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  1. Esophageal cancer is the sixth leading cause of cancer death worldwide; current early detection screening tests are inadequate. Esophageal balloon cytology successfully retrieves exfoliated and scraped superfi...

    Authors: Shih-Wen Lin, Christian C Abnet, Neal D Freedman, Gwen Murphy, Rosana Risques, Donna Prunkard, Peter Rabinovitch, Qin-Jing Pan, Mark J Roth, Guo-Qing Wang, Wen-Qiang Wei, Ning Lu, Philip R Taylor, You-Lin Qiao and Sanford M Dawsey
    Citation: BMC Cancer 2013 13:578
  2. The placenta-specific 1 (PLAC1) gene encodes a membrane-associated protein which is selectively expressed in the placental syncytiotrophoblast and in murine fetal tissues during embryonic development. In contrast...

    Authors: Meike Wagner, Michael Koslowski, Claudia Paret, Marcus Schmidt, Özlem Türeci and Ugur Sahin
    Citation: BMC Cancer 2013 13:570
  3. Biomarkers allowing the characterization of malignancy and therapy response of oral squamous cell carcinomas (OSCC) or other types of carcinomas are still outstanding. The biochemical suicide molecule endonucl...

    Authors: Martin Grimm, Steffen Schmitt, Peter Teriete, Thorsten Biegner, Arnulf Stenzl, Jörg Hennenlotter, Hans-Joachim Muhs, Adelheid Munz, Tatjana Nadtotschi, Klemens König, Jörg Sänger, Oliver Feyen, Heiko Hofmann, Siegmar Reinert and Johannes F Coy
    Citation: BMC Cancer 2013 13:569
  4. Optimal therapy for patients with unresectable locally advanced extrahepatic cholangiocarcinoma (ULAC) remains controversial. We analysed the role of radiotherapy in the management of such tumors.

    Authors: Laurence Moureau-Zabotto, Olivier Turrini, Michel Resbeut, Jean-Luc Raoul, Marc Giovannini, Flora Poizat, Gilles Piana, Jean-Robert Delpero and Francois Bertucci
    Citation: BMC Cancer 2013 13:568
  5. The incidence of brain metastasis from hepatocellular carcinoma (HCC) is expected to increase as a result of prolonged survival due to the recent advances in HCC treatment. However, there is no definite treatm...

    Authors: Moon-Soo Han, Kyung-Sub Moon, Kyung-Hwa Lee, Sung-Bum Cho, Sa-Hoe Lim, Woo-Youl Jang, Tae-Young Jung, In-Young Kim and Shin Jung
    Citation: BMC Cancer 2013 13:567
  6. DNA methylation is a well-known epigenetic mechanism involved in epigenetic gene regulation. Several genes were reported hypermethylated in CRC, althought no gene marker was proven to be individually of suffic...

    Authors: Jean-Pierre Roperch, Roberto Incitti, Solène Forbin, Floriane Bard, Hicham Mansour, Farida Mesli, Isabelle Baumgaertner, Francesco Brunetti and Iradj Sobhani
    Citation: BMC Cancer 2013 13:566
  7. Lifestyle factors, including food and nutrition, physical activity, body composition and reproductive factors, and single nucleotide polymorphisms (SNPs) are associated with breast cancer risk, but few studies...

    Authors: Taeko Mizoo, Naruto Taira, Keiko Nishiyama, Tomohiro Nogami, Takayuki Iwamoto, Takayuki Motoki, Tadahiko Shien, Junji Matsuoka, Hiroyoshi Doihara, Setsuko Ishihara, Hiroshi Kawai, Kensuke Kawasaki, Youichi Ishibe, Yutaka Ogasawara, Yoshifumi Komoike and Shinichiro Miyoshi
    Citation: BMC Cancer 2013 13:565
  8. Treatment of early and multiple cutaneous unresectable recurrences is a major therapeutic problem with around 80% of patients relapsing within 5 years. For lesions refractory to elective treatments, electroche...

    Authors: Corrado Caracò, Nicola Mozzillo, Ugo Marone, Ester Simeone, Lucia Benedetto, Gianluca Di Monta, Maria Luisa Di Cecilia, Gerardo Botti and Paolo Antonio Ascierto
    Citation: BMC Cancer 2013 13:564
  9. Myxofibrosarcoma comprises a spectrum of malignant neoplasms withprominent myxoid stromata, cellular pleomorphism, and distinct curvilinear vascular patterns. These neoplasms mainly affect patients in the sixt...

    Authors: Birgit Lohberger, Nicole Stuendl, Elisabeth Wolf, Bernadette Liegl-Atzwanger, Andreas Leithner and Beate Rinner
    Citation: BMC Cancer 2013 13:563
  10. Genetic BRCA2 insufficiency is associated with breast cancer development; however, in sporadic breast cancer cases, high BRCA2 expression is paradoxically correlated with poor prognosis. Because DSS1, a mammal...

    Authors: Andri Rezano, Kazuhiko Kuwahara, Mutsuko Yamamoto-Ibusuki, Masahiro Kitabatake, Penpak Moolthiya, Suchada Phimsen, Taiji Suda, Shigenobu Tone, Yutaka Yamamoto, Hirotaka Iwase and Nobuo Sakaguchi
    Citation: BMC Cancer 2013 13:562
  11. Vemurafenib, an inhibitor of genetically activated BRAF, is now commonly prescribed for metastatic melanoma harboring a BRAF mutation. Reports on side effects have focused on cutaneous complications. We here pres...

    Authors: Sanne EJ Wolf, Christina Meenken, Annette C Moll, John B Haanen and Michiel S van der Heijden
    Citation: BMC Cancer 2013 13:561
  12. The aim of this study was to evaluate the role of family history of cancer and personal history of other medical conditions in the aetiology of the oral cavity cancer in France.

    Authors: Loredana Radoï, Sophie Paget-Bailly, Florence Guida, Diane Cyr, Gwenn Menvielle, Annie Schmaus, Matthieu Carton, Sylvie Cénée, Marie Sanchez, Anne-Valérie Guizard, Brigitte Trétarre, Isabelle Stücker and Danièle Luce
    Citation: BMC Cancer 2013 13:560
  13. A diagnosis of prostate cancer leads to emotional distress and anxiety, prompting calls for rapid diagnostic pathways. Nevertheless, it remains unclear what impact time between diagnosis and surgery has upon p...

    Authors: Maria Theresa Redaniel, Richard M Martin, David Gillatt, Julia Wade and Mona Jeffreys
    Citation: BMC Cancer 2013 13:559
  14. The St Gallen surrogate molecular subtype definitions classify the oestrogen (ER) positive breast cancer into the luminal A and luminal B subtypes according to proliferation rate and/or expression of human epi...

    Authors: Anna-Karin Falck, Mårten Fernö, Pär-Ola Bendahl and Lisa Rydén
    Citation: BMC Cancer 2013 13:558
  15. WNT signaling pathways are significantly altered during cancer development. Vertebrates possess two classes of WNT signaling pathways: the “canonical” WNT/β-catenin signaling pathway, and the “non-canonical” p...

    Authors: Beatriz García-Castro, Monserrat Alvarez-Zavala, Alma R Riveros-Magaña, Pablo C Ortíz-Lazareno, Sarah Ratkovich-González, Georgina Hernández-Flores, Alejandro Bravo-Cuellar, Luis F Jave-Suarez and Adriana Aguilar-Lemarroy
    Citation: BMC Cancer 2013 13:557
  16. We have previously shown that a functional polymorphism of the UGT2B15 gene (rs1902023) was associated with increased risk of prostate cancer (PC). Novel functional polymorphisms of the UGT2B17 and UGT2B15 genes ...

    Authors: Adriana C Vidal, Cocoa Tucker, Joellen M Schildkraut, Ricardo M Richardson, Megan McPhail, Stephen J Freedland, Cathrine Hoyo and Delores J Grant
    Citation: BMC Cancer 2013 13:556
  17. Glutamate decarboxylase 1 (GAD1), a rate-limiting enzyme in the production of γ-aminobutyric acid (GABA), is found in the GABAergic neurons of the central nervous system. Little is known about the relevance of...

    Authors: Ryota Kimura, Atsushi Kasamatsu, Tomoyoshi Koyama, Chonji Fukumoto, Yukinao Kouzu, Morihiro Higo, Yosuke Endo-Sakamoto, Katsunori Ogawara, Masashi Shiiba, Hideki Tanzawa and Katsuhiro Uzawa
    Citation: BMC Cancer 2013 13:555
  18. Pancreatic cancer (PC) is an aggressive disease with an urgent need for biomarkers. Hallmarks of PC include increased collagen deposition (desmoplasia) and increased matrix metalloproteinase (MMP) activity. Th...

    Authors: Nicholas Willumsen, Cecilie L Bager, Diana J Leeming, Victoria Smith, Morten A Karsdal, David Dornan and Anne-Christine Bay-Jensen
    Citation: BMC Cancer 2013 13:554
  19. Data on the current burden of adenocarcinoma (ADC) and histology-specific human papillomavirus (HPV) type distribution are relevant to predict the future impact of prophylactic HPV vaccines.

    Authors: Jeanne M Pimenta, Claudia Galindo, David Jenkins and Sylvia M Taylor
    Citation: BMC Cancer 2013 13:553
  20. The tumor suppressor p53 is a sequence-specific transcription factor that regulates an extensive network of coding genes, long non-coding RNAs and microRNAs, that establish intricate gene regulatory circuits i...

    Authors: Alessandra Bisio, Veronica De Sanctis, Valerio Del Vescovo, Michela A Denti, Anil G Jegga, Alberto Inga and Yari Ciribilli
    Citation: BMC Cancer 2013 13:552
  21. Heterogeneous echogenicity of the thyroid gland has been associated with diffuse thyroid disease and benign and malignant nodules can coexist with diffuse thyroid disease. Underlying heterogeneous echogenicity...

    Authors: Mina Park, So Hee Park, Eun-Kyung Kim, Jung Hyun Yoon, Hee Jung Moon, Hye Sun Lee and Jin Young Kwak
    Citation: BMC Cancer 2013 13:550
  22. Resistance to platinum-based chemotherapy remains a major impediment in the treatment of serous epithelial ovarian cancer. The objective of this study was to use gene expression profiling to delineate major de...

    Authors: Madhuri Koti, Robert J Gooding, Paulo Nuin, Alexandria Haslehurst, Colleen Crane, Johanne Weberpals, Timothy Childs, Peter Bryson, Moyez Dharsee, Kenneth Evans, Harriet E Feilotter, Paul C Park and Jeremy A Squire
    Citation: BMC Cancer 2013 13:549
  23. Replanning in intensity-modulated radiotherapy (IMRT) has been reported to improve quality of life and loco-regional control in patients with nasopharyngeal cancer (NPC). Determination of the criteria for repl...

    Authors: DanFang Yan, SenXiang Yan, QiDong Wang, XinBiao Liao, ZhongJie Lu and YiXiang Wang
    Citation: BMC Cancer 2013 13:548
  24. Nivestim™ (filgrastim) is a follow-on biologic agent licensed in the EU for the treatment of neutropenia and febrile neutropenia induced by myelosuppressive chemotherapy. Nivestim™ has been studied in phase 2 ...

    Authors: Didier Kamioner, Stefan Fruehauf, Fréderic Maloisel, Laurent Cals, Stéphane Lepretre and Christian Berthou
    Citation: BMC Cancer 2013 13:547
  25. The chemotherapy resistance of non-small cell lung cancer (NSCLC) remains a clinic challenge and is closely associated with several biomarkers including epidermal growth factor receptor (EGFR) ( Drugs 72(Suppl...

    Authors: Xiao-Yi Duan, Wen Wang, Jian-Sheng Wang, Jin Shang, Jun-Gang Gao and You-Min Guo
    Citation: BMC Cancer 2013 13:546
  26. The present study focused on the prognostic roles of PIK3CA and PIK3R1 genes and additional PI3K pathway-associated genes in breast cancer.

    Authors: Magdalena Cizkova, Sophie Vacher, Didier Meseure, Martine Trassard, Aurélie Susini, Dana Mlcuchova, Celine Callens, Etienne Rouleau, Frederique Spyratos, Rosette Lidereau and Ivan Bièche
    Citation: BMC Cancer 2013 13:545
  27. During cancer treatment children have reduced contact with their social network of friends, and have limited participation in education, sports, and leisure activities. During and following cancer treatment, c...

    Authors: Troels Thorsteinsson, Anne Sofie Helms, Lis Adamsen, Lars Bo Andersen, Karen Vitting Andersen, Karl Bang Christensen, Henrik Hasle, Carsten Heilmann, Nete Hejgaard, Christoffer Johansen, Marianne Madsen, Svend Aage Madsen, Venka Simovska, Birgit Strange, Lone Friis Thing, Peder Skov Wehner…
    Citation: BMC Cancer 2013 13:544
  28. Nowadays, evaluation of colorectal cancer prognosis and decision-making for treatment continues to be based primarily on TNM tumour stage. Administration of adjuvant chemotherapy is especially challenging for ...

    Authors: Daniel Ayude, Francisco Javier Rodríguez-Berrocal, José Ayude, Sonia Blanco-Prieto, Lorena Vázquez-Iglesias, Marta Vázquez-Cedeira and María Páez de la Cadena
    Citation: BMC Cancer 2013 13:543
  29. Systemic capillary leak syndrome is a rare disease with a high mortality rate. This syndrome is characterised by generalised edema, hypotension, hemoconcentration, and hypoproteinemia. The cause is the sudden ...

    Authors: Andrea Casadei Gardini, Michele Aquilina, Devil Oboldi, Alessandro Lucchesi, Silvia Carloni, Elena Tenti, Marco Angelo Burgio, Dino Amadori and Giovanni Luca Frassineti
    Citation: BMC Cancer 2013 13:542
  30. The purpose of the present study was to retrospectively evaluate whether copy number changes of the genes encoding the ribonucleotide reductase subunit M1 (RRM1) and/or subunit M2B (RRM2B) predict sensitivity to ...

    Authors: Charlotte LT Jørgensen, Bent Ejlertsen, Karsten D Bjerre, Eva Balslev, Dorte L Nielsen and Kirsten V Nielsen
    Citation: BMC Cancer 2013 13:541
  31. In a previously published report we characterized the expression of the metastasis-associated proteins S100A4, osteopontin (OPN) and ephrin-A1 in a prospectively collected panel of non-small cell lung cancer (...

    Authors: Ane Kongsgaard Rud, Kjetil Boye, Miriam Øijordsbakken, Marius Lund-Iversen, Ann Rita Halvorsen, Steinar K Solberg, Gisle Berge, Åslaug Helland, Odd Terje Brustugun and Gunhild M Mælandsmo
    Citation: BMC Cancer 2013 13:540
  32. Esophageal cancer (EC) is a frequently occurring cancer with poor prognosis despite combined therapeutic strategies. Many biomarkers have been proposed as predictors of adverse events. We sought to assess the ...

    Authors: Meilan Chen, Jizheng Huang, Zhenli Zhu, Jun Zhang and Ke Li
    Citation: BMC Cancer 2013 13:539

    The Erratum to this article has been published in BMC Cancer 2014 14:892

  33. Molecular imaging of breast cancer is a promising emerging technology, potentially able to improve clinical care. Valid imaging targets for molecular imaging tracer development are membrane-bound hypoxia-relat...

    Authors: Arthur Adams, Aram SA van Brussel, Jeroen F Vermeulen, Willem PThM Mali, Elsken van der Wall, Paul J van Diest and Sjoerd G Elias
    Citation: BMC Cancer 2013 13:538
  34. Triple Negative subset of (TN) Breast Cancers (BC), a close associate of the basal-like subtype (with limited discordance) is an aggressive form of the disease which convey unpredictable, and poor prognosis du...

    Authors: Nandini Dey, Benjamin G Barwick, Carlos S Moreno, Maja Ordanic-Kodani, Zhengjia Chen, Gabriella Oprea-Ilies, Weining Tang, Charles Catzavelos, Kimberly F Kerstann, George W Sledge Jr., Mark Abramovitz, Mark Bouzyk, Pradip De and Brian R Leyland-Jones
    Citation: BMC Cancer 2013 13:537
  35. Gastric cancer (GC) is a threat to human health with increasing incidence and mortality worldwide. Down-regulation or absence of RAF kinase inhibitor protein (RKIP) was associated with the occurrence, differen...

    Authors: Huan Gu, Xianquan Zhan, Guiying Zhang, Lu Yan, William CS Cho, Maoyu Li, Ting Liu and Zhuchu Chen
    Citation: BMC Cancer 2013 13:536
  36. Mesenchymal stromal cells (MSCs) represent heterogeneous cell population suitable for cell therapies in regenerative medicine. MSCs can also substantially affect tumor biology due to their ability to be recrui...

    Authors: Lucia Kucerova, Svetlana Skolekova, Miroslava Matuskova, Martin Bohac and Zuzana Kozovska
    Citation: BMC Cancer 2013 13:535
  37. National organizations recommend screening for hepatitis B virus (HBV) before chemotherapy but differ regarding which patients should be screened. We aimed to determine contemporary screening rates at a cancer...

    Authors: Jessica P Hwang, Michael J Fisch, Anna S-F Lok, Hong Zhang, John M Vierling and Maria E Suarez-Almazor
    Citation: BMC Cancer 2013 13:534
  38. Current evidence implicates aberrant microRNA expression patterns in human malignancies; measurement of microRNA expression may have diagnostic and prognostic applications. Roles for microRNAs in head and neck...

    Authors: Patricia Severino, Holger Brüggemann, Flavia Maziero Andreghetto, Carme Camps, Maria de Fatima Garrido Klingbeil, Welbert Oliveira de Pereira, Renata Machado Soares, Raquel Moyses, Victor Wünsch-Filho, Monica Beatriz Mathor, Fabio Daumas Nunes, Jiannis Ragoussis and Eloiza Helena Tajara
    Citation: BMC Cancer 2013 13:533
  39. An imbalance between proliferation and apoptosis is one of the main features of carcinogenesis. TRAIL (TNF-related apoptosis-inducing ligand) induces apoptosis upon binding to the TRAIL death receptors, TRAIL ...

    Authors: Ronald Koschny, Sylvia Brost, Ulf Hinz, Jaromir Sykora, Emanuela M Batke, Stephan Singer, Kai Breuhahn, Wolfgang Stremmel, Henning Walczak, Peter Schemmer, Peter Schirmacher and Tom M Ganten
    Citation: BMC Cancer 2013 13:532
  40. In contrast to sessile serrated adenomas and traditional serrated adenomas which are associated with a significant cancer risk, the role of hyperplastic polyps (HP) in colorectal carcinogenesis as well as the ...

    Authors: Catherine Do, Claudine Bertrand, Julien Palasse, Marie-Bernadette Delisle, Elizabeth Cohen-Jonathan-Moyal and Catherine Seva
    Citation: BMC Cancer 2013 13:531
  41. The objective of this work was to assess the overall survival, cause-specific survival and biochemical failure-free survival of a contemporary cohort of patients with localized prostate cancer (PCa) treated wi...

    Authors: Tomás Merino, Ignacio F San Francisco, Pablo A Rojas, Piero Bettoli, Álvaro Zúñiga and Pelayo Besa
    Citation: BMC Cancer 2013 13:530
  42. Small-cell lung cancer with epidermal growth factor receptor (EGFR) gene mutation typically manifests as a transformation occurring after EGFR tyrosine kinase inhibitor therapy for adenocarcinoma with EGFR mutati...

    Authors: Yusuke Takagi, Yoshiro Nakahara, Yukio Hosomi and Tsunekazu Hishima
    Citation: BMC Cancer 2013 13:529
  43. A total of 2,514,346 metric tons (Mt) of asbestos were imported into Spain from 1906 until the ban on asbestos in 2002. Our objective was to study pleural cancer mortality trends as an indicator of mesotheliom...

    Authors: Gonzalo López-Abente, Montserrat García-Gómez, Alfredo Menéndez-Navarro, Pablo Fernández-Navarro, Rebeca Ramis, Javier García-Pérez, Marta Cervantes, Eva Ferreras, María Jiménez-Muñoz and Roberto Pastor-Barriuso
    Citation: BMC Cancer 2013 13:528
  44. Recent studies have demonstrated that synthetic dsRNAs may produce therapeutic effects in a target-independent manner through stimulation of the toll-like receptor-3 (TLR3)/interferon pathway; as a result, ang...

    Authors: Yu-Yin Xu, Li Chen, Gui-Lan Wang, Jia-Ming Zhou, Yi-Xin Zhang, Yin-Ze Wei, Yuan-Yuan Zhu and Jing Qin
    Citation: BMC Cancer 2013 13:527
  45. Colorectal cancer (CRC) is one of the most common and comprehensively studied malignancies. Hypoxic conditions during formation of CRC may support the development of more aggressive cancers. Hypoxia inducible ...

    Authors: Agnieszka A Rawluszko, Katarzyna E Bujnicka, Karolina Horbacka, Piotr Krokowicz and Paweł P Jagodziński
    Citation: BMC Cancer 2013 13:526
  46. The purpose of this study was to evaluate whether early changes in 3′-deoxy-3′-3H-fluorothymidine (3H-FLT) uptake can reflect the antiproliferative effect of gefitinib in a human tumor xenograft, in comparison wi...

    Authors: Songji Zhao, Yuji Kuge, Yan Zhao, Satoshi Takeuchi, Kenji Hirata, Toshiki Takei, Tohru Shiga, Hirotoshi Dosaka-Akita and Nagara Tamaki
    Citation: BMC Cancer 2013 13:525
  47. Clear cell carcinomas are aggressive tumors with a distinct biologic behaviour. In a genome-wide screening for genes involved in chemo-resistance, NAPA was over-expressed in cisplatin-resistant cells. The NAPA...

    Authors: Ingiridur Skirnisdottir, Kathrine Bjersand, Helena Åkerud and Tomas Seidal
    Citation: BMC Cancer 2013 13:524
  48. Poly(adenosine diphosphate–ribose) polymerase 1 (PARP-1) and the balance between BRCA1 and 53BP1 play a key role in the DNA repair and cell stress response. PARP inhibitors show promising clinical activity in ...

    Authors: William Jacot, Simon Thezenas, Romain Senal, Cathy Viglianti, Anne-Claire Laberenne, Evelyne Lopez-Crapez, Frédéric Bibeau, Jean-Pierre Bleuse, Gilles Romieu and Pierre-Jean Lamy
    Citation: BMC Cancer 2013 13:523
  49. Ezrin, a member of the ezrin/radixin/moesin (ERM) protein family, plays a pivotal role in tumor invasion and metastasis. This study is aimed to investigate the clinicopathological significance of upregulated e...

    Authors: Jienan Kong, Yan Li, Shuangping Liu, Haidan Jin, Yongjun Shang, Chengshi Quan, Yulin Li and Zhenhua Lin
    Citation: BMC Cancer 2013 13:520

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