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  1. Neuroblastoma is a paediatric cancer which originates from precursor cells of the sympathetic nervous system and accounts for 15% of childhood cancer mortalities. With regards to the role of miRNAs in neurobla...

    Authors: Amanda Tivnan, Lorraine Tracey, Patrick G Buckley, Leah C Alcock, Andrew M Davidoff and Raymond L Stallings
    Citation: BMC Cancer 2011 11:33
  2. Retinoid receptor-induced gene-1 (RRIG1) is a novel gene that has been lost in several types of human cancers. The aim of this study was to determine whether RRIG1 plays a role in breast cancer, such as in the...

    Authors: Guihong Zhang, Abenaa Brewster, Baoxiang Guan, Zhen Fan, Powel H Brown and Xiao-Chun Xu
    Citation: BMC Cancer 2011 11:32
  3. The c-Myb transcription factor regulates differentiation and proliferation in hematopoietic cells, stem cells and epithelial cells. Although oncogenic versions of c-Myb were first associated with leukemias, ov...

    Authors: Anita M Quintana, Fan Liu, John P O'Rourke and Scott A Ness
    Citation: BMC Cancer 2011 11:30
  4. Breast cancer (BrCa) is the most commonly diagnosed cancer among women in the industrialized world. More than half of women presenting with metastatic BrCa develop bone metastases. Bone metastases increase the...

    Authors: Annette Ø Jensen, Jacob B Jacobsen, Mette Nørgaard, Mellissa Yong, Jon P Fryzek and Henrik T Sørensen
    Citation: BMC Cancer 2011 11:29
  5. Antiangiogenesis is a promising therapy for advanced hepatocellular carcinoma (HCC), but the effects are difficult to be evaluated. Pazopanib (GW786034B) is a pan-vascular endothelial growth factor receptor in...

    Authors: Xiao-Dong Zhu, Ju-Bo Zhang, Pei-Li Fan, Yu-Quan Xiong, Peng-Yuan Zhuang, Wei Zhang, Hua-Xiang Xu, Dong-Mei Gao, Ling-Qun Kong, Lu Wang, Wei-Zhong Wu, Zhao-You Tang, Hong Ding and Hui-Chuan Sun
    Citation: BMC Cancer 2011 11:28
  6. Two clinically relevant high-risk HPV (HR-HPV) types 16 and 18 are etiologically associated with the development of cervical carcinoma and are also reported to be present in many other carcinomas in extra-geni...

    Authors: Suresh Hedau, Umesh Kumar, Showket Hussain, Shirish Shukla, Shailja Pande, Neeraj Jain, Abhishek Tyagi, Trivikram Deshpande, Dilafroze Bhat, Mohammad Muzaffar Mir, Sekhar Chakraborty, Y Mohan Singh, Rakesh Kumar, Kumaravel Somasundaram, Alok C Bharti and Bhudev C Das
    Citation: BMC Cancer 2011 11:27
  7. Osteopontin (OPN) is a secreted phosphoprotein often overexpressed at high levels in the blood and primary tumors of breast cancer patients. OPN contains two integrin-binding sites and a thrombin cleavage doma...

    Authors: Michel S Beausoleil, Erika B Schulze, David Goodale, Carl O Postenka and Alison L Allan
    Citation: BMC Cancer 2011 11:25
  8. The JAK2V617F mutation plays a major role in the pathogenesis of myeloproliferative neoplasms and is found in the vast majority of patients suffering from polycythemia vera and in roughly every second patient suf...

    Authors: Joëlle Rubert, Zhiyan Qian, Rita Andraos, Daniel A Guthy and Thomas Radimerski
    Citation: BMC Cancer 2011 11:24
  9. Transitional cell carcinoma (TCC) of the female urethra is a rare urological malignancy, and intracranial metastasis of this cancer has not yet been reported in the literature. This review is intended to prese...

    Authors: Kyung-Sub Moon, Shin Jung, Kyung-Hwa Lee, Eu Chang Hwang and In-Young Kim
    Citation: BMC Cancer 2011 11:23
  10. ARHI is a Ras-related imprinted gene that inhibits cancer cell growth and motility. ARHI is downregulated in the majority of breast cancers, and loss of its expression is associated with its progression from duc...

    Authors: Chun-Fang Zou, Luoqi Jia, Hongyan Jin, Ming Yao, Naiqing Zhao, Jin Huan, Zhen Lu, Robert C Bast Jr, Youji Feng and Yinhua Yu
    Citation: BMC Cancer 2011 11:22
  11. The treatment of high-risk neuroblastoma patients consists of multimodal induction therapy to achieve remission followed by consolidation therapy to prevent relapses. However, the type of consolidation therapy...

    Authors: Thorsten Simon, Barbara Hero, Andreas Faldum, Rupert Handgretinger, Martin Schrappe, Thomas Klingebiel and Frank Berthold
    Citation: BMC Cancer 2011 11:21
  12. Metformin protection against cancer risk in Orientals is uncertain. We examined the possible metformin effect on total, esophageal, gastric, colorectal (CRC), hepatocellular (HCC) and pancreatic cancers in a T...

    Authors: Meei-Shyuan Lee, Chih-Cheng Hsu, Mark L Wahlqvist, Hsin-Ni Tsai, Yu-Hung Chang and Yi-Chen Huang
    Citation: BMC Cancer 2011 11:20
  13. Many cancer patients seek homeopathy as a complementary therapy. It has rarely been studied systematically, whether homeopathic care is of benefit for cancer patients.

    Authors: Matthias Rostock, Johannes Naumann, Corina Guethlin, Lars Guenther, Hans H Bartsch and Harald Walach
    Citation: BMC Cancer 2011 11:19
  14. Sentinel node (SN) biopsy has been practiced in gastric cancer in recent years, and many studies focused on the distribution of solitary lymph node metastasis (SLM) to assess the pattern of SN. In fact, there ...

    Authors: Baojun Huang, Zhenning Wang, Zhe Sun, Bo Zhao and Huimian Xu
    Citation: BMC Cancer 2011 11:18
  15. "High risk" Human Papillomavirus strains are the causative agents of the vast majority of carcinomas of the uterine cervix. In these tumors, the physical integration of the HPV genome is a frequent, though not...

    Authors: Luisa Accardi, Maria Gabriella Donà, Anna M Mileo, Marco G Paggi, Antonio Federico, Paola Torreri, Tamara C Petrucci, Rosita Accardi, David Pim, Massimo Tommasino, Lawrence Banks, Barbara Chirullo and Colomba Giorgi
    Citation: BMC Cancer 2011 11:17
  16. Local pelvic recurrence after radical cystectomy for muscle invasive bilharzial related squamous cell carcinoma accounts for 75% of treatment failures even in organ confined tumors. Despite the proven value of...

    Authors: Ahmad M Abdel Raheem, Diaa A Hameed, Ehab O ElGanainy, Eman Mosad, Mostafa E Abdelwanis, Nermen A Kamel, Hisham M Hammouda, Mohammad A Abdelaziz and Khaled Hemeyda
    Citation: BMC Cancer 2011 11:16
  17. Pancreatic ductal adenocarcinoma (PDAC) is highly resistant to conventional chemotherapy, in part due to the overexpression of inhibitors of apoptosis proteins (IAPs). Smac is an endogenous IAP-antagonist, whi...

    Authors: Niranjan Awasthi, Amanda Kirane, Margaret A Schwarz, Jason E Toombs, Rolf A Brekken and Roderich E Schwarz
    Citation: BMC Cancer 2011 11:15
  18. Several studies have shown that NDRG2 mRNA is down-regulated or undetectable in various human cancers and cancer cell-lines. Although the function of NDRG2 is currently unknown, high NDRG2 expression correlates w...

    Authors: Anders Lorentzen, Rikke H Lewinsky, Jette Bornholdt, Lotte K Vogel and Cathy Mitchelmore
    Citation: BMC Cancer 2011 11:14
  19. Authors: Yoon-La Choi, Ensel Oh, Sarah Park, Yeonju Kim, Yeon-Hee Park, Kyug Song, Eun Yoon Cho, Yun-Chul Hong, Jong Sun Choi, Jeong Eon Lee, Jung Han Kim, Seok Jin Nam, Young-Hyuck Lim, Jung-Hyun Yang and Young Kee Shin
    Citation: BMC Cancer 2011 11:13

    The original article was published in BMC Cancer 2010 10:507

  20. Carbonic anhydrase IX (CAIX) is a membranous expressed metalloenzyme involved in pH homeostasis and cell adhesion. The protein is overexpressed in a variety of tumors and potentially associated with negative o...

    Authors: Linn Woelber, Kerstin Kress, Jan F Kersten, Matthias Choschzick, Ergin Kilic, Uwe Herwig, Christoph Lindner, Joerg Schwarz, Fritz Jaenicke, Sven Mahner, Karin Milde-Langosch, Volkmar Mueller and Maike Ihnen
    Citation: BMC Cancer 2011 11:12
  21. Mounting evidence has indicated that ABI3 (ABI family member 3) function as a tumor suppressor gene, although the molecular mechanism by which ABI3 acts remains largely unknown.

    Authors: Flavia RM Latini, Jefferson P Hemerly, Beatriz CG Freitas, Gisele Oler, Gregory J Riggins and Janete M Cerutti
    Citation: BMC Cancer 2011 11:11
  22. Lymph node metastasis (LNM) of gastric cancer is an important prognostic factor regarding long-term survival. But several imaging techniques which are commonly used in stomach cannot satisfactorily assess the ...

    Authors: Xiao-Peng Zhang, Zhi-Long Wang, Lei Tang, Ying-Shi Sun, Kun Cao and Yun Gao
    Citation: BMC Cancer 2011 11:10
  23. Ribonucleases are promising agents for use in anticancer therapy. Among the different ribonucleases described to be cytotoxic, a paradigmatic example is onconase which manifests cytotoxic and cytostatic effect...

    Authors: Jessica Castro, Marc Ribó, Susanna Navarro, Maria Victòria Nogués, Maria Vilanova and Antoni Benito
    Citation: BMC Cancer 2011 11:9
  24. The extracellular signal-regulated kinase-1 and 2 (ERK1/2) proteins play an important role in cancer cell proliferation and survival. ERK1/2 proteins also are important for normal cell functions. Thus, anti-ca...

    Authors: Sarice R Boston, Rahul Deshmukh, Scott Strome, U Deva Priyakumar, Alexander D MacKerell Jr and Paul Shapiro
    Citation: BMC Cancer 2011 11:7
  25. It has been estimated that between 5% and 10% of women diagnosed with breast cancer have a hereditary form of the disease, primarily caused by a BRCA1 or BRCA2 gene mutation. Such women have an increased risk of ...

    Authors: Marijke R Wevers, Margreet GEM Ausems, Senno Verhoef, Eveline MA Bleiker, Daniela EE Hahn, Frans BL Hogervorst, Rob B van der Luijt, Heiddis B Valdimarsdottir, Richard van Hillegersberg, Emiel JTh Rutgers and Neil K Aaronson
    Citation: BMC Cancer 2011 11:6
  26. A number of studies have identified advanced age as a barrier to accessing specialised oncological care. Many factors can influence the care provided for elderly patients after a diagnosis of cancer has been e...

    Authors: Fleur Delva, Emilie Marien, Marianne Fonck, Muriel Rainfray, Jean-Louis Demeaux, Philippe Moreaud, Pierre Soubeyran, Annie J Sasco and Simone Mathoulin-Pélissier
    Citation: BMC Cancer 2011 11:5
  27. As cell-free circulating DNA exists predominantly as mono- and oligonucleosomes, the focus of the current study was to examine the interplay of circulating nucleosomes, DNA, proteases and caspases in blood of ...

    Authors: Carina Roth, Klaus Pantel, Volkmar Müller, Brigitte Rack, Sabine Kasimir-Bauer, Wolfgang Janni and Heidi Schwarzenbach
    Citation: BMC Cancer 2011 11:4
  28. Runt-related transcription factor 3 (RUNX3) is known as a tumor suppressor gene for gastric cancer and other cancers, this gene may be involved in the development of hepatocellular carcinoma (HCC).

    Authors: Yutaka Nakanishi, Hidenori Shiraha, Shin-ichi Nishina, Shigetomi Tanaka, Minoru Matsubara, Shigeru Horiguchi, Masaya Iwamuro, Nobuyuki Takaoka, Masayuki Uemura, Kenji Kuwaki, Hiroaki Hagihara, Junichi Toshimori, Hideki Ohnishi, Akinobu Takaki, Shinichiro Nakamura, Yoshiyuki Kobayashi…
    Citation: BMC Cancer 2011 11:3
  29. Adequate nodal harvest (≥ 12 lymph nodes) in colorectal cancer has been shown to optimize staging and proposed as a quality indicator of colorectal cancer care. An audit within a single health district in Nova...

    Authors: Geoffrey A Porter, Robin Urquhart, Jingyu Bu, Paul Johnson and Eva Grunfeld
    Citation: BMC Cancer 2011 11:2
  30. Gefitinib was the first epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) approved for the treatment of advanced non-small cell lung cancer (NSCLC). Few treatment options are available for ...

    Authors: Satoshi Watanabe, Junta Tanaka, Takeshi Ota, Rie Kondo, Hiroshi Tanaka, Hiroshi Kagamu, Kosuke Ichikawa, Jun Koshio, Junko Baba, Takao Miyabayashi, Ichiei Narita and Hirohisa Yoshizawa
    Citation: BMC Cancer 2011 11:1
  31. In the setting of recurrent events, research studies commonly count only the first occurrence of an outcome in a subject. However this approach does not correctly reflect the natural history of the disease. Th...

    Authors: Virginie Rondeau, Simone Mathoulin-Pélissier, Lucie Tanneau, Annie J Sasco, Gaétan MacGrogan and Marc Debled
    Citation: BMC Cancer 2010 10:697
  32. Stereotactic body radiation therapy (SBRT) applied by helical tomotherapy (HT) is feasible for lung cancer in clinical. Using SBRT concurrently with erlotinib for non-small cell lung cancer (NSCLC) is not repo...

    Authors: Chen-Hsi Hsieh, Hou-Tai Chang, Shih-Chiang Lin, Yu-Jen Chen, Li-Ying Wang, Yen-Ping Hsieh, Chien-An Chen, Ngot-Swan Chong, Shoei Long Lin, Chun-Yi Chen and Pei-Wei Shueng
    Citation: BMC Cancer 2010 10:696
  33. Tyrosine kinase inhibitors (TKI) have enriched the therapeutic options in patients with renal cell carcinoma (RCC), which frequently induce morphological changes in tumors. However, only little is known about ...

    Authors: Viktor Gruenwald, Gernot Beutel, Susanne Schuch-Jantsch, Christoph Reuter, Philipp Ivanyi, Arnold Ganser and Marion Haubitz
    Citation: BMC Cancer 2010 10:695
  34. iASPP is a key inhibitor of tumour suppressor p53 and is found to be up-regulated in certain malignant conditions. The present study investigated the expression of iASPP in clinical lung cancer, a leading canc...

    Authors: Jinfeng Chen, Fei Xie, Lijian Zhang and Wen G Jiang
    Citation: BMC Cancer 2010 10:694
  35. Dexamethasone has been reported to reduce postoperative symptoms after different surgical procedures. We evaluated the efficacy of preoperative dexamethasone in ameliorating postoperative nausea and vomiting (...

    Authors: Jorge Gómez-Hernández, Alba Lorena Orozco-Alatorre, Marisela Domínguez-Contreras, Antonio Oceguera-Villanueva, Salvador Gómez-Romo, Andrea Socorro Alvarez Villaseñor, Clotilde Fuentes-Orozco and Alejandro González-Ojeda
    Citation: BMC Cancer 2010 10:692
  36. The Oncotype DX® Colon Cancer Assay is a new diagnostic test for determining the likelihood of recurrence in stage II colon cancer patients after surgical resection using fixed paraffin embedded (FPE) primary col...

    Authors: Kim M Clark-Langone, Chithra Sangli, Jayadevi Krishnakumar and Drew Watson
    Citation: BMC Cancer 2010 10:691
  37. The amino-acid balance in cancer patients often differs from that in healthy individuals, because of metabolic changes. This study investigated the use of plasma amino-acid profiles as a novel marker for scree...

    Authors: Jun Maeda, Masahiko Higashiyama, Akira Imaizumi, Tomio Nakayama, Hiroshi Yamamoto, Takashi Daimon, Minoru Yamakado, Fumio Imamura and Ken Kodama
    Citation: BMC Cancer 2010 10:690
  38. We evaluate the long-term survival of patients with peritoneal carcinomatosis (PC) treated with systemic chemotherapy regimens, and the impact of the of the retrospective peritoneal disease severity score (PSD...

    Authors: Joerg OW Pelz, Terence C Chua, Jesus Esquivel, Alexander Stojadinovic, Joerg Doerfer, David L Morris, Uwe Maeder, Christoph-Thomas Germer and Alexander G Kerscher
    Citation: BMC Cancer 2010 10:689
  39. Old age at diagnosis is associated with poor survival in colorectal cancer (CRC) for unknown reasons. Recent data show that colonoscopy is efficient in preventing left-sided cancers only. We examine the associ...

    Authors: Kari Hemminki, Irene Santi, Marianne Weires, Hauke Thomsen, Jan Sundquist and Justo Lorenzo Bermejo
    Citation: BMC Cancer 2010 10:688
  40. To date, there are no clinically reliable predictive markers of response to the current treatment regimens for advanced colorectal cancer. The aim of the current study was to compare and assess the power of tr...

    Authors: Wendy L Allen, Puthen V Jithesh, Gavin R Oliver, Irina Proutski, Daniel B Longley, Heinz-Josef Lenz, Vitali Proutski, Paul Harkin and Patrick G Johnston
    Citation: BMC Cancer 2010 10:687
  41. Polycomb Group (PcG) proteins are epigenetic silencers involved in maintaining cellular identity, and their deregulation can result in cancer. Expression of Mel-18 and Bmi-1 has been studied in tumor tissue, b...

    Authors: Margit LH Riis, Torben Lüders, Anne-Jorunn Nesbakken, Hilde S Vollan, Vessela Kristensen and Ida RK Bukholm
    Citation: BMC Cancer 2010 10:686
  42. Oral leukoplakia (OL) is the best-known potentially malignant disorder. A new binary system to grade dysplasia was proposed by WHO, but the biological significance in predicting malignant transformation risk i...

    Authors: Wei Liu, Yu-Feng Wang, Hai-Wei Zhou, Peng Shi, Zeng-Tong Zhou and Guo-Yao Tang
    Citation: BMC Cancer 2010 10:685
  43. Differentiation therapy has been shown effective in treatment of several types of cancer cells and may prove to be effective in treatment of glioblastoma multiforme, the most common and most aggressive primary...

    Authors: Xijun Liu, Jin-Ming Yang, Samuel S Zhang, Xin-Yuan Liu and David X Liu
    Citation: BMC Cancer 2010 10:684
  44. Targeting tumor vasculature is a strategy with great promise in the treatment of many cancers. However, anti-angiogenic reagents that target VEGF/VEGFR2 signaling have met with variable results clinically. Amo...

    Authors: Steven G Patten, Una Adamcic, Kristen Lacombe, Kanwal Minhas, Karolina Skowronski and Brenda L Coomber
    Citation: BMC Cancer 2010 10:683
  45. Gene expression of peripheral myelin protein 22 (PMP22) and the epithelial membrane proteins (EMPs) was found to be differentially expressed in invasive and non-invasive breast cell lines in a previous study. We ...

    Authors: Dan Tong, Georg Heinze, Dietmar Pils, Andrea Wolf, Christian F Singer, Nicole Concin, Gerda Hofstetter, Ingrid Schiebel, Margaretha Rudas and Robert Zeillinger
    Citation: BMC Cancer 2010 10:682
  46. Stable disease (SD) has ambiguous clinical significance for patients according to the dominant Response Evaluation Criteria in Solid Tumours (RECIST). The primary aims of the study were: (1) to clarify the cli...

    Authors: Lijie He, Yuee Teng, Bo Jin, Mingfang Zhao, Ping Yu, Xuejun Hu, Jingdong Zhang, Songbai Li, Yaling Gao and Yunpeng Liu
    Citation: BMC Cancer 2010 10:681
  47. The pharmacotherapeutic treatment of patients with cancer is generally associated with multiple side-effects. Drug interactions and duplicate prescriptions between anti-cancer drugs or interactions with medica...

    Authors: Roelof WF van Leeuwen, Eleonora L Swart, Frits A Boom, Martin S Schuitenmaker and Jacqueline G Hugtenburg
    Citation: BMC Cancer 2010 10:679

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