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  1. The etiology of hemangiosarcoma remains incompletely understood. Its common occurrence in dogs suggests predisposing factors favor its development in this species. These factors could represent a constellation...

    Authors: Beth A Tamburini, Tzu L Phang, Susan P Fosmire, Milcah C Scott, Susan C Trapp, Megan M Duckett, Sally R Robinson, Jill E Slansky, Leslie C Sharkey, Gary R Cutter, John W Wojcieszyn, Donald Bellgrau, Robert M Gemmill, Lawrence E Hunter and Jaime F Modiano
    Citation: BMC Cancer 2010 10:619
    Content type: Research article Published on:

  2. Epigenetic silencing of tumor suppressor genes play important roles in NPC tumorgenesis. Tissue factor pathway inhibitor-2 (TFPI-2), is a protease inhibitor. Recently, TFPI-2 was suggested to be a tumor suppresso...

    Authors: Shumin Wang, Xue Xiao, Xiaoying Zhou, Tingting Huang, Chunping Du, Nana Yu, Yingxi Mo, Longde Lin, Jinyan Zhang, Ning Ma, Mariko Murata, Guangwu Huang and Zhe Zhang
    Citation: BMC Cancer 2010 10:617
    Content type: Research article Published on:

  3. The Sonic hedgehog (Shh) signaling pathway is critical for cell growth and differentiation. Impairment of this pathway can result in both birth defects and cancer. Despite its importance in cancer development,...

    Authors: Mehdi H Shahi, Mohammad Afzal, Subrata Sinha, Charles G Eberhart, Juan A Rey, Xing Fan and Javier S Castresana
    Citation: BMC Cancer 2010 10:614
    Content type: Research article Published on:

  4. Cyclooxygenase-2 (COX-2) is up-regulated in several types of cancer, and it is hypothesized that COX-2 expression may be genetically influenced. Here, we evaluate the association between single-nucleotide poly...

    Authors: Diogo N Piranda, Juliana S Festa-Vasconcellos, Laura M Amaral, Anke Bergmann and Rosane Vianna-Jorge
    Citation: BMC Cancer 2010 10:613
    Content type: Research article Published on:

  5. Currently the majority of cancer patients are considered ineligible for intensive care treatment and oncologists are struggling to get their patients admitted to intensive care units. Critical care and oncolog...

    Authors: Michael von Bergwelt-Baildon, Michael J Hallek, Alexander A Shimabukuro-Vornhagen and Matthias Kochanek
    Citation: BMC Cancer 2010 10:612
    Content type: Debate Published on:

  6. Elevated Plexin-B1 expression has been found in diverse human cancers and in non-neoplastic tissues, and it mediates diverse biological and pathological activities. However, whether or not Plexin-B1 expression...

    Authors: Shuangmei Ye, Xing Hao, Ting Zhou, Mingfu Wu, Juncheng Wei, Yongjun Wang, Li Zhou, Xuefeng Jiang, Li Ji, Yin Chen, Lanying You, Yiqun Zhang, Gang Xu, Jianfeng Zhou, Ding Ma and Shixuan Wang
    Citation: BMC Cancer 2010 10:611
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2019 19:1164

  7. Oridonin, a tetracycline diterpenoid compound, has the potential antitumor activities. Here, we evaluate the antitumor activity and action mechanisms of oridonin in colorectal cancer.

    Authors: Feng-Hou Gao, Xiao-Hui Hu, Wei Li, Hua Liu, Yan-Jie Zhang, Zhu-Ying Guo, Mang-Hua Xu, Shi-Ting Wang, Bin Jiang, Feng Liu, Ying-Zheng Zhao, Yong Fang, Fang-Yuan Chen and Ying-Li Wu
    Citation: BMC Cancer 2010 10:610
    Content type: Research article Published on:

  9. The validation of novel prognostic indicators is of greatest interest for the management of esophageal adenocarcinoma (Barrett's cancer), particularly for non-metastasized (stage I-IIA) disease. The prognostic...

    Authors: Sandra Rauser, Rupert Langer, Sebastian Tschernitz, Peter Gais, Uta Jütting, Marcus Feith, Heinz Höfler and Axel Walch
    Citation: BMC Cancer 2010 10:608
    Content type: Research article Published on:

  10. Chordomas of the skull base are relative rare lesions of the bones. Surgical resection is the primary treatment standard, though complete resection is nearly impossible due to close proximity to critical and h...

    Authors: Anna V Nikoghosyan, Irini Karapanagiotou-Schenkel, Marc W Münter, Alexandra D Jensen, Stephanie E Combs and Jürgen Debus
    Citation: BMC Cancer 2010 10:607
    Content type: Study protocol Published on:

  11. Low and intermediate grade chondrosarcomas are relative rare bone tumours. About 5-12% of all chondrosarcomas are localized in base of skull region. Low grade chondrosarcoma has a low incidence of distant meta...

    Authors: Anna V Nikoghosyan, Geraldine Rauch, Marc W Münter, Alexandra D Jensen, Stephanie E Combs, Meinhard Kieser and Jürgen Debus
    Citation: BMC Cancer 2010 10:606
    Content type: Study protocol Published on:

  12. Hypoxia induces activation of the HIF-1 pathway and is an essential characteristic of malignant gliomas. Hypoxia has been linked to tumor progression, therapy resistance and poor prognosis. However, little is ...

    Authors: Jacqueline Kessler, Antje Hahnel, Henri Wichmann, Swetlana Rot, Matthias Kappler, Matthias Bache and Dirk Vordermark
    Citation: BMC Cancer 2010 10:605
    Content type: Research article Published on:

  13. Elucidating the activation pattern of molecular pathways across a given tumour type is a key challenge necessary for understanding the heterogeneity in clinical response and for developing novel more effective...

    Authors: Andrew E Teschendorff, Sergio Gomez, Alex Arenas, Dorraya El-Ashry, Marcus Schmidt, Mathias Gehrmann and Carlos Caldas
    Citation: BMC Cancer 2010 10:604
    Content type: Research article Published on:

  14. In the US, foreign-born Hispanics tend to live in socioeconomic conditions typically associated with later stage of breast cancer diagnosis, yet they have lower breast cancer mortality rates than their US-born...

    Authors: Theresa HM Keegan, Thu Quach, Sarah Shema, Sally L Glaser and Scarlett L Gomez
    Citation: BMC Cancer 2010 10:603
    Content type: Research article Published on:

  15. Neuroblastoma (NB) is the second most common solid malignancy of childhood that usually undergoes rapid progression with a poor prognosis upon metastasis. The Src-family tyrosine kinases (SFKs) are a group of ...

    Authors: Michele Navarra, Marilena Celano, Jessica Maiuolo, Silvia Schenone, Maurizio Botta, Adriano Angelucci, Placido Bramanti and Diego Russo
    Citation: BMC Cancer 2010 10:602
    Content type: Research article Published on:

  16. Very low density lipoprotein receptor (VLDLR) has been considered as a multiple function receptor due to binding numerous ligands, causing endocytosis and regulating cellular signaling. Our group previously re...

    Authors: Lei He, Yanjun Lu, Peng Wang, Jun Zhang, Chuanchang Yin and Shen Qu
    Citation: BMC Cancer 2010 10:601
    Content type: Research article Published on:

  17. This study aimed to show that SHOX2 DNA methylation is a tumor marker in patients with suspected lung cancer by using bronchial fluid aspirated during bronchoscopy. Such a biomarker would be clinically valuabl...

    Authors: Bernd Schmidt, Volker Liebenberg, Dimo Dietrich, Thomas Schlegel, Christoph Kneip, Anke Seegebarth, Nadja Flemming, Stefanie Seemann, Jürgen Distler, Jörn Lewin, Reimo Tetzner, Sabine Weickmann, Ulrike Wille, Triantafillos Liloglou, Olaide Raji, Martin Walshaw…
    Citation: BMC Cancer 2010 10:600
    Content type: Research article Published on:

  18. The genetic control of prostate cancer development is poorly understood. Large numbers of gene-expression datasets on different aspects of prostate tumorigenesis are available. We used these data to identify a...

    Authors: Ivan P Gorlov, Kanishka Sircar, Hongya Zhao, Sankar N Maity, Nora M Navone, Olga Y Gorlova, Patricia Troncoso, Curtis A Pettaway, Jin Young Byun and Christopher J Logothetis
    Citation: BMC Cancer 2010 10:599
    Content type: Research article Published on:

  19. Pancreatic cancer is the fourth leading cause of death in the US. Unlike other solid tumors such as testicular cancer which are now curable, more than 90% of pancreatic cancer patients die due to lack of respo...

    Authors: Zhaomin Li, Zizheng Dong, David Myer, Michele Yip-Schneider, Jianguo Liu, Ping Cui, C Max Schmidt and Jian-Ting Zhang
    Citation: BMC Cancer 2010 10:598
    Content type: Research article Published on:

  20. Several investigators have employed high throughput mitochondrial sequencing array (MitoChip) in clinical studies to search mtDNA for markers linked to cancers. In consequence, a host of somatic mtDNA mutation...

    Authors: Malliya Gounder Palanichamy and Ya-Ping Zhang
    Citation: BMC Cancer 2010 10:597
    Content type: Research article Published on:

  21. Prostate tumours are commonly poorly oxygenated which is associated with tumour progression and development of resistance to chemotherapeutic drugs and radiotherapy. Fibroblast growth factor 8b (FGF8b) is a mi...

    Authors: Johanna Tuomela, Tove J Grönroos, Maija P Valta, Jouko Sandholm, Aleksi Schrey, Jani Seppänen, Päivi Marjamäki, Sarita Forsback, Ilpo Kinnunen, Olof Solin, Heikki Minn and Pirkko L Härkönen
    Citation: BMC Cancer 2010 10:596
    Content type: Research article Published on:

  22. The anti-infective agent Taurolidine (TRD) has been shown to have cell death inducing properties, but the mechanism of its action is largely unknown. The aim of this study was to identify potential common targ...

    Authors: Ansgar M Chromik, Stephan A Hahn, Adrien Daigeler, Annegret Flier, Daniel Bulut, Christina May, Kamran Harati, Jan Roschinsky, Dominique Sülberg, Dirk Weyhe, Ulrich Mittelkötter and Waldemar Uhl
    Citation: BMC Cancer 2010 10:595
    Content type: Research article Published on:

  23. The prevalence of anxiety and depressive disorders in cancer patients and its associated factors in Pakistan is not known. There is a need to develop an evidence base to help introduce interventions as untreat...

    Authors: Nauman A Jadoon, Waqar Munir, Mohammad A Shahzad and Zeshan S Choudhry
    Citation: BMC Cancer 2010 10:594
    Content type: Research article Published on:

  24. Glioblastoma multiforme (GBM) is the most malignant intracranial tumour that develops in both adults and children. Microarray gene analyses have confirmed that the human YKL-40 gene is one of the most over-exp...

    Authors: Wei Zhang, Koji Murao, Xiang Zhang, Kensuke Matsumoto, Suwarni Diah, Masaki Okada, Keisuke Miyake, Nobuyuki Kawai, Zhou Fei and Takashi Tamiya
    Citation: BMC Cancer 2010 10:593
    Content type: Research article Published on:

  25. Intrinsic to "Patient-Centered Care" is being respectful and responsive to individual patient preferences, expressed needs, and personal values. Establishing a patient's preferences for active and aggressive i...

    Authors: Vincent Maida, Jonathan Peck, Marguerite Ennis, Navjot Brar and Alexandria R Maida
    Citation: BMC Cancer 2010 10:592
    Content type: Research article Published on:

  26. Circulating cell-free microRNAs have been identified as potential cancer biomarkers. However, the existence and the potential application of cell-free miRNAs in effusion samples are still uncertain. In order t...

    Authors: Li Xie, Xi Chen, Lifeng Wang, Xiaoping Qian, Tingting Wang, Jia Wei, Lixia Yu, Yitao Ding, Chenyu Zhang and Baorui Liu
    Citation: BMC Cancer 2010 10:591
    Content type: Research article Published on:

  27. Lung cancer remains the leading cause of cancer-related mortality despite continuous efforts to find effective treatments. Data from the American Cancer Society indicate that while the overall incidence of lun...

    Authors: Dharmendra K Maurya, Chiyo Doi, Atsushi Kawabata, Marla M Pyle, Clay King, Zhihong Wu, Deryl Troyer and Masaaki Tamura
    Citation: BMC Cancer 2010 10:590
    Content type: Research article Published on:

  28. Electrotherapy effectiveness at different doses has been demonstrated in preclinical and clinical studies; however, several aspects that occur in the tumor growth kinetics before and after treatment have not y...

    Authors: Luis E Bergues Cabrales, Juan J Godina Nava, Andrés Ramírez Aguilera, Javier A González Joa, Héctor M Camué Ciria, Maraelys Morales González, Miriam Fariñas Salas, Manuel Verdecia Jarque, Tamara Rubio González, Miguel A O'Farril Mateus, Soraida C Acosta Brooks, Fabiola Suárez Palencia, Lisset Ortiz Zamora, María C Céspedes Quevedo, Sarah Edward Seringe, Vladimir Crombet Cuitié…
    Citation: BMC Cancer 2010 10:589
    Content type: Research article Published on:

  29. It is known that alpha-defensin expression is enhanced in colon cancer. However, the expression of human alpha defensin 6 (DEFA 6) in earlier stages, such as adenoma, has so far not yet been studied in a patie...

    Authors: Mariya Y Radeva, Franziska Jahns, Anne Wilhelm, Michael Glei, Utz Settmacher, Karl Otto Greulich and Henning Mothes
    Citation: BMC Cancer 2010 10:588
    Content type: Research article Published on:

  30. Only a few studies have addressed the molecular pathways specifically involved in carcinogenesis of the distal colon and rectum. We aimed to identify potential differences among genetic alterations in distal c...

    Authors: Manuela Pinheiro, Terje Ahlquist, Stine A Danielsen, Guro E Lind, Isabel Veiga, Carla Pinto, Vera Costa, Luís Afonso, Olga Sousa, Maria Fragoso, Lúcio Santos, Rui Henrique, Paula Lopes, Carlos Lopes, Ragnhild A Lothe and Manuel R Teixeira
    Citation: BMC Cancer 2010 10:587
    Content type: Research article Published on:

  31. Developing the right drugs for the right patients has become a mantra of drug development. In practice, it is very difficult to identify subsets of patients who will respond to a drug under evaluation. Most of...

    Authors: Erich P Huang, Jane Fridlyand, Nicholas Lewin-Koh, Peng Yue, Xiaoyan Shi, David Dornan and Bart Burington
    Citation: BMC Cancer 2010 10:586
    Content type: Research article Published on:

  32. Ovarian fibrosarcomas are very rare tumors, and therefore, few case studies have evaluated the prognostic factors of this disease. To our knowledge, this study represents the largest study to evaluate the clin...

    Authors: Long Huang, Ling-Min Liao, Hui-Yun Wang and Min Zheng
    Citation: BMC Cancer 2010 10:585
    Content type: Research article Published on:

  33. Lung cancer causes the highest rate of cancer-related deaths both in men and women. As many current treatment modalities are inadequate in increasing patient survival, new therapeutic strategies are required. ...

    Authors: Cigdem Aydin, Ahter D Sanlioglu, Atil Bisgin, Burcak Yoldas, Levent Dertsiz, Bahri Karacay, Thomas S Griffith and Salih Sanlioglu
    Citation: BMC Cancer 2010 10:584
    Content type: Research article Published on:

  34. Cisplatin-based chemotherapy, in combination with fluoropyrimidines or taxanes, have demonstrated efficacy against advanced gastric cancer (AGC). This retrospective study was performed with the data obtained f...

    Authors: Do Hyoung Lim, Se Hoon Park, Keon Woo Park, Jung Hun Kang, Sung Yong Oh, In Gyu Hwang, Jung Mi Kwon, Sang-Cheol Lee, Hui-Young Lee, Hyeong Su Kim, Ho Yeong Lim and Won Ki Kang
    Citation: BMC Cancer 2010 10:583
    Content type: Research article Published on:

  35. This study investigated potential prognostic factors in patients treated with whole-brain irradiation (WBI) alone for brain metastases from relatively radioresistant tumors such as malignant melanoma, renal ce...

    Authors: Thekla Meyners, Christine Heisterkamp, Jan-Dirk Kueter, Theo Veninga, Lukas JA Stalpers, Steven E Schild and Dirk Rades
    Citation: BMC Cancer 2010 10:582
    Content type: Research article Published on:

  36. Chemotherapy-induced anemia (CIA) is responsive to treatment with erythropoiesis-stimulating agents (ESAs) such as darbepoetin alfa. Administration of ESAs on a synchronous schedule with chemotherapy administr...

    Authors: Lee Schwartzberg, Ronald Burkes, Barry Mirtsching, Timothy Rearden, Peter Silberstein, Lorrin Yee, Amy Inamoto and Tom Lillie
    Citation: BMC Cancer 2010 10:581
    Content type: Research article Published on:

  37. Liver resection is a widely accepted treatment for hepatocellular carcinoma (HCC). Our previous clinical study showed that the rate of palliative resection was 34.0% (1958-2008, 2754 of 8107). However, the inf...

    Authors: Xiu-Yan Huang, Zi-Li Huang, Lu Wang, Yong-Hua Xu, Xin-Yu Huang, Kai-Xing Ai, Qi Zheng and Zhao-You Tang
    Citation: BMC Cancer 2010 10:580
    Content type: Research article Published on:

  40. NORE1 (RASSF5) is a newly described member of the RASSF family with Ras effector function. NORE1 expression is frequently inactivated by aberrant promoter hypermethylation in many human cancers, suggesting that N...

    Authors: Chang Kyun Lee, Jin-Hee Lee, Min-Goo Lee, Seong-In Jeong, Tae-Kyu Ha, Min-Ju Kang, Byung-Kyu Ryu, Young Hwangbo, Jae-Jun Shim, Jae Young Jang, Kil Yeon Lee, Hyo Jong Kim and Sung-Gil Chi
    Citation: BMC Cancer 2010 10:577
    Content type: Research article Published on:

  41. Most patients with ovarian cancer are diagnosed with advanced stage disease (i.e., stage III-IV), which is associated with a poor prognosis. Differentially expressed genes (DEGs) in stage III serous ovarian carci...

    Authors: Yun-Sook Kim, Jin Hwan Do, Sumi Bae, Dong-Han Bae and Woong Shick Ahn
    Citation: BMC Cancer 2010 10:576
    Content type: Research article Published on:

  42. CYP2E1 encodes a member of the cytochrome P450 superfamily of enzymes which play a central role in activating and detoxifying many carcinogens and endogenous compounds thought to be involved in the development o...

    Authors: Kefu Tang, Yang Li, Zhao Zhang, Yunmin Gu, Yuyu Xiong, Guoyin Feng, Lin He and Shengying Qin
    Citation: BMC Cancer 2010 10:575
    Content type: Research article Published on:

  43. Nasopharyngeal carcinoma (NPC) is a type of neoplasm that is highly prevalent in East Asia and Africa with Epstein-Barr virus (EBV), genetic, and dietary factors implicated as possible aetiologic factors. Prev...

    Authors: Michelle MS Chew, Sook-Yee Gan, Alan SB Khoo and Eng-Lai Tan
    Citation: BMC Cancer 2010 10:574
    Content type: Research article Published on:

  44. An estimated 12% of females in the United States will develop breast cancer in their lifetime. Although, there are advances in treatment options including surgery and chemotherapy, breast cancer is still the s...

    Authors: Jeffrey C Miecznikowski, Dan Wang, Song Liu, Lara Sucheston and David Gold
    Citation: BMC Cancer 2010 10:573
    Content type: Research article Published on:

  45. The optimal protocol for 125I-transperineal prostatic brachytherapy (TPPB) in intermediate-risk prostate cancer (PCa) patients remains controversial. Data on the efficacy of combining androgen-deprivation therapy...

    Authors: Kenta Miki, Takayoshi Kiba, Hiroshi Sasaki, Masahito Kido, Manabu Aoki, Hiroyuki Takahashi, Keiko Miyakoda, Takushi Dokiya, Hidetoshi Yamanaka, Masanori Fukushima and Shin Egawa
    Citation: BMC Cancer 2010 10:572
    Content type: Study protocol Published on:

  46. Telomerase activation, a critical step in cell immortalization and oncogenesis, is partly regulated by alternative splicing. In this study, we aimed to use the Marek's disease virus (MDV) T-cell lymphoma model...

    Authors: Souheila Amor, Sylvie Remy, Ginette Dambrine, Yves Le Vern, Denis Rasschaert and Sylvie Laurent
    Citation: BMC Cancer 2010 10:571
    Content type: Research article Published on:

  47. Gallbladder cancer typically follows an aggressive course, with chemotherapy the standard of care for advanced disease; complete remissions are rarely encountered. The epidermal growth factor receptor (EGFR) i...

    Authors: Kabir Mody, Edward Strauss, Robert Lincer and Richard C Frank
    Citation: BMC Cancer 2010 10:570
    Content type: Case report Published on:

  48. Various studies reported remarkable high incidence rates of depression in cancer patients compared with the general population. Pancreatic cancer is still one of the malignancies with the worst prognosis and t...

    Authors: Martina Mayr and Roland M Schmid
    Citation: BMC Cancer 2010 10:569
    Content type: Debate Published on:

  49. Recent studies have suggested that the Src inhibitor dasatinib preferentially inhibits the growth of breast cancer cells of the basal-like subtype. To clarify this finding and further investigate combined anti...

    Authors: Junichi Kurebayashi, Naoki Kanomata, Takuya Moriya, Yuji Kozuka, Mika Watanabe and Hiroshi Sonoo
    Citation: BMC Cancer 2010 10:568
    Content type: Research article Published on:

  50. Preclinical studies demonstrated that small chain RNA fragments accelerate the recovery of platelets numbers in animals exposed to high doses of chemotherapeutic drugs. There is anecdotal data supporting the s...

    Authors: Robert D Levin, MaryAnn Daehler, James F Grutsch, John L Hall, Digant Gupta and Christopher G Lis
    Citation: BMC Cancer 2010 10:565
    Content type: Research article Published on:

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