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  1. Cancer cells may undergo metabolic adaptations that support their growth as well as drug resistance properties. The purpose of this study is to test if oral cancer cells can overcome the metabolic defects intr...

    Authors: Min Zhang, Yang D Chai, Jeffrey Brumbaugh, Xiaojun Liu, Ramin Rabii, Sizhe Feng, Kaori Misuno, Diana Messadi and Shen Hu
    Citation: BMC Cancer 2014 14:223
    Content type: Research article Published on:

  2. We previously reported that women from high-risk families who tested negative for a BRCA1 or BRCA2 (BRCA1/2) mutation were four times more likely to develop breast cancer compared to women in the general populati...

    Authors: Joanne Kotsopoulos, Kelly Metcalfe, Jill Alston, Dina Nikitina, Ophira Ginsburg, Andrea Eisen, Rochelle Demsky, Mohammad Akbari, Kevin Zbuk and Steven A Narod
    Citation: BMC Cancer 2014 14:221
    Content type: Study protocol Published on:

  4. Impairment of cognitive functioning has been reported in several studies in patients treated with chemotherapy. So far, no studies have been published on the effects of the vascular endothelial growth factor r...

    Authors: Sasja F Mulder, Dirk Bertens, Ingrid ME Desar, Kris CP Vissers, Peter FA Mulders, Cornelis JA Punt, Dick-Johan van Spronsen, Johan F Langenhuijsen, Roy PC Kessels and Carla ML van Herpen
    Citation: BMC Cancer 2014 14:219
    Content type: Research article Published on:

  5. Recent studies have shown that miR-199a-5p plays opposite roles in cancer initiation and progression of different cancer types, acting as oncogene for some cancer types but as tumor suppressor gene for others....

    Authors: Xu-Jun He, Ying-Yu Ma, Sheng Yu, Xiao-Ting Jiang, Yi-Ding Lu, Liang Tao, Hua-Ping Wang, Zhi-Ming Hu and Hou-Quan Tao
    Citation: BMC Cancer 2014 14:218
    Content type: Research article Published on:

  6. Gallbladder cancer is the most frequent malignancy of the bile duct with high aggressive and extremely poor prognosis. The main objective of the paper was to investigate the inhibitory effects of oridonin, a d...

    Authors: Runfa Bao, Yijun Shu, Xiangsong Wu, Hao Weng, Qian Ding, Yang Cao, Maolan Li, Jiasheng Mu, Wenguang Wu, Qichen Ding, Zhujun Tan, Tianyu Liu, Lin Jiang, Yunping Hu, Jianfeng Gu and Yingbin Liu
    Citation: BMC Cancer 2014 14:217
    Content type: Research article Published on:

  7. Recently, the cancer stem cell hypothesis has become widely accepted. Cancer stem cells are thought to possess the ability to undergo self-renewal and differentiation, similar to normal stem cells. Nucleostemi...

    Authors: Takayuki Kobayashi, Kenkichi Masutomi, Kenji Tamura, Tomoyuki Moriya, Tamio Yamasaki, Yasuhiro Fujiwara, Shunji Takahashi, Junji Yamamoto and Hitoshi Tsuda
    Citation: BMC Cancer 2014 14:215
    Content type: Research article Published on:

  8. Seventy percent of all bladder tumours tend to recur and need intensive surveillance, and a subset of tumours progress to muscle-invasive and metastatic disease. However, it is still difficult to find the adeq...

    Authors: Anja Rogler, Sabine Hoja, Johannes Giedl, Arif B Ekici, Sven Wach, Helge Taubert, Peter J Goebell, Bernd Wullich, Michael Stöckle, Jan Lehmann, Sabrina Petsch, Arndt Hartmann and Robert Stoehr
    Citation: BMC Cancer 2014 14:214
    Content type: Research article Published on:

  9. Pleomorphic xanthoastrocytoma (PXA) is a rare WHO grade II tumor accounting for less than 1% of all astrocytomas. Malignant transformation into PXA with anaplastic features, is unusual and correlates with poor...

    Authors: Ramón Martínez, F Javier Carmona, Miguel Vizoso, Veit Rohde, Matthias Kirsch, Gabriele Schackert, Santiago Ropero, Werner Paulus, Alonso Barrantes, Antonio Gomez and Manel Esteller
    Citation: BMC Cancer 2014 14:213
    Content type: Research article Published on:

  10. Cancer is the leading cause of deaths in the world. A widening disparity in cancer burden has emerged between high income and low-middle income countries. Closing this cancer divide is an ethical imperative bu...

    Authors: Gerard CC Lim, Emran N Aina, Soon K Cheah, Fuad Ismail, Gwo F Ho, Lye M Tho, Cheng H Yip, Nur A Taib, Kwang J Chong, Jayendran Dharmaratnam, Matin M Abdullah, Ahmad K Mohamed, Kean F Ho, Kananathan Ratnavelu, Chiao M Lim, Kin W Leong…
    Citation: BMC Cancer 2014 14:212
    Content type: Research article Published on:

  11. The aim was to assess and compare prognostic power of nine breast cancer gene signatures (Intrinsic, PAM50, 70-gene, 76-gene, Genomic-Grade-Index, 21-gene-Recurrence-Score, EndoPredict, Wound-Response and Hypo...

    Authors: Xi Zhao, Einar Andreas Rødland, Therese Sørlie, Hans Kristian Moen Vollan, Hege G Russnes, Vessela N Kristensen, Ole Christian Lingjærde and Anne-Lise Børresen-Dale
    Citation: BMC Cancer 2014 14:211
    Content type: Research article Published on:

  12. Skin cancer survivors experience an increased risk for subsequent malignancies but the associated risk factors are poorly understood. This study examined the risk of a new primary cancer following an initial s...

    Authors: Trude E Robsahm, Margaret R Karagas, Judy R Rees and Astri Syse
    Citation: BMC Cancer 2014 14:210
    Content type: Research article Published on:

  13. Extended systemic lymphadenectomy (D2) is standard procedure for surgical treatment of advanced gastric cancer (AGC) although less extensive lymphadenectomy (D1) can be applied to early gastric cancer. Complet...

    Authors: Hyoung-Il Kim, Hoon Hur, Youn Nam Kim, Hyuk-Joon Lee, Min-Chan Kim, Sang-Uk Han and Woo Jin Hyung
    Citation: BMC Cancer 2014 14:209
    Content type: Study protocol Published on:

  14. Unraveling the signaling pathways responsible for the establishment of a metastatic phenotype in carcinoma cells is critically important for understanding the pathology of cancer. The acquisition of cell motil...

    Authors: Kun Cai, Kirk Mulatz, Ryan Ard, Thanh Nguyen and Stephen H Gee
    Citation: BMC Cancer 2014 14:208
    Content type: Research article Published on:

  15. Organized screening based on Pap tests has substantially reduced deaths from cervical cancer in many countries, including Australia. However, the impact of the program depends upon the degree to which women pa...

    Authors: Farhana Sultana, Dallas R English, Julie A Simpson, Julia ML Brotherton, Kelly Drennan, Robyn Mullins, Stella Heley, C David Wrede, Marion Saville and Dorota M Gertig
    Citation: BMC Cancer 2014 14:207
    Content type: Study protocol Published on:

  16. Medulloblastoma is the most common type of pediatric brain tumor. Although numerous factors influence patient survival rates, more than 30% of all cases will ultimately be refractory to conventional therapies....

    Authors: Brian Hutzen, Hemant Kumar Bid, Peter J Houghton, Christopher R Pierson, Kimerly Powell, Anna Bratasz, Corey Raffel and Adam W Studebaker
    Citation: BMC Cancer 2014 14:206
    Content type: Research article Published on:

  17. The predictive value of thymidylate synthase (TS) for clinical sensitivity to pemetrexed-containing chemotherapy in patients with non-small cell lung cancer (NSCLC) remains controversial. This meta-analysis is...

    Authors: Lei Wang, Rui Wang, Yunjian Pan, Yihua Sun, Jie Zhang and Haiquan Chen
    Citation: BMC Cancer 2014 14:205
    Content type: Research article Published on:

  18. Advanced pancreatic cancer (APC), beside its high mortality, causes the highest rates of venous thromboembolic events (VTE). Enoxaparin, a low molecular weight heparin (LMWH), is effective in prevention and tr...

    Authors: Uwe Pelzer, Andreas Hilbig, Jens M Stieler, Marcus Bahra, Marianne Sinn, Bernhard Gebauer, Bernd Dörken and Hanno Riess
    Citation: BMC Cancer 2014 14:204
    Content type: Research article Published on:

  19. Companion animals like dogs frequently develop tumors with age and similarly to human malignancies, display interpatient tumoral heterogeneity. Tumors are frequently characterized with regard to their mutation...

    Authors: Nicole Grosse, Barbara van Loon and Carla Rohrer Bley
    Citation: BMC Cancer 2014 14:203
    Content type: Debate Published on:

  20. Due to physical characteristics, ions like protons or carbon ions can administer the dose to the target volume more efficiently than photons since the dose can be lowered at the surrounding normal tissue. Radi...

    Authors: Gregor Habl, Gencay Hatiboglu, Lutz Edler, Matthias Uhl, Sonja Krause, Matthias Roethke, Heinz P Schlemmer, Boris Hadaschik, Juergen Debus and Klaus Herfarth
    Citation: BMC Cancer 2014 14:202
    Content type: Study protocol Published on:

  21. Febrile neutropenia (FN) is common in breast cancer patients undergoing chemotherapy. Risk factors for FN have been reported, but risk models that include genetic variability have yet to be described. This stu...

    Authors: Alena M Pfeil, Christof Vulsteke, Robert Paridaens, Anne-Sophie Dieudonné, Ruth Pettengell, Sigrid Hatse, Patrick Neven, Diether Lambrechts, Thomas D Szucs, Matthias Schwenkglenks and Hans Wildiers
    Citation: BMC Cancer 2014 14:201
    Content type: Research article Published on:

  22. Previous studies have profiled breast cancer compared to normal breast tissue and identified differentially expressed microRNAs (miRNAs). These miRNAs are then assessed in serum of breast cancer patients compa...

    Authors: Silvia Zearo, Edward Kim, Ying Zhu, Jing Ting Zhao, Stan B Sidhu, Bruce G Robinson and Patsy SH Soon
    Citation: BMC Cancer 2014 14:200
    Content type: Research article Published on:

  23. Despite being a critical survivorship care issue, there is a clear gap in current knowledge of the optimal treatment of sexual dysfunction in men with prostate cancer. There is sound theoretical rationale and ...

    Authors: Prue Cormie, Suzanne K Chambers, Robert U Newton, Robert A Gardiner, Nigel Spry, Dennis R Taaffe, David Joseph, M Akhlil Hamid, Peter Chong, David Hughes, Kyra Hamilton and Daniel A Galvão
    Citation: BMC Cancer 2014 14:199
    Content type: Study protocol Published on:

  24. ST2, a member of the interleukin (IL)-1receptor family, regulates Th1/Th2 immune responses in autoimmune and inflammatory conditions. However, the role of ST2 signaling in tumor growth and metastasis of breast...

    Authors: Da-peng Lu, Xiang-yu Zhou, Lu-tian Yao, Cai-gang Liu, Wei Ma, Feng Jin and Yun-fei Wu
    Citation: BMC Cancer 2014 14:198
    Content type: Research article Published on:

  25. We conducted a dose–response meta-analysis of prospective studies to summarize evidence of the association between tea consumption and the risk of breast, colorectal, liver, prostate, and stomach cancer.

    Authors: Feifei Yu, Zhichao Jin, Hong Jiang, Chun Xiang, Jianyuan Tang, Tuo Li and Jia He
    Citation: BMC Cancer 2014 14:197
    Content type: Research article Published on:

  26. Methionine adenosyltransferase 2A (MAT2A) is an enzyme that catalyzes the formation of S-adenosylmethionine (SAMe) by joining methionine and ATP. SAMe is a methyl donor for transmethylation and has an importan...

    Authors: Xuliang Wang, Xiaoqiang Guo, Wenshui Yu, Cailing Li, Yaoting Gui and Zhiming Cai
    Citation: BMC Cancer 2014 14:196
    Content type: Research article Published on:

  27. The serine-threonine kinase AKT1 plays essential roles during normal mammary gland development as well as the initiation and progression of breast cancer. AKT1 is generally considered a ubiquitously expressed gen...

    Authors: Jeffrey W Schmidt, Barbara L Wehde, Kazuhito Sakamoto, Aleata A Triplett, William W West and Kay-Uwe Wagner
    Citation: BMC Cancer 2014 14:195
    Content type: Research article Published on:

  28. KIAA1199 is a recently identified novel gene that is up-regulated in human cancer with poor survival. Our proteomic study on signaling polarity in chemotactic cells revealed KIAA1199 as a novel protein target th...

    Authors: Mohammad-Saeid Jami, Jinxuan Hou, Miao Liu, Michelle L Varney, Hesham Hassan, Jixin Dong, Liying Geng, Jing Wang, Fang Yu, Xin Huang, Hong Peng, Kai Fu, Yan Li, Rakesh K Singh and Shi-Jian Ding
    Citation: BMC Cancer 2014 14:194
    Content type: Research article Published on:

  29. Vasculogenic mimicry (VM) is a novel tumor blood supply in some highly aggressive malignant tumors. Recently, we reported VM existed in gallbladder carcinomas (GBCs) and the formation of the special passage th...

    Authors: Jing-Tao Zhang, Wei Sun, Wen-Zhong Zhang, Chun-Yan Ge, Zhong-Yan Liu, Ze-Ming Zhao, Xing-Sui Lu and Yue-Zu Fan
    Citation: BMC Cancer 2014 14:193
    Content type: Research article Published on:

  30. Preoperative chemoradiotherapy (CRT) is the cornerstone of treatment for locally advanced rectal cancer (LARC). Although high local control is achieved, overall rates of distant control remain suboptimal. Colo...

    Authors: Jaime Gomez-Millan, Lydia Perez, Ines Aroca, Maria del Mar Delgado, Vanessa De Luque, Alicia Román, Esperanza Torres, Soraya Ramos, Sofia Perez, Eloisa Bayo and Jose Antonio Medina
    Citation: BMC Cancer 2014 14:192
    Content type: Research article Published on:

  31. The cytoskeletal organizer ezrin is a member of the ezrin-radixin-moesin (ERM) family and plays important roles in not only cell motility, cell adhesion, and apoptosis, but also in various cell signaling pathw...

    Authors: Tiefeng Jin, Jingchun Jin, Xiangyu Li, Songnan Zhang, Yun Ho Choi, Yingshi Piao, Xionghu Shen and Zhenhua Lin
    Citation: BMC Cancer 2014 14:191
    Content type: Research article Published on:

  32. The epidermal growth factor receptor (EGFR) is differently expressed in breast cancer, and its presence may favor cancer progression. We hypothesized that two EGFR functional polymorphisms, a (CA)n repeat in intr...

    Authors: Marcelo Sobral Leite, Letícia Carlos Giacomin, Diogo Nascimento Piranda, Juliana Simões Festa-Vasconcellos, Vanessa Indio-do-Brasil, Sérgio Koifman, Rodrigo Soares de Moura-Neto, Marcelo Alex de Carvalho and Rosane Vianna-Jorge
    Citation: BMC Cancer 2014 14:190
    Content type: Research article Published on:

  33. Nuclear alterations are a well-known manifestation of cancer. However, little is known about the early, microscopically-undetectable stages of malignant transformation. Based on the phenomenon of field canceri...

    Authors: Lusik Cherkezyan, Yolanda Stypula-Cyrus, Hariharan Subramanian, Craig White, Mart Dela Cruz, Ramesh K Wali, Michael J Goldberg, Laura K Bianchi, Hemant K Roy and Vadim Backman
    Citation: BMC Cancer 2014 14:189
    Content type: Research article Published on:

  35. Prospective data on alcohol consumption, cigarette smoking and risk of head-neck cancer (HNC) subtypes, i.e. oral cavity cancer (OCC), oro-/hypopharyngeal cancer (OHPC), and laryngeal cancer (LC), are limited....

    Authors: Denise HE Maasland, Piet A van den Brandt, Bernd Kremer, R Alexandra (Sandra) Goldbohm and Leo J Schouten
    Citation: BMC Cancer 2014 14:187
    Content type: Research article Published on:

  36. Since the “War on Cancer” was declared in 1971, the United States alone has expended some $300 billion on research, with a heavy focus on the role of genomics in anticancer therapy. Voluminous data have been c...

    Authors: Björn LDM Brücher, Gary Lyman, Richard van Hillegersberg, Raphael E Pollock, Florian Lordick, Han-Kwang Yang, Toshikazu Ushijima, Khay-Guan Yeoh, Tomas Skricka, Wojciech Polkowski, Grzegorz Wallner, Vic Verwaal, Alfredo Garofalo, Domenico D’Ugo, Franco Roviello, Hans-Ulrich Steinau…
    Citation: BMC Cancer 2014 14:186
    Content type: Debate Published on:

  37. Non-small cell lung cancers (NSCLC) are highly heterogeneous at the molecular level and comprise 75% of all lung tumors. We have previously shown that the receptor tyrosine kinase (RTK) MET frequently suffers ...

    Authors: Rajani Kanteti, Essam El-Hashani, Immanuel Dhanasingh, Maria Tretiakova, Aliya N Husain, Sherven Sharma, Jay Sharma, Everett E Vokes and Ravi Salgia
    Citation: BMC Cancer 2014 14:185
    Content type: Research article Published on:

  38. We assessed the activity and toxicity of the XELBEVOCT regimen in patients with metastatic well-to-moderately differentiated neuroendocrine neoplasms (WMD-NEN). Ancillary studies evaluated hypertension, protei...

    Authors: Alfredo Berruti, Nicola Fazio, Anna Ferrero, Maria Pia Brizzi, Marco Volante, Elisabetta Nobili, Lucia Tozzi, Lisa Bodei, Mirella Torta, Antonio D’Avolio, Adriano Massimiliano Priola, Nadia Birocco, Vito Amoroso, Guido Biasco, Mauro Papotti and Luigi Dogliotti
    Citation: BMC Cancer 2014 14:184
    Content type: Research article Published on:

  39. In Europe, gastric cancer remains diagnosed at advanced stage (serosal and/or lymph node involvement). Despite curative management combining perioperative systemic chemotherapy and gastrectomy with D1-D2 lymph...

    Authors: Olivier Glehen, Guillaume Passot, Laurent Villeneuve, Delphine Vaudoyer, Sylvie Bin-Dorel, Gilles Boschetti, Eric Piaton and Alfredo Garofalo
    Citation: BMC Cancer 2014 14:183
    Content type: Study protocol Published on:

  40. MLK3 gene mutations were described to occur in about 20% of microsatellite unstable gastrointestinal cancers and to harbor oncogenic activity. In particular, mutation P252H, located in the kinase domain, was f...

    Authors: Sérgia Velho, Ana Pinto, Danilo Licastro, Maria José Oliveira, Filipa Sousa, Elia Stupka and Raquel Seruca
    Citation: BMC Cancer 2014 14:182
    Content type: Research article Published on:

  41. SMAD4 is a gastrointestinal malignancy-specific tumor suppressor gene found mutated in one third of colorectal cancer specimens and half of pancreatic tumors. SMAD4 inactivation by allelic deletion or intragen...

    Authors: Yu-Wen Chen, Pi-Jung Hsiao, Ching-Chieh Weng, Kung-Kai Kuo, Tzu-Lei Kuo, Deng-Chyang Wu, Wen-Chun Hung and Kuang-Hung Cheng
    Citation: BMC Cancer 2014 14:181
    Content type: Research article Published on:

  42. The adaptive immune response to colorectal cancer is important for survival. Less is understood about the role of innate lymphocytes, such as Natural Killer (NK) cells, which are abundant in human liver.

    Authors: Siân A Pugh, Rebecca J Harrison, John N Primrose and Salim I Khakoo
    Citation: BMC Cancer 2014 14:180
    Content type: Research article Published on:

  43. PTEN inactivation is the most frequent genetic aberration in endometrial cancer. One of the phosphatase-independent roles of PTEN is associated with homologous recombination (HR) in nucleus. Poly (ADP-ribose) ...

    Authors: Aki Miyasaka, Katsutoshi Oda, Yuji Ikeda, Osamu Wada-Hiraike, Tomoko Kashiyama, Atsushi Enomoto, Noriko Hosoya, Takahiro Koso, Tomohiko Fukuda, Kanako Inaba, Kenbun Sone, Yuriko Uehara, Reiko Kurikawa, Kazunori Nagasaka, Yoko Matsumoto, Takahide Arimoto…
    Citation: BMC Cancer 2014 14:179
    Content type: Research article Published on:

  44. Tumor endothelial transdifferentiation and VEGFR1/2 expression by cancer cells have been reported in glioblastoma but remain poorly documented for many other cancer types.

    Authors: Ivan Bieche, Sophie Vacher, David Vallerand, Sophie Richon, Rana Hatem, Ludmilla De Plater, Ahmed Dahmani, Fariba Némati, Eric Angevin, Elisabetta Marangoni, Sergio Roman-Roman, Didier Decaudin and Virginie Dangles-Marie
    Citation: BMC Cancer 2014 14:178
    Content type: Research article Published on:

  45. NanoString’s Prosigna™ Breast Cancer Prognostic Gene Signature Assay is based on the PAM50 gene expression signature. The test outputs a risk of recurrence (ROR) score, risk category, and intrinsic subtype (Lu...

    Authors: Torsten Nielsen, Brett Wallden, Carl Schaper, Sean Ferree, Shuzhen Liu, Dongxia Gao, Garrett Barry, Naeem Dowidar, Malini Maysuria and James Storhoff
    Citation: BMC Cancer 2014 14:177
    Content type: Technical advance Published on:

  46. The inhibitor of apoptosis (IAP) protein Survivin and its splice variants are differentially expressed in breast cancer tissues. Our previous work showed Survivin is released from tumor cells via small membran...

    Authors: Salma Khan, Heather Ferguson Bennit, David Turay, Mia Perez, Saied Mirshahidi, Yuan Yuan and Nathan R Wall
    Citation: BMC Cancer 2014 14:176
    Content type: Research article Published on:

  48. Despite introduction of effective chemotherapy protocols, it has remained uncertain, if patients with colorectal cancer (CRC) liver metastases should receive adjuvant therapy. Clinical or molecular predictors ...

    Authors: Nuh N Rahbari, Christoph Reissfelder, Henning Schulze-Bergkamen, Dirk Jäger, Markus W Büchler, Jürgen Weitz and Moritz Koch
    Citation: BMC Cancer 2014 14:174
    Content type: Research article Published on:

  50. Tamoxifen, an endocrine therapy drug used to treat breast cancer, is designed to interrupt estrogen signaling by blocking the estrogen receptor (ER). However, many ER-positive patients are low reactive or resi...

    Authors: Ji Ma, Yan Guo, Suning Chen, Cuiping Zhong, Yan Xue, Yuan Zhang, Xiaofeng Lai, Yifang Wei, Shentong Yu, Jian Zhang and Wenchao Liu
    Citation: BMC Cancer 2014 14:172
    Content type: Research article Published on:

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