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  1. Pancreatic carcinoma is a significant cause of cancer-related death in developed countries. As the level of circulating endothelial cells (CECs) is known to increase in response to various cancers, we investig...

    Authors: Shunsuke Kondo, Hideki Ueno, Jun Hashimoto, Chigusa Morizane, Fumiaki Koizumi, Takuji Okusaka and Kenji Tamura
    Citation: BMC Cancer 2012 12:268
    Content type: Research article Published on:

  2. Tumor suppressor genes function to regulate and block tumor cell proliferation. To explore the mechanisms underlying the tumor suppression of BLU/ZMYND10 gene on a frequently lost human chromosomal region, an ade...

    Authors: Xiangning Zhang, Hui Liu, Binbin Li, Peichun Huang, Jianyong Shao and Zhiwei He
    Citation: BMC Cancer 2012 12:267
    Content type: Research article Published on:

  3. Recent evidence suggests an emerging role for S100 protein in breast cancer and tumor progression. These ubiquitous proteins are involved in numerous normal and pathological cell functions including inflammato...

    Authors: Jodie M Fleming, Erika Ginsburg, Shannon D Oliver, Paul Goldsmith and Barbara K Vonderhaar
    Citation: BMC Cancer 2012 12:266
    Content type: Research article Published on:

  4. Advanced ovarian cancer is treated with cytoreductive surgery and combination platinum- and taxane-based chemotherapy. Although most patients have acute clinical response to this strategy, the disease ultimate...

    Authors: Carlos D Gamarra-Luques, Alicia A Goyeneche, Maria B Hapon and Carlos M Telleria
    Citation: BMC Cancer 2012 12:200
    Content type: Research article Published on:

  5. Cancer cachexia is a progressive wasting syndrome and the most prevalent characteristic of cancer in patients with advanced pancreatic adenocarcinoma. We hypothesize that genes expressed in wasted skeletal mus...

    Authors: Alexander Skorokhod, Jeannine Bachmann, Nathalia A Giese, Marc E Martignoni and Holger Krakowski-Roosen
    Citation: BMC Cancer 2012 12:265
    Content type: Research article Published on:

  6. Palliative surgery followed by postoperative chemotherapy is a challenging approach in the treatment of stage IV gastric cancer yet patients must be carefully selected on the basis of likely clinical benefit.

    Authors: John Syrios, Stavros Sougioultzis, Ioannis D Xynos, Nikolaos Kavantzas, Christos Kosmas, George Agrogiannis, John Griniatsos, Ioannis Karavokyros, Emmanouil Pikoulis, Efstratios S Patsouris and Nikolas Tsavaris
    Citation: BMC Cancer 2012 12:264
    Content type: Research article Published on:

  7. The long-term survival in hepatocellullar carcinoma (HCC) patients after transarterial chemoembolization (TACE) remains dismal due to local and/or regional recurrence as well as distant metastasis. The efficac...

    Authors: Xu-Dong Qu, Cheng-Shi Chen, Jian-Hua Wang, Zhi-ping Yan, Jie-min Chen, Gao-quan Gong, Qin-xin Liu, Jian-jun Luo, Lin-xiao Liu, Rong Liu and Sheng Qian
    Citation: BMC Cancer 2012 12:263
    Content type: Research article Published on:

  8. Endometrial carcinoma is a common malignancy of female genital tract. Insulin-like growth factor is known to elicit estrogen-induced mitogenic activity and anti-apoptotic effect in endometrial tissues.

    Authors: Yuan-Jiao Liang, Qun Hao, Hui-Ming Zhang, Yuan-Zhe Wu and Jian-Dong Wang
    Citation: BMC Cancer 2012 12:262
    Content type: Research article Published on:

  9. Patients with cancer of unknown primary account for 10% of patients with metastatic spinal cord compression (MSCC). This retrospective study was performed to identify prognostic factors for functional outcome,...

    Authors: Sarah Douglas, Stefan Huttenlocher, Amira Bajrovic, Volker Rudat, Steven E Schild and Dirk Rades
    Citation: BMC Cancer 2012 12:261
    Content type: Research article Published on:

  10. Colon cancer patients with the same stage show diverse clinical behavior dueto tumor heterogeneity. We aimed to discover distinct classes of tumorsbased on microarray expression patterns, to analyze whether th...

    Authors: Beatriz Perez Villamil, Alejandro Romera Lopez, Susana Hernandez Prieto, Guillermo Lopez Campos, Antonio Calles, Jose Antonio Lopez Asenjo, Julian Sanz Ortega, Cristina Fernandez Perez, Javier Sastre, Rosario Alfonso, Trinidad Caldes, Fernando Martin Sanchez and Eduardo Diaz Rubio
    Citation: BMC Cancer 2012 12:260
    Content type: Research article Published on:

  11. Promoter methylation of the tumor suppressor gene Cyclin A1 could be associated with Human Papillomavirus 16 (HPV16) induced Head and Neck Squamous Cell Carcinoma (HNSCC) and Cervical Carcinoma. There is disagree...

    Authors: Daniel Weiss, Mario Koopmann, Türker Basel and Claudia Rudack
    Citation: BMC Cancer 2012 12:259
    Content type: Research article Published on:

  12. Risk for Ovarian Malignancy Algorithm (ROMA) and Human epididymis protein 4 (HE4) appear to be promising predictors for epithelial ovarian cancer (EOC), however, conflicting results exist in the diagnostic per...

    Authors: Fake Li, Ruxiu Tie, Kai Chang, Feng Wang, Shaoli Deng, Weiping Lu, Lili Yu and Ming Chen
    Citation: BMC Cancer 2012 12:258
    Content type: Research article Published on:

  13. Sulfotransferase 1A1 (SULT1A1) participates in the elimination of 4-hydroxy-tamoxifen (4-OH-TAM), which is one of the major active metabolites of tamoxifen (TAM). Homozygous SULT1A1 variant allele genotype has be...

    Authors: Maria Tengström, Arto Mannermaa, Veli-Matti Kosma, Ari Hirvonen and Vesa Kataja
    Citation: BMC Cancer 2012 12:257
    Content type: Research article Published on:

  14. Postcancer fatigue is a frequently occurring, severe, and invalidating problem, impairing quality of life. Although it is possible to effectively treat postcancer fatigue with cognitive behaviour therapy, the ...

    Authors: Hetty Prinsen, Gijs Bleijenberg, Machiel J Zwarts, Maria T E Hopman, Arend Heerschap and Hanneke W M van Laarhoven
    Citation: BMC Cancer 2012 12:256
    Content type: Study protocol Published on:

  15. Most cases of colorectal cancer (CRC) arise from adenomatous polyps and malignant potential is greatest in high risk adenomas. There is convincing observational evidence that red and processed meat increase th...

    Authors: George Dowswell, Angela Ryan, Aliki Taylor, Amanda Daley, Nick Freemantle, Matthew Brookes, Janet Jones, Richard Haslop, Chloe Grimmett, Kar-Keung Cheng and Wilson Sue
    Citation: BMC Cancer 2012 12:255
    Content type: Research article Published on:

  16. Breast cancer screening in Denmark is organised by the health services in the five regions. Although general practitioners (GPs) are not directly involved in the screening process, they are often the first poi...

    Authors: Line Flytkjær Jensen, Thomas Ostersen Mukai, Berit Andersen and Peter Vedsted
    Citation: BMC Cancer 2012 12:254
    Content type: Research article Published on:

  17. The aim of the study is to assess the effectiveness of intensity-modulated radiotherapy (IMRT) or image-guided radiotherapy (IGRT) for the prevention of retropharyngeal nodal recurrences in locally advanced he...

    Authors: Nam P Nguyen, Jacqueline Vock, Vincent Vinh-Hung, Fabio Almeida, Lars Ewell, Michael Betz, Siyoung Jang, Richard A Vo, Suresh Dutta, Juan Godinez, Ulf Karlsson and Alexander Chi
    Citation: BMC Cancer 2012 12:253
    Content type: Research article Published on:

  18. While it is now more than a decade since the first description of the gene mutation underlying the tumour predisposition syndrome multiple endocrine neoplasia type 1 (MEN1), the mechanism by which its protein ...

    Authors: Kelly A Loffler, Arne W Mould, Paul M Waring, Nicholas K Hayward and Graham F Kay
    Citation: BMC Cancer 2012 12:252
    Content type: Research article Published on:

  19. This pilot study used a prospective longitudinal design to compare the effect of adjuvant whole breast radiation therapy (WBRT) versus partial breast radiation therapy (PBRT) on fatigue, perceived stress, qual...

    Authors: Kevin Albuquerque, Dina Tell, Philip Lobo, Linda Millbrandt, Herbert L Mathews and Linda Witek Janusek
    Citation: BMC Cancer 2012 12:251
    Content type: Research article Published on:

  21. Many miR genes are located within or around CpG islands. It is unclear whether methylation of these CpG islands represses miR transcription regularly. The aims of this study are to characterize gastric carcinoma ...

    Authors: Yantao Du, Zhaojun Liu, Liankun Gu, Jing Zhou, Bu-dong Zhu, Jiafu Ji and Dajun Deng
    Citation: BMC Cancer 2012 12:249
    Content type: Research article Published on:

  22. SOX genes play an important role in a number of developmental processes. Potential roles of SOXs have been demonstrated in various neoplastic tissues as tumor suppressors or promoters depending on tumor status...

    Authors: Wei-de Zhong, Guo-qiang Qin, Qi-shan Dai, Zhao-dong Han, Shan-ming Chen, Xiao-hui Ling, Xin Fu, Chao Cai, Jia-hong Chen, Xi-bin Chen, Zhuo-yuan Lin, Ye-han Deng, Shu-lin Wu, Hui-chan He and Chin-lee Wu
    Citation: BMC Cancer 2012 12:248
    Content type: Research article Published on:

  23. Steroid receptor coactivators (SRCs) may modulate estrogen receptor (ER) activity and the response to endocrine treatment in breast cancer, in part through interaction with growth factor receptor signaling pat...

    Authors: Line L Haugan Moi, Marianne Hauglid Flågeng, Jennifer Gjerde, Andre Madsen, Therese Halvorsen Røst, Oddrun Anita Gudbrandsen, Ernst A Lien and Gunnar Mellgren
    Citation: BMC Cancer 2012 12:247
    Content type: Research article Published on:

  24. Identification of novel, highly penetrant, breast cancer susceptibility genes will require the application of additional strategies beyond that of traditional linkage and candidate gene approaches. Approximate...

    Authors: Julie K Johnson, Nic Waddell and Georgia Chenevix-Trench
    Citation: BMC Cancer 2012 12:246
    Content type: Research article Published on:

  25. Microtubules have been one of the most effective targets for the development of anticancer agents. Cancer cells treated by these agents are characterized by cell arrest at G2/M phase. Microtubule-targeting drugs ...

    Authors: Wei Chen, Teresa Seefeldt, Alan Young, Xiaoying Zhang, Yong Zhao, John Ruffolo, Radhey S Kaushik and Xiangming Guan
    Citation: BMC Cancer 2012 12:245
    Content type: Research article Published on:

  26. Invasion and metastasis are two important hallmarks of malignant tumors caused by complex genetic and epigenetic alterations. The present study investigated the contribution of aberrant methylation profiles of...

    Authors: Zeinab Barekati, Ramin Radpour, Qing Lu, Johannes Bitzer, Hong Zheng, Paolo Toniolo, Per Lenner and Xiao Yan Zhong
    Citation: BMC Cancer 2012 12:244
    Content type: Research article Published on:

  27. Aberrant promoter CpG island hypermethylation is associated with transcriptional silencing. Tumor suppressor genes are the key targets of hypermethylation in breast cancer and therefore may lead to malignancy ...

    Authors: Jia Xu, Priya B Shetty, Weiwei Feng, Carol Chenault, Robert C Bast Jr, Jean-Pierre J Issa, Susan G Hilsenbeck and Yinhua Yu
    Citation: BMC Cancer 2012 12:243
    Content type: Research article Published on:

  28. One of the most important biological characteristics of Glioblastoma multiforme (GBM) is high vascular density. Vadimezan (ASA404, DMXAA) belongs to the class of small molecule vascular disrupting agents (VDA)...

    Authors: Dušan Milanović, Friederike Braun, Wolfgang Weber, Anca Ligia Grosu, Martin Behe and Gabriele Niedermann
    Citation: BMC Cancer 2012 12:242
    Content type: Research article Published on:

  29. Lung cancer in young patients (less or equal to 45 years) is uncommon and has clinical characteristics different from that in older patients. We investigated the outcomes and prognostic factors of young patien...

    Authors: Chia-Lin Hsu, Kuan-Yu Chen, Jin-Yuan Shih, Chao-Chi Ho, Chih-Hsin Yang, Chong-Jen Yu and Pan-Chyr Yang
    Citation: BMC Cancer 2012 12:241
    Content type: Research article Published on:

  30. Mammographic population screening in The Netherlands has increased the number of breast cancer patients with small and non-palpable breast tumors. Nevertheless, mammography is not ultimately sensitive and spec...

    Authors: Jeroen F Vermeulen, Aram SA van Brussel, Petra van der Groep, Folkert HM Morsink, Peter Bult, Elsken van der Wall and Paul J van Diest
    Citation: BMC Cancer 2012 12:240
    Content type: Research article Published on:

  33. Li-Fraumeni (LFS) and Li-Fraumeni-like (LFL) syndromes are associated to germline TP53 mutations, and are characterized by the development of central nervous system tumors, sarcomas, adrenocortical carcinomas, an...

    Authors: Amanda Gonçalves Silva, Ingrid Petroni Ewald, Marina Sapienza, Manuela Pinheiro, Ana Peixoto, Amanda França de Nóbrega, Dirce M Carraro, Manuel R Teixeira, Patricia Ashton-Prolla, Maria Isabel W Achatz, Carla Rosenberg and Ana C V Krepischi
    Citation: BMC Cancer 2012 12:237
    Content type: Research article Published on:

  34. How to properly manage clinically negative neck of head and neck cancer patients is a controversial topic. Research is now directed toward finding a method sensitive enough to bring the risk of occult metastas...

    Authors: Li-Jen Liao, Wu-Chia Lo, Wan-Lun Hsu, Chi-Te Wang and Mei-Shu Lai
    Citation: BMC Cancer 2012 12:236
    Content type: Research article Published on:

  35. Cancer-related genes show racial differences. Therefore, identification and characterization of DNA copy number alteration regions in different racial groups helps to dissect the mechanism of tumorigenesis.

    Authors: Fang-Yi Lo, Jer-Wei Chang, I-Shou Chang, Yann-Jang Chen, Han-Shui Hsu, Shiu-Feng Kathy Huang, Fang-Yu Tsai, Shih Sheng Jiang, Rajani Kanteti, Suvobroto Nandi, Ravi Salgia and Yi-Ching Wang
    Citation: BMC Cancer 2012 12:235
    Content type: Research article Published on:

  36. The finite replicative lifespan of cells, termed cellular senescence, has been proposed as a protective mechanism against the proliferation of oncogenically damaged cells, that fuel cancer. This concept is fur...

    Authors: Julie Lafontaine, Guergana Tchakarska, Francis Rodier and Anne-Marie Mes-Masson
    Citation: BMC Cancer 2012 12:234
    Content type: Research article Published on:

  37. The ubiquitin-proteasome system (UPS) and the heat shock response (HSR) are two critical regulators of cell homeostasis, as their inhibition affects growth and survival of normal cells, as well as stress respo...

    Authors: Marica Peron, Paolo Bonvini and Angelo Rosolen
    Citation: BMC Cancer 2012 12:233
    Content type: Research article Published on:

  38. MicroRNAs (miRNAs) are well recognized as gene regulators and have been implicated in the regulation of development as well as human diseases. miR-143 is located at a fragile site on chromosome 5 frequently de...

    Authors: Lea H Gregersen, Anders Jacobsen, Lisa B Frankel, Jiayu Wen, Anders Krogh and Anders H Lund
    Citation: BMC Cancer 2012 12:232
    Content type: Research article Published on:

  39. Tyrosine kinase inhibitors (TKIs) are currently approved for the treatment of metastatic renal cell carcinoma (mRCC). The cardiotoxic effects of sorafenib and sunitinib may cause hypertension, left ventricular...

    Authors: Maria Abbondanza Pantaleo, Anna Mandrioli, Maristella Saponara, Margherita Nannini, Giovanna Erente, Cristian Lolli and Guido Biasco
    Citation: BMC Cancer 2012 12:231
    Content type: Case report Published on:

  40. This randomised controlled trial (RCT) aims to evaluate the effectiveness of a guided self-help cognitive behavioural intervention to alleviate problematic hot flushes (HF) and night sweats (NS) in men who are...

    Authors: Omar Yousaf, Evgenia Stefanopoulou, Elizabeth A Grunfeld and Myra S Hunter
    Citation: BMC Cancer 2012 12:230
    Content type: Study protocol Published on:

  41. Anaplastic lymphoma kinase-positive, anaplastic large cell lymphoma (ALK+ ALCL) is a T cell lymphoma defined by the presence of chromosomal translocations involving the ALK tyrosine kinase gene. These translocati...

    Authors: Joel D Pearson, Zubair Mohammed, Julinor T C Bacani, Raymond Lai and Robert J Ingham
    Citation: BMC Cancer 2012 12:229
    Content type: Research article Published on:

  42. Abundant research suggested that the cancer cells avoid destruction by the immune system through down-regulation or mutation of death receptors. Therefore, it is very important that finding the agents that inc...

    Authors: Mi Hee Park, MiRan Jo, Dohee Won, Ho Sueb Song, Sang Bae Han, Min Jong Song and Jin Tae Hong
    Citation: BMC Cancer 2012 12:228
    Content type: Research article Published on:

  43. miR-182 is one of the most significantly up-regulated miRNAs in hepatocellular carcinoma (HCC). Metastasis suppressor 1 (MTSS1), one target gene of miR-182, plays an important role in the metastasis of cancers. ...

    Authors: Jian Wang, Jingwu Li, Junling Shen, Chen Wang, Lili Yang and Xinwei Zhang
    Citation: BMC Cancer 2012 12:227
    Content type: Research article Published on:

  44. Treatment options for pancreatic ductal adenocarcinoma (PDAC) are limited. Histone deacetylase inhibitors are a new and promising drug family with strong anticancer activity. The aim of this study was to exami...

    Authors: Dmitriy I Dovzhanskiy, Stefanie M Arnold, Thilo Hackert, Ina Oehme, Olaf Witt, Klaus Felix, Nathalia Giese and Jens Werner
    Citation: BMC Cancer 2012 12:226
    Content type: Research article Published on:

  45. Amplification of the 8p11-12 region has been found in approximately 15% of human breast cancer and is associated with poor prognosis. Previous genomic analysis has led us to identify the endoplasmic reticulum (ER...

    Authors: Guohui Wang, Gang Liu, Xiaogang Wang, Seema Sethi, Rouba Ali-Fehmi, Judith Abrams, Ze Zheng, Kezhong Zhang, Stephen Ethier and Zeng-Quan Yang
    Citation: BMC Cancer 2012 12:225
    Content type: Research article Published on:

  46. Struma ovarii (SO) is a rare form of ovarian mature teratoma in which thyroid tissue is the predominant element. Because of its rarity, the differential diagnosis between benign and malignant SO has not been c...

    Authors: Boban Stanojevic, Radan Dzodic, Vladimir Saenko, Zorka Milovanovic, Vesna Krstevski, Petar Radlovic, Marko Buta, Bozidar Rulic, Lidija Todorovic, Bogomir Dimitrijevic and Shunichi Yamashita
    Citation: BMC Cancer 2012 12:224
    Content type: Case report Published on:

  47. Regional lymph node (LN) status is a well-known prognostic factor for vulvar carcinoma (VC) patients. Although the reliable LN assessment in VC is crucial, it presents significant diagnostic problems. We aimed...

    Authors: Magdalena Kowalewska, Jakub Radziszewski, Krzysztof Goryca, Mateusz Bujko, Malgorzata Oczko-Wojciechowska, Michal Jarzab, Janusz Aleksander Siedlecki and Mariusz Bidzinski
    Citation: BMC Cancer 2012 12:223
    Content type: Research article Published on:

  48. Prostate cancer is the most commonly diagnosed malignancy in men in Sweden and Geneva, and the third most common in men in Singapore. This population-based study describes trends in the incidence and mortality...

    Authors: Cynthia Chen, Nasheen Naidoo, Qian Yang, Mikael Hartman, Helena M Verkooijen, En Yun Loy, Christine Bouchardy, Kee Seng Chia and Sin Eng Chia
    Citation: BMC Cancer 2012 12:222
    Content type: Research article Published on:

  49. Melanocytic meningeal tumours are rare extra-axial neoplasms of the nervous system, with only three reported cases in the cavernous sinus. Herein we describe for the first time the association of ocular melano...

    Authors: Francesco Doglietto, Cesare Colosimo, Libero Lauriola, Mario Balducci, Pasquale De Bonis, Nicola Montano, Gelareh Zadeh, Giulio Maira and Roberto Pallini
    Citation: BMC Cancer 2012 12:220
    Content type: Case report Published on:

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