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  1. Advances in high-throughput technologies and bioinformatics have transformed gene expression profiling methodologies. The results of microarray experiments are often validated using reverse transcription quant...

    Authors: Kah Hoong Chang, Pieter Mestdagh, Jo Vandesompele, Michael J Kerin and Nicola Miller
    Citation: BMC Cancer 2010 10:173
  2. We reported increased levels of Phosphatidyl Inositol synthase (PI synthase), (enzyme that catalyses phosphatidyl inositol (PI) synthesis-implicated in intracellular signaling and regulation of cell growth) in...

    Authors: Jatinder Kaur, Meenakshi Sawhney, Siddartha DattaGupta, Nootan K Shukla, Anurag Srivastava and Ranju Ralhan
    Citation: BMC Cancer 2010 10:168
  3. We performed multicenter study to define clinical characteristics of noncutaneous melanomas and to establish prognostic factors patients who received curative resection.

    Authors: Hyo Song Kim, Eun Kyoung Kim, Hyun Jung Jun, Sung Yong Oh, Keon Woo Park, Do Hyoung Lim, Soon Il Lee, Jung Han Kim, Kyoung Mee Kim, Dae Ho Lee and Jeeyun Lee
    Citation: BMC Cancer 2010 10:167
  4. Subsets of cells with stem-like properties have been previously isolated from human epithelial cancers and their resistance to apoptosis-inducing stimuli has been related to carcinoma recurrence and treatment ...

    Authors: Lisa J Harper, Daniela Elena Costea, Luke Gammon, Bilal Fazil, Adrian Biddle and Ian C Mackenzie
    Citation: BMC Cancer 2010 10:166
  5. The prostate gland represents a multifaceted system in which prostate epithelia and stroma have distinct physiological roles. To understand the interaction between stroma and glandular epithelia, it is essenti...

    Authors: Jennifer L Gregg, Kathleen E Brown, Eric M Mintz, Helen Piontkivska and Gail C Fraizer
    Citation: BMC Cancer 2010 10:165
  6. Lymphovascular invasion (LVI) and lymph node metastasis are conventional pathological factors associated with an unfavorable prognosis of urothelial carcinoma of the upper urinary tract (UC-UUT), but little is...

    Authors: Takao Kamai, Hiromichi Shirataki, Kimihiro Nakanishi, Nobutaka Furuya, Tsunehito Kambara, Hideyuki Abe, Tetsunari Oyama and Ken-Ichiro Yoshida
    Citation: BMC Cancer 2010 10:164
  7. Inverse associations between cruciferous vegetable intake and lung cancer risk have been consistently reported. However, associations within smoking status subgroups have not been consistently addressed.

    Authors: Li Tang, Gary R Zirpoli, Vijayvel Jayaprakash, Mary E Reid, Susan E McCann, Chukwumere E Nwogu, Yuesheng Zhang, Christine B Ambrosone and Kirsten B Moysich
    Citation: BMC Cancer 2010 10:162
  8. Human cervical cancer oncoprotein 1 (HCCR-1), reported as a negative regulator of p53, is over-expressed in a variety of human cancers. However, it is yet unknown whether HCCR-1 plays any role in pancreatic ca...

    Authors: Zekuan Xu, Yi Zhang, Jiakai Jiang, Yang Yang, Ruihua Shi, Bo Hao, Zhihong Zhang, Zuhu Huang, Jin W Kim and Guoxin Zhang
    Citation: BMC Cancer 2010 10:161
  9. Nasopharyngeal carcinoma associated gene 6 (NGX6) is down-regulated in most colon cancer cell lines and tumor tissues when compared with their normal tissue samples. As a novel suppress tumor gene, it could in...

    Authors: Minji Liu, Ya Peng, Xiaoyan Wang, Qin Guo, Shourong Shen and Guiyuan Li
    Citation: BMC Cancer 2010 10:160
  10. Recently, extremely low frequency electromagnetic fields (ELF-EMF) have been studied with great interest due to their possible effects on human health. In this study, we evaluated the effect of 4.5 mT - 120 Hz...

    Authors: Mónica Noemí Jiménez-García, Jaime Arellanes-Robledo, Diana Ivette Aparicio-Bautista, Miguel Ángel Rodríguez-Segura, Saúl Villa-Treviño and Juan José Godina-Nava
    Citation: BMC Cancer 2010 10:159
  11. Serum tartrate-resistant acid phosphatase 5b (TRACP 5b) activity is a marker of osteoclast number and is elevated in breast cancer (BC) patients with extensive bone metastasis, which might in turn reflect the ...

    Authors: Yi-Ying Wu, Anthony J Janckila, Chih-Hung Ku, Cheng-Ping Yu, Jyh-Cherng Yu, Su-Hui Lee, Hsin-Yi Liu, Lung T Yam and Tsu-Yi Chao
    Citation: BMC Cancer 2010 10:158
  12. Hypoxic microenvironments in tumors contribute to transformation, which may alter metabolism, growth, and therapeutic responsiveness. The α-enolase gene encodes both a glycolytic enzyme (α-enolase) and a DNA-b...

    Authors: Kara C Sedoris, Shelia D Thomas and Donald M Miller
    Citation: BMC Cancer 2010 10:157
  13. Breast cancer is the most frequently diagnosed cancer in women. Intraepithelial lesions (IELs), such as usual ductal hyperplasia (UH), atypical ductal hyperplasia (ADH), and ductal carcinoma in situ (DCIS) are...

    Authors: Giovanni P Burrai, Sulma I Mohammed, Margaret A Miller, Vincenzo Marras, Salvatore Pirino, Maria F Addis, Sergio Uzzau and Elisabetta Antuofermo
    Citation: BMC Cancer 2010 10:156
  14. The Lung Cancer Exercise Training Study (LUNGEVITY) is a randomized trial to investigate the efficacy of different types of exercise training on cardiorespiratory fitness (VO2peak), patient-reported outcomes, and...

    Authors: Lee W Jones, Neil D Eves, William E Kraus, Anil Potti, Jeffrey Crawford, James A Blumenthal, Bercedis L Peterson and Pamela S Douglas
    Citation: BMC Cancer 2010 10:155
  15. Racial and ethnic disparities in breast cancer incidence, stage at diagnosis, survival and mortality are well documented; but few studies have reported on disparities in breast cancer treatment. This paper com...

    Authors: Parvin Yavari, Maria Cristina Barroetavena, T Greg Hislop and Chris D Bajdik
    Citation: BMC Cancer 2010 10:154
  16. Large number of patients with colorectal liver metastasis show recurrent disease after curative surgical resection. Identification of these high-risk patients may guide therapeutic strategies. The aim of this ...

    Authors: F Jeroen Vogelaar, Wilma E Mesker, Arjen M Rijken, Gaby W van Pelt, Antonia M van Leeuwen, Hans J Tanke, Rob A Tollenaar and Gerrit J Liefers
    Citation: BMC Cancer 2010 10:153
  17. Despite the large number of men diagnosed with localized prostate cancer, there is as yet no consensus concerning appropriate treatment. The purpose of this study was to describe the initial treatment patterns...

    Authors: Maria J Schymura, Amy R Kahn, Robert R German, Mei-Chin Hsieh, Rosemary D Cress, Jack L Finch, John P Fulton, Tiefu Shen and Erik Stuckart
    Citation: BMC Cancer 2010 10:152
  18. The urokinase plasminogen activating system (uPAS) is implicated in neoplastic progression and high tissue levels of uPAS components correlate with a poor prognosis in different human cancers. Despite that, re...

    Authors: Salvatore Ulisse, Enke Baldini, Marcella Mottolese, Steno Sentinelli, Patrizia Gargiulo, Brancato Valentina, Salvatore Sorrenti, Anna Di Benedetto, Enrico De Antoni and Massimino D'Armiento
    Citation: BMC Cancer 2010 10:151
  19. Sarcomas are rare malignant tumors. Accurate initial histological diagnosis is essential for adequate management. We prospectively assessed the medical management of all patients diagnosed with sarcoma in a Eu...

    Authors: Antoine Lurkin, Francoise Ducimetière, Dominique Ranchère Vince, Anne-Valérie Decouvelaere, Dominic Cellier, François N Gilly, Dimitri Salameire, Pierre Biron, Guy de Laroche, Jean Yves Blay and Isabelle Ray-Coquard
    Citation: BMC Cancer 2010 10:150
  20. Succinate dehydrogenase (SDH) has been associated with carcinogenesis in pheochromocytoma and paraganglioma. In the present study we investigated components of the oxidative phosphorylation system in human neu...

    Authors: Rene' G Feichtinger, Franz Zimmermann, Johannes A Mayr, Daniel Neureiter, Cornelia Hauser-Kronberger, Freimut H Schilling, Neil Jones, Wolfgang Sperl and Barbara Kofler
    Citation: BMC Cancer 2010 10:149
  21. Medulloblastomas (MBs) and supratentorial primitive neuroectodermal tumours (PNETs) are the most common highly aggressive paediatric brain tumours. In spite of extensive research on these tumours, there are on...

    Authors: Kristiina Nordfors, Joonas Haapasalo, Miikka Korja, Anssi Niemelä, Jukka Laine, Anna-Kaisa Parkkila, Silvia Pastorekova, Jaromir Pastorek, Abdul Waheed, William S Sly, Seppo Parkkila and Hannu Haapasalo
    Citation: BMC Cancer 2010 10:148
  22. The tumor suppressor TP53 and its negative regulator MDM2 play crucial roles in carcinogenesis. Previous case-control studies also revealed TP53 72Arg>Pro and MDM2 309T>G polymorphisms contribute to the risk of c...

    Authors: Mang Xiao, Lei Zhang, Xinhua Zhu, Jun Huang, Huifen Jiang, Sunhong Hu and Yuehui Liu
    Citation: BMC Cancer 2010 10:147
  23. Bacterial targeting of tumours is an important anti-cancer strategy. We previously showed that strain SL7838 of Salmonella typhimurium targets and kills cancer cells. Whether NO generation by the bacteria has a r...

    Authors: Yoram Barak, Frank Schreiber, Steve H Thorne, Christopher H Contag, Dirk deBeer and A Matin
    Citation: BMC Cancer 2010 10:146
  24. Germline mutations in the BRCA1 gene predispose to the development of breast cancer, exhibiting a specific histological phenotype. Identification of possible hallmarks of these tumors is important for selectin...

    Authors: Marise R Heerma van Voss, Petra van der Groep, Jos Bart, Elsken van der Wall and Paul J van Diest
    Citation: BMC Cancer 2010 10:145
  25. Despite evidence that breast cancer screening reduces morbidity and mortality, until recently most women have not undergone regular mammogram examinations in Korea. We aimed to identify factors associated with...

    Authors: Kiheon Lee, Hyung Taek Lim and Sang Min Park
    Citation: BMC Cancer 2010 10:144
  26. Emerging reports suggest resistance, increased tumor invasiveness and metastasis arising from treatment with drugs targeting vascular endothelial growth factor (VEGF). It is believed that increased tumoral hyp...

    Authors: Mohammad H Pourgholami, Zhao Y Cai, Samina Badar, Kiran Wangoo, Marianne S Poruchynsky and David L Morris
    Citation: BMC Cancer 2010 10:143
  27. Endogenously produced interferons can regulate the growth of melanoma cells and are administered exogenously as therapeutic agents to patients with advanced cancer. We investigated the role of negative regulat...

    Authors: Gregory B Lesinski, Jason M Zimmerer, Melanie Kreiner, John Trefry, Matthew A Bill, Gregory S Young, Brian Becknell and William E Carson III
    Citation: BMC Cancer 2010 10:142
  28. Previous studies showed a differential distribution of the four regulatory subunits of cAMP-dependent protein kinases inside the brain, that changed in rodent gliomas: therefore, the distribution of these prot...

    Authors: Carla Mucignat-Caretta, Luca Denaro, Marco Redaelli, Domenico D'Avella and Antonio Caretta
    Citation: BMC Cancer 2010 10:141
  29. Tumor cell proliferation is a predictor of survival in cutaneous melanoma. The aim of the present study was to evaluate the prognostic impact of mitotic count, Ki-67 expression and novel proliferation markers ...

    Authors: Rita G Ladstein, Ingeborg M Bachmann, Oddbjørn Straume and Lars A Akslen
    Citation: BMC Cancer 2010 10:140
  30. Angiogenesis appears to play an important role in ovarian cancer. Vascular endothelial growth factor (VEGF) has recently been implicated as a therapeutic target in ovarian cancer. The tissue inhibitor of metal...

    Authors: Sven Mahner, Linn Woelber, Christine Eulenburg, Joerg Schwarz, Walter Carney, Fritz Jaenicke, Karin Milde-Langosch and Volkmar Mueller
    Citation: BMC Cancer 2010 10:139
  31. Tumor suppressor genes p53 and p16 INK4a and the proto-oncogene MDM2 are considered to be essential G1 cell cycle regulatory genes whose loss of function is associated with ESCC carcinogenesis. We assessed the ab...

    Authors: Noushin Taghavi, Firouzeh Biramijamal, Masoud Sotoudeh, Hooman Khademi, Reza Malekzadeh, Omeed Moaven, Bahram Memar, Azadeh A'rabi and Mohammad Reza Abbaszadegan
    Citation: BMC Cancer 2010 10:138
  32. The aim of our study was to analyze the effect of taxane-based chemotherapy on tumor angiogenesis in patients with advanced epithelial ovarian cancer.

    Authors: Martin Pölcher, Christian Rudlowski, Nicolaus Friedrichs, Marieke Mielich, Tobias Höller, Mathias Wolfgarten, Kirsten Kübler, Reinhard Büttner, Walther Kuhn and Michael Braun
    Citation: BMC Cancer 2010 10:137
  33. Mutational analysis of the KRAS gene has recently been established as a complementary in vitro diagnostic tool for the identification of patients with colorectal cancer who will not benefit from anti-epidermal gr...

    Authors: Alfonso Sánchez-Muñoz, Elena Gallego, Vanessa de Luque, Luís G Pérez-Rivas, Luís Vicioso, Nuria Ribelles, José Lozano and Emilio Alba
    Citation: BMC Cancer 2010 10:136
  34. Microtubules are considered major therapeutic targets in patients with breast cancer. In spite of their essential role in biological functions including cell motility, cell division and intracellular transport...

    Authors: Rouba Hage-Sleiman, Stéphanie Herveau, Eva-Laure Matera, Jean-Fabien Laurier and Charles Dumontet
    Citation: BMC Cancer 2010 10:135
  35. Blockade of the renin angiotensin system (RAS) via angiotensin I converting enzyme (ACE) inhibition reduces growth of colorectal cancer (CRC) liver metastases in a mouse model. In this work we defined the expr...

    Authors: Jaclyn H Neo, Eleanor I Ager, Peter W Angus, Jin Zhu, Chandana B Herath and Christopher Christophi
    Citation: BMC Cancer 2010 10:134
  36. It has been suggested that the B-cell specific moloney leukemia virus insertion site 1 (Bmi-1) gene plays an oncogenic role in several types of human cancer, but the status of Bmi-1 amplification and expression i...

    Authors: Guo-Fen Yang, Wei-Peng He, Mu-Yan Cai, Li-Ru He, Jun-Hang Luo, Hai-Xia Deng, Xin-Yuan Guan, Mu-Sheng Zeng, Yi-Xin Zeng and Dan Xie
    Citation: BMC Cancer 2010 10:133
  37. Osteopontin (OPN) overexpression is correlated with a poor prognosis for tumor patients. However, only a few studies investigated the prognostic impact of expression of OPN in soft tissue sarcomas (STS) yet.

    Authors: Matthias Bache, Matthias Kappler, Henri Wichmann, Swetlana Rot, Antje Hahnel, Thomas Greither, Harun M Said, Matthias Kotzsch, Peter Würl, Helge Taubert and Dirk Vordermark
    Citation: BMC Cancer 2010 10:132
  38. The lymphatic system is a major route for cancer cell dissemination and also a potential target for antitumor therapy. To investigate whether increased lymphatic vessel density (LVD) is a prognostic factor for...

    Authors: Ying Gao, Zi Liu, Fei Gao and Xiao-yu Meng
    Citation: BMC Cancer 2010 10:131
  39. Moxibustion is a traditional Chinese method that uses the heat generated by burning herbal preparations containing Artemisia vulgaris to stimulate acupuncture points. Considering moxibustion is closely related to...

    Authors: Myeong Soo Lee, Tae-Young Choi, Ji-Eun Park, Song-Shil Lee and Edzard Ernst
    Citation: BMC Cancer 2010 10:130
  40. Prostate stem cell antigen (PSCA) is a glycosylphosphatidylinositol (GPI) anchored protein expressed not only in prostate but also in pancreas and bladder cancer as shown by immunohistochemistry and mRNA analy...

    Authors: Emanuele Marra, Paolo Uva, Valentina Viti, Valeria Simonelli, Eugenia Dogliotti, Emanuele De Rinaldis, Armin Lahm, Nicola La Monica, Alfredo Nicosia, Gennaro Ciliberto and Fabio Palombo
    Citation: BMC Cancer 2010 10:129
  41. Steroid receptors play major roles in the development, differentiation, and homeostasis of normal and malignant tissue. STAMP is a novel coregulator that not only enhances the ability of p160 coactivator famil...

    Authors: Yuanzheng He, John A Blackford Jr, Elise C Kohn and S Stoney Simons Jr
    Citation: BMC Cancer 2010 10:128
  42. To evaluate the safety of focal dose escalation to regions with standardized uptake value (SUV) >2.0 using intensity-modulated radiation therapy (IMRT) by comparison of radiotherapy plans using dose-volume his...

    Authors: Keiichi Jingu, Hisanori Ariga, Tomohiro Kaneta, Yoshihiro Takai, Ken Takeda, Lindel Katja, Kakutaro Narazaki, Takahiro Metoki, Keisuke Fujimoto, Rei Umezawa, Yoshihiro Ogawa, Kenji Nemoto, Masashi Koto, Masatoshi Mitsuya, Naruhiro Matsufuji, Shoki Takahashi…
    Citation: BMC Cancer 2010 10:127
  43. The discordance between steady-state levels of mRNAs and protein has been attributed to posttranscriptional control mechanisms affecting mRNA stability and translation. Traditional methods of genome wide micro...

    Authors: Robert Calaluce, Matthew M Gubin, J Wade Davis, Joseph D Magee, Jing Chen, Yuki Kuwano, Myriam Gorospe and Ulus Atasoy
    Citation: BMC Cancer 2010 10:126
  44. Our group previously reported that tumour-specific expression of the rate-limiting enzyme in the mevalonate pathway, 3-hydroxy-3-methylglutharyl-coenzyme A reductase (HMG-CoAR) is associated with more favourab...

    Authors: Donal J Brennan, Jenny Brändstedt, Elton Rexhepaj, Michael Foley, Fredrik Pontén, Mathias Uhlén, William M Gallagher, Darran P O'Connor, Colm O'Herlihy and Karin Jirstrom
    Citation: BMC Cancer 2010 10:125
  45. Gastric cancer peritoneal carcinomatosis is a common clinical problem, but there are no suitable large animal models to study this problem. This study was to establish a stable rabbit peritoneal carcinomatosis...

    Authors: Lie-Jun Mei, Xiao-Jun Yang, Li Tang, Alaa Hammed al-shammaa Hassan, Yutaka Yonemura and Yan Li
    Citation: BMC Cancer 2010 10:124
  46. The post-translational modification of proteins, including glycosylation, differs between normal and tumor cells. The UDP-N-acetyl-D-galactosamine polypeptide N-acetylgalactosaminyltransferases (GalNAc-Tases) ...

    Authors: Chen Wu, Xiaodan Guo, Weina Wang, Yun Wang, Yaojun Shan, Bo Zhang, Wenqian Song, Sisi Ma, Jianfeng Ge, Hao Deng and Mingsheng Zhu
    Citation: BMC Cancer 2010 10:123
  47. Since hepatocellular carcinoma (HCC) is one of the leading causes of cancer death worldwide, it is still important to understand hepatocarcinogenesis mechanisms and identify effective markers for tumor progres...

    Authors: Hye-Sun Choi, Seon-Hee Yim, Hai-Dong Xu, Seung-Hyun Jung, Seung-Hun Shin, Hae-Jin Hu, Chan-Kwon Jung, Jong Young Choi and Yeun-Jun Chung
    Citation: BMC Cancer 2010 10:122
  48. Spontaneous Regression/Complete Resistant (SR/CR) mice are a colony of cancer-resistant mice that can detect and rapidly destroy malignant cells with innate cellular immunity, predominately mediated by granulo...

    Authors: Anne M Sanders, John R Stehle Jr, Michael J Blanks, Gregory Riedlinger, Jung W Kim-Shapiro, Arta M Monjazeb, Jonathan M Adams, Mark C Willingham and Zheng Cui
    Citation: BMC Cancer 2010 10:121
  49. Mollicutes contamination is recognized to be a critical issue for the cultivation of continuous cell lines. In this work we characterized the effect of Mycoplasma hyorhinis contamination on CD133 expression in h...

    Authors: Elisabetta Mariotti, Marica Gemei, Peppino Mirabelli, Francesca D'Alessio, Rosa Di Noto, Giuliana Fortunato and Luigi Del Vecchio
    Citation: BMC Cancer 2010 10:120

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