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  1. The role of urine markers in the surveillance of patients with non-muscle invasive bladder cancer (NMIBC) is discussed extensively. In case of negative cystoscopy the additional prognostic value of these marke...

    Authors: Tilman Todenhöfer, Jörg Hennenlotter, Philipp Guttenberg, Sarah Mohrhardt, Ursula Kuehs, Michael Esser, Stefan Aufderklamm, Simone Bier, Niklas Harland, Steffen Rausch, Georgios Gakis, Arnulf Stenzl and Christian Schwentner
    Citation: BMC Cancer 2015 15:155
    Content type: Research article Published on:

  3. One of the major controversies of contemporary medicine is created by an increased consumption of nicotine and growing evidence of its connection to cancer, which urges elucidation of the molecular mechanisms ...

    Authors: Alex I Chernyavsky, Igor B Shchepotin, Valentin Galitovkiy and Sergei A Grando
    Citation: BMC Cancer 2015 15:152
    Content type: Research article Published on:

  4. Cancers of unknown primary (CUPs) constitute ~5% of all cancers. The tumors have an aggressive biological and clinical behavior. The aim of the present study has been to uncover whether CUPs exhibit distinct m...

    Authors: Jonas Vikeså, Anne Kirstine H Møller, Bogumil Kaczkowski, Rehannah Borup, Ole Winther, Ricardo Henao, Anders Krogh, Katharina Perell, Flemming Jensen, Gedske Daugaard and Finn C Nielsen
    Citation: BMC Cancer 2015 15:151
    Content type: Research article Published on:

  5. Tobacco smoking and red meat consumption are some of the known risk factors associated with the development of oesophageal cancer. N-acetytransferases (NAT1 and NAT2) play a key role in metabolism of carcinogenic...

    Authors: Marco Matejcic, Matjaz Vogelsang, Yabing Wang and Iqbal M Parker
    Citation: BMC Cancer 2015 15:150
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Cancer 2015 15:658

  6. To compare the prognosis of upper urinary tract (UUT)-urothelial carcinoma (UC) and UC of the bladder (UCB) by pathological staging in patients treated with radical surgeries.

    Authors: Myong Kim, Chang Wook Jeong, Cheol Kwak, Hyeon Hoe Kim and Ja Hyeon Ku
    Citation: BMC Cancer 2015 15:149
    Content type: Research article Published on:

  7. Mutations in the TP53 (Tumour Protein 53) gene can lead to expression of mutant p53 proteins that accumulate in cancer cells and can induce circulating p53 antibodies in cancer patients. Our aim was to evaluate t...

    Authors: Manlio Mattioni, Silvia Soddu, Andrea Prodosmo, Paolo Visca, Salvatore Conti, Gabriele Alessandrini, Francesco Facciolo and Lidia Strigari
    Citation: BMC Cancer 2015 15:148
    Content type: Research article Published on:

  8. Studies evaluating the presence of viral sequences in breast cancer (BC), including various strains of human papillomavirus and human herpes virus, have yielded conflicting results. Most were based on RT-PCR and

    Authors: Danai Fimereli, David Gacquer, Debora Fumagalli, Roberto Salgado, Françoise Rothé, Denis Larsimont, Christos Sotiriou and Vincent Detours
    Citation: BMC Cancer 2015 15:147
    Content type: Research article Published on:

  9. With advances in hepatocellular carcinoma (HCC) screening and treatment, the incidence of diagnosing a case of extrahepatic primary malignancy (EHPM) in patients with HCC has increased. This study aimed to elu...

    Authors: Sukho Hong, Sook-Hyang Jeong, Sang Soo Lee, Jung Wha Chung, Sung Wook Yang, Seong Min Chung, Eun Sun Jang, Jin-Wook Kim, Jee Hyun Kim, Haeryoung Kim, Jai Young Cho, Yoo-Seok Yoon and Ho-Seong Han
    Citation: BMC Cancer 2015 15:146
    Content type: Research article Published on:

  10. CBX7 is a Polycomb group protein that shows variable expression changes in various cancers that are often contradictive. A mouse knockout experiment has validated the tumor suppressor role in carcinogenesis. T...

    Authors: Xiang Zheng, Jing Zhou, Baozhen Zhang, Jun Zhang, James Wilson, Liankun Gu, Budong Zhu, Jin Gu, Jiafu Ji and Dajun Deng
    Citation: BMC Cancer 2015 15:145
    Content type: Research article Published on:

  11. HIV infection is a known risk factor for cancer but little is known about HIV testing patterns and the burden of HIV infection in cancer patients. We did a cross-sectional analysis to identify predictors of pr...

    Authors: Mazvita Sengayi, Chantal Babb, Matthias Egger and Margaret I Urban
    Citation: BMC Cancer 2015 15:144
    Content type: Research article Published on:

  12. Breast density and single-nucleotide polymorphisms (SNPs) have both been associated with breast cancer risk. To determine the extent to which these two breast cancer risk factors are associated, we investigate...

    Authors: Brad M Keller, Anne Marie McCarthy, Jinbo Chen, Katrina Armstrong, Emily F Conant, Susan M Domchek and Despina Kontos
    Citation: BMC Cancer 2015 15:143
    Content type: Research article Published on:

  13. Preoperative radiochemotherapy improves outcomes in patients with locally advanced rectal carcinoma, and has been used increasingly in patient management. However, there is a strong clinical need to assess tum...

    Authors: Lianhuang Li, Zhifen Chen, Xingfu Wang, Hongsheng Li, Weizhong Jiang, Shuangmu Zhuo, Guoxian Guan and Jianxin Chen
    Citation: BMC Cancer 2015 15:142
    Content type: Research article Published on:

  14. Lactate dehydrogenase A (LDHA) and Pyruvate Kinase M2 (PKM2) are important enzymes of glycolysis. Both of them can be phosphorylated and therefore regulated by Fibroblast growth factor receptor 1 (FGFR1). Whil...

    Authors: Paul Kachel, Bogusz Trojanowicz, Carsten Sekulla, Hanna Prenzel, Henning Dralle and Cuong Hoang-Vu
    Citation: BMC Cancer 2015 15:140
    Content type: Research article Published on:

  15. Annonaceous acetogenins are a family of natural products with antitumor activities. Annonaceous acetogenin mimic AA005 reportedly inhibits mammalian mitochondrial NADH-ubiquinone reductase (Complex I) and indu...

    Authors: Bing Han, Tong-Dan Wang, Shao-Ming Shen, Yun Yu, Chan Mao, Zhu-Jun Yao and Li-Shun Wang
    Citation: BMC Cancer 2015 15:139
    Content type: Research article Published on:

  16. Response to endocrine therapy in breast cancer correlates with estrogen receptor (ER) and progesterone receptor (PR) status. Generally, hormone receptor-positive (HR+) breast cancers have favorable prognosis. ...

    Authors: Soo Youn Bae, Sangmin Kim, Jun Ho Lee, Hyun-chul Lee, Se Kyung Lee, Won Ho Kil, Seok Won Kim, Jeong Eon Lee and Seok Jin Nam
    Citation: BMC Cancer 2015 15:138
    Content type: Research article Published on:

  17. The use of imaging to implement on-treatment adaptation of radiotherapy is a promising paradigm but current data on imaging changes during radiotherapy is limited. This is a hypothesis-generating pilot study t...

    Authors: Manil Subesinghe, Andrew F Scarsbrook, Steven Sourbron, Daniel J Wilson, Garry McDermott, Richard Speight, Neil Roberts, Brendan Carey, Roan Forrester, Sandeep Vijaya Gopal, Jonathan R Sykes and Robin JD Prestwich
    Citation: BMC Cancer 2015 15:137
    Content type: Research article Published on:

  18. Exactly assessing tumor response to different dose of chemotherapy would help to tailor therapy for individual patients. This study was to determine the feasibility of dynamic contrast-enhanced ultrasound (CEU...

    Authors: Yao Chen, Feng Han, Long-hui Cao, Cheng Li, Jian-wei Wang, Qing Li, Wei Zheng, Zhi-xing Guo, An-hua Li and Jian-hua Zhou
    Citation: BMC Cancer 2015 15:136
    Content type: Research article Published on:

  19. Insulin-like growth factor binding protein 7 (IGFBP7) has been suggested to act as a tumour suppressor gene in various human cancers, yet its role in epithelial ovarian cancer (EOC) has not yet been investigated....

    Authors: Karen Gambaro, Michael CJ Quinn, Katia Y Cáceres-Gorriti, Rebecca S Shapiro, Diane Provencher, Kurosh Rahimi, Anne-Marie Mes-Masson and Patricia N Tonin
    Citation: BMC Cancer 2015 15:135
    Content type: Research article Published on:

  20. Hepatocellular carcinoma (HCC) is a major cause of cancer deaths worldwide. However, current chemotherapeutic drugs for HCC are either poorly effective or expensive, and treatment with these drugs has not led ...

    Authors: Yu-Min Feng, Chin-Wen Feng, Syue-Yi Chen, Hsiao-Yen Hsieh, Yu-Hsin Chen and Cheng-Da Hsu
    Citation: BMC Cancer 2015 15:134
    Content type: Research article Published on:

  21. The burden of cancer is likely to increase among the human immunodeficiency virus (HIV)-positive population as it ages due to successful antiretroviral therapy (ART). The purpose of this study was to determine...

    Authors: Chang-Hua Chen, Chih-Yuan Chung, Li-Hsuan Wang, Che Lin, Hsiu-Li Lin and Hsiu-Chen Lin
    Citation: BMC Cancer 2015 15:133
    Content type: Research article Published on:

  22. ETS variant 1 (ETV1) and E3 ubiquitin ligase constitutive photomorphogenetic 1 (COP1) have been proposed to be a pair of oncogene and tumor suppressor. However, the co-existing status of ETV1 and COP1 in tripl...

    Authors: Mao Ouyang, Hua Wang, Jieyi Ma, Weiming Lü, Jie Li, Chen Yao, Guangqi Chang, Jiong Bi, Shenming Wang and Wenjian Wang
    Citation: BMC Cancer 2015 15:132
    Content type: Research article Published on:

  23. Eukaryotic Initiation factor 6 (eIF6) is a peculiar translation initiation factor that binds to the large 60S ribosomal subunits, controlling translation initiation and participating in ribosome biogenesis. In...

    Authors: Michela Pinzaglia, Claudia Montaldo, Dorina Polinari, Mattei Simone, Anna La Teana, Marco Tripodi, Carmine Mancone, Paola Londei and Dario Benelli
    Citation: BMC Cancer 2015 15:131
    Content type: Research article Published on:

  24. Cancer-associated fibroblasts (CAFs) play an important role in breast cancer pathogenesis by paracrine regulation of breast cancer cell biology. Several in vitro and mouse models have characterized the role of ce...

    Authors: Abdel Nasser Hosein, Julie Livingstone, Marguerite Buchanan, James F Reid, Michael Hallett and Mark Basik
    Citation: BMC Cancer 2015 15:130
    Content type: Research article Published on:

  25. Of many specialized blood cells, monocytes are gaining increasing attention for their role in neoplastic disorders. The purpose of the present investigation was to determine the expression of selected peripher...

    Authors: Maciej Jóźwik, Osazee E Okungbowa, Alina Lipska, Marcin Jóźwik, Marzena Smoktunowicz, Andrzej Semczuk, Michał Jóźwik and Piotr Radziwon
    Citation: BMC Cancer 2015 15:129
    Content type: Research article Published on:

  26. Osteopontin (OPN) can recruit macrophages to the site of inflammation and promote tumorigenesis. M2 tumor-associated macrophages (M2-TAMs) also play an important role in cancer progression. This study aimed to...

    Authors: Chang-Ni Lin, Chih-Jung Wang, Ying-Jui Chao, Ming-Derg Lai and Yan-Shen Shan
    Citation: BMC Cancer 2015 15:128
    Content type: Research article Published on:

  27. Angiogenesis, among other signaling pathways, plays a key-role in sarcoma biology. Regorafenib (RE) has recently been shown to be effective in imatinib and sunitinib-refractory GIST in a phase III trial.

    Authors: Thomas Brodowicz, Bernadette Liegl-Atzwager, Emmanuelle Tresch, Sophie Taieb, Andrew Kramar, Viktor Gruenwald, Marie Vanseymortier, Stéphanie Clisant, Jean-Yves Blay, Axel Le Cesne and Nicolas Penel
    Citation: BMC Cancer 2015 15:127
    Content type: Study protocol Published on:

  28. Intrahepatic cholangiocarcinomas (ICC) are relatively rare malignant tumors associated with a poor prognosis. Recent studies using genome-wide sequencing technologies have mainly focused on identifying new dri...

    Authors: Cyril Dalmasso, Wassila Carpentier, Catherine Guettier, Sophie Camilleri-Broët, Wyllians Vendramini Borelli, Cedália Rosane Campos dos Santos, Denis Castaing, Jean-Charles Duclos-Vallée and Philippe Broët
    Citation: BMC Cancer 2015 15:126
    Content type: Research Article Published on:

  29. Molecular alterations are well studied in colon cancer, however there is still need for an improved understanding of their prognostic impact. This study aims to characterize colon cancer with regard to KRAS, B...

    Authors: Helgi Birgisson, Karolina Edlund, Ulrik Wallin, Lars Påhlman, Hanna Göransson Kultima, Markus Mayrhofer, Patrick Micke, Anders Isaksson, Johan Botling, Bengt Glimelius and Magnus Sundström
    Citation: BMC Cancer 2015 15:125
    Content type: Research article Published on:

  30. Alcohol consumption is associated with higher breast cancer risk. While studies suggest a modest association between alcohol intake and mammographic density, few studies have examined the association in racial...

    Authors: Zoe Quandt, Julie D Flom, Parisa Tehranifar, Diane Reynolds, Mary Beth Terry and Jasmine A McDonald
    Citation: BMC Cancer 2015 15:124
    Content type: Research article Published on:

  31. Inflammatory cytokines in the colonic microenvironment have been shown to increase with advance colorectal cancer disease state. However, the contribution of inflammatory cytokines to pre-malignant disease, su...

    Authors: Curtis J Henry, Rebecca L Sedjo, Andrii Rozhok, Jennifer Salstrom, Dennis Ahnen, Theodore R Levin, Ralph D’Agostino Jr, Steven Haffner, James DeGregori and Tim Byers
    Citation: BMC Cancer 2015 15:123
    Content type: Research article Published on:

  32. We performed a multicenter, double-blind, placebo-controlled, phase II clinical trial of human dsDNA-based preparation Panagen in a tablet form. In total, 80 female patients with stage II-IV breast cancer were...

    Authors: Anastasia S Proskurina, Tatiana S Gvozdeva, Ekaterina A Alyamkina, Evgenia V Dolgova, Konstantin E Orishchenko, Valeriy P Nikolin, Nelly A Popova, Sergey V Sidorov, Elena R Chernykh, Alexandr A Ostanin, Olga Y Leplina, Victoria V Dvornichenko, Dmitriy M Ponomarenko, Galina S Soldatova, Nikolay A Varaksin, Tatiana G Ryabicheva…
    Citation: BMC Cancer 2015 15:122
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Cancer 2016 16:117

  33. Despite multimodal therapy esophageal cancer often presents with poor prognosis. To improve outcome, tumor angiogenesis and anti-angiogenic therapeutic agents have recently gained importance. However, patient ...

    Authors: Lena Dreikhausen, Susanne Blank, Leila Sisic, Ulrike Heger, Wilko Weichert, Dirk Jäger, Thomas Bruckner, Natalia Giese, Lars Grenacher, Christine Falk, Katja Ott and Thomas Schmidt
    Citation: BMC Cancer 2015 15:121
    Content type: Research article Published on:

  34. This study aimed to evaluate the behavior of non-muscle-invasive bladder cancer (NMIBC) in patients submitted to transurethral bladder resection (TURB) comparing subjects in chronic therapy with aspirin, stati...

    Authors: Antonio Luigi Pastore, Giovanni Palleschi, Andrea Fuschi, Luigi Silvestri, Yazan Al Salhi, Elisabetta Costantini, Alessandro Zucchi, Vincenzo Petrozza, Cosimo de Nunzio and Antonio Carbone
    Citation: BMC Cancer 2015 15:120
    Content type: Research article Published on:

  35. Everolimus (RAD001) is an orally administered mTOR inhibitor that is well known for its antitumor efficacy and that has been approved for the treatment of several solid tumors, including renal cell carcinoma. ...

    Authors: Ji Hyun Park, Min-Hee Ryu, Young Soo Park, Sook Ryun Park, Young-Soon Na, Baek-Yeol Rhoo and Yoon-Koo Kang
    Citation: BMC Cancer 2015 15:119
    Content type: Case report Published on:

  36. Malignant glioma is one of the most devastating tumors in adults with poor patient prognosis. Notably, glioma often exhibits resistance to conventional chemotherapeutic approaches, complicating patient treatme...

    Authors: Sangeetha Sukumari-Ramesh, Niyathi Prasad, Cargill H Alleyne Jr, John R Vender and Krishnan M Dhandapani
    Citation: BMC Cancer 2015 15:118
    Content type: Research article Published on:

  38. Tumor suppression of Transforming Growth Factor (TGF-β) signaling pathway requires an adaptor protein, Embryonic Liver Fodrin (ELF). Disruption of ELF expression resulted in miscolocalization of Smad3 and Smad...

    Authors: Fei Ji, Shun-Jun Fu, Shun-Li Shen, Long-Juan Zhang, Qing-Hua Cao, Shao-Qiang Li, Bao-Gang Peng, Li-Jian Liang and Yun-Peng Hua
    Citation: BMC Cancer 2015 15:116
    Content type: Research article Published on:

  39. Capecitabine has activity against several types of cancer. In 10-15% of patients treated with capecitabine, treatment is discontinued because of serious adverse reactions, mostly within the first weeks of trea...

    Authors: Melanie JM van Pelt-Sprangers, Eric CT Geijteman, Jelmer Alsma, Ingrid A Boere, Ron HJ Mathijssen and Stephanie CE Schuit
    Citation: BMC Cancer 2015 15:115
    Content type: Case report Published on:

  40. The relationship between the clinicopathological features and molecular changes associated with standardized uptake value (SUV) determined by Positron emission tomography (PET) with [18F] fluorodeoxyglucose (1...

    Authors: Tomoya Mizuno, Takao Kamai, Hideyuki Abe, Setsu Sakamoto, Kazuhiro Kitajima, Daisaku Nishihara, Hideo Yuki, Tsunehito Kambara, Hironori Betsunoh, Masahiro Yashi, Yoshitatsu Fukabori, Yasushi Kaji and Ken-Ichiro Yoshida
    Citation: BMC Cancer 2015 15:114
    Content type: Research article Published on:

  42. The growth of solid tumors and their regrowth after treatment is dependent upon functional tumor vasculature. Some chemotherapeutic agents have shown anti-angiogenic properties but there are limited studies of...

    Authors: Andrea S Fung, Carol Lee, Man Yu and Ian F Tannock
    Citation: BMC Cancer 2015 15:112
    Content type: Research article Published on:

  43. Chronic comorbidities and some of the commonly-used medications are thought to affect cancer patients’ outcomes, but their relative impact on esophageal carcinoma (EC) has not been well studied. The purpose of...

    Authors: Li-Ru He, Wei Qiao, Zhong-Xing Liao, Ritsuko Komaki, Linus Ho, Wayne L Hofstetter and Steven H Lin
    Citation: BMC Cancer 2015 15:111
    Content type: Research article Published on:

  44. Conditional deletion of the tumour suppressor gene Apc within the murine intestine results in acute Wnt signalling activation. The associated over-expression of a myriad of Wnt signalling target genes yields phen...

    Authors: Karen R Reed, Igor V Korobko, Natalia Ninkina, Elena V Korobko, Ben R Hopkins, James L Platt, Vladimir Buchman and Alan R Clarke
    Citation: BMC Cancer 2015 15:110
    Content type: Research article Published on:

  45. The Src homology phosphotyrosyl phosphatase 2 (SHP2) is a positive effector of cell growth and survival signaling as well transformation induced by multiple tyrosine kinase oncogenes. Since the basal-like and ...

    Authors: Hua Zhao and Yehenew M Agazie
    Citation: BMC Cancer 2015 15:109
    Content type: Research article Published on:

  47. Non-small cell lung cancer (NSCLC) is a highly metastatic cancer with limited therapeutic options, so development of novel therapies that target NSCLC is needed. During the early stage of metastasis, the cance...

    Authors: Weiling He, Shanyang He, Zuo Wang, Hongwei Shen, Wenfeng Fang, Yang Zhang, Wei Qian, Millicent Lin, Jinglun Yuan, Jinyang Wang, Wenhua Huang, Liantang Wang and Zunfu Ke
    Citation: BMC Cancer 2015 15:107
    Content type: Research article Published on:

  48. There is increasing evidence that vitamin D deficiency is a risk factor for cancer, however it remains uncertain whether vitamin D deficiency also predisposes to death from cancer. The aim of the study was to ...

    Authors: Germaine Wong, Wai Hon Lim, Joshua Lewis, Jonathan C Craig, Robin Turner, Kathy Zhu, Ee Mun Lim and Richard Prince
    Citation: BMC Cancer 2015 15:106
    Content type: Research article Published on:

  49. Ovarian cancer is a common gynaecological malignancy still remaining a challenge to treat. The objective of this study was to evaluate the impact of platinum dose reduction and chemotherapy delays on progressi...

    Authors: Sigita Liutkauskiene, Rasa Janciauskiene, Kristina Jureniene, Saulius Grizas, Rasa Malonyte and Elona Juozaityte
    Citation: BMC Cancer 2015 15:105
    Content type: Research article Published on:

  50. Lymphangiogenesis plays a significant role in metastasis and recurrence of gastric cancer. There is no report yet focusing on the modulation of VEGF pathway and lymphangiogenesis of gastric cancer by targeting...

    Authors: Hongxia Chen, Runnian Guan, Yupeng Lei, Jianyong Chen, Qi Ge, Xiaoshen Zhang, Ruoxu Dou, Hongyuan Chen, Hao Liu, Xiaolong Qi, Xiaodong Zhou and Changyan Chen
    Citation: BMC Cancer 2015 15:103
    Content type: Research article Published on:

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