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  1. The aim of this study was to evaluate the expression of the cell adhesion-related glycoproteins MUC-1, β-catenin and E-cadherin in multicentric/multifocal breast cancer in comparison to unifocal disease in ord...

    Authors: Tobias Weissenbacher, Eva Hirte, Christina Kuhn, Wolfgang Janni, Doris Mayr, Uwe Karsten, Brigitte Rack, Klaus Friese, Udo Jeschke, Sabine Heublein, Darius Dian and Nina Ditsch
    Citation: BMC Cancer 2013 13:361
    Content type: Research article Published on:

  2. It is widely recognized that spiritual care plays an important role in physical and psychosocial well-being of cancer patients, but there is little evidence based research on the effects of spiritual care. We ...

    Authors: Renske Kruizinga, Michael Scherer-Rath, Johannes BAM Schilderman, Mirjam AG Sprangers and Hanneke WM Van Laarhoven
    Citation: BMC Cancer 2013 13:360
    Content type: Study protocol Published on:

  3. Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a multifunctional Ig-like cell adhesion molecule that has a wide range of biological functions. According to previous reports, serum CEACA...

    Authors: Mu-qing Zhou, Yan Du, Yi-wen Liu, Ying-zhi Wang, Yi-qing He, Cui-xia Yang, Wen-juan Wang and Feng Gao
    Citation: BMC Cancer 2013 13:359
    Content type: Research article Published on:

  4. Cancer stem cell model hypothesizes existence of a small proportion of tumor cells capable of sustaining tumor formation, self-renewal and differentiation. In breast cancer, these cells were found to be associ...

    Authors: Marija Balic, Daniela Schwarzenbacher, Stefanie Stanzer, Ellen Heitzer, Martina Auer, Jochen B Geigl, Richard J Cote, Ram H Datar and Nadia Dandachi
    Citation: BMC Cancer 2013 13:358
    Content type: Research article Published on:

  5. Invasive cervical cancer is the second most common malignant tumor affecting Brazilian women. Knowledge on Human Papillomavirus (HPV) genotypes in invasive cervical cancer cases is crucial to guide the introdu...

    Authors: Cristina Mendes de Oliveira, José Humberto Tavares Guerreiro Fregnani, Jesus Paula Carvalho, Adhemar Longatto-Filho and José Eduardo Levi
    Citation: BMC Cancer 2013 13:357
    Content type: Research article Published on:

  6. Abnormal expression of Baculoviral inhibitor of apoptosis repeat-containing 5 (BIRC5, also called as survivin), a novel member of the inhibitor of apoptosis protein (IAP) family, has implications in many types of...

    Authors: Jiawei Chen, Xinhai Cui, Hai Zhou, Chao Qin, Qiang Cao, Xiaobing Ju, Pu Li, Hongzhou Cai, Jian Zhu, Xiaoxin Meng, Meilin Wang, Zhengdong Zhang, Pengfei Shao, Jie Li and Changjun Yin
    Citation: BMC Cancer 2013 13:356
    Content type: Research article Published on:

  8. Serum CYFRA 21–1 is one of the most important serum markers in the diagnosis of non-small cell lung cancer (NSCLC), especially squamous-cell carcinoma. However, it remains unknown whether pretreatment serum CY...

    Authors: Akira Ono, Toshiaki Takahashi, Keita Mori, Hiroaki Akamatsu, Takehito Shukuya, Tetsuhiko Taira, Hirotsugu Kenmotsu, Tateaki Naito, Haruyasu Murakami, Takashi Nakajima, Masahiro Endo and Nobuyuki Yamamoto
    Citation: BMC Cancer 2013 13:354
    Content type: Research article Published on:

  9. To evaluate if human papillomavirus (HPV) self-sampling (Self-HPV) using a dry vaginal swab is a valid alternative for HPV testing.

    Authors: Isabelle Eperon, Pierre Vassilakos, Isabelle Navarria, Pierre-Alain Menoud, Aude Gauthier, Jean-Claude Pache, Michel Boulvain, Sarah Untiet and Patrick Petignat
    Citation: BMC Cancer 2013 13:353
    Content type: Research article Published on:

  10. Venous thromboembolism (VTE) has been associated with a higher risk of developing malignancy and mortality, and patients with VTE may therefore benefit from increased surveillance. We aimed to construct a clin...

    Authors: Bruno L Ferreyro, Federico Angriman, Diego Giunta, María Lourdes Posadas-Martínez, Fernando Vazquez, Fernán Gonzalez Bernaldo De Quirós, Andre C K B Amaral and Damon C Scales
    Citation: BMC Cancer 2013 13:352
    Content type: Research article Published on:

  11. Until now, FISH has been the gold standard technique to identify HER2 amplification status in ambiguous cases of breast cancer. Alternative techniques have been developed to increase the capacities of investigati...

    Authors: Jocelyne Jacquemier, Frédérique Spyratos, Benjamin Esterni, Marie-Joëlle Mozziconacci, Martine Antoine, Laurent Arnould, Sarab Lizard, Philippe Bertheau, Jacqueline Lehmann-Che, Cécile Blanc Fournier, Sophie Krieger, Frédéric Bibeau, Pierre-Jean Lamy, Marie Pierre Chenard, Michèle Legrain, Jean-Marc Guinebretière…
    Citation: BMC Cancer 2013 13:351
    Content type: Technical advance Published on:

  12. Several inflammatory response materials could be used for prediction of prognosis of cancer patients. The neutrophil lymphocyte ratio (NLR), and the platelet lymphocyte ratio (PLR) have been introduced for pro...

    Authors: Suee Lee, Sung Yong Oh, Sung Hyun Kim, Ji Hyun Lee, Min Chan Kim, Ki Han Kim and Hyo-Jin Kim
    Citation: BMC Cancer 2013 13:350
    Content type: Research article Published on:

  13. Yes-associated protein 1 (YAP 1), the nuclear effector of the Hippo pathway, is a key regulator of organ size and a candidate human oncogene in multiple tumors. However, the expression dynamics of YAP 1 in uro...

    Authors: Jian-Ye Liu, Yong-Hong Li, Huan-Xin Lin, Yi-Ji Liao, Shi-Juan Mai, Zhou-Wei Liu, Zhi-Ling Zhang, Li-Juan Jiang, Jia-Xing Zhang, Hsiang-Fu Kung, Yi-Xin Zeng, Fang-Jian Zhou and Dan Xie
    Citation: BMC Cancer 2013 13:349
    Content type: Research article Published on:

  14. Mutation(s) of the JAK2 gene (V617F) has been described in a significant proportion of Philadelphia negative Myeloproliferative Neoplasms (MPN) patients and its detection is now a cornerstone in the diagnostic al...

    Authors: Enrico Bracco, Valentina Rosso, Anna Serra, Francesca Carnuccio, Valentina Gaidano, Paolo Nicoli, Pellegrino Musto, Giuseppe Saglio, Francesco Frassoni and Daniela Cilloni
    Citation: BMC Cancer 2013 13:348
    Content type: Research article Published on:

  16. Pygopus 2 (Pygo2) is a Pygo family member and an important component of the Wnt signaling transcriptional complex. Despite this data, no clinical studies investigating Pygo2 expression in lung cancer have yet ...

    Authors: Yang Liu, Qian-Ze Dong, Si Wang, Chang-Qing Fang, Yuan Miao, Liang Wang, Ming-Zhu Li and En-Hua Wang
    Citation: BMC Cancer 2013 13:346
    Content type: Research article Published on:

  17. In order to improve the clinical outcome of patients with locally advanced squamous cell carcinoma of the head and neck (LASCCHN) not being capable to receive platinum-based chemoradiation, radiotherapy can be...

    Authors: G Habl, K Potthoff, MF Haefner, A Abdollahi, JC Hassel, E Boller, M Indorf and J Debus
    Citation: BMC Cancer 2013 13:345
    Content type: Study protocol Published on:

  19. SNAT1 is a subtype of the amino acid transport system A that has been implicated to play a potential role in cancer development and progression, yet its role in breast cancer remains unclear. In present study,...

    Authors: Kuo Wang, Fang Cao, Wenzheng Fang, Yongwei Hu, Ying Chen, Houzhong Ding and Guanzhen Yu
    Citation: BMC Cancer 2013 13:343
    Content type: Research article Published on:

  21. The tumour suppressor and transcription factor p53 is a major determinant of the therapeutic response to anthracyclines. In healthy tissue, p53 is also considered pivotal for side effects of anthracycline trea...

    Authors: Lars Herfindal, Lene Myhren, Bjørn Tore Gjertsen, Stein Ove Døskeland and Gro Gausdal
    Citation: BMC Cancer 2013 13:341
    Content type: Research article Published on:

  22. Anemia refers to low hemoglobin (Hb) level and is a risk factor of cancer patient survival. The National Comprehensive Cancer Network recently suggested that post-diagnosis Hb change, regardless of baseline Hb...

    Authors: Shaogui Wan, Yinzhi Lai, Ronald E Myers, Bingshan Li, Juan P Palazzo, Ashlie L Burkart, Guokai Chen, Jinliang Xing and Hushan Yang
    Citation: BMC Cancer 2013 13:340
    Content type: Research article Published on:

  23. Women with mutations in BRCA1 or BRCA2 are at high risk of developing breast cancer and, in British Columbia, Canada, are offered screening with both magnetic resonance imaging (MRI) and mammography to facilit...

    Authors: Reka Pataky, Linlea Armstrong, Stephen Chia, Andrew J Coldman, Charmaine Kim-Sing, Barbara McGillivray, Jenna Scott, Christine M Wilson and Stuart Peacock
    Citation: BMC Cancer 2013 13:339
    Content type: Research article Published on:

  24. Melanoma represents one of the most aggressive and therapeutically challenging malignancies as it often gives rise to metastases and develops resistance to classical chemotherapeutic agents. Although diverse t...

    Authors: Valerie Kedinger, Aline Meulle, Omar Zounib, Marie-Elise Bonnet, Jean-Baptiste Gossart, Elodie Benoit, Melanie Messmer, Pattabhiraman Shankaranarayanan, Jean-Paul Behr, Patrick Erbacher and Anne-Laure Bolcato-Bellemin
    Citation: BMC Cancer 2013 13:338
    Content type: Research article Published on:

  25. It is clear that genetic variations in the fat mass and obesity-associated (FTO) gene affect body mass index and the risk of obesity. Given the mounting evidence showing a positive association between obesity ...

    Authors: Yingsong Lin, Junko Ueda, Kiyoko Yagyu, Hiroshi Ishii, Makoto Ueno, Naoto Egawa, Haruhisa Nakao, Mitsuru Mori, Keitaro Matsuo and Shogo Kikuchi
    Citation: BMC Cancer 2013 13:337
    Content type: Research article Published on:

  26. Cysteinyl leukotrienes (CysLTs) are potent pro-inflammatory mediators that are increased in samples from patients with inflammatory bowel diseases (IBDs). Individuals with IBDs have enhanced susceptibility to ...

    Authors: Astrid M Bengtsson, Gunilla Jönsson, Cecilia Magnusson, Tavga Salim, Cecilia Axelsson and Anita Sjölander
    Citation: BMC Cancer 2013 13:336
    Content type: Research article Published on:

  27. Cryptogenic hepatocellular carcinoma (HCC) is thought to arise due to non-alcoholic fatty liver disease (NAFLD). This study investigated the prevalence, clinical features, and outcomes of cryptogenic HCC and c...

    Authors: Sang Soo Lee, Sook-Hyang Jeong, Young-Sang Byoun, Seong Min Chung, Mun Hyuk Seong, Hyung Rae Sohn, Bo-young Min, Eun Sun Jang, Jin-Wook Kim, Guan Jung Park, Yoon Jin Lee, Kyoung Ho Lee and Soyeon Ahn
    Citation: BMC Cancer 2013 13:335
    Content type: Research article Published on:

  28. Thyroid hormones have been shown to regulate breast cancer cells growth, the absence or reduction of thyroid hormones in cells could provoke a proliferation arrest in G0-G1 or weak mitochondrial activity, whic...

    Authors: Jianbo Huang, Liangbin Jin, Guangyan Ji, Lei Xing, Chaobo Xu, Xiong Xiong, Hongyuan Li, Kainan Wu, Guosheng Ren and Lingquan Kong
    Citation: BMC Cancer 2013 13:334
    Content type: Research article Published on:

  29. Considerable global variation in the incidence of lip, of oral cavity and of pharyngeal cancers exists. Whilst this reflects regional or population differences in risk, interpretation is uncertain due to heter...

    Authors: Anura Ariyawardana and Newell W Johnson
    Citation: BMC Cancer 2013 13:333
    Content type: Research article Published on:

  30. To explore the necessity of maintenance, efficacy of low-dose and superiority of various combination therapies of Bacillus Calmette-Guérin (BCG) in treatment of superficial bladder cancer (BCa).

    Authors: Shimiao Zhu, Yang Tang, Kai Li, Zhiqun Shang, Ning Jiang, Xuewu Nian, Libin Sun and Yuanjie Niu
    Citation: BMC Cancer 2013 13:332
    Content type: Research article Published on:

  31. Environment inside even a small tumor is characterized by total (anoxia) or partial oxygen deprivation, (hypoxia). It has been shown that radiotherapy and some conventional chemotherapies may be less effective...

    Authors: Sara Strese, Mårten Fryknäs, Rolf Larsson and Joachim Gullbo
    Citation: BMC Cancer 2013 13:331
    Content type: Research article Published on:

  32. Post-surgery therapies are given to early-stage breast cancer patients due to the possibility of residual micrometastasis, and optimized by clincopathological parameters such as tumor stage, and hormone recept...

    Authors: Mei-Chi Hsu, Kuo-Ting Lee, Wei-Chiang Hsiao, Chih-Hsing Wu, Hung-Yu Sun, I-Ling Lin and Kung-Chia Young
    Citation: BMC Cancer 2013 13:330
    Content type: Research article Published on:

  33. Due to changes in cancer-related risk factors, improvements in diagnostic procedures and treatments, and the aging of the population, in most developed countries cancer accounts for an increasing proportion of...

    Authors: Silvia Francisci, Stefano Guzzinati, Maura Mezzetti, Emanuele Crocetti, Francesco Giusti, Guido Miccinesi, Eugenio Paci, Catia Angiolini and Anna Gigli
    Citation: BMC Cancer 2013 13:329
    Content type: Research article Published on:

  34. Tumour size in breast cancer influences therapeutic decisions. The purpose of this study was to evaluate sizing of primary breast cancer using mammography, sonography and magnetic resonance imaging (MRI) and t...

    Authors: Ines V Gruber, Miriam Rueckert, Karl O Kagan, Annette Staebler, Katja C Siegmann, Andreas Hartkopf, Diethelm Wallwiener and Markus Hahn
    Citation: BMC Cancer 2013 13:328
    Content type: Research article Published on:

  35. Although advanced-stage cervical cancer can benefit from current treatments, approximately 30% patients may fail after definitive treatment eventually. Therefore, exploring alternative molecular therapeutic ap...

    Authors: Mingo Ming Ho Yung, David Wai Chan, Vincent Wing Sun Liu, Kwok-Ming Yao and Hextan Yuen-Sheung Ngan
    Citation: BMC Cancer 2013 13:327
    Content type: Research article Published on:

  37. The influence of variants at the 9p21 locus on melanoma risk has been reported through investigation of CDKN2A variants through candidate gene approach as well as by genome wide association studies (GWAS).

    Authors: Livia Maccioni, Panduranga Sivaramakrishna Rachakonda, Justo Lorenzo Bermejo, Dolores Planelles, Celia Requena, Kari Hemminki, Eduardo Nagore and Rajiv Kumar
    Citation: BMC Cancer 2013 13:325
    Content type: Research article Published on:

  38. Malignant pleural effusions (MPE) are a common and fatal complication in cancers including lung or breast cancers, or malignant pleural mesothelioma (MPM). MPE animal models and immunotherapy trials in MPM pat...

    Authors: Arnaud Scherpereel, Bogdan Dragos Grigoriu, Marc Noppen, Thomas Gey, Bachar Chahine, Simon Baldacci, Jacques Trauet, Marie-Christine Copin, Jean-Paul Dessaint, Henri Porte and Myriam Labalette
    Citation: BMC Cancer 2013 13:324
    Content type: Research article Published on:

  39. Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus–associated malignancy that is most common in East Asia, Africa, and Alaska. Radiotherapy is the main treatment option; unfortunately, disease response to...

    Authors: Yunbao Pan, Mengyao Wang, Xianzhang Bu, Yinglin Zuo, Sumei Wang, Dujuan Wang, Qing Liu, Bojin Su, Tao Xu, Chunhua Wang, Francois X Claret and Huiling Yang
    Citation: BMC Cancer 2013 13:323
    Content type: Research article Published on:

  40. Chemokines, including chemokine (C-X-C motif) ligand 1 (CXCL1), may regulate tumor epithelial-stromal interactions that facilitate tumor growth and invasion. Studies have linked CXCL1 expression to gastric, co...

    Authors: Makito Miyake, Adrienne Lawton, Steve Goodison, Virginia Urquidi, Evan Gomes-Giacoia, Ge Zhang, Shanti Ross, Jeongsoon Kim and Charles J Rosser
    Citation: BMC Cancer 2013 13:322
    Content type: Research article Published on:

  41. Human mitochondrial peptide deformylase (PDF) has been proposed as a novel cancer therapeutic target. However, very little is known about its expression and regulation in human tissues. The purpose of this stu...

    Authors: Harsharan Randhawa, Shireen Chikara, Drew Gehring, Tuba Yildirim, Jyotsana Menon and Katie M Reindl
    Citation: BMC Cancer 2013 13:321
    Content type: Research article Published on:

  42. Tumor dissemination to cervical lymph nodes via lymphatics represents the first step in the metastasis of head and neck squamous cell carcinoma (HNSCC) and is the most significant predictor of tumor recurrence...

    Authors: Oleksandr Ekshyyan, Tara N Moore-Medlin, Matthew C Raley, Kunal Sonavane, Xiaohua Rong, Michael A Brodt, Fleurette Abreo, Jonathan Steven Alexander and Cherie-Ann O Nathan
    Citation: BMC Cancer 2013 13:320
    Content type: Research article Published on:

  43. Understanding the physical activity experiences of patients with multiple myeloma (MM) is essential to inform the development of evidence-based interventions and to quantify the benefits of physical activity. ...

    Authors: Melinda J Craike, Kaye Hose, Kerry S Courneya, Simon J Harrison and Patricia M Livingston
    Citation: BMC Cancer 2013 13:319
    Content type: Research article Published on:

  44. To present our experience of intensity-modulated radiotherapy (IMRT) with simultaneous modulated accelerated radiotherapy (SMART) boost technique in patients with nasopharyngeal carcinoma (NPC).

    Authors: Muhammad M Fareed, Abdullah S AlAmro, Yasser Bayoumi, Mutahir A Tunio, Abdul S Ismail, Rashad Akasha, Mohamed Mubasher and Mushabbab Al Asiri
    Citation: BMC Cancer 2013 13:318
    Content type: Research article Published on:

  45. Sox2, an embryonic stem cell marker, is aberrantly expressed in a subset of breast cancer (BC). While the aberrant expression of Sox2 has been shown to significantly correlate with a number of clinicopathologi...

    Authors: Fang Wu, Xiaoxia Ye, Peng Wang, Karen Jung, Chengsheng Wu, Donna Douglas, Norman Kneteman, Gilbert Bigras, Yupo Ma and Raymond Lai
    Citation: BMC Cancer 2013 13:317
    Content type: Research article Published on:

  46. Wnt-2 plays an oncogenic role in cancer, but which Frizzled receptor(s) mediates the Wnt-2 signaling pathway in lung cancer remains unclear. We sought to (1) identify and evaluate the activation of Wnt-2 signa...

    Authors: Dawn T Bravo, Yi-Lin Yang, Kristopher Kuchenbecker, Ming-Szu Hung, Zhidong Xu, David M Jablons and Liang You
    Citation: BMC Cancer 2013 13:316
    Content type: Research article Published on:

  47. There are strong indications for a causal association between areca-nut consumption and cancers. In Meghalaya, India, the variety of areca-nut is used as raw and unprocessed form whose chemical composition and...

    Authors: Sillarine Kurkalang, Atanu Banerjee, Nitin Ghoshal, Hughbert Dkhar and Anupam Chatterjee
    Citation: BMC Cancer 2013 13:315
    Content type: Research article Published on:

  48. Circulating tumor cells (CTCs) detection has previously been used for diagnosing gastric cancer. However, the previous studies failed to make an agreement whether the detection of CTCs contributes to the diagn...

    Authors: Lanhua Tang, Shushan Zhao, Wei Liu, Nicholas F Parchim, Jin Huang, Youhong Tang, Pingping Gan and Meizuo Zhong
    Citation: BMC Cancer 2013 13:314
    Content type: Research article Published on:

  49. Aberrant DNA methylation is a prominent feature of many cancers, and may be especially relevant in germ cell tumors (GCTs) due to the extensive epigenetic reprogramming that occurs in the germ line during norm...

    Authors: James F Amatruda, Julie A Ross, Brock Christensen, Nicholas J Fustino, Kenneth S Chen, Anthony J Hooten, Heather Nelson, Jacquelyn K Kuriger, Dinesh Rakheja, A Lindsay Frazier and Jenny N Poynter
    Citation: BMC Cancer 2013 13:313
    Content type: Research article Published on:

  50. Less than 20% of Pakistani women with early-onset or familial breast/ovarian cancer harbor germ line mutations in the high-penetrance genes BRCA1, BRCA2 and TP53. Thus, mutations in other genes confer genetic sus...

    Authors: Muhammad U Rashid, Noor Muhammad, Saima Faisal, Asim Amin and Ute Hamann
    Citation: BMC Cancer 2013 13:312
    Content type: Research article Published on:

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