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  1. There are large ethnic differences in cervical cancer survival in New Zealand that are only partly explained by stage at diagnosis. We investigated the association of comorbidity with cervical cancer survival,...

    Authors: Naomi Brewer, Barry Borman, Diana Sarfati, Mona Jeffreys, Steven T Fleming, Soo Cheng and Neil Pearce
    Citation: BMC Cancer 2011 11:132
  2. Chemotherapy dose delay and/or reduction lower relative total dose intensity (RTDI) and may affect short- and long-term outcome of metastatic breast cancer (MBC) patients.

    Authors: Sibylle Loibl, Tomas Skacel, Valentina Nekljudova, Hans Joachim Lück, Matthias Schwenkglenks, Thomas Brodowicz, Christoph Zielinski and Gunter von Minckwitz
    Citation: BMC Cancer 2011 11:131
  3. The inflammatory chemokines CCL2 (MCP-1) & CCL5 (RANTES) and the inflammatory cytokines TNFα & IL-1β were shown to contribute to breast cancer development and metastasis. In this study, we wished to determine ...

    Authors: Gali Soria, Maya Ofri-Shahak, Ilana Haas, Neora Yaal-Hahoshen, Leonor Leider-Trejo, Tal Leibovich-Rivkin, Polina Weitzenfeld, Tsipi Meshel, Esther Shabtai, Mordechai Gutman and Adit Ben-Baruch
    Citation: BMC Cancer 2011 11:130
  4. Oral (p.o.) chemotherapy treatments gained increasing importance in the palliative treatment of metastatic breast cancer (MBC). Aim of this survey was to evaluate the acceptance of p.o. treatment and patients'...

    Authors: Sarah Schott, Andreas Schneeweiss, Judith Reinhardt, Thomas Bruckner, Christoph Domschke, Christof Sohn and Michael H Eichbaum
    Citation: BMC Cancer 2011 11:129
  5. With the advances in modern radiotherapy (RT), many patients with head and neck cancer (HNC) can be effectively cured, and their health-related quality of life (HR-QoL) has become an important issue. In this s...

    Authors: Stephen Wan Leung, Tsair-Fwu Lee, Chih-Yen Chien, Pei-Ju Chao, Wen-Ling Tsai and Fu-Min Fang
    Citation: BMC Cancer 2011 11:128
  6. Mortality is high in patients with esophageal carcinoma as tumors are rarely detected before the disease has progressed to an advanced stage. Here, we sought to isolate cell-free DNA released into the plasma o...

    Authors: Immacolata Andolfo, Giuseppe Petrosino, Loredana Vecchione, Pasqualino De Antonellis, Mario Capasso, Donatella Montanaro, Marica Gemei, Giancarlo Troncone, Achille Iolascon, Michele Orditura, Fortunato Ciardiello, Fernando De Vita and Massimo Zollo
    Citation: BMC Cancer 2011 11:126
  7. We have previously demonstrated that both canine and human OSA cell lines, as well as 8 fresh canine OSA tumor samples, exhibit constitutive phosphorylation of STAT3, and that this correlates with enhanced exp...

    Authors: Stacey L Fossey, Misty D Bear, William C Kisseberth, Michael Pennell and Cheryl A London
    Citation: BMC Cancer 2011 11:125
  8. Chemotherapy for glioblastoma (GBM) patients is compromised in part by poor perfusion in the tumor. The present study evaluates how treatment with liposomal formulation of irinotecan (Irinophore C™), and other...

    Authors: Maite Verreault, Dita Strutt, Dana Masin, Malathi Anantha, Andrew Yung, Piotr Kozlowski, Dawn Waterhouse, Marcel B Bally and Donald T Yapp
    Citation: BMC Cancer 2011 11:124
  9. The PTEN tumour suppressor gene and PIK3CA proto-oncogene encode proteins which contribute to regulation and propagation of signal transduction through the PI3K/AKT signalling pathway. This study investigates the...

    Authors: Adam Naguib, James C Cooke, Lisa Happerfield, Lucy Kerr, Laura J Gay, Robert N Luben, Richard Y Ball, Panagiota N Mitrou, Alison McTaggart and Mark J Arends
    Citation: BMC Cancer 2011 11:123
  10. Phosphatase of regenerating liver-3 (PRL-3) has deserved attention as a crucial molecule in the multiple steps of metastasis. In the present study, we examined the mechanisms regulating PRL-3 expression, and a...

    Authors: Akira Ooki, Keishi Yamashita, Shiro Kikuchi, Shinichi Sakuramoto, Natsuya Katada, Mina Waraya, Hiroshi Kawamata, Hiroshi Nishimiya, Kazunori Nakamura and Masahiko Watanabe
    Citation: BMC Cancer 2011 11:122
  11. Latexin, also known as endogenous carboxypeptidase inhibitor (CPI), has been found to inhibit mouse stem cell populations and lymphoma cell proliferation, demonstrating its potential role as a tumor suppressor...

    Authors: Yong Li, Zhuoma Basang, Huirong Ding, Zheming Lu, Tao Ning, Haoran Wei, Hong Cai and Yang Ke
    Citation: BMC Cancer 2011 11:121
  12. Chondrosarcoma is virtually resistant to chemotherapy and radiation therapy. Survivin, the smallest member of the inhibitor of apoptosis protein family, is a critical factor for tumor progression and resistanc...

    Authors: Philipp Lechler, Tobias Renkawitz, Valentina Campean, Sanjeevi Balakrishnan, Markus Tingart, Joachim Grifka and Jens Schaumburger
    Citation: BMC Cancer 2011 11:120
  13. KLK15 over-expression is reported to be a significant predictor of reduced progression-free survival and overall survival in ovarian cancer. Our aim was to analyse the KLK15 gene for putative functional single n...

    Authors: Jyotsna Batra, Christina M Nagle, Tracy O'Mara, Melanie Higgins, Ying Dong, Olivia L Tan, Felicity Lose, Lene Marie Skeie, Srilakshmi Srinivasan, Kelly L Bolton, Honglin Song, Susan J Ramus, Simon A Gayther, Paul DP Pharoah, Mary-Anne Kedda, Amanda B Spurdle…
    Citation: BMC Cancer 2011 11:119
  14. It is unclear whether individualized treatments based on biological factors have improved the prognosis of recurrent breast cancer. The purpose of this study is to evaluate the survival improvement of patients...

    Authors: Hideo Shigematsu, Hidetoshi Kawaguchi, Yoshiaki Nakamura, Kimihiro Tanaka, Satoko Shiotani, Chinami Koga, Sumiko Nishimura, Kenichi Taguchi, Kenichi Nishiyama and Shinji Ohno
    Citation: BMC Cancer 2011 11:118
  15. In patients with advanced hepatocellular carcinoma (HCC), combination chemotherapy using 5- fluorouracil, cisplatin, and mitoxantrone (FMP) could achieve a response rate > 20%, but the beneficial effect was co...

    Authors: Chau-Ting Yeh, Hui-Chin Chen, Chang-Mu Sung, Cheng-Lung Hsu, Chen-Chun Lin, Kuang-Tse Pan, Jeng-Hwei Tseng and Chien-Fu Hung
    Citation: BMC Cancer 2011 11:117
  16. Several naturally occurring cationic antimicrobial peptides (CAPs), including bovine lactoferricin (LfcinB), display promising anticancer activities. These peptides are unaffected by multidrug resistance mecha...

    Authors: Bodil Fadnes, Lars Uhlin-Hansen, Inger Lindin and Øystein Rekdal
    Citation: BMC Cancer 2011 11:116
  17. Many adjuvant trials have been undertaken in an attempt to reduce the risk of recurrence among patients who undergo surgical resection for locally advanced renal cancer. However, no clear benefit has been iden...

    Authors: Adolfo JO Scherr, Joao Paulo SN Lima, Emma C Sasse, Carmen SP Lima and André D Sasse
    Citation: BMC Cancer 2011 11:115
  18. Curcumin is a naturally occurring phenolic compound shown to have a wide variety of antitumor activities; however, it does not attain sufficient blood levels to do so when ingested. Using structure-based desig...

    Authors: Stacey L Fossey, Misty D Bear, Jiayuh Lin, Chenglong Li, Eric B Schwartz, Pui-Kai Li, James R Fuchs, Joelle Fenger, William C Kisseberth and Cheryl A London
    Citation: BMC Cancer 2011 11:112
  19. Metastasis to the seminal vesicle is extremely rare for hepatocellular carcinoma (HCC). To our knowledge, it has been not reported in literature. The purpose of the present paper was to report a case of metast...

    Authors: Li Gong, Minwen Zheng, Yanhong Li, Wendong Zhang, Wangjun Bu, Lifang Shi, Wei Zhang and Hong Yan
    Citation: BMC Cancer 2011 11:111
  20. Double stranded RNA (dsRNA) has multiple anti-tumor mechanisms. Over the past several decades, there have been numerous attempts to utilize synthetic dsRNA to control tumor growth in animal models and clinical...

    Authors: B Leticia Rodriguez, Zhen Yu, Woon-Gye Chung, Richard Weiss and Zhengrong Cui
    Citation: BMC Cancer 2011 11:110
  21. Gastric cancer is the second most common cause of global cancer-related mortality. Although dedifferentiation predicts poor prognosis in gastric cancer, the molecular mechanism underlying dedifferentiation, wh...

    Authors: Min Wei, Zhiwei Wang, Hongliang Yao, Zhongyin Yang, Qing Zhang, Bingya Liu, Yingyan Yu, Liping Su, Zhenggang Zhu and Qinlong Gu
    Citation: BMC Cancer 2011 11:109
  22. Exosomes consist of membrane vesicles that are secreted by several cell types, including tumors and have been found in biological fluids. Exosomes interact with other cells and may serve as vehicles for the tr...

    Authors: Cristina Escrevente, Sascha Keller, Peter Altevogt and Júlia Costa
    Citation: BMC Cancer 2011 11:108
  23. As supplement to KRAS mutational analysis, BRAF and PIK3CA mutations as well as expression of PTEN may account for additional non-responders to anti-EGFR-MoAbs treatment. The aim of the present study was to inves...

    Authors: Karen-Lise G Spindler, Niels Pallisgaard, Jan Lindebjerg, Sanne K Frifeldt and Anders Jakobsen
    Citation: BMC Cancer 2011 11:107
  24. Interactions of stromal hyaluronic acid (HA) with its binding protein RHAMM (receptor for HA-mediated motility) (CD168) have been reported to affect tumor extension and the migration of crucial molecules to pr...

    Authors: Sumiya Ishigami, Shinichi Ueno, Yuka Nishizono, Masataka Matsumoto, Hiroshi Kurahara, Takaaki Arigami, Yasuto Uchikado, Tetsuro Setoyama, Hideo Arima, Kita Yoshiaki, Yuko Kijima, Masaki Kitazono and Shoji Natsugoe
    Citation: BMC Cancer 2011 11:106
  25. Multikinase inhibitors (MKIs) sunitinib and sorafenib have become a standard of care for metastatic renal cell carcinoma (mRCC). This study assessed safety and treatment patterns for these agents in a real-wor...

    Authors: Camillo Porta, Chiara Paglino, Ilaria Imarisio, Cinzia Canipari, Kristina Chen, Maureen Neary and Mei Sheng Duh
    Citation: BMC Cancer 2011 11:105
  26. The human apurinic/apyrimidinic endonuclease 1/Redox effector factor-1 (APE1/Ref-1) is implicated in tumor development and progression. Recently, the APE1/Ref-1 promoter -141T/G variant (rs1760944) has been repor...

    Authors: Keke Zhou, Dezhi Hu, Juan Lu, Weiwei Fan, Hongliang Liu, Hongyan Chen, Gong Chen, Qingyi Wei, Guhong Du, Ying Mao, Daru Lu and Liangfu Zhou
    Citation: BMC Cancer 2011 11:104
  27. The adaptor protein PINCH is overexpressed in the stroma of several types of cancer, and is an independent prognostic marker in colorectal cancer. In this study we further investigate the relationship of PINCH...

    Authors: Jasmine Lööf, Johan Rosell, Charlotte Bratthäll, Siv Doré, Hans Starkhammar, Hong Zhang and Xiao-Feng Sun
    Citation: BMC Cancer 2011 11:103
  28. DNA methylation in the SHOX2 locus was previously used to reliably detect lung cancer in a group of critical controls, including 'cytologically negative' samples with no visible tumor cell content, at a high spec...

    Authors: Katja U Schneider, Dimo Dietrich, Michael Fleischhacker, Gunda Leschber, Johannes Merk, Frank Schäper, Henk R Stapert, Erik R Vossenaar, Sabine Weickmann, Volker Liebenberg, Christoph Kneip, Anke Seegebarth, Fikret Erdogan, Gudrun Rappold and Bernd Schmidt
    Citation: BMC Cancer 2011 11:102
  29. In this work, we have conducted a case-control study in order to assess the effect of tobacco and three genetic polymorphisms in XPC, ERCC2 and ERCC5 genes (rs2228001, rs13181 and rs17655) in bladder cancer devel...

    Authors: Kamel Rouissi, Islem Ben Bahria, Karim Bougatef, Raja Marrakchi, Nejla Stambouli, Khouloud Hamdi, Mohamed Cherif, Mohamed Riadh Ben Slama, Mohamed Sfaxi, Fethi Ben Othman, Mohamed Chebil, Amel Benammar Elgaaied and Slah Ouerhani
    Citation: BMC Cancer 2011 11:101
  30. Recently EBUS-TBNA, which has a sensitivity of 94.6%, specificity of 100% and diagnostic accuracy rate of 96.3% as previously reported, has been widely used for patients with mediastinal and hilar lymphadenopa...

    Authors: Ting Ye, Hong Hu, Xiaoyang Luo and Haiquan Chen
    Citation: BMC Cancer 2011 11:100
  31. It was reported recently that resveratrol could sensitize a number of cancer cells to the antitumoral effects of some conventional chemotherapy drugs. The current study was designed to investigate whether resv...

    Authors: Xiao-Fang Niu, Bao-Qin Liu, Zhen-Xian Du, Yan-Yan Gao, Chao Li, Ning Li, Yifu Guan and Hua-Qin Wang
    Citation: BMC Cancer 2011 11:99
  32. Considerable variation in intravenous 5-fluorouracil (5-FU) metabolism can occur due to the wide range of dihydropyrimidine dehydrogenase (DPD) enzyme activity, which can affect both tolerability and efficacy....

    Authors: Patrice Cellier, Bernard Leduc, Laurent Martin, Brigitte Vié, Christian Chevelle, Véronique Vendrely, Augustin Salemkour, Christian Carrie, Gilles Calais, Pascal Burtin, Loïc Campion, Michèle Boisdron-Celle, Alain Morel, Virginie Berger and Erick Gamelin
    Citation: BMC Cancer 2011 11:98
  33. CXCL12 has been widely reported to play a biologically relevant role in tumor growth and spread. In epithelial ovarian cancer (EOC), CXCL12 enhances tumor angiogenesis and contributes to the immunosuppressive ...

    Authors: Véronique Machelon, Françoise Gaudin, Sophie Camilleri-Broët, Salam Nasreddine, Laurence Bouchet-Delbos, Eric Pujade-Lauraine, Jerôme Alexandre, Laurence Gladieff, Fernando Arenzana-Seisdedos, Dominique Emilie, Sophie Prévot, Philippe Broët and Karl Balabanian
    Citation: BMC Cancer 2011 11:97
  34. We aimed to validate prognostic scores for survival in patients undergoing chemotherapy for advanced or metastatic cancer after first-line treatment.

    Authors: Olivier Trédan, Isabelle Ray-Coquard, Gisèle Chvetzoff, Paul Rebattu, Agathe Bajard, Sylvie Chabaud, David Pérol, Chadi Saba, Florent Quiblier, Jean-Yves Blay and Thomas Bachelot
    Citation: BMC Cancer 2011 11:95
  35. Lymphoedema is a common and troublesome condition that develops following breast cancer treatment. The aim of this study is to analyze the effectiveness of Manual Lymphatic Drainage in the treatment of postmas...

    Authors: Marta López Martín, Miguel A Hernández, Cristina Avendaño, Francisco Rodríguez and Helena Martínez
    Citation: BMC Cancer 2011 11:94
  36. The aim of this study was to identify critical genes involved in non-small cell lung cancer (NSCLC) pathogenesis that may lead to a more complete understanding of this disease and identify novel molecular targ...

    Authors: Genni M Newnham, Matthew Conron, SueAnne McLachlan, Alexander Dobrovic, Hongdo Do, Jason Li, Kenneth Opeskin, Natalie Thompson, Gavin M Wright and David M Thomas
    Citation: BMC Cancer 2011 11:93
  37. The Mayo Lung Project (MLP), a randomized controlled clinical trial of lung cancer screening conducted between 1971 and 1986 among male smokers aged 45 or above, demonstrated an increase in lung cancer surviva...

    Authors: Lu Shi, Haijun Tian, William J McCarthy, Barbara Berman, Shinyi Wu and Rob Boer
    Citation: BMC Cancer 2011 11:92
  38. Folic acid may affect the development of human cancers. However, few studies have evaluated the consumption of diet folate in the prognosis of patients with esophageal squamous cell carcinoma (ESCC).

    Authors: Cheng Lu, Hui Xie, Fengliang Wang, Hongbing Shen and Jianming Wang
    Citation: BMC Cancer 2011 11:91
  39. Patients with advanced or metastatic non-small cell lung cancer (NSCLC) can develop acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (TKIs) erlotinib and gefitinib. Here, we r...

    Authors: Renhua Guo, Xiaofen Chen, Tongshan Wang, Zhiyuan Zhang, Jin Sun and Yongqian Shu
    Citation: BMC Cancer 2011 11:90
  40. The importance of changes in tumour-associated stroma for tumour initiation and progression has been established. Endosialin is expressed in fibroblasts and pericytes of blood vessels in several types of tumou...

    Authors: Zhi-Yong Zhang, Hong Zhang, Gunnar Adell and Xiao-Feng Sun
    Citation: BMC Cancer 2011 11:89
  41. The purpose of this study was to assess the expression levels for TβRI, TβRII, and TβRIII in epithelial layers of oral premalignant lesions (oral leukoplakia, OLK) and oral squamous cell carcinoma (OSCC), as w...

    Authors: Wenxia Meng, Qingjie Xia, Lanyan Wu, Sixiu Chen, Xin He, Lin Zhang, Qinghong Gao and Hongmei Zhou
    Citation: BMC Cancer 2011 11:88
  42. The optimal treatment of early stage follicular Lymphoma is a matter of debate. Radiation therapy has frequently been applied with a curative approach beside watchful waiting. Involved field, extended field an...

    Authors: Mathias Witzens-Harig, Manfred Hensel, Michael Unterhalt and Klaus Herfarth
    Citation: BMC Cancer 2011 11:87
  43. By using cDNA microarray analysis, we identified a G protein-coupled receptor, GPR39, that is significantly up-regulated in ESCC. The aim of this study is to investigate the role of GPR39 in human esophageal canc...

    Authors: Fajun Xie, Haibo Liu, Ying-Hui Zhu, Yan-Ru Qin, Yongdong Dai, Tingting Zeng, Leilei Chen, Changjun Nie, Hong Tang, Yan Li, Li Fu and Xin-Yuan Guan
    Citation: BMC Cancer 2011 11:86
  44. Malignant melanoma is a rare disease in Asia, and knowledge on its characteristics and clinical outcome in Asian patients is limited. The purpose of this observational study was to determine the clinical prese...

    Authors: Zhihong Chi, Siming Li, Xinan Sheng, Lu Si, Chuanliang Cui, Mei Han and Jun Guo
    Citation: BMC Cancer 2011 11:85
  45. Fibroblast growth factor receptor 4 (FGFR4) displays multiple biological activities, including mitogenic and angiogenic activity, and plays important roles in the etiology and progression of prostate cancer. Gly3...

    Authors: Bin Xu, Na Tong, Shu Q Chen, Li X Hua, Zeng J Wang, Zheng D Zhang and Ming Chen
    Citation: BMC Cancer 2011 11:84

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