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  1. Serum tartrate-resistant acid phosphatase 5b (TRACP 5b) activity is a marker of osteoclast number and is elevated in breast cancer (BC) patients with extensive bone metastasis, which might in turn reflect the ...

    Authors: Yi-Ying Wu, Anthony J Janckila, Chih-Hung Ku, Cheng-Ping Yu, Jyh-Cherng Yu, Su-Hui Lee, Hsin-Yi Liu, Lung T Yam and Tsu-Yi Chao
    Citation: BMC Cancer 2010 10:158
    Content type: Research article Published on:

  2. Hypoxic microenvironments in tumors contribute to transformation, which may alter metabolism, growth, and therapeutic responsiveness. The α-enolase gene encodes both a glycolytic enzyme (α-enolase) and a DNA-b...

    Authors: Kara C Sedoris, Shelia D Thomas and Donald M Miller
    Citation: BMC Cancer 2010 10:157
    Content type: Research article Published on:

  3. Breast cancer is the most frequently diagnosed cancer in women. Intraepithelial lesions (IELs), such as usual ductal hyperplasia (UH), atypical ductal hyperplasia (ADH), and ductal carcinoma in situ (DCIS) are...

    Authors: Giovanni P Burrai, Sulma I Mohammed, Margaret A Miller, Vincenzo Marras, Salvatore Pirino, Maria F Addis, Sergio Uzzau and Elisabetta Antuofermo
    Citation: BMC Cancer 2010 10:156
    Content type: Research article Published on:

  4. The Lung Cancer Exercise Training Study (LUNGEVITY) is a randomized trial to investigate the efficacy of different types of exercise training on cardiorespiratory fitness (VO2peak), patient-reported outcomes, and...

    Authors: Lee W Jones, Neil D Eves, William E Kraus, Anil Potti, Jeffrey Crawford, James A Blumenthal, Bercedis L Peterson and Pamela S Douglas
    Citation: BMC Cancer 2010 10:155
    Content type: Study protocol Published on:

  5. Racial and ethnic disparities in breast cancer incidence, stage at diagnosis, survival and mortality are well documented; but few studies have reported on disparities in breast cancer treatment. This paper com...

    Authors: Parvin Yavari, Maria Cristina Barroetavena, T Greg Hislop and Chris D Bajdik
    Citation: BMC Cancer 2010 10:154
    Content type: Research article Published on:

  6. Large number of patients with colorectal liver metastasis show recurrent disease after curative surgical resection. Identification of these high-risk patients may guide therapeutic strategies. The aim of this ...

    Authors: F Jeroen Vogelaar, Wilma E Mesker, Arjen M Rijken, Gaby W van Pelt, Antonia M van Leeuwen, Hans J Tanke, Rob A Tollenaar and Gerrit J Liefers
    Citation: BMC Cancer 2010 10:153
    Content type: Research article Published on:

  7. Despite the large number of men diagnosed with localized prostate cancer, there is as yet no consensus concerning appropriate treatment. The purpose of this study was to describe the initial treatment patterns...

    Authors: Maria J Schymura, Amy R Kahn, Robert R German, Mei-Chin Hsieh, Rosemary D Cress, Jack L Finch, John P Fulton, Tiefu Shen and Erik Stuckart
    Citation: BMC Cancer 2010 10:152
    Content type: Research article Published on:

  8. The urokinase plasminogen activating system (uPAS) is implicated in neoplastic progression and high tissue levels of uPAS components correlate with a poor prognosis in different human cancers. Despite that, re...

    Authors: Salvatore Ulisse, Enke Baldini, Marcella Mottolese, Steno Sentinelli, Patrizia Gargiulo, Brancato Valentina, Salvatore Sorrenti, Anna Di Benedetto, Enrico De Antoni and Massimino D'Armiento
    Citation: BMC Cancer 2010 10:151
    Content type: Research article Published on:

  9. Sarcomas are rare malignant tumors. Accurate initial histological diagnosis is essential for adequate management. We prospectively assessed the medical management of all patients diagnosed with sarcoma in a Eu...

    Authors: Antoine Lurkin, Francoise Ducimetière, Dominique Ranchère Vince, Anne-Valérie Decouvelaere, Dominic Cellier, François N Gilly, Dimitri Salameire, Pierre Biron, Guy de Laroche, Jean Yves Blay and Isabelle Ray-Coquard
    Citation: BMC Cancer 2010 10:150
    Content type: Research article Published on:

  10. Succinate dehydrogenase (SDH) has been associated with carcinogenesis in pheochromocytoma and paraganglioma. In the present study we investigated components of the oxidative phosphorylation system in human neu...

    Authors: Rene' G Feichtinger, Franz Zimmermann, Johannes A Mayr, Daniel Neureiter, Cornelia Hauser-Kronberger, Freimut H Schilling, Neil Jones, Wolfgang Sperl and Barbara Kofler
    Citation: BMC Cancer 2010 10:149
    Content type: Research article Published on:

  11. Medulloblastomas (MBs) and supratentorial primitive neuroectodermal tumours (PNETs) are the most common highly aggressive paediatric brain tumours. In spite of extensive research on these tumours, there are on...

    Authors: Kristiina Nordfors, Joonas Haapasalo, Miikka Korja, Anssi Niemelä, Jukka Laine, Anna-Kaisa Parkkila, Silvia Pastorekova, Jaromir Pastorek, Abdul Waheed, William S Sly, Seppo Parkkila and Hannu Haapasalo
    Citation: BMC Cancer 2010 10:148
    Content type: Research article Published on:

  12. The tumor suppressor TP53 and its negative regulator MDM2 play crucial roles in carcinogenesis. Previous case-control studies also revealed TP53 72Arg>Pro and MDM2 309T>G polymorphisms contribute to the risk of c...

    Authors: Mang Xiao, Lei Zhang, Xinhua Zhu, Jun Huang, Huifen Jiang, Sunhong Hu and Yuehui Liu
    Citation: BMC Cancer 2010 10:147
    Content type: Research article Published on:

  13. Bacterial targeting of tumours is an important anti-cancer strategy. We previously showed that strain SL7838 of Salmonella typhimurium targets and kills cancer cells. Whether NO generation by the bacteria has a r...

    Authors: Yoram Barak, Frank Schreiber, Steve H Thorne, Christopher H Contag, Dirk deBeer and A Matin
    Citation: BMC Cancer 2010 10:146
    Content type: Research article Published on:

  14. Germline mutations in the BRCA1 gene predispose to the development of breast cancer, exhibiting a specific histological phenotype. Identification of possible hallmarks of these tumors is important for selectin...

    Authors: Marise R Heerma van Voss, Petra van der Groep, Jos Bart, Elsken van der Wall and Paul J van Diest
    Citation: BMC Cancer 2010 10:145
    Content type: Research article Published on:

  15. Despite evidence that breast cancer screening reduces morbidity and mortality, until recently most women have not undergone regular mammogram examinations in Korea. We aimed to identify factors associated with...

    Authors: Kiheon Lee, Hyung Taek Lim and Sang Min Park
    Citation: BMC Cancer 2010 10:144
    Content type: Research article Published on:

  16. Emerging reports suggest resistance, increased tumor invasiveness and metastasis arising from treatment with drugs targeting vascular endothelial growth factor (VEGF). It is believed that increased tumoral hyp...

    Authors: Mohammad H Pourgholami, Zhao Y Cai, Samina Badar, Kiran Wangoo, Marianne S Poruchynsky and David L Morris
    Citation: BMC Cancer 2010 10:143
    Content type: Research article Published on:

  17. Endogenously produced interferons can regulate the growth of melanoma cells and are administered exogenously as therapeutic agents to patients with advanced cancer. We investigated the role of negative regulat...

    Authors: Gregory B Lesinski, Jason M Zimmerer, Melanie Kreiner, John Trefry, Matthew A Bill, Gregory S Young, Brian Becknell and William E Carson III
    Citation: BMC Cancer 2010 10:142
    Content type: Research article Published on:

  18. Previous studies showed a differential distribution of the four regulatory subunits of cAMP-dependent protein kinases inside the brain, that changed in rodent gliomas: therefore, the distribution of these prot...

    Authors: Carla Mucignat-Caretta, Luca Denaro, Marco Redaelli, Domenico D'Avella and Antonio Caretta
    Citation: BMC Cancer 2010 10:141
    Content type: Research article Published on:

  19. Tumor cell proliferation is a predictor of survival in cutaneous melanoma. The aim of the present study was to evaluate the prognostic impact of mitotic count, Ki-67 expression and novel proliferation markers ...

    Authors: Rita G Ladstein, Ingeborg M Bachmann, Oddbjørn Straume and Lars A Akslen
    Citation: BMC Cancer 2010 10:140
    Content type: Research article Published on:

  20. Angiogenesis appears to play an important role in ovarian cancer. Vascular endothelial growth factor (VEGF) has recently been implicated as a therapeutic target in ovarian cancer. The tissue inhibitor of metal...

    Authors: Sven Mahner, Linn Woelber, Christine Eulenburg, Joerg Schwarz, Walter Carney, Fritz Jaenicke, Karin Milde-Langosch and Volkmar Mueller
    Citation: BMC Cancer 2010 10:139
    Content type: Research article Published on:

  21. Tumor suppressor genes p53 and p16 INK4a and the proto-oncogene MDM2 are considered to be essential G1 cell cycle regulatory genes whose loss of function is associated with ESCC carcinogenesis. We assessed the ab...

    Authors: Noushin Taghavi, Firouzeh Biramijamal, Masoud Sotoudeh, Hooman Khademi, Reza Malekzadeh, Omeed Moaven, Bahram Memar, Azadeh A'rabi and Mohammad Reza Abbaszadegan
    Citation: BMC Cancer 2010 10:138
    Content type: Research article Published on:

  22. The aim of our study was to analyze the effect of taxane-based chemotherapy on tumor angiogenesis in patients with advanced epithelial ovarian cancer.

    Authors: Martin Pölcher, Christian Rudlowski, Nicolaus Friedrichs, Marieke Mielich, Tobias Höller, Mathias Wolfgarten, Kirsten Kübler, Reinhard Büttner, Walther Kuhn and Michael Braun
    Citation: BMC Cancer 2010 10:137
    Content type: Research article Published on:

  23. Mutational analysis of the KRAS gene has recently been established as a complementary in vitro diagnostic tool for the identification of patients with colorectal cancer who will not benefit from anti-epidermal gr...

    Authors: Alfonso Sánchez-Muñoz, Elena Gallego, Vanessa de Luque, Luís G Pérez-Rivas, Luís Vicioso, Nuria Ribelles, José Lozano and Emilio Alba
    Citation: BMC Cancer 2010 10:136
    Content type: Research article Published on:

  24. Microtubules are considered major therapeutic targets in patients with breast cancer. In spite of their essential role in biological functions including cell motility, cell division and intracellular transport...

    Authors: Rouba Hage-Sleiman, Stéphanie Herveau, Eva-Laure Matera, Jean-Fabien Laurier and Charles Dumontet
    Citation: BMC Cancer 2010 10:135
    Content type: Research article Published on:

  25. Blockade of the renin angiotensin system (RAS) via angiotensin I converting enzyme (ACE) inhibition reduces growth of colorectal cancer (CRC) liver metastases in a mouse model. In this work we defined the expr...

    Authors: Jaclyn H Neo, Eleanor I Ager, Peter W Angus, Jin Zhu, Chandana B Herath and Christopher Christophi
    Citation: BMC Cancer 2010 10:134
    Content type: Research article Published on:

  26. It has been suggested that the B-cell specific moloney leukemia virus insertion site 1 (Bmi-1) gene plays an oncogenic role in several types of human cancer, but the status of Bmi-1 amplification and expression i...

    Authors: Guo-Fen Yang, Wei-Peng He, Mu-Yan Cai, Li-Ru He, Jun-Hang Luo, Hai-Xia Deng, Xin-Yuan Guan, Mu-Sheng Zeng, Yi-Xin Zeng and Dan Xie
    Citation: BMC Cancer 2010 10:133
    Content type: Research article Published on:

  27. Osteopontin (OPN) overexpression is correlated with a poor prognosis for tumor patients. However, only a few studies investigated the prognostic impact of expression of OPN in soft tissue sarcomas (STS) yet.

    Authors: Matthias Bache, Matthias Kappler, Henri Wichmann, Swetlana Rot, Antje Hahnel, Thomas Greither, Harun M Said, Matthias Kotzsch, Peter Würl, Helge Taubert and Dirk Vordermark
    Citation: BMC Cancer 2010 10:132
    Content type: Research article Published on:

  28. The lymphatic system is a major route for cancer cell dissemination and also a potential target for antitumor therapy. To investigate whether increased lymphatic vessel density (LVD) is a prognostic factor for...

    Authors: Ying Gao, Zi Liu, Fei Gao and Xiao-yu Meng
    Citation: BMC Cancer 2010 10:131
    Content type: Research article Published on:

  29. Moxibustion is a traditional Chinese method that uses the heat generated by burning herbal preparations containing Artemisia vulgaris to stimulate acupuncture points. Considering moxibustion is closely related to...

    Authors: Myeong Soo Lee, Tae-Young Choi, Ji-Eun Park, Song-Shil Lee and Edzard Ernst
    Citation: BMC Cancer 2010 10:130
    Content type: Research article Published on:

  30. Prostate stem cell antigen (PSCA) is a glycosylphosphatidylinositol (GPI) anchored protein expressed not only in prostate but also in pancreas and bladder cancer as shown by immunohistochemistry and mRNA analy...

    Authors: Emanuele Marra, Paolo Uva, Valentina Viti, Valeria Simonelli, Eugenia Dogliotti, Emanuele De Rinaldis, Armin Lahm, Nicola La Monica, Alfredo Nicosia, Gennaro Ciliberto and Fabio Palombo
    Citation: BMC Cancer 2010 10:129
    Content type: Research article Published on:

  31. Steroid receptors play major roles in the development, differentiation, and homeostasis of normal and malignant tissue. STAMP is a novel coregulator that not only enhances the ability of p160 coactivator famil...

    Authors: Yuanzheng He, John A Blackford Jr, Elise C Kohn and S Stoney Simons Jr
    Citation: BMC Cancer 2010 10:128
    Content type: Research article Published on:

  32. To evaluate the safety of focal dose escalation to regions with standardized uptake value (SUV) >2.0 using intensity-modulated radiation therapy (IMRT) by comparison of radiotherapy plans using dose-volume his...

    Authors: Keiichi Jingu, Hisanori Ariga, Tomohiro Kaneta, Yoshihiro Takai, Ken Takeda, Lindel Katja, Kakutaro Narazaki, Takahiro Metoki, Keisuke Fujimoto, Rei Umezawa, Yoshihiro Ogawa, Kenji Nemoto, Masashi Koto, Masatoshi Mitsuya, Naruhiro Matsufuji, Shoki Takahashi…
    Citation: BMC Cancer 2010 10:127
    Content type: Research article Published on:

  33. The discordance between steady-state levels of mRNAs and protein has been attributed to posttranscriptional control mechanisms affecting mRNA stability and translation. Traditional methods of genome wide micro...

    Authors: Robert Calaluce, Matthew M Gubin, J Wade Davis, Joseph D Magee, Jing Chen, Yuki Kuwano, Myriam Gorospe and Ulus Atasoy
    Citation: BMC Cancer 2010 10:126
    Content type: Research article Published on:

  34. Our group previously reported that tumour-specific expression of the rate-limiting enzyme in the mevalonate pathway, 3-hydroxy-3-methylglutharyl-coenzyme A reductase (HMG-CoAR) is associated with more favourab...

    Authors: Donal J Brennan, Jenny Brändstedt, Elton Rexhepaj, Michael Foley, Fredrik Pontén, Mathias Uhlén, William M Gallagher, Darran P O'Connor, Colm O'Herlihy and Karin Jirstrom
    Citation: BMC Cancer 2010 10:125
    Content type: Research article Published on:

  35. Gastric cancer peritoneal carcinomatosis is a common clinical problem, but there are no suitable large animal models to study this problem. This study was to establish a stable rabbit peritoneal carcinomatosis...

    Authors: Lie-Jun Mei, Xiao-Jun Yang, Li Tang, Alaa Hammed al-shammaa Hassan, Yutaka Yonemura and Yan Li
    Citation: BMC Cancer 2010 10:124
    Content type: Research article Published on:

  36. The post-translational modification of proteins, including glycosylation, differs between normal and tumor cells. The UDP-N-acetyl-D-galactosamine polypeptide N-acetylgalactosaminyltransferases (GalNAc-Tases) ...

    Authors: Chen Wu, Xiaodan Guo, Weina Wang, Yun Wang, Yaojun Shan, Bo Zhang, Wenqian Song, Sisi Ma, Jianfeng Ge, Hao Deng and Mingsheng Zhu
    Citation: BMC Cancer 2010 10:123
    Content type: Research article Published on:

  37. Since hepatocellular carcinoma (HCC) is one of the leading causes of cancer death worldwide, it is still important to understand hepatocarcinogenesis mechanisms and identify effective markers for tumor progres...

    Authors: Hye-Sun Choi, Seon-Hee Yim, Hai-Dong Xu, Seung-Hyun Jung, Seung-Hun Shin, Hae-Jin Hu, Chan-Kwon Jung, Jong Young Choi and Yeun-Jun Chung
    Citation: BMC Cancer 2010 10:122
    Content type: Research article Published on:

  38. Spontaneous Regression/Complete Resistant (SR/CR) mice are a colony of cancer-resistant mice that can detect and rapidly destroy malignant cells with innate cellular immunity, predominately mediated by granulo...

    Authors: Anne M Sanders, John R Stehle Jr, Michael J Blanks, Gregory Riedlinger, Jung W Kim-Shapiro, Arta M Monjazeb, Jonathan M Adams, Mark C Willingham and Zheng Cui
    Citation: BMC Cancer 2010 10:121
    Content type: Research article Published on:

  39. Mollicutes contamination is recognized to be a critical issue for the cultivation of continuous cell lines. In this work we characterized the effect of Mycoplasma hyorhinis contamination on CD133 expression in h...

    Authors: Elisabetta Mariotti, Marica Gemei, Peppino Mirabelli, Francesca D'Alessio, Rosa Di Noto, Giuliana Fortunato and Luigi Del Vecchio
    Citation: BMC Cancer 2010 10:120
    Content type: Research article Published on:

  40. There is renewed interest in magnetic hyperthermia as a treatment modality for cancer, especially when it is combined with other more traditional therapeutic approaches, such as the co-delivery of anticancer d...

    Authors: Sivasai Balivada, Raja Shekar Rachakatla, Hongwang Wang, Thilani N Samarakoon, Raj Kumar Dani, Marla Pyle, Franklin O Kroh, Brandon Walker, Xiaoxuan Leaym, Olga B Koper, Masaaki Tamura, Viktor Chikan, Stefan H Bossmann and Deryl L Troyer
    Citation: BMC Cancer 2010 10:119
    Content type: Research article Published on:

  41. The clinical course of human papillomavirus (HPV) associated with Bowenoid papulosis and condyloma acuminatum of anogenital tumors are still unknown. Here we evaluated molecules that are relevant to cellular p...

    Authors: Tsuyoshi Mitsuishi, Yukie Iwabu, Kenzo Tokunaga, Tetsutaro Sata, Takehiko Kaneko, Kuniaki Ohara, Ikuroh Ohsawa, Fumino Oda, Yuko Yamada, Seiji Kawana, Kohji Ozaki, Mayuka Nakatake and Osamu Yamada
    Citation: BMC Cancer 2010 10:118
    Content type: Research article Published on:

  42. Based on the well-recognized etiological role of human papillomavirus (HPV) in cervical, anogenital and oropharyngeal carcinogenesis, a potential role of HPV in colorectal carcinogenesis has been suggested. Fo...

    Authors: Vanessa Deschoolmeester, Veerle Van Marck, Marc Baay, Christine Weyn, Peter Vermeulen, Eric Van Marck, Filip Lardon, Veronique Fontaine and Jan B Vermorken
    Citation: BMC Cancer 2010 10:117
    Content type: Research article Published on:

  43. Some human cancers demonstrate cellular hierarchies in which tumor-initiating cancer stem cells generate progeny cells with reduced tumorigenic potential. This cancer stem cell population is proposed to be a s...

    Authors: Xiaohua Jiang, Ynnez Gwye, Darren Russell, Christine Cao, Dorothea Douglas, Long Hung, Heinrich Kovar, Timothy J Triche and Elizabeth R Lawlor
    Citation: BMC Cancer 2010 10:116
    Content type: Research article Published on:

  44. Birth size, and particularly birth length, is positively associated with breast cancer risk in adulthood. The objective of this study was to examine whether birth size is associated with survival among breast ...

    Authors: Bjørn O Mæhle, Lars J Vatten and Steinar Tretli
    Citation: BMC Cancer 2010 10:115
    Content type: Research article Published on:

  45. Breast cancer is one of the leading causes of women's death worldwide. It is important to discover a reliable biomarker for the detection of breast cancer. Plasma is the most ideal source for cancer biomarker ...

    Authors: Un-Beom Kang, Younghee Ahn, Jong Won Lee, Yong-Hak Kim, Joon Kim, Myeong-Hee Yu, Dong-Young Noh and Cheolju Lee
    Citation: BMC Cancer 2010 10:114
    Content type: Research article Published on:

  46. Melanoma is the most aggressive form of skin cancer and the most rapidly expanding cancer in terms of worldwide incidence. Chemotherapeutic approaches to treat melanoma have had only marginal success. Previous...

    Authors: Fernando SF Guimarães, Lucas F Andrade, Sharon T Martins, Ana PR Abud, Reginaldo V Sene, Carla Wanderer, Inés Tiscornia, Mariela Bollati-Fogolín, Dorly F Buchi and Edvaldo S Trindade
    Citation: BMC Cancer 2010 10:113
    Content type: Research article Published on:

  47. Tumor-associated macrophages (TAMs) play an important role in growth, progression and metastasis of tumors. In non-small cell lung cancer (NSCLC), TAMs' anti-tumor or pro-tumor role is not determined. Macropha...

    Authors: Junliang Ma, Lunxu Liu, Guowei Che, Nanbin Yu, Fuqiang Dai and Zongbing You
    Citation: BMC Cancer 2010 10:112
    Content type: Research article Published on:

  48. In the HPV FOCAL trial, we will establish the efficacy of hr-HPV DNA testing as a stand-alone screening test followed by liquid based cytology (LBC) triage of hr-HPV-positive women compared to LBC followed by ...

    Authors: Gina S Ogilvie, Dirk J van Niekerk, Mel Krajden, Ruth E Martin, Thomas G Ehlen, Kathy Ceballos, Stuart J Peacock, Laurie W Smith, Lisa Kan, Darrel A Cook, Wendy Mei, Gavin CE Stuart, Eduardo L Franco and Andrew J Coldman
    Citation: BMC Cancer 2010 10:111
    Content type: Study protocol Published on:

  49. Circadian genes continue to gain attention as important transcriptional regulators with the potential to influence a variety of biological pathways, including many cancer-related processes. The core circadian ...

    Authors: Aaron E Hoffman, Tongzhang Zheng, Yue Ba, Richard G Stevens, Chun-Hui Yi, Derek Leaderer and Yong Zhu
    Citation: BMC Cancer 2010 10:110
    Content type: Research article Published on:

  50. The discovery of small non-coding RNAs and the subsequent analysis of microRNA expression patterns in human cancer specimens have provided completely new insights into cancer biology. Genetic and epigenetic da...

    Authors: Ulrich Lehmann, Thomas Streichert, Benjamin Otto, Cord Albat, Britta Hasemeier, Henriette Christgen, Elisa Schipper, Ursula Hille, Hans H Kreipe and Florian Länger
    Citation: BMC Cancer 2010 10:109
    Content type: Research article Published on:

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