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  1. In cervical cancer patients with intermediate-risk factors, the optimal adjuvant therapy is still controversial. We undertook a randomized trial (ClinicalTrials.gov Identifier: NCT01418859) to compare the effi...

    Authors: Wenze Sun, Tao Wang, Fan Shi, Jiquan Wang, Juan Wang, Beina Hui, Yingbing Zhang, Jinli Lu, Hongwei Chen and Zi Liu
    Citation: BMC Cancer 2015 15:353
    Content type: Research article Published on:

  2. Tumour relapse is recognized to be the prime fatal burden in patients affected by head and neck squamous cell carcinoma (HNSCC), but no discrete molecular trait has yet been identified to make reliable early p...

    Authors: Anna Farnedi, Silvia Rossi, Nicoletta Bertani, Mariolina Gulli, Enrico Maria Silini, Maria Teresa Mucignat, Tito Poli, Enrico Sesenna, Davide Lanfranco, Lucio Montebugnoli, Elisa Leonardi, Claudio Marchetti, Renato Cocchi, Andrea Ambrosini-Spaltro, Maria Pia Foschini and Roberto Perris
    Citation: BMC Cancer 2015 15:352
    Content type: Research article Published on:

  3. The complex cellular networks within tumors, the cytokine milieu, and tumor immune escape mechanisms affecting infiltration and anti-tumor activity of immune cells are of great interest to understand tumor for...

    Authors: Ariane Giannattasio, Sandra Weil, Stephan Kloess, Nariman Ansari, Ernst H K Stelzer, Adelheid Cerwenka, Alexander Steinle, Ulrike Koehl and Joachim Koch
    Citation: BMC Cancer 2015 15:351
    Content type: Technical advance Published on:

  4. Plenty of studies have demonstrated the prognostic value of various inflammation-based indexes in cancer. This study was designed to investigate the prognostic value of the C-reactive protein/albumin (CRP/Alb)...

    Authors: Xiao-li Wei, Feng-hua Wang, Dong-sheng Zhang, Miao-zhen Qiu, Chao Ren, Ying Jin, Yi-xin Zhou, De-shen Wang, Ming-ming He, Long Bai, Feng Wang, Hui-yan Luo, Yu-hong Li and Rui-hua Xu
    Citation: BMC Cancer 2015 15:350
    Content type: Research article Published on:

  5. Clusterin (CLU) is a ubiquitous multifunctional factor involved in neoplastic transformation. The CLU transcript variants and protein forms play a crucial role in balancing cells proliferation and death.

    Authors: Paolo Fuzio, Anna Napoli, Anna Ciampolillo, Serafina Lattarulo, Angela Pezzolla, Nicoletta Nuzziello, Sabino Liuni, Francesco Giorgino, Eugenio Maiorano and Elda Perlino
    Citation: BMC Cancer 2015 15:349
    Content type: Research article Published on:

  6. The aim of this study was to evaluate the clinical efficacy of postoperative radiotherapy (PORT), administered using three-dimensional conformal radiotherapy (3D-CRT) and our institutional standard clinical ta...

    Authors: Wen Feng, Qin Zhang, Xiao-Long Fu, Xu-Wei Cai, Zheng-Fei Zhu, Huan-Jun Yang, Jia-Qing Xiang, Ya-Wei Zhang and Hai-Quan Chen
    Citation: BMC Cancer 2015 15:348
    Content type: Research article Published on:

  7. The pretreatment albumin to globulin ratio (AGR) has been reported to correlate with the long-term survival in patients with various cancers. However, there are no reports regarding the correlation between the...

    Authors: Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Hiroshi Ohtani, Yasuhito Iseki, Tetsuro Ikeya, Kenji Sugano and Kosei Hirakawa
    Citation: BMC Cancer 2015 15:347
    Content type: Research article Published on:

  8. Previous study showed that mitochondrial ND6 (mitND6) gene missense mutation resulted in NADH dehydrogenase deficiency and was associated with tumor metastasis in several mouse tumor cell lines. In the present...

    Authors: Yang Yuan, Weixing Wang, Huizhong Li, Yongwei Yu, Jin Tao, Shengdong Huang and Zhiyong Zeng
    Citation: BMC Cancer 2015 15:346
    Content type: Research article Published on:

  9. MicroRNAs (miRNAs) are short non-coding RNA molecules that play a critical role in mRNA cleavage and translational repression, and are known to be altered in many diseases including breast cancer. MicroRNA-10a...

    Authors: Sonja Khan, Deirdre Wall, Catherine Curran, John Newell, Michael J Kerin and Roisin M Dwyer
    Citation: BMC Cancer 2015 15:345
    Content type: Research article Published on:

  10. Acute myeloid leukaemia (AML) with central nervous system (CNS) involvement in adults is uncommon, and studies of this subject are scant.

    Authors: Chieh-Lung Cheng, Chi-Cheng Li, Hsin-An Hou, Wei-Quan Fang, Chin-Hao Chang, Chien-Ting Lin, Jih-Luh Tang, Wen-Chien Chou, Chien-Yuan Chen, Ming Yao, Shang-Yi Huang, Bor-Sheng Ko, Shang-Ju Wu, Woei Tsay and Hwei-Fang Tien
    Citation: BMC Cancer 2015 15:344
    Content type: Research article Published on:

  11. We have preliminarily reported MTA2 expression in gastric cancer and its biological functions by using knockdown cell models, while the molecular mechanisms of MTA2 in regulating malignant behaviors are still ...

    Authors: Chenfei Zhou, Jun Ji, Qu Cai, Min Shi, Xuehua Chen, Yingyan Yu, Zhenggang Zhu and Jun Zhang
    Citation: BMC Cancer 2015 15:343
    Content type: Research article Published on:

  12. Wilms’ tumor gene 1 (WT1) can act as a suppressor or activator of tumourigenesis in different types of human malignancies. The role of WT1 in squamous cell carcinoma of the head and neck (SCCHN) is not clear. Ove...

    Authors: Xingru Li, Sofia Ottosson, Sihan Wang, Emma Jernberg, Linda Boldrup, Xiaolian Gu, Karin Nylander and Aihong Li
    Citation: BMC Cancer 2015 15:342
    Content type: Research article Published on:

  13. B-cell leukemia 3 (Bcl-3) is a member of the inhibitor of κB family, which regulates a wide range of biological processes by functioning as a transcriptional activator or as a repressor of target genes. Elevat...

    Authors: Karunakar Saamarthy, Sofie Björner, Martin Johansson, Göran Landberg, Ramin Massoumi, Karin Jirström and Katarzyna Chmielarska Masoumi
    Citation: BMC Cancer 2015 15:341
    Content type: Research article Published on:

  14. KRAS mutation occurs in 35%-40% of colorectal cancer (CRC). The aim of our study was to evaluate the pathological and molecular features of specific KRAS mutated colorectal carcinomas. KRAS and BRAF ...

    Authors: Wenbin Li, Tian Qiu, Wenxue Zhi, Susheng Shi, Shuangmei Zou, Yun Ling, Ling Shan, Jianming Ying and Ning Lu
    Citation: BMC Cancer 2015 15:340
    Content type: Research article Published on:

  15. Axitinib is an orally active and potent tyrosine kinase inhibitor of vascular endothelial growth factor receptors 1, 2 and 3. This phase II study assessed the efficacy and safety of axitinib combined with cisp...

    Authors: Igor M Bondarenko, Antonella Ingrosso, Paul Bycott, Sinil Kim and Cristina L Cebotaru
    Citation: BMC Cancer 2015 15:339
    Content type: Research article Published on:

  16. We analyzed the relationship between prostate cancer outcomes and pretreatment clinical factors and developed a prognostic nomogram of overall survival (OS) of patients with bone metastasis.

    Authors: Yasuhide Miyoshi, Kazumi Noguchi, Masahiro Yanagisawa, Masataka Taguri, Satoshi Morita, Ichiro Ikeda, Kiyoshi Fujinami, Takeshi Miura, Kazuki Kobayashi and Hiroji Uemura
    Citation: BMC Cancer 2015 15:338
    Content type: Research article Published on:

  17. DNA methylation variability regions (MVRs) across the oestrogen receptor alpha (ESR1) gene have been identified in peripheral blood cells from breast cancer patients and healthy individuals. In contrast to promot...

    Authors: Natalie S Shenker, Kirsty J Flower, Charlotte S Wilhelm-Benartzi, Wei Dai, Emma Bell, Edmund Gore, Mona El Bahrawy, Gillian Weaver, Robert Brown and James M Flanagan
    Citation: BMC Cancer 2015 15:337
    Content type: Research article Published on:

  19. Cancer cells exhibit increased glycolysis for ATP production (the Warburg effect) and macromolecular biosynthesis; it is also linked with therapeutic resistance that is generally associated with compromised re...

    Authors: Anant Narayan Bhatt, Ankit Chauhan, Suchit Khanna, Yogesh Rai, Saurabh Singh, Ravi Soni, Namita Kalra and Bilikere S Dwarakanath
    Citation: BMC Cancer 2015 15:335
    Content type: Research article Published on:

  20. Optimising population-based cervical screening policies is becoming more complex due to the expanding range of screening technologies available and the interplay with vaccine-induced changes in epidemiology. M...

    Authors: Diana Mendes, Iren Bains, Tazio Vanni and Mark Jit
    Citation: BMC Cancer 2015 15:334
    Content type: Research article Published on:

  21. Cancer-associated fibroblasts (CAFs), which reside around tumor cells, are suggested to play a pivotal role in tumor progression. Here we performed microarray analyses to compare gene expression profiles betwe...

    Authors: Chao Sun, Hirokazu Fukui, Ken Hara, Xinxing Zhang, Yoshitaka Kitayama, Hirotsugu Eda, Toshihiko Tomita, Tadayuki Oshima, Shojiro Kikuchi, Jiro Watari, Mitsuru Sasako and Hiroto Miwa
    Citation: BMC Cancer 2015 15:333
    Content type: Research article Published on:

  22. Talin-1 is a cytoskeletal protein that plays an important role in tumourgenesis, migration and metastasis in several malignant tumors. The aim of this study was to evaluate the expression and prognostic value ...

    Authors: Ya-Fei Xu, Xian-Yue Ren, Ying-Qin Li, Qing-Mei He, Xin-Ran Tang, Ying Sun, Jian-Yong Shao, Wei-Hua Jia, Tie-Bang Kang, Mu-Sheng Zeng, Na Liu and Jun Ma
    Citation: BMC Cancer 2015 15:332
    Content type: Research article Published on:

  23. DNA damage repair genes JWA, XRCC1 and BRCA1 were associated with clinical outcomes and could convert the response to the cisplatin-based therapy in some carcinomas. The synergistic effects of JWA, XRCC1 and B...

    Authors: Bin Wei, Qin Han, Lijuan Xu, Xiaohui Zhang, Jing Zhu, Li Wan, Yan Jin, Zhaoye Qian, Jingjing Wu, Yong Gao, Jianwei Zhou and Xiaofei Chen
    Citation: BMC Cancer 2015 15:331
    Content type: Research article Published on:

  24. The aim of our study was to investigate the incidence of papillary thyroid microcarcinoma (PTMC) in patients operated for benign thyroid diseases (BTD) and its relation to age, sex, extent of surgery and type ...

    Authors: Nikola Slijepcevic, Vladan Zivaljevic, Jelena Marinkovic, Sandra Sipetic, Aleksandar Diklic and Ivan Paunovic
    Citation: BMC Cancer 2015 15:330
    Content type: Research article Published on:

  25. Screening for the early detection of colorectal cancer is important to improve patient survival. The aim of this study was to investigate the potential of circulating cell-free miRNAs as biomarkers of CRC, and...

    Authors: Sinéad T Aherne, Stephen F Madden, David J Hughes, Barbara Pardini, Alessio Naccarati, Miroslav Levy, Pavel Vodicka, Paul Neary, Paul Dowling and Martin Clynes
    Citation: BMC Cancer 2015 15:329
    Content type: Research article Published on:

  26. A cancer diagnosis elicits greater distress than any other medical diagnosis, and yet very few studies have evaluated the efficacy of structured online self-help therapeutic programs to alleviate this distress...

    Authors: Lisa Beatty, Emma Kemp, Tracey Wade and Bogda Koczwara
    Citation: BMC Cancer 2015 15:328
    Content type: Study protocol Published on:

  27. The optimal sequence of chemotherapeutic agents is not firmly established for the treatment of metastatic colorectal cancer (mCRC). This phase II multi-centre study investigated the efficacy and tolerability o...

    Authors: Pilar Garcia-Alfonso, Manuel Chaves, Andrés Muñoz, Antonieta Salud, Maria García-Gonzalez, Cristina Grávalos, Bartomeu Massuti, Encarna González-Flores, Bernardo Queralt, Amelia López-Ladrón, Ferran Losa, Maria Jose Gómez, Amparo Oltra and Enrique Aranda
    Citation: BMC Cancer 2015 15:327
    Content type: Research article Published on:

  28. The local invasion of tumor cells into the surrounding tissue is the first and most critical step of the metastatic cascade. Cells can invade either collectively, or individually. Individual cancer cell invasi...

    Authors: Katarína Vaškovičová, Emilia Szabadosová, Vladimír Čermák, Aneta Gandalovičová, Lenka Kasalová, Daniel Rösel and Jan Brábek
    Citation: BMC Cancer 2015 15:326
    Content type: Research article Published on:

  29. Hepatocyte carcinoma (HCC) is one of the most common malignancies worldwide. Despite many achievements in diagnosis and treatment, HCC mortality remains high due to the malignant nature of the disease. Novel a...

    Authors: Hao Liu, Qun Wei, Jia Wang, Xiaoming Huang, Chunchun Li, Qiaoli Zheng, Jiang Cao and Zhenyu Jia
    Citation: BMC Cancer 2015 15:325
    Content type: Research article Published on:

  30. No previous study has addressed the efficacy of NF-κB blockade when bladder tumors develop acquired resistance toward CDDP-treatments. We investigated the changes in NF-κB activation and therapeutic impact of ...

    Authors: Yujiro Ito, Eiji Kikuchi, Nobuyuki Tanaka, Takeo Kosaka, Eriko Suzuki, Ryuichi Mizuno, Toshiaki Shinojima, Akira Miyajima, Kazuo Umezawa and Mototsugu Oya
    Citation: BMC Cancer 2015 15:324
    Content type: Research article Published on:

  31. Chemoradiation therapy (CRT) is one of the most useful treatments for esophageal squamous cell carcinoma (ESCC). However, because some patients respond well to CRT and others do not, it is important to be able...

    Authors: Kiyokazu Tamotsu, Hiroshi Okumura, Yasuto Uchikado, Yoshiaki Kita, Ken Sasaki, Itaru Omoto, Tetsuhiro Owaki, Takaaki Arigami, Yoshikazu Uenosono, Akihiro Nakajo, Yuko Kijima, Sumiya Ishigami and Shoji Natsugoe
    Citation: BMC Cancer 2015 15:323
    Content type: Research article Published on:

  32. The efficacy and safety of preoperative chemoradiation therapy (CRT) for advanced esophago-gastric adenocarcinoma are still in question, and the prognosis of these patients is poor.

    Authors: Tao Fu, Zhao-De Bu, Zi-Yu Li, Lian-Hai Zhang, Xiao-Jiang Wu, Ai-Wen Wu, Fei Shan, Xin Ji, Qiu-Shi Dong and Jia-Fu Ji
    Citation: BMC Cancer 2015 15:322
    Content type: Research article Published on:

  33. Sexual dysfunction is a prevalent, long-term complication of breast cancer and its treatment and can be treated effectively with face-to-face sexual counselling. However, relatively few women actually opt for ...

    Authors: Susanna B Hummel, Jacques JDM van Lankveld, Hester SA Oldenburg, Daniela EE Hahn, Eva Broomans and Neil K Aaronson
    Citation: BMC Cancer 2015 15:321
    Content type: Study protocol Published on:

  34. The spectrum of RB1gene mutations in Retinoblastoma (RB) patients and the necessity of multiple traditional methods for complete variant analysis make the molecular diagnosis a cumbersome, labor-intensive and tim...

    Authors: Bharanidharan Devarajan, Logambiga Prakash, Thirumalai Raj Kannan, Aloysius A Abraham, Usha Kim, Veerappan Muthukkaruppan and Ayyasamy Vanniarajan
    Citation: BMC Cancer 2015 15:320
    Content type: Research article Published on:

  35. Histologically similar tumors even from the same anatomical position may still show high variability at molecular level hindering analysis of genome-wide data. Leveling the analysis to a gene regulatory networ...

    Authors: Chengyu Liu, Riku Louhimo, Marko Laakso, Rainer Lehtonen and Sampsa Hautaniemi
    Citation: BMC Cancer 2015 15:319
    Content type: Research Article Published on:

  36. The optimal treatment for patients with brain metastasis from gestational trophoblastic neoplasia (GTN) has not been established. This study aims to investigate the clinical characteristics and the management ...

    Authors: Changji Xiao, Junjun Yang, Jing Zhao, Tong Ren, Fengzhi Feng, Xirun Wan and Yang Xiang
    Citation: BMC Cancer 2015 15:318
    Content type: Research article Published on:

  37. To evaluate the effects of intravesical administration of paclitaxel (PTX-30W), which was prepared by solubilization with a water-soluble amphiphilic polymer composed of PMB30W, a copolymer of 2-methacryloylox...

    Authors: Koetsu Tamura, Eiji Kikuchi, Tomohiro Konno, Kazuhiko Ishihara, Kazuhiro Matsumoto, Akira Miyajima and Mototsugu Oya
    Citation: BMC Cancer 2015 15:317
    Content type: Research article Published on:

  38. 5-fluorouracil (5-FU) is employed to enhance radiotherapy (RT) effect. Here, we evaluated the influence of whole-pelvic irradiation on the pharmacokinetics (PK) of 5-FU in plasma and lymphatic system of rats a...

    Authors: Chen-Hsi Hsieh, Mei-Ling Hou, Li-Ying Wang, Hung-Chi Tai, Tung-Hu Tsai and Yu-Jen Chen
    Citation: BMC Cancer 2015 15:316
    Content type: Research article Published on:

  40. The association between epidermal growth factor (EGF) gene +61A/G polymorphism (rs4444903) and hepatocellular carcinoma (HCC) susceptibility has been widely reported, but the results were inconsistent. To clar...

    Authors: Guoping Jiang, Ke Yu, Lifang Shao, Xiaobo Yu, Chen Hu, Pei Qian, Haiyang Xie, Jinjun Li, Jie Zheng and Shusen Zheng
    Citation: BMC Cancer 2015 15:314
    Content type: Research article Published on:

  41. Lynch syndrome is an autosomal dominant cancer predisposition syndrome caused by mutations in the DNA mismatch repair genes MLH1, MSH2, MSH6 and PMS2. Individuals with Lynch syndrome have an increased risk of col...

    Authors: Tristan Snowsill, Nicola Huxley, Martin Hoyle, Tracey Jones-Hughes, Helen Coelho, Chris Cooper, Ian Frayling and Chris Hyde
    Citation: BMC Cancer 2015 15:313
    Content type: Research article Published on:

  42. Androgen deprivation therapy is commonly used to treat prostate cancer, the most common visceral cancer in men. However, various side effects often worsen physical functioning and reduce well-being among men o...

    Authors: Shabbir MH Alibhai, Daniel Santa Mina, Paul Ritvo, Catherine Sabiston, Murray Krahn, George Tomlinson, Andrew Matthew, Roanne Segal, Padraig Warde, Sara Durbano, Meagan O’Neill and Nicole Culos-Reed
    Citation: BMC Cancer 2015 15:312
    Content type: Study protocol Published on:

  45. Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive tumor of the bile duct, and a significant public health problem in East Asia, where it is associated with infection by the parasite Opisthorchis viverr...

    Authors: Jordan Plieskatt, Gabriel Rinaldi, Yanjun Feng, Jin Peng, Samantha Easley, Xinying Jia, Jeremy Potriquet, Chawalit Pairojkul, Vajarabhongsa Bhudhisawasdi, Banchob Sripa, Paul J Brindley, Jeffrey Bethony and Jason Mulvenna
    Citation: BMC Cancer 2015 15:309
    Content type: Research article Published on:

  46. From 2008, Danish general practitioners could refer patients suspected of having cancer to standardised cancer patient pathways (CPPs).

    Authors: Henry Jensen, Marie Louise Tørring, Frede Olesen, Jens Overgaard, Morten Fenger-Grøn and Peter Vedsted
    Citation: BMC Cancer 2015 15:308
    Content type: Research article Published on:

  47. Microcalcifications (MCs) are tiny deposits of calcium in breast soft tissue. Approximately 30% of early invasive breast cancers have fine, granular MCs detectable on mammography; however, their significance i...

    Authors: Madiha Naseem, Joshua Murray, John F Hilton, Jason Karamchandani, Derek Muradali, Hala Faragalla, Chanele Polenz, Dolly Han, David C Bell and Christine Brezden-Masley
    Citation: BMC Cancer 2015 15:307
    Content type: Research article Published on:

  49. Intensity-modulated radiation therapy (IMRT) has represented a technical milestone that has facilitated the clinical implementation. The purpose of this study was to evaluate the prognostic value of maximum pr...

    Authors: Yong Chen, Xue-Feng Hu, Yan Wang, Hai-Yang Chen, Lin Yang, Li-Zhi Liu, Chun-Yan Cui, Dong-Sheng Liu and Shao-Bo Liang
    Citation: BMC Cancer 2015 15:305
    Content type: Research article Published on:

  50. Angiogenesis plays a role in tumor growth and is partly mediated by factors in both the fibroblast growth factor (FGF) and vascular endothelial growth factor (VEGF) pathways. Durable clinical responses with VE...

    Authors: Thai H Ho, Xian-De Liu, Yanqing Huang, Carla L Warneke, Marcella M Johnson, Anh Hoang, Pheroze Tamboli, Fen Wang and Eric Jonasch
    Citation: BMC Cancer 2015 15:304
    Content type: Research article Published on:

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