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  1. A life threatening illness such as breast cancer can lead to a secondary diagnosis of PTSD (post traumatic stress disorder) with intrusive thoughts and avoidance as major symptoms. In a former study by the res...

    Authors: Karin Nordin, Ritva Rissanen, Johan Ahlgren, Gunilla Burell, Marie-Louise Fjällskog, Susanne Börjesson and Cecilia Arving
    Citation: BMC Cancer 2012 12:167
  2. Despite recent advances in the treatment of hepatocellular carcinoma (HCC), the chemotherapy efficacy against HCC is still unsatisfactory. The mammalian target of rapamycin (mTOR) has been emerged as an import...

    Authors: Cun Wang, Dongmei Gao, Kun Guo, Xiaonan Kang, Kai Jiang, Chun Sun, Yan Li, Lu Sun, Hong Shu, Guangzhi Jin, Haiyan Sun, Weizhong Wu and Yinkun Liu
    Citation: BMC Cancer 2012 12:166
  3. The 3-weekly combination of trastuzumab and paclitaxel has been approved for the treatment of advanced breast cancer based on a large pivotal study. However, mono and combination chemotherapy trials suggest th...

    Authors: Matthias John, Axel Hinke, Martina Stauch, Heiner Wolf, Benno Mohr, Hans-Joachim Hindenburg, Jens Papke and Joachim Schlosser
    Citation: BMC Cancer 2012 12:165
  4. It has previously been shown that indirubin derivative E804 (IDR-E804) blocks signal transducer and activator of transcription-3 signaling in human breast and prostate cancer cells and inhibits Src kinase acti...

    Authors: Eun-Kyung Shin and Jin-Kyung Kim
    Citation: BMC Cancer 2012 12:164
  5. The COSMIC trial is designed to evaluate toxicity in dose-escalated treatment with intensity-modulated radiotherapy (IMRT) and carbon ion boost for malignant salivary gland tumors (MSGT) of the head and neck i...

    Authors: Alexandra D Jensen, Anna V Nikoghosyan, Karen Lossner, Klaus K Herfarth, Jürgen Debus and Marc W Münter
    Citation: BMC Cancer 2012 12:163
  6. We reported previously that 18F-2-fluoro-2-deoxyglucose positron emission tomography/ computed tomography (FDG PET/CT) had potential for evaluating early response to treatment by tyrosine kinase inhibitors (TKIs)...

    Authors: Daiki Ueno, Masahiro Yao, Ukihide Tateishi, Ryogo Minamimoto, Kazuhide Makiyama, Narihiko Hayashi, Futoshi Sano, Takayuki Murakami, Takeshi Kishida, Takeshi Miura, Kazuki Kobayashi, Sumio Noguchi, Ichiro Ikeda, Yoshiharu Ohgo, Tomio Inoue, Yoshinobu Kubota…
    Citation: BMC Cancer 2012 12:162
  7. In premenopausal women, endocrine adjuvant therapy for breast cancer primarily consists of tamoxifen alone or with ovarian suppressive strategies. Toremifene is a chlorinated derivative of tamoxifen, but with ...

    Authors: Ran Gu, Weijuan Jia, Yunjie Zeng, Nanyan Rao, Yue Hu, Shunrong Li, Jiannan Wu, Liang Jin, Lijuan Chen, Meijun Long, Kai Chen, Lili Chen, Qiaozhen Xiao, Mei Wu, Erwei Song and Fengxi Su
    Citation: BMC Cancer 2012 12:161
  8. Studies have shown that type-specific persistence of high-risk human papillomavirus (HPV) infection contributed significantly to cervical carcinogenesis.

    Authors: Shizhuo Wang, Heng Wei, Ning Wang, Shulan Zhang, Yao Zhang, Qiang Ruan, Weiguo Jiang, Qian Xiao, Xiaomei Luan, Xiuyan Qian, Lili Zhang, Xiang Gao and Xiaowei Sun
    Citation: BMC Cancer 2012 12:160
  9. The cooperation between phorbol 12-myristate 13-acetate induced protein 1 (NOXA) and myeloid cell leukemia 1 (MCL1) is critical in the intrinsic apoptotic pathway. Human papillomavirus 16 (HPV16), by inducing ...

    Authors: Ziyuan Zhou, Erich M Sturgis, Zhensheng Liu, Li-E Wang, Qingyi Wei and Guojun Li
    Citation: BMC Cancer 2012 12:159
  10. The prognosis of pT1a-pT1b breast cancer (BC) used to be considered very good, with a 10-y RFS of 90%. However, some retrospective studies reported a 10-y RFS of 81%–86% and suggested benefit from adjuvant sys...

    Authors: Stefania Gori, Matteo Clavarezza, Salvatore Siena, Jennifer Foglietta, Emiliana Tarenzi, Monica Giordano, Annamaria Molino, Claudio Graiff, Vittorio Fusco, Oscar Alabiso, Editta Baldini, Teresa Gamucci, Giuseppe Altavilla, Davide Dondi and Marco Venturini
    Citation: BMC Cancer 2012 12:158
  11. According to a fundamental law of radiobiology (“Law of Bergonié and Tribondeau”, 1906), the brain is a paradigm of a highly differentiated organ with low mitotic activity, and is thus radio-resistant. This as...

    Authors: Eugenio Picano, Eliseo Vano, Luciano Domenici, Matteo Bottai and Isabelle Thierry-Chef
    Citation: BMC Cancer 2012 12:157
  12. Glioblastoma multiforme (GBM) is the most aggressive of the primary brain tumors, with a grim prognosis despite intensive treatment. In the past decades, progress in research has not significantly increased ov...

    Authors: Cristina Trejo-Solís, Dolores Jimenez-Farfan, Sara Rodriguez-Enriquez, Francisca Fernandez-Valverde, Arturo Cruz-Salgado, Lena Ruiz-Azuara and Julio Sotelo
    Citation: BMC Cancer 2012 12:156
  13. To construct the Bifidobacterium infantis-mediated soluble kinase insert domain receptor (sKDR) prokaryotic expression system and to observe its inhibitory effect on growth of human umbilicus vessel endothelial c...

    Authors: Zhao-Jun Li, Hong Zhu, Bu-Yun Ma, Fen Zhao, Shu-Hua Mao, Tai-Guo Liu, Jian-Ping He, Li-Cong Deng, Cheng Yi and Ying Huang
    Citation: BMC Cancer 2012 12:155
  14. Alveolar rhabdomyosarcoma (ARMS) has a high propensity to metastasize, leading to its aggressiveness and a poor survival rate among those with the disease. More than 80% of aggressive ARMSs harbor a PAX3-FKHR ...

    Authors: Lingling Liu, Yong-Dong Wang, Jing Wu, Jimmy Cui and Taosheng Chen
    Citation: BMC Cancer 2012 12:154
  15. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) functions as a cytokine to selectively kill various cancer cells without toxicity to most normal cells. Numerous studies have demonstrated the po...

    Authors: Liu Zheng, Zhang Weilun, Jiang Minghong, Zhang Yaxi, Liu Shilian, Liu Yanxin and Zheng Dexian
    Citation: BMC Cancer 2012 12:153
  16. The financial burden of medical expenses has been increasing for cancer patients. We investigated the relationship between household income and financial burden among patients with chronic myelogenous leukaemi...

    Authors: Yuko Kodama, Ryoko Morozumi, Tomoko Matsumura, Yukiko Kishi, Naoko Murashige, Yuji Tanaka, Morihito Takita, Nobuyo Hatanaka, Eiji Kusumi, Masahiro Kami and Akihiko Matsui
    Citation: BMC Cancer 2012 12:152
  17. Increasing incidence and lack of survival improvement in adolescents and young adults (AYAs) with cancer have led to increased awareness of the cancer burden in this population. The objective of this study was...

    Authors: Fatima A Haggar, David B Preen, Gavin Pereira, Cashel DJ Holman and Kristjana Einarsdottir
    Citation: BMC Cancer 2012 12:151
  18. An understanding of the nature and magnitude of the impact of cancer is critical to planning how best to deliver supportive care to the growing population of cancer survivors whose need for care may span many ...

    Authors: Allison W Boyes, Afaf Girgis, Catherine D’Este and Alison C Zucca
    Citation: BMC Cancer 2012 12:150
  19. Body mass index (BMI) may be an important factor affecting breast cancer outcome. Studies conducted mainly in Western countries have reported a relationship between higher BMI and a higher risk of all-cause de...

    Authors: Masaaki Kawai, Yuko Minami, Yoshikazu Nishino, Kayoko Fukamachi, Noriaki Ohuchi and Yoichiro Kakugawa
    Citation: BMC Cancer 2012 12:149
  20. The prolonged survival of individuals diagnosed with cancer has led to an increase in the number of secondary primary malignancies. We undertook to perform a definitive study to characterize and predict progno...

    Authors: Qing-An Zeng, Jiliang Qiu, Ruhai Zou, Yijie Li, Shengping Li, Binkui Li, Pinzhu Huang, Jian Hong, Yun Zheng, Xiangming Lao and Yunfei Yuan
    Citation: BMC Cancer 2012 12:148
  21. Our recent study showed that tetrathiomolybdate (TM), a drug to treat copper overload disorders, can sensitize drug-resistant endometrial cancer cells to reactive oxygen species (ROS)-generating anticancer dru...

    Authors: Kyu Kwang Kim, Thilo S Lange, Rakesh K Singh, Laurent Brard and Richard G Moore
    Citation: BMC Cancer 2012 12:147
  22. HOX genes encode homeodomain-containing transcription factors involved in the regulation of cellular proliferation and differentiation during embryogenesis. However, members of this family demonstrated oncogen...

    Authors: Carolina Cavalcante Bitu, Maria Fernanda de Souza Setúbal Destro, Manoela Carrera, Sabrina Daniela da Silva, Edgard Graner, Luiz Paulo Kowalski, Fernando Augusto Soares and Ricardo D Coletta
    Citation: BMC Cancer 2012 12:146
  23. Among American men, prostate cancer is the most common, non-cutaneous malignancy that accounted for an estimated 241,000 new cases and 34,000 deaths in 2011. Previous studies have suggested that Wnt pathway in...

    Authors: Cornel J Phillip, Christopher K Giardina, Birdal Bilir, David J Cutler, Yu-Heng Lai, Omer Kucuk and Carlos S Moreno
    Citation: BMC Cancer 2012 12:145
  24. 15-20% of all patients initially diagnosed with colorectal cancer develop metastatic disease and surgical resection remains the only potentially curative treatment available. Current 5-year survival following ...

    Authors: Carl Christoph Schimanski, Markus Möhler, Michael Schön, Eric van Cutsem, Richard Greil, Wolf Otto Bechstein, Susanna Hegewisch-Becker, Götz von Wichert, Matthias Vöhringer, Michael Heike, Volker Heinemann, Marc Peeters, Stephan Kanzler, Stefan Kasper, Friedrich Overkamp, Jan Schröder…
    Citation: BMC Cancer 2012 12:144
  25. Glioblastoma multiforme (GBM) is the most common primary central nervous system malignancy and its unique invasiveness renders it difficult to treat. This invasive phenotype, like other cellular processes, may...

    Authors: Sunwoo Koo, Gail S Martin, Kevin J Schulz, Matthew Ronck and L Gerard Toussaint
    Citation: BMC Cancer 2012 12:143
  26. Currently, it remains unclear, if patients with colon cancer and synchronous unresectable metastases who present without severe symptoms should undergo resection of the primary tumour prior to systemic chemoth...

    Authors: Nuh N Rahbari, Florian Lordick, Christine Fink, Ulrich Bork, Annika Stange, Dirk Jäger, Steffen P Luntz, Stefan Englert, Inga Rossion, Moritz Koch, Markus W Büchler, Meinhard Kieser and Jürgen Weitz
    Citation: BMC Cancer 2012 12:142
  27. The phosphatidylinositol-3-kinase (PI3K-PKB), mitogen activated protein kinase (MEK-ERK) and the mammalian target of rapamycin (mTOR- p70S6K), are thought to regulate many aspects of tumour cell proliferation ...

    Authors: Ji Eun Kim, Clare Stones, Wayne R Joseph, Euphemia Leung, Graeme J Finlay, Andrew N Shelling, Wayne A Phillips, Peter R Shepherd and Bruce C Baguley
    Citation: BMC Cancer 2012 12:141
  28. An altered expression of the activated leukocyte cell adhesion molecule (ALCAM) is associated with cancer progression in various cancer types. In some cancers ALCAM has a prognostic value or is predictive for ...

    Authors: Maike Ihnen, Kerstin Kress, Jan Felix Kersten, Ergin Kilic, Matthias Choschzick, Hilke Zander, Volkmar Müller, Sven Mahner, Fritz Jänicke, Linn Woelber and Karin Milde-Langosch
    Citation: BMC Cancer 2012 12:140
  29. Osteosarcoma is a bone-forming tumor of mesenchymal origin that presents a clinical pattern that is consistent with the cancer stem cell model. Cells with stem-like properties (CSCs) have been identified in se...

    Authors: Sara R Martins-Neves, Áurio O Lopes, Anália do Carmo, Artur A Paiva, Paulo C Simões, Antero J Abrunhosa and Célia MF Gomes
    Citation: BMC Cancer 2012 12:139
  30. Sound and rigorous well-established, and newly extended, methods for genetic epidemiological analysis were used to analyze population evidence for genetic contributions to risk for numerous common cancer sites...

    Authors: Frederick Albright, Craig Teerlink, Theresa L Werner and Lisa A Cannon-Albright
    Citation: BMC Cancer 2012 12:138
  31. Treatment standard for patients with rectal cancer depends on the initial staging and includes surgical resection, radiotherapy as well as chemotherapy. For stage II and III tumors, radiochemotherapy should be...

    Authors: Stephanie E Combs, Meinhard Kieser, Daniel Habermehl, Jürgen Weitz, Dirk Jäger, Piero Fossati, Roberto Orrechia, Rita Engenhart-Cabillic, Richard Pötter, Manjit Dosanjh, Oliver Jäkel, Markus W Büchler and Jürgen Debus
    Citation: BMC Cancer 2012 12:137
  32. Common measures of surgical quality are 30-day morbidity and mortality, which poorly describe breast cancer surgical quality with extremely low morbidity and mortality rates. Several national quality programs ...

    Authors: Erin J Aiello Bowles, Heather Spencer Feigelson, Tom Barney, Katherine Broecker, Andrew Sterrett, Kimberly Bischoff, Jessica Engel, Gabrielle Gundersen, Johanna Sheehey-Jones, Richard Single, Adedayo Onitilo, Ted A James and Laurence E McCahill
    Citation: BMC Cancer 2012 12:136
  33. Clinical relevance of tumor infiltrating lymphocytes (TILs) in breast cancer is controversial. Here, we used a tumor microarray including a large series of ductal and lobular breast cancers with long term foll...

    Authors: Raoul Droeser, Inti Zlobec, Ergin Kilic, Uwe Güth, Michael Heberer, Giulio Spagnoli, Daniel Oertli and Coya Tapia
    Citation: BMC Cancer 2012 12:134
  34. The purpose of this clinical study is to investigate the clinical feasibility and effectiveness of offline Positron-Emission-Tomography (PET) quality assurance for promoting the accuracy of proton and carbon i...

    Authors: Stephanie E Combs, Julia Bauer, Daniel Unholtz, Christopher Kurz, Thomas Welzel, Daniel Habermehl, Thomas Haberer, Jürgen Debus and Katia Parodi
    Citation: BMC Cancer 2012 12:133
  35. Breast cancer outcome, including response to therapy, risk of metastasis and survival, is difficult to predict using currently available methods, highlighting the urgent need for more informative biomarkers. A...

    Authors: Kate M Peters, Stacey L Edwards, Shalima S Nair, Juliet D French, Peter J Bailey, Kathryn Salkield, Sandra Stein, Sarah Wagner, Glenn D Francis, Susan J Clark and Melissa A Brown
    Citation: BMC Cancer 2012 12:132
  36. It is well known that osteopontin (OPN) plays an important role in tumor progression and that a high OPN expression level in several tumor entities correlates with poor prognosis in cancer patients. However, l...

    Authors: Antje Hahnel, Henri Wichmann, Thomas Greither, Matthias Kappler, Peter Würl, Matthias Kotzsch, Helge Taubert, Dirk Vordermark and Matthias Bache
    Citation: BMC Cancer 2012 12:131
  37. Nitric oxide (NO) and its oxidative reaction products have been repeatedly shown to block steroid receptor function via nitrosation of zinc finger structures in the DNA-binding domain (DBD). In consequence NO-...

    Authors: Martin Laschak, Klaus-Dieter Spindler, Andres J Schrader, Andrea Hessenauer, Wolfgang Streicher, Mark Schrader and Marcus V Cronauer
    Citation: BMC Cancer 2012 12:130
  38. Angiogenesis plays an important role in tumor growth and metastasis, therefore antiangiogenic therapy was widely investigated as a promising approach for cancer therapy. Recently, pigment epithelium-derived fa...

    Authors: Qin Jie Wu, Chang Yang Gong, Shun Tao Luo, Dong Mei Zhang, Shuang Zhang, Hua Shan Shi, Lian Lu, Heng Xiu Yan, Sha Sha He, Dan Dan Li, Li Yang, Xia Zhao and Yu Quan Wei
    Citation: BMC Cancer 2012 12:129
  39. Population-based studies on endometrial cancer providing survival estimates by age, histology, and stage have been sparse. We aimed to derive most up-to-date and detailed survival estimates for endometrial can...

    Authors: Tianhui Chen, Lina Jansen, Adam Gondos, Meike Ressing, Bernd Holleczek, Alexander Katalinic and Hermann Brenner
    Citation: BMC Cancer 2012 12:128
  40. Activation of MEK5 in many cancers is associated with carcinogenesis through aberrant cell proliferation. In this study, we determined the level of phosphorylated MEK5 (pMEK5) expression in human colorectal ca...

    Authors: Bang Hu, Donglin Ren, Dan Su, Hongcheng Lin, Zhenyu Xian, Xingyang Wan, Junxiao Zhang, Xinhui Fu, Li Jiang, Dechan Diao, Xinjuan Fan, Lei Wang and Jianping Wang
    Citation: BMC Cancer 2012 12:127
  41. Cutaneous squamous cell carcinoma (SCC) is associated with underlying immunosuppression, so it may be a prognostic marker in patients with subsequent cancer. We therefore conducted a nationwide population-base...

    Authors: Sigrun Alba Johannesdottir, Timothy L Lash, Annette Østergaard Jensen, Dóra Körmendiné Farkas and Anne Braae Olesen
    Citation: BMC Cancer 2012 12:126
  42. Epstein-Barr virus (EBV) establishes its latency in EBV-associated malignancies, accompanied by occasionally reactivated lytic cycle. Promoter CpG methylation of EBV genome plays an essential role in maintaini...

    Authors: Lili Li, Xianwei Su, Gigi Ching Gee Choi, Ya Cao, Richard F Ambinder and Qian Tao
    Citation: BMC Cancer 2012 12:125
  43. With over 20 million formalin-fixed, paraffin-embedded (FFPE) tissue samples archived each year in the United States alone, archival tissues remain a vast and under-utilized resource in the genomic study of ca...

    Authors: Levi Waldron, Peter Simpson, Giovanni Parmigiani and Curtis Huttenhower
    Citation: BMC Cancer 2012 12:124
  44. Studies indicate that strength training has beneficial effects on clinical health outcomes in prostate cancer patients during androgen deprivation therapy. However, randomized controlled trials are needed to s...

    Authors: Lene Thorsen, Tormod S Nilsen, Truls Raastad, Kerry S Courneya, Eva Skovlund and Sophie D Fosså
    Citation: BMC Cancer 2012 12:123
  45. Although socioeconomic status (SES) has been focused on as a key determinant of cancer stage at diagosis in western countries, there has been no systemic study on the relationship of SES and breast cancer stag...

    Authors: Qiong Wang, Jing Li, Shan Zheng, Jia-Yuan Li, Yi Pang, Rong Huang, Bao-Ning Zhang, Bin Zhang, Hong-Jian Yang, Xiao-Ming Xie, Zhong-Hua Tang, Hui Li, Jian-Jun He, Jin-Hu Fan and You-Lin Qiao
    Citation: BMC Cancer 2012 12:122
  46. Matrix metalloproteases (MMPs) are proteolytic enzymes that contribute to all stages of tumour progression, including the later stages of invasion and metastasis. Genetic variants in the MMP genes may influence t...

    Authors: Patricia González-Arriaga, Teresa Pascual, Arturo García-Alvarez, Ana Fernández-Somoano, M Felicitas López-Cima and Adonina Tardón
    Citation: BMC Cancer 2012 12:121
  47. Triple-negative breast cancer (TNBC) exhibit characteristics quite distinct from other kinds of breast cancer, presenting as an aggressive disease--recurring and metastasizing more often than other kinds of br...

    Authors: Punit Kaur, Ganachari M Nagaraja, Hongying Zheng, Dawit Gizachew, Moses Galukande, Sunil Krishnan and Alexzander Asea
    Citation: BMC Cancer 2012 12:120
  48. P53 mutations are an adverse prognostic factor in esophageal cancer. P53 and KRas mutations are involved in chemo-radioresistance. Circulating anti-p53 or anti-KRas antibodies are associated with gene mutation...

    Authors: Pierre Blanchard, Laurent Quero, Vincent Pacault, Marie-Helene Schlageter, Valerie Baruch-Hennequin and Christophe Hennequin
    Citation: BMC Cancer 2012 12:119
  49. Colorectal cancer is one of the major neoplasms and a leading cause of cancer death worldwide, and new preventive strategies are needed to lower the burden of this disease. Metformin, a biguanide, which is wid...

    Authors: Takuma Higurashi, Hirokazu Takahashi, Hiroki Endo, Kunihiro Hosono, Eiji Yamada, Hidenori Ohkubo, Eiji Sakai, Takashi Uchiyama, Yasuo Hata, Nobutaka Fujisawa, Shiori Uchiyama, Akiko Ezuka, Hajime Nagase, Takaomi Kessoku, Nobuyuki Matsuhashi, Shoji Yamanaka…
    Citation: BMC Cancer 2012 12:118

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