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  1. Second-line treatment of advanced non-small-cell lung cancer (NSCLC) improves overall survival. There is a lack of data regarding the impact on patients' overall health condition. This prospective, non-interve...

    Authors: Wolfgang Schuette, Hans Tesch, Hartwig Büttner, Thomas Krause, Victoria Soldatenkova and Clemens Stoffregen
    Citation: BMC Cancer 2012 12:14
  2. Major changes in the incidence of oesophageal and gastric cancers have been reported internationally. This study describes recent trends in incidence and survival of subgroups of oesophageal and gastric cancer...

    Authors: Victoria H Coupland, William Allum, Jane M Blazeby, Michael A Mendall, Richard H Hardwick, Karen M Linklater, Henrik Møller and Elizabeth A Davies
    Citation: BMC Cancer 2012 12:11
  3. The study of breast cancer metastasis depends on the use of established breast cancer cell lines that do not accurately represent the heterogeneity and complexity of human breast tumors. A tumor model was deve...

    Authors: Carolyn G Marsden, Mary Jo Wright, Latonya Carrier, Krzysztof Moroz, Radhika Pochampally and Brian G Rowan
    Citation: BMC Cancer 2012 12:10
  4. Molecular alterations occur frequently in T-ALL and the potential impact of those abnormalities on outcome is still controversial. The current study aimed to test whether NOTCH1 mutations and additional molecular...

    Authors: Marcela Braga Mansur, Rocio Hassan, Thayana C Barbosa, Alessandra Splendore, Patricia Y Jotta, José Andrés Yunes, Joseph L Wiemels and Maria S Pombo-de-Oliveira
    Citation: BMC Cancer 2012 12:9
  5. The frequency of E-cadherin germline mutations in countries with different incidence rates for gastric carcinoma has not been well established. The goal of this study was to assess the worldwide frequency of CDH1

    Authors: Giovanni Corso, Daniele Marrelli, Valeria Pascale, Carla Vindigni and Franco Roviello
    Citation: BMC Cancer 2012 12:8
  6. The association between the TERT rs2736100 single nucleotide polymorphism (SNP) and cancer risk has been studied by many researchers, but the results remain inconclusive. To further explore this association, we p...

    Authors: Peng Zou, Aihua Gu, Guixiang Ji, Lin Zhao, Peng Zhao and Ailin Lu
    Citation: BMC Cancer 2012 12:7
  7. Several conservative (i.e., nonpharmacologic, nonsurgical) treatments exist for secondary lymphedema. The optimal treatment is unknown. We examined the effectiveness of conservative treatments for secondary ly...

    Authors: Mark Oremus, Ian Dayes, Kathryn Walker and Parminder Raina
    Citation: BMC Cancer 2012 12:6
  8. Selective Internal Radiation Therapy (SIRT) is a new and effective locoregional anticancer therapy for colorectal cancer patients with liver metastases. Markers for prediction of therapy response and prognosis...

    Authors: Yvonne Nadine Fahmueller, Dorothea Nagel, Ralf-Thorsten Hoffmann, Klaus Tatsch, Tobias Jakobs, Petra Stieber and Stefan Holdenrieder
    Citation: BMC Cancer 2012 12:5
  9. Invasive micropapillary carcinoma (IMPC) of the breast is a distinct and aggressive variant of luminal type B breast cancer that does not respond to neoadjuvant chemotherapy. It is characterized by small pseud...

    Authors: Sophie Doublier, Dimas C Belisario, Manuela Polimeni, Laura Annaratone, Chiara Riganti, Elena Allia, Dario Ghigo, Amalia Bosia and Anna Sapino
    Citation: BMC Cancer 2012 12:4
  10. In this study several tumor-related volumes were assessed by means of a computer-based application and a survival analysis was conducted to evaluate the prognostic significance of pre- and postoperative volume...

    Authors: Georgios Iliadis, Vassiliki Kotoula, Athanasios Chatzisotiriou, Despina Televantou, Anastasia G Eleftheraki, Sofia Lambaki, Despina Misailidou, Panagiotis Selviaridis and George Fountzilas
    Citation: BMC Cancer 2012 12:3
  11. An influence of gonadotropins (hCG) on the development of ovarian cancer has been discussed. Therefore, we quantified serum hCG levels in patients with benign and malignant ovarian tumors and the hCG expressio...

    Authors: Miriam Lenhard, Alexandra Tsvilina, Lan Schumacher, Markus Kupka, Nina Ditsch, Doris Mayr, Klaus Friese and Udo Jeschke
    Citation: BMC Cancer 2012 12:2
  12. Most skin cancers are preventable by encouraging consistent use of sun protective behaviour. In Australia, adolescents have high levels of knowledge and awareness of the risks of skin cancer but exhibit signif...

    Authors: Anna L Hawkes, Kyra Hamilton, Katherine M White and Ross McD Young
    Citation: BMC Cancer 2012 12:1
  13. The biological mechanisms underlying cancer cell motility and invasiveness remain unclear, although it has been hypothesized that they involve some type of epithelial-mesenchymal transition (EMT).

    Authors: Dimitris Anastassiou, Viktoria Rumjantseva, Weiyi Cheng, Jianzhong Huang, Peter D Canoll, Darrell J Yamashiro and Jessica J Kandel
    Citation: BMC Cancer 2011 11:529
  14. Leukemia is a heterogeneous disease commonly associated with recurrent chromosomal translocations that involve tyrosine kinases including BCR-ABL, TEL-PDGFRB and TEL-JAK2. Most studies on the activated tyrosin...

    Authors: Hani Kim, Lisa C Gillis, Jordan D Jarvis, Stuart Yang, Kai Huang, Sandy Der and Dwayne L Barber
    Citation: BMC Cancer 2011 11:528
  15. Ezrin is highly expressed in skin cancer and promotes tumor metastasis. Ezrin serves as a promising target for anti-metastasis therapy. The aim of this study is to determine if the flavonoid bacailein inhibits...

    Authors: Bin Wu, Ji Li, Damao Huang, Weiwei Wang, Yu Chen, Youxiang Liao, Xiaowei Tang, Hongfu Xie and Faqing Tang
    Citation: BMC Cancer 2011 11:527
  16. The aim of this study was to identify factors associated with satisfaction with care in cancer patients undergoing ambulatory treatment. We investigated associations between patients' baseline clinical and soc...

    Authors: Nguyen Thanh Vân France, Jean-François Bosset, Alain Monnier, Jacqueline Fournier, Valérie Perrin, Cédric Baumann, Anne Brédart and Mariette Mercier
    Citation: BMC Cancer 2011 11:526
  17. The Anaplastic Lymphoma Kinase (ALK) is an orphan receptor tyrosine kinase, which undergoes post-translational N-linked glycosylation. The catalytic domain of ALK was originally identified in the t(2;5) transl...

    Authors: Federica Del Grosso, Marilena De Mariano, Lorena Passoni, Roberto Luksch, Gian Paolo Tonini and Luca Longo
    Citation: BMC Cancer 2011 11:525
  18. Expression of neuronal elements has been identified in various glial tumors, and glioblastomas (GBMs) with neuronal differentiation patterns have reportedly been associated with longer survival. However, the n...

    Authors: Tao Yan, Kai Ove Skaftnesmo, Lina Leiss, Linda Sleire, Jian Wang, Xingang Li and Per Øyvind Enger
    Citation: BMC Cancer 2011 11:524
  19. Clinical outcome of patients with high-grade ccRCC (clear cell renal cell carcinoma) remains still poor despite recent advances in treatment strategies. Molecular mechanism of pathogenesis in developing high-g...

    Authors: Keiko Matsuura, Chisato Nakada, Mizuho Mashio, Takahiro Narimatsu, Taichiro Yoshimoto, Masato Tanigawa, Yoshiyuki Tsukamoto, Naoki Hijiya, Ichiro Takeuchi, Takeo Nomura, Fuminori Sato, Hiromitsu Mimata, Masao Seto and Masatsugu Moriyama
    Citation: BMC Cancer 2011 11:523
  20. The importance of 17β-estradiol (E2) in the prevention of large bowel tumorigenesis has been shown in many epidemiological studies. Extragonadal E2 may form by the aromatase pathway from androstenedione or the...

    Authors: Agnieszka Anna Rawłuszko, Karolina Horbacka, Piotr Krokowicz and Paweł Piotr Jagodziński
    Citation: BMC Cancer 2011 11:522
  21. APE1 (apurinic/apyrimidinic endonuclease 1) is an important DNA repair protein in the base excision repair pathway. Polymorphisms in APE1 have been implicated in susceptibility to cancer; however, results from th...

    Authors: Bin Zhou, Hailin Shan, Ying Su, Kai Xia, Xiaxia Shao, Weidong Mao and Qing Shao
    Citation: BMC Cancer 2011 11:521
  22. Perturbing Hsp90 chaperone function targets hypoxia inducible factor (HIF) function in a von Hippel-Lindau (VHL) independent manner, and represents an approach to combat the contribution of HIF to cell renal c...

    Authors: Jessica ES Bohonowych, Shuping Peng, Udhayakumar Gopal, Michael W Hance, Shane B Wing, Kelley M Argraves, Karen Lundgren and Jennifer S Isaacs
    Citation: BMC Cancer 2011 11:520
  23. To determine the impact of preexisting ischemic heart disease (IHD) and stroke on overall survival in prostate cancer patients.

    Authors: Christina G Jespersen, Mette Nørgaard, Truls E Bjerklund Johansen, Mette Søgaard and Michael Borre
    Citation: BMC Cancer 2011 11:519
  24. The transcription factor SOX2, which is involved in the induction of pluripotent stem cells and contributes to colorectal carcinogenesis, is associated with a poor prognosis in colon cancer (CC). Furthermore, ...

    Authors: Jens Neumann, Fiorina Bahr, David Horst, Lydia Kriegl, Jutta Engel, Raquel Mejías-Luque, Markus Gerhard, Thomas Kirchner and Andreas Jung
    Citation: BMC Cancer 2011 11:518
  25. The presence of bone metastases has excluded participation of prostate cancer patients in exercise intervention studies to date and is also a relative contraindication to supervised exercise in the community s...

    Authors: Daniel A Galvão, Dennis R Taaffe, Prue Cormie, Nigel Spry, Suzanne K Chambers, Carolyn Peddle-McIntyre, Michael Baker, James Denham, David Joseph, Geoff Groom and Robert U Newton
    Citation: BMC Cancer 2011 11:517
  26. We previously found that administration of an interleukin 2/diphtheria toxin conjugate (DAB/IL2; Denileukin Diftitox; ONTAK) to stage IV melanoma patients depleted CD4+CD25HIFoxp3+ regulatory T cells and expanded...

    Authors: Sucheta Telang, Mary Ann Rasku, Amy L Clem, Karen Carter, Alden C Klarer, Wesley R Badger, Rebecca A Milam, Shesh N Rai, Jianmin Pan, Hana Gragg, Brian F Clem, Kelly M McMasters, Donald M Miller and Jason Chesney
    Citation: BMC Cancer 2011 11:515
  27. Five-year survival for lung cancer has remained at 16% over last several decades largely due to the fact that over 50% of patients are diagnosed with locally-advanced or metastatic disease. Diagnosis at an ear...

    Authors: Elena Kupert, Marshall Anderson, Yin Liu, Paul Succop, Linda Levin, Jiang Wang, Kathryn Wikenheiser-brokamp, Pingping Chen, Susan M Pinney, Trudy Macdonald, Zhongyun Dong, Sandra Starnes and Shan Lu
    Citation: BMC Cancer 2011 11:513
  28. The cytogenetic characteristic of Chronic Myeloid Leukemia (CML) is the formation of the Philadelphia chromosome gene product, BCR-ABL. Given that BCR-ABL is the specific target of Gleevec in CML treatment, we...

    Authors: Juin Hsien Chai, Yong Zhang, Wei Han Tan, Wee Joo Chng, Baojie Li and Xueying Wang
    Citation: BMC Cancer 2011 11:512
  29. The availability of well-annotated prostate tissue samples through biobanks is key for research. Whereas fresh-frozen tissue is well suited for a broad spectrum of molecular analyses, its storage and handling ...

    Authors: Martin Braun, Roopika Menon, Pavel Nikolov, Robert Kirsten, Karen Petersen, David Schilling, Christina Schott, Sibylle Gündisch, Falko Fend, Karl-Friedrich Becker and Sven Perner
    Citation: BMC Cancer 2011 11:511
  30. The role of chemotherapy in high-risk soft tissue sarcoma is controversial. Though many patients undergo initial curative resection, distant metastasis is a frequent event, resulting in 5-year overall survival...

    Authors: Thomas Schmitt, Burkhard Lehner, Bernd Kasper, Marc Bischof, Falk Roeder, Sascha Dietrich, Antonia Dimitrakopoulou-Strauss, Ludwig G Strauss, Gunhild Mechtersheimer, Patrick Wuchter, Anthony D Ho and Gerlinde Egerer
    Citation: BMC Cancer 2011 11:510
  31. The activity of the epidermal growth factor receptor (EGFR)-directed monoclonal antibody cetuximab combined with oxaliplatin/leucovorin/5-fluorouracil (FUFOX) was assessed in first-line metastatic gastric and ...

    Authors: Birgit Luber, Joëlle Deplazes, Gisela Keller, Axel Walch, Sandra Rauser, Martin Eichmann, Rupert Langer, Heinz Höfler, Susanna Hegewisch-Becker, Gunnar Folprecht, Ewald Wöll, Thomas Decker, Esther Endlicher, Sylvie Lorenzen, Falko Fend, Christian Peschel…
    Citation: BMC Cancer 2011 11:509
  32. A universal hallmark of cancer cells is the change in their glycosylation phenotype. One of the most frequent alterations in the normal glycosylation pattern observed during carcinogenesis is the enhancement o...

    Authors: Laura Muinelo-Romay, Susana Villar-Portela, Elisa Cuevas, Emilio Gil-Martín and Almudena Fernández-Briera
    Citation: BMC Cancer 2011 11:508
  33. TMPRSS2-ERG gene fusions occur in about 50% of all prostate cancer cases and represent promising markers for molecular subtyping. Although TMPRSS2-ERG fusion seems to be a critical event in prostate cancer, the ...

    Authors: Jan C Brase, Marc Johannes, Heiko Mannsperger, Maria Fälth, Jennifer Metzger, Lukasz A Kacprzyk, Tatjana Andrasiuk, Stephan Gade, Michael Meister, Hüseyin Sirma, Guido Sauter, Ronald Simon, Thorsten Schlomm, Tim Beißbarth, Ulrike Korf, Ruprecht Kuner…
    Citation: BMC Cancer 2011 11:507
  34. Signal transducer and activator of transcription 3 (STAT3) is an important transcription factor ubiquitously expressed in different cell types. STAT3 plays an essential role in cell survival, proliferation, an...

    Authors: Wen-Yong Wu, Jun Li, Zheng-Sheng Wu, Chang-Le Zhang and Xiang-Ling Meng
    Citation: BMC Cancer 2011 11:506
  35. For patients with metastatic renal cell cancer (mRCC) who progressed on vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitor therapy, the orally administered mammalian target of rapamyc...

    Authors: Charlotte M Huijts, Saskia J Santegoets, Alfons J van den Eertwegh, Laura S Pijpers, John B Haanen, Tanja D de Gruijl, Henk M Verheul and Hans J van der Vliet
    Citation: BMC Cancer 2011 11:505
  36. The microenvironment within solid tumours can influence the metastatic dissemination of tumour cells, and recent evidence suggests that poorly oxygenated (hypoxic) cells in primary tumours can also affect the ...

    Authors: Kevin L Bennewith and Shoukat Dedhar
    Citation: BMC Cancer 2011 11:504
  37. Over the last decade, BMC Cancer has continuously published important research from the field of radiation oncology. Major developments in this field include the introduction of new imaging modalities into radiot...

    Authors: Dirk Vordermark
    Citation: BMC Cancer 2011 11:503
  38. Molecular classification has added important knowledge to breast cancer biology, but has yet to be implemented as a clinical standard. Full sequencing of breast cancer genomes could potentially refine classifi...

    Authors: Hans Kristian Moen Vollan and Carlos Caldas
    Citation: BMC Cancer 2011 11:501
  39. We analyzed the influence of 8 germinal polymorphisms of candidate genes potentially related to EGFR signalling (EGFR, EGF, CCND1) or antibody-directed cell cytotoxicity (FCGR2A and FCGR3A) on outcome of colorect...

    Authors: Laetitia Dahan, Emmanuelle Norguet, Marie-Christine Etienne-Grimaldi, Jean-Louis Formento, Mohamed Gasmi, Isabelle Nanni, Jean Gaudart, Stéphane Garcia, L'Houcine Ouafik, Jean-François Seitz and Gérard Milano
    Citation: BMC Cancer 2011 11:496
  40. In Taiwan, there is a high incidence of breast cancer and a high prevalence of viral hepatitis. In this case-control study, we used a population-based insurance dataset to evaluate whether breast cancer in wom...

    Authors: Fu-Hsiung Su, Shih-Ni Chang, Pei-Chun Chen, Fung-Chang Sung, Chien-Tien Su and Chih-Ching Yeh
    Citation: BMC Cancer 2011 11:495
  41. Laparoscopy-assisted surgery, fast-track perioperative treatment are both increasingly used in colorectal cancer treatment, for their short-time benefits of enhanced recovery and short hospital stays. However,...

    Authors: Jiao-Jiao Zhou, Jun Li, Xiao-Jiang Ying, Yong-Mao Song, Rong Chen, Gang Chen, Min Yan and Ke-Feng Ding
    Citation: BMC Cancer 2011 11:494
  42. Cancer cachexia is a syndrome of progressive weight loss. Non-small cell lung cancer patients experience a high incidence of cachexia of 61%. Research into methods to combat cancer cachexia in various tumour s...

    Authors: Elaine S Rogers, Roderick D MacLeod, Joanna Stewart, Stephen P Bird and Justin WL Keogh
    Citation: BMC Cancer 2011 11:493
  43. Little is known about the clinical features and prognostic factors of bone metastases of hepatocellular carcinoma (HCC) following liver transplantation (LT).

    Authors: Jian He, Zhao-Chong Zeng, Jia Fan, Jian Zhou, Jing Sun, Bing Chen, Ping Yang, Bin-Liang Wang, Bo-Heng Zhang and Jian-Ying Zhang
    Citation: BMC Cancer 2011 11:492

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