyang Lu, Jiabei Wang, Tongsen Zheng, Yingjian Liang, Dalong Yin, Ruipeng Song, Tiemin Pei, Shangha Pan, Hongchi Jiang and Lianxin Liu
    Citation: BMC Cancer 2014 14:783
    Content type: Research article Published on:

  41. The sensitivity of a mammography program is normally evaluated by comparing the interval cancer rate to the expected breast cancer incidence without screening, i.e. the proportional interval cancer rate (PICR)...

    Authors: Sune Bangsbøll Andersen, Sven Törnberg, Elsebeth Lynge, My Von Euler-Chelpin and Sisse Helle Njor
    Citation: BMC Cancer 2014 14:782
    Content type: Research article Published on:

  42. CXCL1 is a chemotactic cytokine shown to regulate breast cancer progression and chemo-resistance. However, the prognostic significance of CXCL1 expression in breast cancer has not been fully characterized. Fib...

    Authors: An Zou, Diana Lambert, Henry Yeh, Ken Yasukawa, Fariba Behbod, Fang Fan and Nikki Cheng
    Citation: BMC Cancer 2014 14:781
    Content type: Research article Published on:

  43. Patients with primary cutaneous melanomas that are ulcerated and >2 mm in thickness, >4 mm in thickness and those with nodal micrometastases at diagnosis, have few options for adjuvant treatment. Recent studie...

    Authors: Robyn PM Saw, Bruce K Armstrong, Rebecca S Mason, Rachael L Morton, Kerwin F Shannon, Andrew J Spillane, Jonathan R Stretch and John F Thompson
    Citation: BMC Cancer 2014 14:780
    Content type: Study protocol Published on:

  44. Patients with transitional cell carcinoma of the urothelial tract (TCCU) who fail initial platinum-based chemotherapy for advanced disease represent a challenge in daily clinical practice. Vinflunine is approv...

    Authors: Daniel Castellano, Javier Puente, Guillermo de Velasco, Isabel Chirivella, Pilar López-Criado, Nicolás Mohedano, Ovidio Fernández, Icíar García-Carbonero, María Belén González and Enrique Grande
    Citation: BMC Cancer 2014 14:779
    Content type: Research article Published on:

  45. Cigarette smoke is associated with the majority of lung cancers: however, 25% of lung cancer patients are non-smokers, and half of all newly diagnosed lung cancer patients are former smokers. Lung tumors exhib...

    Authors: Emily A Vucic, Kelsie L Thu, Larissa A Pikor, Katey SS Enfield, John Yee, John C English, Calum E MacAulay, Stephen Lam, Igor Jurisica and Wan L Lam
    Citation: BMC Cancer 2014 14:778
    Content type: Research article Published on:

  46. Hürthle cell thyroid carcinoma (HCTC) is a rare disease. It is believed that it is more aggressive than follicular thyroid carcinoma. The aim of our study was to identify factors associated with disease-specif...

    Authors: Rok Petric, Barbara Gazic and Nikola Besic
    Citation: BMC Cancer 2014 14:777
    Content type: Research article Published on:

  47. It is unclear whether liver transplantation is associated with an increased incidence of post-transplant head and neck cancer. This comprehensive meta-analysis evaluated the association between liver transplan...

    Authors: Qian Liu, Lifeng Yan, Cheng Xu, Aihua Gu, Peng Zhao and Zhao-Yan Jiang
    Citation: BMC Cancer 2014 14:776
    Content type: Research article Published on:

  48. Embelin, a quinone derivative, is found in the fruits of Embelia ribes Burm (Myrsinaceae). It has been shown to have a variety of therapeutic potentials including anthelmintic, anti-tumor, anti-diabetic, anti-bac...

    Authors: Jaspreet Kaur Dhanjal, Nupur Nigam, Sudhanshu Sharma, Anupama Chaudhary, Sunil C Kaul, Abhinav Grover and Renu Wadhwa
    Citation: BMC Cancer 2014 14:775
    Content type: Research article Published on:

  49. Endoscopic treatments for early esophageal squamous cell carcinoma and the esophageal neoplasm are two types: endoscopic resection (ER) and ablation. Resection enables evaluation of the lesion in the ER specim...

    Authors: Xiumin Qin, Shun He, Yueming Zhang, Liyan Xue, Ning Lu and Guiqi Wang
    Citation: BMC Cancer 2014 14:774
    Content type: Research article Published on:

  50. Circulating tumor cells (CTCs) are metastatic cells disseminated into the bloodstreams. They have been proposed to monitor disease progression for decades. However, the prognostic value of CTCs in gastric canc...

    Authors: Zhen-yu Zhang, Zhen-ling Dai, Xiao-wei Yin, Shu-heng Li, Shu-ping Li and Hai-yan Ge
    Citation: BMC Cancer 2014 14:773
    Content type: Research article Published on:

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