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  1. S100A4 is a small Ca2+-binding protein of the S100 family with metastasis-promoting properties. Recently, secreted S100A4 protein has been shown to possess a number of functions, including induction of angiogenes...

    Authors: Kjetil Boye Pedersen, Kristin Andersen, Øystein Fodstad and Gunhild Mari Mælandsmo

    Citation: BMC Cancer 2004 4:52

    Content type: Research article

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  2. The gefitinib compassionate-use programme has enabled >39,000 patients worldwide to receive gefitinib ('Iressa', ZD1839) treatment. This paper reports the outcome of gefitinib treatment in Chinese patients who...

    Authors: Xin-Lin Mu, Long-Yun Li, Xiao-Tong Zhang, Shu-Lan Wang and Meng-Zhao Wang

    Citation: BMC Cancer 2004 4:51

    Content type: Research article

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  3. The objective of this article is to present the frequency of cancer in Mexican children who were treated in the hospitals of the Instituto Mexicano del Seguro Social in Mexico City (IMSS-MC) in the period 1996...

    Authors: Servando Juárez-Ocaña, Guadalupe González-Miranda, Juan Manuel Mejía-Aranguré, Mario Enrique Rendón-Macías, María del Carmen Martínez-García and Arturo Fajardo-Gutiérrez

    Citation: BMC Cancer 2004 4:50

    Content type: Research article

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  4. Tamoxifen is being used successfully to treat breast cancer. However, tamoxifen also increases the risk of developing endometrial cancer in postmenopausal women. Raloxifene also decreases breast cancer in wome...

    Authors: Lawrence Levine

    Citation: BMC Cancer 2004 4:49

    Content type: Research article

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  5. Neo-adjuvant chemotherapy is an integral part of multi-modality approach in the management of locally advanced breast cancer and it is vital to predict the response in order to tailor the regime for a patient....

    Authors: Chintamani, Vinay Singhal, JP Singh, Ashima Lyall, Sunita Saxena and Anju Bansal

    Citation: BMC Cancer 2004 4:48

    Content type: Research article

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  6. We sought to evaluate the hypothesis that the high incidence of cutaneous melanoma in white persons in central Alabama is associated with a predominance of Irish and Scots descent.

    Authors: Ronald T Acton, Ellen H Barton, William W Hollowell, Amy L Dreibelbis, Rodney CP Go and James C Barton

    Citation: BMC Cancer 2004 4:47

    Content type: Research article

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  7. We studied the expression of DMBT1 (deleted in malignant brain tumor 1), a putative tumor suppressor gene, in normal, proliferative, and malignant breast epithelium and its possible relation to cell cycle.

    Authors: P Braidotti, PG Nuciforo, J Mollenhauer, A Poustka, C Pellegrini, A Moro, G Bulfamante, G Coggi, S Bosari and GG Pietra

    Citation: BMC Cancer 2004 4:46

    Content type: Research article

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  8. Osteosarcoma is a highly malignant bone neoplasm of children and young adults. It is characterized by extremely complex karyotypes and high frequency of chromosomal amplifications. Currently, only the histolog...

    Authors: Tsz-Kwong Man, Xin-Yan Lu, Kim Jaeweon, Laszlo Perlaky, Charles P Harris, Shishir Shah, Marc Ladanyi, Richard Gorlick, Ching C Lau and Pulivarthi H Rao

    Citation: BMC Cancer 2004 4:45

    Content type: Research article

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  9. The fusion protein RUNX1-CBFA2T1 associated with t(8;21)-positive acute myeloid leukaemia is a potent inhibitor of haematopoetic differentiation. The role of RUNX1-CBFA2T1 in leukaemic cell proliferation is le...

    Authors: Natalia Martinez, Bettina Drescher, Heidemarie Riehle, Claire Cullmann, Hans-Peter Vornlocher, Arnold Ganser, Gerhard Heil, Alfred Nordheim, Jürgen Krauter and Olaf Heidenreich

    Citation: BMC Cancer 2004 4:44

    Content type: Research article

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  10. The Hedgehog (Hh) signaling pathway regulates a variety of developmental processes, including vasculogenesis, and can also induce the expression of pro-angiogenic factors in fibroblasts postnatally. Misregulat...

    Authors: Catherine L Olsen, Pin-Pin Hsu, Jens Glienke, Gabor M Rubanyi and Alan R Brooks

    Citation: BMC Cancer 2004 4:43

    Content type: Research article

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  11. Matrix metalloproteinases [MMPs], which degrade the extracellular matrix, play an important role in the invasion and metastasis of squamous cell carcinomas. One MMP, MMP-13, is thought to play a central role i...

    Authors: Nil Culhaci, Kubilay Metin, Eray Copcu and Emel Dikicioglu

    Citation: BMC Cancer 2004 4:42

    Content type: Research article

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  12. Matrix metalloproteinases (MMPs) are central to degradation of the extracellular matrix and basement membrane during both normal and carcinogenic tissue remodeling. MT1-MMP (MMP-14) and stromelysin-3 (MMP-11) ...

    Authors: Saxon Selvey, Larisa M Haupt, Erik W Thompson, Klaus I Matthaei, Michael G Irving and Lyn R Griffiths

    Citation: BMC Cancer 2004 4:40

    Content type: Research article

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  13. Combination therapy of irinotecan, folinic acid (FA) and 5-fluorouracil (5-FU) has been proven to be highly effective for the treatment of metastatic colorectal cancer. However, in light of safety and efficacy...

    Authors: Andreas Teufel, Silke Steinmann, Jürgen Siebler, Christiane Zanke, Herbert Hohl, Bernd Adami, M Schroeder, O Klein, Thomas Höhler, Peter R Galle, Michael Heike and Markus Moehler

    Citation: BMC Cancer 2004 4:38

    Content type: Research article

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  14. Atypical glandular cells on cervical smears are often associated with clinically significant uterine lesions. The frequency and accuracy of AGC-NOS (i.e. atypical glandular cells, not otherwise specified) diag...

    Authors: René Scheiden, Catherine Wagener, Ulrich Knolle, Walter Dippel and Catherine Capesius

    Citation: BMC Cancer 2004 4:37

    Content type: Research article

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  15. This multicentre phase I/II study was designed to determine the maximum tolerated dose of irinotecan when combined with 5-fluorouracil and folinic acid according to the Mayo Clinic schedule and to evaluate the...

    Authors: Thomas Kuehr, Paul Ruff, Bernardo L Rapoport, Stephen Falk, Francis Daniel, Conrad Jacobs, Neville Davidson, Josef Thaler, Blandine Boussard and James Carmichael

    Citation: BMC Cancer 2004 4:36

    Content type: Research article

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  16. The expression profiles of solid tumor models in rodents have been only minimally studied despite their extensive use to develop anticancer agents. We have applied RNA expression profiling using Affymetrix U95...

    Authors: Michael A Gieseg, Michael Z Man, Nicholas A Gorski, Steven J Madore, Eric P Kaldjian and Wilbur R Leopold

    Citation: BMC Cancer 2004 4:35

    Content type: Research article

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  17. The importance of various inflammatory cytokines in maintaining tumor cell growth and viability is well established. Increased expression of the proinflammatory cytokine macrophage migration inhibitory factor ...

    Authors: Katherine L Meyer-Siegler, Erica C Leifheit and Pedro L Vera

    Citation: BMC Cancer 2004 4:34

    Content type: Research article

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  18. BAK (Bcl-2 homologous antagonist/killer) is a novel pro-apoptotic gene of the Bcl-2 family. It has been reported that gastric tumors have reduced BAK levels when compared with the normal mucosa. Moreover, muta...

    Authors: Qiang-Song Tong, Li-Duan Zheng, Liang Wang, Jun Liu and Wei Qian

    Citation: BMC Cancer 2004 4:33

    Content type: Research article

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  19. Following resection of liver metastases from colorectal cancer, 5-year survivals are reportedly 30 – 39%. It can be assumed that this clinical situation represents systemic disease. Therefore, it is postulated...

    Authors: Oliver F Bathe, Scot Dowden, Francis Sutherland, Elijah Dixon, Charles Butts, David Bigam, Barb Walley, Dean Ruether and Scott Ernst

    Citation: BMC Cancer 2004 4:32

    Content type: Study protocol

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  20. A novel member of the Wnt signalling pathway, Chibby, was recently identified. This protein inhibits Wnt/β-catenin mediated transcriptional activation by competing with Lef-1 (the transcription factor and targ...

    Authors: Sophie Gad, David Teboul, Astrid Lièvre, Nicolas Goasguen, Anne Berger, Philippe Beaune and Pierre Laurent-Puig

    Citation: BMC Cancer 2004 4:31

    Content type: Research article

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  21. North central China has some of the highest rates of esophageal squamous cell carcinoma in the world with cumulative mortality surpassing 20%. Mitochondrial DNA (mtDNA) accumulates more mutations than nuclear ...

    Authors: Christian C Abnet, Konrad Huppi, Ana Carrera, David Armistead, Keith McKenney, Nan Hu, Ze-Zong Tang, Philip R Taylor and Sanford M Dawsey

    Citation: BMC Cancer 2004 4:30

    Content type: Research article

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  22. Serum leptin level is associated with appetite and energy expenditure in healthy individuals. We aimed to evaluate the serum leptin concentration and the other factors which may be associated with weight loss ...

    Authors: F Fusun Bolukbas, Hasan Kilic, Cengiz Bolukbas, Mahmut Gumus, Mehmet Horoz, Nazım S Turhal and Birsel Kavakli

    Citation: BMC Cancer 2004 4:29

    Content type: Research article

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  23. The Duffy antigen receptor for chemokines (DARC) is known to be a promiscuous chemokine receptor that binds a variety of CXC and CC chemokines in the absence of any detectable signal transduction events. Withi...

    Authors: Christina L Addison, John A Belperio, Marie D Burdick and Robert M Strieter

    Citation: BMC Cancer 2004 4:28

    Content type: Research article

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  24. Recent evidence suggests that progesterone metabolites play important roles in regulating breast cancer. Previous studies have shown that tumorous tissues have higher 5α-reductase (5αR) and lower 3α-hydroxyste...

    Authors: Michael J Lewis, John P Wiebe and J Godfrey Heathcote

    Citation: BMC Cancer 2004 4:27

    Content type: Research article

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  25. Based on the site of breakpoint in t(9;22) (q34;q11), bcr-abl fusion in leukemia patients is associated with different types of transcript proteins. In this study we have seen the association of HLA genes with di...

    Authors: Shailendra Mundhada, Rajyalakshmi Luthra and Pedro Cano

    Citation: BMC Cancer 2004 4:25

    Content type: Research article

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  26. Signaling networks promoting cell growth and proliferation are frequently deregulated in cancer. Tumors often are highly dependent on such signaling pathways and may become hypersensitive to downregulation of ...

    Authors: Boris W Kramer, Rudolf Götz and Ulf R Rapp

    Citation: BMC Cancer 2004 4:24

    Content type: Research article

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  27. Therapeutic options to effectively inhibit growth and spread of neuroendocrine gastrointestinal tumors are still limited. As both meta-iodobenzylguanidine (MIBG) and interferon-γ (IFNγ) cause antineoplastic ef...

    Authors: Michael Höpfner, Andreas P Sutter, Alexander Huether, Gudrun Ahnert-Hilger and Hans Scherübl

    Citation: BMC Cancer 2004 4:23

    Content type: Research article

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  28. Patients with cancer must make frequent visits to the clinic not only for chemotherapy but also for the management of treatment-related adverse effects. Neutropenia, the most common dose-limiting toxicity of m...

    Authors: Barry V Fortner, Kurt Tauer, Ling Zhu, Theodore A Okon, Kelley Moore, Davis Templeton and Lee Schwartzberg

    Citation: BMC Cancer 2004 4:22

    Content type: Research article

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  29. DNA microarray profiling performed on clinical tissue specimens can potentially provide significant information regarding human cancer biology. Biopsy cores, the typical source of human tumor tissue, however, ...

    Authors: Elizabeth M Goley, Soni J Anderson, Cynthia Ménard, Eric Chuang, Xing Lü, Philip J Tofilon and Kevin Camphausen

    Citation: BMC Cancer 2004 4:20

    Content type: Research article

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  30. Integrin-extracellular matrix interactions activate signaling cascades such as mitogen activated protein kinases (MAPK). Integrin binding to extracellular matrix increases tyrosine phosphorylation of focal adh...

    Authors: David L Crowe and Arthur Ohannessian

    Citation: BMC Cancer 2004 4:18

    Content type: Research article

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  31. Surveillance colonoscopy is commonly recommended following potentially curative surgery for colorectal cancer. We determined factors associated with patients undergoing a least one colonoscopy within five year...

    Authors: Robert J Hilsden, Heather E Bryant, Lloyd R Sutherland, Penny MA Brasher and Anthony LA Fields

    Citation: BMC Cancer 2004 4:14

    Content type: Research article

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  32. Most of the steps involved in the initiation and progression of Hürthle (oncocytic, oxyphilic) cell carcinomas of the thyroid remain unknown.

    Authors: Valdemar Máximo, Ana Preto, Ana Crespo, Ana Sofia Rocha, José Carlos Machado, Paula Soares and Manuel Sobrinho-Simões

    Citation: BMC Cancer 2004 4:12

    Content type: Research article

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  33. Fluoropyrimidines such as 5-fluorouracil (5-FU) and 5-fluoro-2'deoxyuridine (FUDR) are among the most effective chemotherapeutic agents for treatment of metastatic colorectal cancer (CRC). Increased expression...

    Authors: Massimo Libra, Patrick M Navolanic, Renato Talamini, Erica Cecchin, Franca Sartor, Salvatore Tumolo, Sara Masier, Salvatore Travali, Mauro Boiocchi and Giuseppe Toffoli

    Citation: BMC Cancer 2004 4:11

    Content type: Research article

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  34. Subtle functional deficiencies in highly conserved DNA repair or growth regulatory processes resulting from polymorphic variation may increase genetic susceptibility to breast cancer. Polymorphisms in DNA repa...

    Authors: Alice J Sigurdson, Michael Hauptmann, Nilanjan Chatterjee, Bruce H Alexander, Michele Morin Doody, Joni L Rutter and Jeffery P Struewing

    Citation: BMC Cancer 2004 4:9

    Content type: Research article

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  35. Carcinoma of uterine cervix is the second most common cancers among women worldwide. Combined radiation and chemotherapy is the choice of treatment for advanced stages of the disease. The prognosis is poor, wi...

    Authors: Pulivarthi H Rao, Hugo Arias-Pulido, Xin-Yan Lu, Charles P Harris, Hernan Vargas, Fang F Zhang, Gopeshwar Narayan, Achim Schneider, Mary Beth Terry and Vundavalli VVS Murty

    Citation: BMC Cancer 2004 4:5

    Content type: Research article

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  36. Carcinogenesis occurs, at least in part, due to the accumulation of mutations in critical genes that control the mechanisms of cell proliferation, differentiation and death. Publicly accessible databases conta...

    Authors: Ping Qiu, Luquan Wang, Mitch Kostich, Wei Ding, Jason S Simon and Jonathan R Greene

    Citation: BMC Cancer 2004 4:4

    Content type: Research article

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  37. A case of Primitive Neuroectodermal Tumor (PNET) of the kidney in a 27-year-old woman is presented. Few cases are reported in the literature with a variable, nonspecific presentation and an aggressive behaviou...

    Authors: Giorgio Pomara, Francesco Cappello, Maria G Cuttano, Francesca Rappa, Girolamo Morelli, Pierantonio Mancini and Cesare Selli

    Citation: BMC Cancer 2004 4:3

    Content type: Case report

    Published on:

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