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  1. Immunomodulatory drugs (IMiDs), such as lenalidomide, are therapeutically active compounds that bind and modulate the E3 ubiquitin ligase substrate recruiter cereblon, thereby affect steady-state levels of cer...

    Authors: Qinqin Xu, Yue-xian Hou, Paul Langlais, Patrick Erickson, James Zhu, Chang-Xin Shi, Moulun Luo, Yuanxiao Zhu, Ye Xu, Lawrence J. Mandarino, Keith Stewart and Xiu-bao Chang
    Citation: BMC Cancer 2016 16:297
    Content type: Research article Published on:

  2. The study aimed to compare urinary symptoms in patients with clinically localized prostate cancer after a combination of either low-dose-rate or high-dose-rate interstitial brachytherapy along with intensity-m...

    Authors: Satoshi Nakamura, Naoya Murakami, Koji Inaba, Akihisa Wakita, Kazuma Kobayashi, Kana Takahashi, Hiroyuki Okamoto, Rei Umezawa, Madoka Morota, Minako Sumi, Hiroshi Igaki, Yoshinori Ito and Jun Itami
    Citation: BMC Cancer 2016 16:296
    Content type: Research article Published on:

  3. Inhibitors of mutant BRAF are emerging as standard of care in patients with metastatic melanoma who carry relevant oncogenic mutations. However, BRAF inhibitors are found to induce cutaneous squamous cell carc...

    Authors: Haojie Li, Lars Pedersen, Mette Nørgaard, Sinna P. Ulrichsen, Sandra K. Thygesen and Jeanenne J. Nelson
    Citation: BMC Cancer 2016 16:295
    Content type: Research article Published on:

  4. No study has been conducted to investigate the spatial pattern and association of socioeconomic status (such as income) with breast and colorectal cancer incidence in Texas, United States. This study aimed to ...

    Authors: Zheyu Liu, Kai Zhang and Xianglin L. Du
    Citation: BMC Cancer 2016 16:294
    Content type: Research article Published on:

  5. This study was performed to design a predictive tool that allows the estimation of overall survival (OS) of elderly myeloma patients (aged ≥65 years) presenting with myeloma-induced spinal cord compression (SCC).

    Authors: Dirk Rades, Antonio Jose Conde-Moreno, Jon Cacicedo, Theo Veninga, Niklas Gebauer, Tobias Bartscht and Steven E. Schild
    Citation: BMC Cancer 2016 16:292
    Content type: Research article Published on:

  6. Clinically significant levels of fear of cancer recurrence (FCR) affect up to 49 % of cancer survivors and are more prevalent among women. FCR is associated with psychological distress, lower quality of life, ...

    Authors: Christine Maheu, Sophie Lebel, Christine Courbasson, Monique Lefebvre, Mina Singh, Lori J. Bernstein, Linda Muraca, Aronela Benea, Lynne Jolicoeur, Cheryl Harris, Agnihotram V. Ramanakumar, Sarah Ferguson and Souraya Sidani
    Citation: BMC Cancer 2016 16:291
    Content type: Study protocol Published on:

  7. Despite novel therapeutic agents, most multiple myeloma (MM) patients eventually relapse. Two large phase III trials have shown significantly improved response rates (RR) of lenalidomide/dexamethasone compared...

    Authors: Marc-Andrea Baertsch, Jana Schlenzka, Elias K. Mai, Maximilian Merz, Jens Hillengaß, Marc S. Raab, Dirk Hose, Patrick Wuchter, Anthony D. Ho, Anna Jauch, Thomas Hielscher, Christina Kunz, Steffen Luntz, Stefan Klein, Ingo G. H. Schmidt-Wolf, Martin Goerner…
    Citation: BMC Cancer 2016 16:290
    Content type: Study protocol Published on:

  8. The aim of this study was to compare surgical treatment received by Aboriginal and non-Aboriginal people with non-small cell lung cancer (NSCLC) in New South Wales (NSW), Australia and to examine whether patie...

    Authors: Alison Gibberd, Rajah Supramaniam, Anthony Dillon, Bruce K. Armstrong and Dianne L. O’Connell
    Citation: BMC Cancer 2016 16:289
    Content type: Research article Published on:

  9. Increasing the biological effective dose (BED) of radiotherapy for non-small cell lung cancer (NSCLC) can increase local control rates and improve overall survival. Compared with conventional fractionated radi...

    Authors: Xiao-Cang Ren, Quan-Yu Wang, Rui Zhang, Xue-Ji Chen, Na Wang, Yue-E Liu, Jie Zong, Zhi-Jun Guo, Dong-Ying Wang and Qiang Lin
    Citation: BMC Cancer 2016 16:288
    Content type: Research article Published on:

  10. Ependymal tumors in adults are rare, accounting for less than 4 % of primary tumors of the central nervous system in this age group. The low prevalence of intracranial ependymoma in adults limits the ability t...

    Authors: Dorothee Gramatzki, Patrick Roth, Jörg Felsberg, Silvia Hofer, Elisabeth J. Rushing, Bettina Hentschel, Manfred Westphal, Dietmar Krex, Matthias Simon, Oliver Schnell, Wolfgang Wick, Guido Reifenberger and Michael Weller
    Citation: BMC Cancer 2016 16:287
    Content type: Research article Published on:

  12. Adequate circadian timing of cancer treatment schedules (chronotherapy) can enhance tolerance and efficacy several-fold in experimental and clinical situations. However, the optimal timing varies according to ...

    Authors: Elisabet Ortiz-Tudela, Pasquale F. Innominato, Maria Angeles Rol, Francis Lévi and Juan Antonio Madrid
    Citation: BMC Cancer 2016 16:285
    Content type: Research article Published on:

  14. Alcohol consumption is associated with increased risk of breast cancer (BC), and the underlying mechanism is thought to be sex-hormone driven. In vitro and observational studies suggest a mechanism involving p...

    Authors: Tine Iskov Kopp, Ditte Marie Jensen, Gitte Ravn-Haren, Arieh Cohen, Helle Molgaard Sommer, Lars Ove Dragsted, Anne Tjonneland, David Michael Hougaard and Ulla Vogel
    Citation: BMC Cancer 2016 16:283
    Content type: Research article Published on:

  15. Primary central nervous system lymphoma (PCNSL) is a highly aggressive Non-Hodgkin lymphoma (NHL) with rising incidence over the past 30 years in immunocompetent patients. Although outcomes have improved, PCNS...

    Authors: Elisabeth Schorb, Juergen Finke, Andrés J. M. Ferreri, Gabriele Ihorst, Kristina Mikesch, Benjamin Kasenda, Kristina Fritsch, Heidi Fricker, Elvira Burger, Olga Grishina, Elke Valk, Emanuele Zucca and Gerald Illerhaus
    Citation: BMC Cancer 2016 16:282
    Content type: Study protocol Published on:

  16. Participation in low-dose CT (LDCT) lung cancer screening offered in the trial context has been poor, especially among smokers from socioeconomically deprived backgrounds; a group for whom the risk-benefit rat...

    Authors: Samantha L. Quaife, Mamta Ruparel, Rebecca J. Beeken, Andy McEwen, John Isitt, Gary Nolan, Karen Sennett, David R. Baldwin, Stephen W. Duffy, Samuel M. Janes and Jane Wardle
    Citation: BMC Cancer 2016 16:281
    Content type: Study protocol Published on:

  17. Few new compounds are available for relapsed osteosarcoma. We retrospectively evaluated the activity of gemcitabine (G) plus docetaxel (D) in patients with relapsed high-grade osteosarcoma and high-grade spind...

    Authors: E. Palmerini, R. L. Jones, E. Marchesi, A. Paioli, M. Cesari, A. Longhi, C. Meazza, L. Coccoli, F. Fagioli, S. Asaftei, G. Grignani, A. Tamburini, S. M. Pollack, P. Picci and S. Ferrari
    Citation: BMC Cancer 2016 16:280
    Content type: Research article Published on:

  18. Acquired resistance towards apoptosis is a hallmark of cancer. Elimination of cells bearing activated oncogenes or stimulation of tumor suppressor mediators may provide a selection pressure to overcome resista...

    Authors: Christiana G. Savva, Sotirios Totokotsopoulos, Kyriakos C. Nicolaou, Christiana M. Neophytou and Andreas I. Constantinou
    Citation: BMC Cancer 2016 16:279
    Content type: Research article Published on:

  19. Metronomic oral vinorelbine is effective in metastatic NSCLC and malignant pleural mesothelioma, but all the studies published thus far were based upon a variety of empirical and possibly suboptimal schedules,...

    Authors: Xavier Elharrar, Dominique Barbolosi, Joseph Ciccolini, Christophe Meille, Christian Faivre, Bruno Lacarelle, Nicolas André and Fabrice Barlesi
    Citation: BMC Cancer 2016 16:278
    Content type: Study protocol Published on:

  20. To assess whether intraoperative use of contrast-enhanced ultrasound (CEUS)-CT/MR image fusion can accurately evaluate ablative margin (AM) and guide supplementary ablation to improve AM after hepatocellular c...

    Authors: Kai Li, Zhong-Zhen Su, Er-Jiao Xu, Jin-Xiu Ju, Xiao-Chun Meng and Rong-Qin Zheng
    Citation: BMC Cancer 2016 16:277
    Content type: Research article Published on:

  21. Surviving expression might serve as a prognostic biomarker predicting the clinical outcome of non-small cell lung cancer (NSCLC). The study was conducted to explore the potential correlation of survivin protei...

    Authors: Liang Duan, Xuefei Hu, Yuxing Jin, Ruijun Liu and Qingjun You
    Citation: BMC Cancer 2016 16:276
    Content type: Research article Published on:

  23. The influence of the tumor microenvironment and tumor-stromal interactions on the heterogeneity of response within breast cancer subtypes have just begun to be explored. This study focuses on patients with est...

    Authors: Alexander S. Brodsky, Jinjun Xiong, Dongfang Yang, Christoph Schorl, Mary Anne Fenton, Theresa A. Graves, William M. Sikov, Murray B. Resnick and Yihong Wang
    Citation: BMC Cancer 2016 16:274
    Content type: Research article Published on:

  24. Despite recent progress, investigating the impact of targeted therapies on Head and Neck Squamous Cell Carcinoma (HNSCC) remains a challenge. We investigated whether short-term culture of tumour fragments woul...

    Authors: Jérôme Donnadieu, Emma Lachaier, Marine Peria, Zuzana Saidak, Stéphanie Dakpe, Jean-Fortune Ikoli, Bruno Chauffert, Cyril Page and Antoine Galmiche
    Citation: BMC Cancer 2016 16:273
    Content type: Research article Published on:

  26. The incidence of and mortality from colorectal cancers (CRC) can be reduced by early detection. Currently there is a lack of established markers to detect early neoplastic changes. We aimed to identify the cop...

    Authors: B. M. Shivakumar, Sanjiban Chakrabarty, Harish Rotti, Venu Seenappa, Lakshmi Rao, Vasudevan Geetha, B. V. Tantry, Hema Kini, Rajesh Dharamsi, C. Ganesh Pai and Kapaettu Satyamoorthy
    Citation: BMC Cancer 2016 16:271
    Content type: Research article Published on:

  27. Hepcidin, a key regulator of iron metabolism, is produced mainly by interleukin-6 (IL-6) during inflammation. A mechanism linking cancer-related anemia and IL-6 through hepcidin production is suggested. To cla...

    Authors: Mariko Noguchi-Sasaki, Yusuke Sasaki, Yasushi Shimonaka, Kazushige Mori and Kaori Fujimoto-Ouchi
    Citation: BMC Cancer 2016 16:270
    Content type: Research article Published on:

  28. Interrogate the impact of IKZF1 deletion on therapy-outcomes of adults with common B-cell acute lymphoblastic leukemia.

    Authors: Qiu-Mei Yao, Kai-Yan Liu, Robert Peter Gale, Bin Jiang, Yan-Rong Liu, Qian Jiang, Hao Jiang, Xiao-Hui Zhang, Mei-Jie Zhang, Shan-Shan Chen, Xiao-Jun Huang, Lan-Ping Xu and Guo-Rui Ruan
    Citation: BMC Cancer 2016 16:269
    Content type: Research article Published on:

  29. Anaplastic pancreatic cancer (APC) cell lines have been scarcely established.

    Authors: Kotaro Miura, Kenjiro Kimura, Ryosuke Amano, Sadaaki Yamazoe, Go Ohira, Akihiro Murata, Kohei Nishio, Tsuyoshi Hasegawa, Masakazu Yashiro, Bunzo Nakata, Masaichi Ohira and Kosei Hirakawa
    Citation: BMC Cancer 2016 16:268
    Content type: Research article Published on:

  30. Rituximab (R) in combination with DHAP is a widely accepted salvage regimen for patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL). A common adverse effect of this protocol is renal tox...

    Authors: K. Lisenko, F. McClanahan, T. Schöning, M. A. Schwarzbich, M. Cremer, T. Dittrich, A. D. Ho and M. Witzens-Harig
    Citation: BMC Cancer 2016 16:267
    Content type: Research article Published on:

  31. Endostatin inhibits the pro-angiogenic action of basic fibroblast growth factor and vascular endothelial growth factor in different human cancers. This study assessed the efficacy of endostatin combined with c...

    Authors: Xiao-Jiang Sun, Qing-Hua Deng, Xin-Min Yu, Yong-Lin Ji, Yuan-Da Zheng, Hao Jiang, Ya-Ping Xu and Sheng-Lin Ma
    Citation: BMC Cancer 2016 16:266
    Content type: Research article Published on:

  32. Extensive-disease small-cell lung cancer (ED-SCLC) is characterized by rapid progression and relapse, despite high initial response rates to chemotherapy. The primary objective of this trial was to demonstrate...

    Authors: Yan Sun, Ying Cheng, Xuezhi Hao, Jie Wang, Chengping Hu, Baohui Han, Xiaoqing Liu, Li Zhang, Huiping Wan, Zhongjun Xia, Yunpeng Liu, Wei Li, Mei Hou, Helong Zhang, Qingyu Xiu, Yunzhong Zhu…
    Citation: BMC Cancer 2016 16:265
    Content type: Research article Published on:

  33. Awareness of preferences regarding medical care should be a central component of the care of patients with advanced cancer. Open communication can facilitate this but can occur in an ad hoc or variable manner....

    Authors: Judith A. C. Rietjens, Ida J. Korfage, Lesley Dunleavy, Nancy J. Preston, Lea J. Jabbarian, Caroline Arnfeldt Christensen, Maja de Brito, Francesco Bulli, Glenys Caswell, Branka ÄŒerv, Johannes van Delden, Luc Deliens, Giuseppe Gorini, Mogens Groenvold, Dirk Houttekier, Francesca Ingravallo…
    Citation: BMC Cancer 2016 16:264
    Content type: Study protocol Published on:

  34. Melphalan has been used in the treatment of various hematologic malignancies for almost 60 years. Today it is part of standard therapy for multiple myeloma and also as part of myeloablative regimens in associa...

    Authors: Maryam Delforoush, Sara Strese, Malin Wickström, Rolf Larsson, Gunilla Enblad and Joachim Gullbo
    Citation: BMC Cancer 2016 16:263
    Content type: Research article Published on:

  35. Among patients with rectal cancer, 5–10 % have a primary rectal cancer beyond the total mesorectal excision plane (PRC-bTME) and 10 % recur locally following primary surgery (LRRC). In both cases, patients ‘ca...

    Authors: Quentin Denost, Florence Saillour, Lindy Masya, Helene Maillou Martinaud, Stephanie Guillon, Marion Kret, Eric Rullier, Bruno Quintard and Michael Solomon
    Citation: BMC Cancer 2016 16:262
    Content type: Study protocol Published on:

  36. MicroRNAs are small non-coding RNAs that have been implicated in tumor initiation and progression. In a previous study we identified 138 miRNAs as differentially expressed in endometrial adenocarcinoma compare...

    Authors: Sanja Jurcevic, Karin Klinga-Levan, Björn Olsson and Katarina Ejeskär
    Citation: BMC Cancer 2016 16:261
    Content type: Research article Published on:

  37. Brain metastases (BM) from colorectal cancer (CRC) are a rare event. However, the implications for affected patients are severe, and the incidence has been reported to be increasing. For clinicians, knowledge ...

    Authors: Troels Dreier Christensen, Karen-Lise Garm Spindler, Jesper Andreas Palshof and Dorte Lisbet Nielsen
    Citation: BMC Cancer 2016 16:260
    Content type: Research article Published on:

  38. The non-canonical Wnt/Planar cell polarity (PCP) signaling pathway is a major player in cell migration during embryonal development and has recently been implicated in tumorigenesis.

    Authors: Cecilia Dyberg, Panagiotis Papachristou, Bjørn Helge Haug, Hugo Lagercrantz, Per Kogner, Thomas Ringstedt, Malin Wickström and John Inge Johnsen
    Citation: BMC Cancer 2016 16:259
    Content type: Research article Published on:

  39. The information surgeons impart to patients and information patients want about surgery for cancer is important but rarely examined. This study explored information provided by surgeons and patient preferences...

    Authors: Angus G. K. McNair, F MacKichan, J. L. Donovan, S. T. Brookes, K. N. L. Avery, S. M. Griffin, T. Crosby and J. M. Blazeby
    Citation: BMC Cancer 2016 16:258
    Content type: Research article Published on:

  40. Nurr1, a member of the orphan receptor family, plays an important role in several types of cancer. Our previous work demonstrated that increased expression of Nurr1 plays a significant role in the initiation a...

    Authors: Jian Wang, Zhi-Hong Yang, Hua Chen, Hua-Hui Li, Li-Yong Chen, Zhu Zhu, Ying Zou, Cong-Cong Ding, Jing Yang and Zhi-Wei He
    Citation: BMC Cancer 2016 16:257
    Content type: Research article Published on:

  41. Endocrine resistance is a major obstacle to optimal treatment effect in breast cancer. Some genetic markers have been proposed to predict response to aromatase inhibitors (AIs) but the data is insufficient. Th...

    Authors: Maria Simonsson, Srinivas Veerla, Andrea Markkula, Carsten Rose, Christian Ingvar and Helena Jernström
    Citation: BMC Cancer 2016 16:256
    Content type: Research article Published on:

  42. Comorbidity at the time of diagnosis is an independent prognostic factor for survival among women suffering from cervical or breast cancer. Although cancer screening practices have proven their efficacy for mo...

    Authors: Panayotis Constantinou, Rosemary Dray-Spira and Gwenn Menvielle
    Citation: BMC Cancer 2016 16:255
    Content type: Research article Published on:

  43. Axitinib is a potent inhibitor of the vascular endothelial growth factor (VEGF) receptor family with clinical activity in patients with metastatic renal cell carcinoma (mRCC). Given this biochemical potency, t...

    Authors: Namita Chittoria, Housam Haddad, Paul Elson, Nizar M. Tannir, Laura S. Wood, Robert Dreicer, Jorge A. Garcia, Brian I. Rini and Eric Jonasch
    Citation: BMC Cancer 2016 16:254
    Content type: Research article Published on:

  44. Osteosarcoma (OS) is well-known for poor prognosis due to its high incidence of proliferation and metastasis. Researches have provided valuable insights into the tumorigenesis of S100A9 in some cancers. We aim...

    Authors: Si Cheng, Xi Zhang, Ning Huang, Quanhe Qiu, Ying Jin and Dianming Jiang
    Citation: BMC Cancer 2016 16:253
    Content type: Research article Published on:

  45. MicroRNAs have been shown to be important regulators of the immune response and the development of the immune system. It was reported that microRNA-125b (miR-125b) was down-regulated in macrophages challenged ...

    Authors: Zhenbiao Xu, Lianmei Zhao, Xin Yang, Sisi Ma, Yehua Ge, Yanxin Liu, Shilian Liu, Juan Shi and Dexian Zheng
    Citation: BMC Cancer 2016 16:252
    Content type: Research article Published on:

  46. Luteinizing hormone-releasing hormone receptor (LHRHr) represents a promising therapeutic target for treating sex hormone-dependent tumors. We coupled cecropin B, an antimicrobial peptide, to LHRH’, a form of ...

    Authors: Xiaoyong Li, Bo Shen, Qi Chen, Xiaohui Zhang, Yiqing Ye, Fengmei Wang and Xinmei Zhang
    Citation: BMC Cancer 2016 16:251
    Content type: Research article Published on:

  49. The pathological and clinical features of invasive lobular carcinoma (ILC) differ from those of invasive ductal carcinoma (IDC). Several studies have indicated that patients with ILC have a better prognosis th...

    Authors: Yayoi Adachi, Junko Ishiguro, Haruru Kotani, Tomoka Hisada, Mari Ichikawa, Naomi Gondo, Akiyo Yoshimura, Naoto Kondo, Masaya Hattori, Masataka Sawaki, Takashi Fujita, Toyone Kikumori, Yasushi Yatabe, Yasuhiro Kodera and Hiroji Iwata
    Citation: BMC Cancer 2016 16:248
    Content type: Research article Published on:

  50. ACFP is an anti-cancer fusion peptide derived from bovine milk protein. This study was to investigate the anti-cancer function and underlying mechanisms of ACFP in ovarian cancer.

    Authors: Juan Zhou, Mengjing Zhao, Yigui Tang, Jing Wang, Cai Wei, Fang Gu, Ting Lei, Zhiwu Chen and Yide Qin
    Citation: BMC Cancer 2016 16:246
    Content type: Research article Published on:

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