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  1. In the American region, Puerto Rico (PR) has the highest incidence of oral and pharyngeal cancer (OPC), but racial/ethnic differences have never been assessed and compared with other groups in the United State...

    Authors: Erick Suárez, William A Calo, Eduardo Y Hernández, Elba C Diaz, Nayda R Figueroa and Ana P Ortiz
    Citation: BMC Cancer 2009 9:129
    Content type: Research article Published on:

  2. Aberrant regulation of cell migration drives progression of many diseases, including cancer cell invasion and metastasis formation. Analysis of tumour invasion and metastasis in living organisms to date is cum...

    Authors: Ines J Marques, Frank Ulrich Weiss, Danielle H Vlecken, Claudia Nitsche, Jeroen Bakkers, Anne K Lagendijk, Lars Ivo Partecke, Claus-Dieter Heidecke, Markus M Lerch and Christoph P Bagowski
    Citation: BMC Cancer 2009 9:128
    Content type: Research article Published on:

  3. Our purpose was to collect preliminary data on newly diagnosed breast cancer patient knowledge of prognosis before and after oncology visits. Many oncologists use a validated prognostic software model, Adjuvan...

    Authors: Jeffrey K Belkora, Hope S Rugo, Dan H Moore, David W Hutton, Daniel F Chen and Laura J Esserman
    Citation: BMC Cancer 2009 9:127
    Content type: Research article Published on:

  4. Compared with viral vectors, nonviral vectors are less immunogenic, more stable, safer and easier to replication for application in cancer gene therapy. However, nonviral gene delivery system has not been exte...

    Authors: Yu Kang, Xiaoyan Zhang, Wei Jiang, Chaoqun Wu, Chunmei Chen, Yufang Zheng, Jianren Gu and Congjian Xu
    Citation: BMC Cancer 2009 9:126
    Content type: Research article Published on:

  5. Similarly to other tumor types, an imbalance between unrestrained cell proliferation and impaired apoptosis appears to be a major unfavorable feature of hepatocellular carcinoma (HCC). The members of IAP famil...

    Authors: Claudia Augello, Luca Caruso, Marco Maggioni, Matteo Donadon, Marco Montorsi, Roberto Santambrogio, Guido Torzilli, Valentina Vaira, Caterina Pellegrini, Massimo Roncalli, Guido Coggi and Silvano Bosari
    Citation: BMC Cancer 2009 9:125
    Content type: Research article Published on:

  7. Methylation of DNA is a common mechanism for silencing genes, and aberrant methylation is increasingly being implicated in many diseases such as cancer. There is a need for robust, inexpensive methods to quant...

    Authors: Eric Smith, Michael E Jones and Paul A Drew
    Citation: BMC Cancer 2009 9:123
    Content type: Technical advance Published on:

  8. Several studies have determined that dietary intake of B vitamins may be associated with breast cancer risk as a result of interactions between 5,10-methylenetetrahydrofolate reductase (MTHFR) and methionine synt...

    Authors: Enbo Ma, Motoki Iwasaki, Ishihara Junko, Gerson Shigeaki Hamada, Ines Nobuko Nishimoto, Solange Maria Torchia Carvalho, Juvenal Motola Jr, Fábio Martins Laginha and Shoichiro Tsugane
    Citation: BMC Cancer 2009 9:122
    Content type: Research article Published on:

  9. A recent model for activation of the zymogen form of matrix metalloproteinase 2 (MMP-2, also known as gelatinase A) has suggested that interactions between the SIBLING protein bone sialoprotein (BSP) and MMP-2...

    Authors: Queena Hwang, Sela Cheifetz, Christopher M Overall, Christopher A McCulloch and Jaro Sodek
    Citation: BMC Cancer 2009 9:121
    Content type: Research article Published on:

  10. Phase II studies have shown that the combination of capecitabine and irinotecan (the XELIRI regimen) is active in metastatic colorectal cancer (MCRC). There are, however, no data about the use of the XELIRI re...

    Authors: Erik Skof, Martina Rebersek, Zvezdana Hlebanja and Janja Ocvirk
    Citation: BMC Cancer 2009 9:120
    Content type: Research article Published on:

  11. Central nervous system is a common site of metastasis in NSCLC and confers worse prognosis and quality of life. The aim of this prospective study was to evaluate the prognostic significance of clinical-patholo...

    Authors: Oscar Arrieta, David Saavedra-Perez, Roberto Kuri, Alejandro Aviles-Salas, Luis Martinez, Daniel Mendoza-Posada, Patricia Castillo, Alma Astorga, Enrique Guzman and Jaime De la Garza
    Citation: BMC Cancer 2009 9:119
    Content type: Research article Published on:

  14. Comorbidity has a well documented detrimental effect on cancer survival. However it is difficult to disentangle the direct effects of comorbidity on survival from indirect effects via the influence of comorbid...

    Authors: Diana Sarfati, Sarah Hill, Tony Blakely, Bridget Robson, Gordon Purdie, Elizabeth Dennett, Donna Cormack and Kevin Dew
    Citation: BMC Cancer 2009 9:116
    Content type: Research article Published on:

  15. Estrogens, environmental chemicals with carcinogenic potential, as well as oxidative and carbonyl stresses play a very important role in breast cancer (BC) genesis and progression. Therefore, polymorphisms of ...

    Authors: Cinzia Antognelli, Chiara Del Buono, Vienna Ludovini, Stefania Gori, Vincenzo N Talesa, Lucio Crinò, Francesco Barberini and Antonio Rulli
    Citation: BMC Cancer 2009 9:115
    Content type: Research article Published on:

  16. The study tested the hypothesis that apoptosis can prevent and control growth of neoplastic cells. Previous studies in-vitro have shown that the pro-apoptotic P2X7 receptor regulates growth of epithelial cells. T...

    Authors: Wen Fu, Tom McCormick, Xiaoping Qi, Liping Luo, Lingyin Zhou, Xin Li, Bing-Cheng Wang, Heidi E Gibbons, Fadi W Abdul-Karim and George I Gorodeski
    Citation: BMC Cancer 2009 9:114
    Content type: Research article Published on:

  17. The study of somatic DNA instabilities constitutes a debatable topic because different causes can lead to seeming DNA alteration patterns between different cells or tissues from the same individual. Carcinogen...

    Authors: Hans-Jürgen Bandelt and Antonio Salas
    Citation: BMC Cancer 2009 9:113
    Content type: Correspondence Published on:

  18. This study was designed to investigate the efficacy and safety of the epidermal growth factor receptor (EGFR) inhibitor cetuximab combined with irinotecan, folinic acid (FA) and two different doses of infusion...

    Authors: Jean-Luc Raoul, Jean-Luc Van Laethem, Marc Peeters, Catherine Brezault, Fares Husseini, Laurent Cals, Johannes Nippgen, Anja-Helena Loos and Philippe Rougier
    Citation: BMC Cancer 2009 9:112
    Content type: Research article Published on:

  19. Mutations in the KRAS gene are one of the most frequent genetic abnormalities in ovarian carcinoma. They are of renewed interest as new epidermal growth factor receptor (EGFR)-targeted therapies are being investi...

    Authors: Veronika Auner, Gernot Kriegshäuser, Dan Tong, Reinhard Horvat, Alexander Reinthaller, Alexander Mustea and Robert Zeillinger
    Citation: BMC Cancer 2009 9:111
    Content type: Research article Published on:

  20. Because treatment of advanced gastric cancer (AGC) patients after failure with first-line chemotherapy remains controversial, we performed this retrospective analysis based on the data obtained from 1455 patie...

    Authors: Sang Hoon Ji, Do Hyoung Lim, Seong Yoon Yi, Hyo Song Kim, Hyun Jung Jun, Kyoung Ha Kim, Myung Hee Chang, Min Jae Park, Ji Eun Uhm, Jeeyun Lee, Se Hoon Park, Joon Oh Park, Young Suk Park, Ho Yeong Lim and Won Ki Kang
    Citation: BMC Cancer 2009 9:110
    Content type: Research article Published on:

  21. Sentinel lymph node (SLN) biopsy is a widely used diagnostic procedure in the management of early breast cancer. When SLN is free of metastasis, complete axillary dissection may be skipped for staging in clini...

    Authors: Anna V Britto, André A Schenka, Natália G Moraes-Schenka, Marcelo Alvarenga, Júlia Y Shinzato, José Vassallo and Laura S Ward
    Citation: BMC Cancer 2009 9:109
    Content type: Research article Published on:

  22. One of the basic prerequisites for generating evidence-based data is the availability of classification systems. Attempts to date to classify breast cancer operations have focussed on specific problems, e.g. t...

    Authors: Jürgen Hoffmann and Diethelm Wallwiener
    Citation: BMC Cancer 2009 9:108
    Content type: Research article Published on:

  23. Antineoplastic drug cisplatin remains the drug of choice for various solid tumours including breast cancer. But dose dependent nephrotoxicity is the major drawback in majority of platinum based chemotherapy re...

    Authors: Kulbhushan Tikoo, Parveen Kumar and Jeena Gupta
    Citation: BMC Cancer 2009 9:107
    Content type: Research article Published on:

  24. Pancreatic cancer is a devastating disease characterized by dismal 5-year survival rates and limited treatment options. In an effort to provide useful models for preclinical evaluation of new experimental ther...

    Authors: Cynthia S Snyder, Sharmeela Kaushal, Yuko Kono, Hop S Tran Cao, Robert M Hoffman and Michael Bouvet
    Citation: BMC Cancer 2009 9:106
    Content type: Research article Published on:

  25. Prognostic scores might be useful tools both in clinical practice and clinical trials, where they can be used as stratification parameter. The available scores for patients with brain metastases have never bee...

    Authors: Carsten Nieder, Kirsten Marienhagen, Sabrina T Astner and Michael Molls
    Citation: BMC Cancer 2009 9:105
    Content type: Research article Published on:

  26. Breast cancer belongs to the most frequent and severe cancer types in human. Since excretion of modified nucleosides from increased RNA metabolism has been proposed as a potential target in pathogenesis of bre...

    Authors: Carsten Henneges, Dino Bullinger, Richard Fux, Natascha Friese, Harald Seeger, Hans Neubauer, Stefan Laufer, Christoph H Gleiter, Matthias Schwab, Andreas Zell and Bernd Kammerer
    Citation: BMC Cancer 2009 9:104
    Content type: Research article Published on:

  27. Insulin-like growth factor binding protein 5 (IGFBP5) has been shown to be associated with breast cancer metastasis in clinical marker studies. However, a major difficulty in understanding how IGFBP5 functions...

    Authors: Mustafa Akkiprik, Limei Hu, Aysegul Sahin, Xishan Hao and Wei Zhang
    Citation: BMC Cancer 2009 9:103
    Content type: Research article Published on:

  28. Bone metastases are frequent complications of breast cancer. Recent literature implicates multiple chemokines in the formation of bone metastases in breast cancer. However, the molecular mechanism of metastati...

    Authors: Dongqing Cai, Jie Cao, Zhen Li, Xin Zheng, Yao Yao, Wanglin Li and Ziqiang Yuan
    Citation: BMC Cancer 2009 9:102
    Content type: Research article Published on:

  29. In recurrent malignant gliomas (MGs), a high rate of haematological toxicity is observed with the use of fotemustine at the conventional schedule (100 mg/m2 weekly for 3 consecutive weeks followed by triweekly ad...

    Authors: Alessandra Fabi, Giulio Metro, Michelangelo Russillo, Antonello Vidiri, Carmine Maria Carapella, Marta Maschio, Francesco Cognetti, Bruno Jandolo, Maria Alessandra Mirri, Isabella Sperduti, Stefano Telera, Mariantonia Carosi and Andrea Pace
    Citation: BMC Cancer 2009 9:101
    Content type: Research article Published on:

  30. During the process of metastasis, cells are subjected to various apoptotic stimuli. Aberrant expression of apoptotic regulators often contribute to cell metastasis. Heat shock protein 27(HSP27) is confirmed as...

    Authors: Kun Guo, Nan Xiao Kang, Yan Li, Lu Sun, Lin Gan, Feng Jie Cui, Mei Dong Gao and Kun Yin Liu
    Citation: BMC Cancer 2009 9:100
    Content type: Research article Published on:

  31. Colorectal carcinoma is one of the major causes of morbidity and mortality in the Western World. Novel therapeutic approaches are needed for colorectal carcinoma. Curcumin, the active component and yellow pigm...

    Authors: Ling Cen, Brian Hutzen, Sarah Ball, Stephanie DeAngelis, Chun-Liang Chen, James R Fuchs, Chenglong Li, Pui-Kai Li and Jiayuh Lin
    Citation: BMC Cancer 2009 9:99
    Content type: Research article Published on:

  32. During the last part of the 1990s the chance of surviving breast cancer increased. Changes in survival functions reflect a mixture of effects. Both, the introduction of adjuvant treatments and early screening ...

    Authors: Ester Vilaprinyo, Montserrat Rué, Rafael Marcos-Gragera and Montserrat Martínez-Alonso
    Citation: BMC Cancer 2009 9:98
    Content type: Research article Published on:

  33. Resistance of high-risk metastatic neuroblastoma (HR-NB) to high dose chemotherapy (HD-CT) raises a major therapeutic challenge in pediatric oncology. Patients are treated by maintenance CT. For some patients,...

    Authors: Gilda Raguénez, Annick Mühlethaler-Mottet, Roland Meier, Caroline Duros, Jean Bénard and Nicole Gross
    Citation: BMC Cancer 2009 9:97
    Content type: Research article Published on:

  35. The extent of angiogenesis is an important prognostic factor for colorectal carcinoma, however, there are few studies concerning changes in angiogenesis with radiotherapy (RTX). Our aim was to investigate chan...

    Authors: Saulius Svagzdys, Vaiva Lesauskaite, Dainius Pavalkis, Irena NedzelskienÄ—, Darius Pranys and Algimantas Tamelis
    Citation: BMC Cancer 2009 9:95
    Content type: Research article Published on:

  36. Interactions between cancer cells and stroma are critical for growth and invasiveness of epithelial tumors. The biochemical mechanisms behind tumor-stromal interactions leading to increased invasiveness and me...

    Authors: Remedios Castelló-Cros, David R Khan, Jeffrey Simons, Matthildi Valianou and Edna Cukierman
    Citation: BMC Cancer 2009 9:94
    Content type: Research article Published on:

  37. The differential diagnosis between follicular thyroid adenoma and minimal invasive follicular thyroid carcinoma is often difficult for several reasons. One major aspect is the lack of typical cytological crite...

    Authors: Nora Hinsch, Matthias Frank, Claudia Döring, Christian Vorländer and Martin-Leo Hansmann
    Citation: BMC Cancer 2009 9:93
    Content type: Research article Published on:

  39. Prostate Cancer (PCa) is the second most frequent neoplasia in men worldwide. Previous reports suggest that the prevalence of PCa in Hispanic males is lower than in Africans (including communities with African...

    Authors: Lauro S Gomez-Guerra, Margarita L Martinez-Fierro, Valeria Alcantara-Aragon, Rocio Ortiz-Lopez, Rebeca T Martinez-Villarreal, Idelma B Morales-Rodriguez, Raquel Garza-Guajardo, Marco A Ponce-Camacho and Augusto Rojas-Martinez
    Citation: BMC Cancer 2009 9:91
    Content type: Research article Published on:

  40. HER-2 gene testing has become an integral part of breast cancer patient diagnosis. The most commonly used assay in the clinical setting for evaluating HER-2 status is immunohistochemistry (IHC) and fluorescence

    Authors: Fabíola E Rosa, Sara M Silveira, Cássia GT Silveira, Nádia A Bérgamo, Francisco A Moraes Neto, Maria AC Domingues, Fernando A Soares, José RF Caldeira and Silvia R Rogatto
    Citation: BMC Cancer 2009 9:90
    Content type: Research article Published on:

  41. There is experimental evidence from animal models favoring the notion that the disruption of interactions between stroma and epithelium plays an important role in the initiation of carcinogenesis. These disrup...

    Authors: Stuart G Baker, Ana M Soto, Carlos Sonnenschein, Antonio Cappuccio, John D Potter and Barnett S Kramer
    Citation: BMC Cancer 2009 9:89
    Content type: Research article Published on:

  43. UbcH10 participates in proper metaphase to anaphase transition, and abrogation of UbcH10 results in the premature separation of sister chromatids. To assess the potential role of UbcH10 in colon cancer progres...

    Authors: Takeo Fujita, Hirokuni Ikeda, Naruto Taira, Shinji Hatoh, Minoru Naito and Hiroyoshi Doihara
    Citation: BMC Cancer 2009 9:87
    Content type: Research article Published on:

  44. Molecular screening for BRCA1 and BRCA2 mutations is now an established component of risk evaluation and management of familial breast cancer. Features of hereditary breast cancer include an early age-of-onset...

    Authors: SR Young, Robert T Pilarski, Talia Donenberg, Charles Shapiro, Lyn S Hammond, Judith Miller, Karen A Brooks, Stephanie Cohen, Beverly Tenenholz, Damini DeSai, Inuk Zandvakili, Robert Royer, Song Li and Steven A Narod
    Citation: BMC Cancer 2009 9:86
    Content type: Research article Published on:

  45. Although cisplatin is one of the most effective chemotherapeutic agents, cisplatin alone does not achieve a satisfactory therapeutic outcome. Also cisplatin accumulation shows toxicity to normal tissues. In th...

    Authors: Hae-Ran Park, Eun-Jin Ju, Sung-Kee Jo, Uhee Jung, Sung-Ho Kim and Sung-Tae Yee
    Citation: BMC Cancer 2009 9:85
    Content type: Research article Published on:

  46. Multidisciplinary attempts to understand the etiology of breast cancer are expanding to increasingly include new potential markers of disease risk. Those efforts may have maximal scientific and practical influ...

    Authors: James V Lacey Jr, Aimee R Kreimer, Saundra S Buys, Pamela M Marcus, Shih-Chen Chang, Michael F Leitzmann, Robert N Hoover, Philip C Prorok, Christine D Berg and Patricia Hartge
    Citation: BMC Cancer 2009 9:84
    Content type: Research article Published on:

  47. BAFF and APRIL share two receptors – TACI and BCMA – and BAFF binds to a third receptor, BAFF-R. Increased expression of BAFF and APRIL is noted in hematological malignancies. BAFF and APRIL are essential for ...

    Authors: Jérôme Moreaux, Jean-Luc Veyrune, John De Vos and Bernard Klein
    Citation: BMC Cancer 2009 9:83
    Content type: Research article Published on:

  48. Sunitinib is a protein tyrosine kinase-inhibitor targeting VEGFR, c-kit and PDGFR. It has been approved for the treatment of metastatic renal-cell carcinoma and gastrointestinal stromal tumors. Although it has...

    Authors: Loukas F Kontovinis, Konstantinos T Papazisis, Panagiota Touplikioti, Charalambos Andreadis, Despoina Mouratidou and Alexandros H Kortsaris
    Citation: BMC Cancer 2009 9:82
    Content type: Research article Published on:

  49. Dysregulation of signal transducer and activator of transcription 3 (STAT3) has been implicated as a key participant in tumor cell survival, proliferation, and metastasis and is often correlated with a more ma...

    Authors: Stacey L Fossey, Albert T Liao, Jennifer K McCleese, Misty D Bear, Jiayuh Lin, Pui-Kai Li, William C Kisseberth and Cheryl A London
    Citation: BMC Cancer 2009 9:81
    Content type: Research article Published on:

  50. The proinflammatory cytokine interleukin-1 (IL-1) is known to play an important role in the carcinogenesis of breast cancer. Although IL-1 gene polymorphisms were reported to be associated with increased risk ...

    Authors: Christoph Grimm, Eva Kantelhardt, Georg Heinze, Stephan Polterauer, Robert Zeillinger, Heinz Kölbl, Alexander Reinthaller and Lukas Hefler
    Citation: BMC Cancer 2009 9:78
    Content type: Research article Published on:

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