Skip to main content

Articles

Page 236 of 330

  1. There is evidence, although inconsistent, that long term exposure to disinfection by products (DBPs) increases the risk of bowel cancer. No study has been conducted in Australia to examine this association and...

    Authors: Md Bayzidur Rahman, Christine Cowie, Tim Driscoll, Richard J Summerhayes, Bruce K Armstrong and Mark S Clements
    Citation: BMC Cancer 2014 14:445
    Content type: Research article Published on:

  3. Tumor invasion and metastasis represent a major unsolved problem in cancer pathogenesis. Recent studies have indicated the involvement of Src-homology 2 domain-containing tyrosine phosphatase 2 (SHP2) in multi...

    Authors: Hsueh-Chun Wang, Wei-Fan Chiang, Hsin-Hsiu Huang, Ying-Ying Shen and Hung-Che Chiang
    Citation: BMC Cancer 2014 14:442
    Content type: Research article Published on:

  4. FOLFOX second-line treatment seems to be a validated option for patients with pancreatic cancer (PC) progressing after gemcitabine chemotherapy. However, other therapeutics strategy has developed in first-line...

    Authors: Aziz Zaanan, Isabelle Trouilloud, Theofano Markoutsaki, Mélanie Gauthier, Anne-Claire Dupont-Gossart, Thierry Lecomte, Thomas Aparicio, Pascal Artru, Anne Thirot-Bidault, Fanny Joubert, Daniella Fanica and Julien Taieb
    Citation: BMC Cancer 2014 14:441
    Content type: Research article Published on:

  5. MicroRNAs (miRNAs) are frequently dysregulated in human cancers and can act as either potent oncogenes or tumor suppressor genes. In the present study, we intend to prove that the gene PTEN (phosphatase and te...

    Authors: Guiyu Zhang, Xinxin Hou, Yue Li and Meng Zhao
    Citation: BMC Cancer 2014 14:440
    Content type: Research article Published on:

  6. Cancer of unknown primary (CUP) is a fatal cancer, accounting for 3–5% of all diagnosed cancers. Finding the primary site is important for therapeutic choices and we believe that the organ which is designated ...

    Authors: Matias Riihimäki, Akseli Hemminki, Kristina Sundquist and Kari Hemminki
    Citation: BMC Cancer 2014 14:439
    Content type: Research article Published on:

  7. The global burden from cancer is rising, especially as low-income countries like Bangladesh observe rapid aging. So far, there are no comprehensive descriptions reporting diagnosed cancer group that include he...

    Authors: Mohammad Sorowar Hossain, Mohd S Iqbal, Mohiuddin Ahmed Khan, Mohammad Golam Rabbani, Hazera Khatun, Sirajam Munira, M Morshed Zaman Miah, Amin Lutful Kabir, Naima Islam, Tashmim Farhana Dipta, Farzana Rahman, Abdul Mottalib, Salma Afrose, Tasneem Ara, Akhil Ranjan Biswas, Mizanur Rahman…
    Citation: BMC Cancer 2014 14:438
    Content type: Research article Published on:

  8. The aim of this study was to evaluate the efficacy of the p53-reactivating drugs RITA and nutlin3a in killing myeloma cells.

    Authors: Sylvanie Surget, Géraldine Descamps, Carole Brosseau, Vincent Normant, Sophie Maïga, Patricia Gomez-Bougie, Nadège Gouy-Colin, Catherine Godon, Marie C Béné, Philippe Moreau, Steven Le Gouill, Martine Amiot and Catherine Pellat-Deceunynck
    Citation: BMC Cancer 2014 14:437
    Content type: Research article Published on:

  9. Heme oxygenase-1 (HO-1) and its major product carbon monoxide (CO) are known to be involved in the development and progression of many tumors. The present study was to elucidate the expression and function of ...

    Authors: Hongzhuan Yin, Jun Fang, Long Liao, Hiroshi Maeda and Qi Su
    Citation: BMC Cancer 2014 14:436
    Content type: Research article Published on:

  10. Tyrosine phosphorylation (pTyr) is an important cancer relevant posttranslational modification since it regulates protein activity and cellular localization. By controlling cell growth and differentiation it p...

    Authors: Lioudmila Elfineh, Christina Classon, Anna Asplund, Ulf Pettersson, Masood Kamali-Moghaddam and Sara Bergström Lind
    Citation: BMC Cancer 2014 14:435
    Content type: Research article Published on:

  11. Mutations in NBN, the gene for Nijmegen Breakage Syndrome (NBS), are thought to predispose women to developing breast cancer, but a breast cancer cell line containing mutations in NBN has not yet been describe...

    Authors: Bianca Schröder-Heurich, Natalia Bogdanova, Britta Wieland, Xiaoxi Xie, Monika Noskowicz, Tjoung-Won Park-Simon, Peter Hillemanns, Hans Christiansen and Thilo Dörk
    Citation: BMC Cancer 2014 14:434
    Content type: Research article Published on:

  12. Especially in human tumor cells, the osteopontin (OPN) primary transcript is subject to alternative splicing, generating three isoforms termed OPNa, OPNb and OPNc. We previously demonstrated that the OPNc spli...

    Authors: Tatiana M Tilli, Akeila Bellahcène, Vincent Castronovo and Etel R P Gimba
    Citation: BMC Cancer 2014 14:433
    Content type: Research article Published on:

  13. Oral squamous cell carcinoma is an aggressive neoplasm with serious morbidity and mortality, which typically spreads through local invasive growth. Lysophosphatidic acid (LPA) is involved in a number of biolog...

    Authors: Ingvild J Brusevold, Ingun H Tveteraas, Monica Aasrum, John Ødegård, Dagny L Sandnes and Thoralf Christoffersen
    Citation: BMC Cancer 2014 14:432
    Content type: Research article Published on:

  14. A common approach to cancer therapy in clinical practice is the combination of several drugs to boost the anticancer activity of available drugs while suppressing their unwanted side effects. In this regard, w...

    Authors: Hye-Kyung Park, Ji-Eun Lee, Jaehwa Lim, Da-Eun Jo, Soo-Ah Park, Pann-Ghill Suh and Byoung Heon Kang
    Citation: BMC Cancer 2014 14:431
    Content type: Research article Published on:

  15. Tumorigenesis is the result of genomic or epigenomic insults and subsequent loss of the proper mechanisms to respond to these alterations leading to unscheduled growth. Tumors arising from these mutations ofte...

    Authors: William N Pappano, Qian Zhang, Lora A Tucker, Chris Tse and Jieyi Wang
    Citation: BMC Cancer 2014 14:430
    Content type: Research article Published on:

  16. Hypoxia is often encountered in solid tumors and known to contribute to aggressive tumor behavior, radiation- and chemotherapy resistance resulting in a poor prognosis for the cancer patient. MicroRNAs (miRNAs...

    Authors: Caroline MM Gits, Patricia F van Kuijk, Jonneke CWM de Rijck, Nikky Muskens, Moniek BE Jonkers, Wilfred F van IJcken, Ron HJ Mathijssen, Jaap Verweij, Stefan Sleijfer and Erik AC Wiemer
    Citation: BMC Cancer 2014 14:429
    Content type: Research article Published on:

  17. Cancer survivorship rates have increased in developed countries largely due to population ageing and improvements in cancer care. Survivorship is a neglected phase of cancer treatment and is often associated w...

    Authors: Lauren J Frensham, Dorota M Zarnowiecki, Gaynor Parfitt, Rebecca M Stanley and James Dollman
    Citation: BMC Cancer 2014 14:428
    Content type: Study protocol Published on:

  18. Survival is poorer in elderly patients with head and neck squamous cell carcinomas [HNSCCs] than in younger patients. Possible explanations include a contribution of co-morbidities to mortality, frequent refus...

    Authors: Lydia Brugel, Marie Laurent, Philippe Caillet, Anne Radenne, Isabelle Durand-Zaleski, Michel Martin, Melany Baron, Héloïse de Kermadec, Sylvie Bastuji-Garin, Florence Canouï-Poitrine and Elena Paillaud
    Citation: BMC Cancer 2014 14:427
    Content type: Study protocol Published on:

  19. Breast cancer is one of the most deadly diseases in women. Inhibiting the synthesis of estrogen is effective in treating patients with estrogen-responsive breast cancer. Previous studies have demonstrated that...

    Authors: Tsz Yan Wong, Fengjuan Li, Shu-mei Lin, Franky L Chan, Shiuan Chen and Lai K Leung
    Citation: BMC Cancer 2014 14:426
    Content type: Research article Published on:

  20. 14-3-3σ is implicated in promoting tumor development of various malignancies. However, the clinical relevance of 14-3-3σ in hepatocellular carcinoma (HCC) tumor progression and modulation and pathway elucidati...

    Authors: Chia-Chia Liu, Yee-Jee Jan, Bor-Sheng Ko, Yao-Ming Wu, Shu-Man Liang, Shyh-Chang Chen, Yen-Ming Lee, Tzu-An Liu, Tzu-Ching Chang, John Wang, Song-Kun Shyue, Li-Ying Sung and Jun-Yang Liou
    Citation: BMC Cancer 2014 14:425
    Content type: Research article Published on:

  21. Ovarian cancer is the most lethal gynecologic malignancy, but its etiology remains poorly understood. This study investigated the role of Fli-1 in ovarian carcinogenesis and disease survival.

    Authors: Wei Song, Lingyun Hu, Wei Li, Guanjun Wang, Yan Li, Lei Yan, Ailing Li and Jiuwei Cui
    Citation: BMC Cancer 2014 14:424
    Content type: Research article Published on:

  22. New effective treatments for metastatic melanoma greatly improve survival in a proportion of patients. However biomarkers to identify patients that are more likely to benefit from a particular treatment are ne...

    Authors: Dragana Klinac, Elin S Gray, James B Freeman, Anna Reid, Samantha Bowyer, Michael Millward and Melanie Ziman
    Citation: BMC Cancer 2014 14:423
    Content type: Research article Published on:

  23. To compare survival of patients with non-small cell lung cancer (NSCLC) who underwent surgical resection and lymph node sampling based on guidelines proposed by the American College of Surgeons Oncology Group ...

    Authors: Dongsheng Yue, Liqun Gong, Jian You, Yanjun Su, Zhenfa Zhang, Zhen Zhang, Feng Gu, Meng Wang and Changli Wang
    Citation: BMC Cancer 2014 14:422
    Content type: Research article Published on:

  24. A germline, variant in the BRCA1 3’UTR (rs8176318) was previously shown to predict breast and ovarian cancer risk in women from high-risk families, as well as increased risk of triple negative breast cancer. Here...

    Authors: Jemima J Dorairaj, David W Salzman, Deirdre Wall, Tiffany Rounds, Carina Preskill, Catherine AW Sullivan, Robert Lindner, Catherine Curran, Kim Lezon-Geyda, Terri McVeigh, Lyndsay Harris, John Newell, Michael J Kerin, Marie Wood, Nicola Miller and Joanne B Weidhaas
    Citation: BMC Cancer 2014 14:421
    Content type: Research article Published on:

  25. In the Republic of Korea, cancer is the most common cause of death, and cancer incidence and mortality rates are the highest in East Asia. As alcoholic beverages are carcinogenic to humans, we estimated the bu...

    Authors: Sohee Park, Hai-Rim Shin, Boram Lee, Aesun Shin, Kyu-Won Jung, Duk-Hee Lee, Sun Ha Jee, Sung-Il Cho, Sue Kyung Park, Mathieu Boniol, Paolo Boffetta and Elisabete Weiderpass
    Citation: BMC Cancer 2014 14:420
    Content type: Research article Published on:

  26. Previous studies have indicated that survivors of childhood acute lymphoblastic leukemia (ALL) have an increased morbidity measured in terms of health care utilization. However, earlier studies have several po...

    Authors: Anna Sällfors Holmqvist, Christian Moëll, Lars Hjorth, Anna Lindgren, Stanislaw Garwicz, Thomas Wiebe and Ingrid Øra
    Citation: BMC Cancer 2014 14:419
    Content type: Research article Published on:

  27. B-cell lymphoma 6 (BCL6) protein, an evolutionarily conserved zinc finger transcription factor, showed to be highly expressed in various human cancers in addition to malignancies in the lymphoid system. This s...

    Authors: Qiang Wu, Xue Liu, Hong Yan, Yin-huan He, Shan Ye, Xing-wang Cheng, Gui-lu Zhu, Wen-yong Wu, Xiao-nan Wang, Xiang-jun Kong, Xiao-chun Xu, Peter E Lobie, Tao Zhu and Zheng-sheng Wu
    Citation: BMC Cancer 2014 14:418
    Content type: Research article Published on:

  28. Cervical carcinoma is the second most common cancer and is an important cause of death in women worldwide. CCAAT/enhancer binding proteins (C/EBPs) are a family of transcription factors that regulate cellular ...

    Authors: Zemin Pan, Weinan Zheng, Jinli Zhang, Rui Gao, Dongmei Li, Xiaoqing Guo, Hu Han, Feng Li, Shen Qu and Renfu Shao
    Citation: BMC Cancer 2014 14:417
    Content type: Research article Published on:

  29. In non-small cell lung cancer patients (NSCLC), median survival from the time patients develop bone metastasis is classically described being inferior to 6 months. We investigated the subcategory of patients h...

    Authors: Mélanie Deberne, Stanislas Ropert, Bertrand Billemont, Catherine Daniel, Jeanne Chapron and François Goldwasser
    Citation: BMC Cancer 2014 14:416
    Content type: Research article Published on:

  30. Liver kinase 1 (LKB1) is an important multi-tasking protein linked with metabolic signaling, also controlling polarity and cytoskeletal rearrangements in diverse cell types including cancer cells. Prolactin (P...

    Authors: Katja Linher-Melville and Gurmit Singh
    Citation: BMC Cancer 2014 14:415
    Content type: Research article Published on:

  31. NQO1 (NAD(P)H: quinone oxidoreductase-1), located on chromosome 16q22, functions primarily to protect normal cells from oxidant stress and electrophilic attack. Recent studies have revealed that NQO1 is expres...

    Authors: Yue Ma, Jienan Kong, Guanghai Yan, Xiangshan Ren, Dan Jin, Tiefeng Jin, Lijuan Lin and Zhenhua Lin
    Citation: BMC Cancer 2014 14:414
    Content type: Research article Published on:

  32. Several studies have described an increased cyclooxygenase-2 (COX-2) expression in pancreatic cancer, but the role of COX-2 in tumour development and progression is not clear. The aim of the present study was ...

    Authors: Ewa Pomianowska, Dagny Sandnes, Krzysztof Grzyb, Aasa R Schjølberg, Monica Aasrum, Ingun H Tveteraas, Vegard Tjomsland, Thoralf Christoffersen and Ivar P Gladhaug
    Citation: BMC Cancer 2014 14:413
    Content type: Research article Published on:

  33. Activation of Rho, one of the small GTPases, and its major downstream target Rho-kinase (ROCK) promotes the development and metastasis of cancer. We previously showed that elevation of Rho and ROCK expression ...

    Authors: Hideyuki Abe, Takao Kamai, Keitaro Hayashi, Naohiko Anzai, Hiromichi Shirataki, Tomoya Mizuno, Yoshiyuki Yamaguchi, Akinori Masuda, Hideo Yuki, Hironori Betsunoh, Masahiro Yashi, Yoshitatsu Fukabori and Ken-Ichiro Yoshida
    Citation: BMC Cancer 2014 14:412
    Content type: Research article Published on:

  34. Median OS after surgery in curative intent for non-metastasized pancreas cancer ranges under study conditions from 17.9 months to 23.6 months. Tumor recurrence occurs locally, at distant sites (liver, peritone...

    Authors: Michael Tachezy, Florian Gebauer, Cordula Petersen, Dirk Arnold, Martin Trepel, Karl Wegscheider, Phillipe Schafhausen, Maximilian Bockhorn, Jakob Robert Izbicki and Emre Yekebas
    Citation: BMC Cancer 2014 14:411
    Content type: Study protocol Published on:

  35. Research has indicated that the rs12203592 and rs872071 interferon regulatory factor 4 (IRF4) gene polymorphisms correlate with the risk of cancer, especially skin cancer and haematological malignancies, but t...

    Authors: Songtao Wang, Qing Yan, Pin Chen, Peng Zhao and Aihua Gu
    Citation: BMC Cancer 2014 14:410
    Content type: Research article Published on:

  36. The treatment of metastatic gastric cancer is not uniform, and the prognostic factors and indications for surgery are currently unclear. This retrospective study aimed to identify the prognostic factors and cl...

    Authors: Yasuhiko Mohri, Koji Tanaka, Masaki Ohi, Susumu Saigusa, Hiromi Yasuda, Yuji Toiyama, Toshimitu Araki, Yasuhiro Inoue and Masato Kusunoki
    Citation: BMC Cancer 2014 14:409
    Content type: Research article Published on:

  37. To determine whether changes in the metabolism of metastatic renal cell carcinoma (mRCC) assessed by F18-FDG-PET after 14 and 28 days of treatment with tyrosine kinase inhibitors can predict overall and progre...

    Authors: Jacob Farnebo, Per Grybäck, Ulrika Harmenberg, Anna Laurell, Peter Wersäll, Lennart K Blomqvist, Anders Ullén and Per Sandström
    Citation: BMC Cancer 2014 14:408
    Content type: Research article Published on:

  38. The orphan receptors COUP-TF (chicken ovalbumin upstream promoter transcription factor) I and II are members of the nuclear receptor superfamily that play distinct and critical roles in vertebrate organogenesi...

    Authors: Antoine Boudot, Gwenneg Kerdivel, Sylvain Lecomte, Gilles Flouriot, Mireille Desille, Florence Godey, Jean Leveque, Patrick Tas, Yves Le Dréan and Farzad Pakdel
    Citation: BMC Cancer 2014 14:407
    Content type: Research article Published on:

  39. Smoking is by far the most important cause of cancer that can be modified at the individual level. Cancer incidence and mortality rates in Korea are the highest among all Asian countries, and smoking prevalenc...

    Authors: Sohee Park, Sun Ha Jee, Hai-Rim Shin, Eun Hye Park, Aesun Shin, Kyu-Won Jung, Seung-Sik Hwang, Eun Shil Cha, Young Ho Yun, Sue Kyung Park, Mathieu Boniol and Paolo Boffetta
    Citation: BMC Cancer 2014 14:406
    Content type: Research article Published on:

  40. After initial treatment of differentiated thyroid carcinoma (DTC) patients are followed with thyroglobulin (Tg) measurements to detect recurrences. In case of elevated levels of Tg and negative neck ultrasonog...

    Authors: Jakob W Kist, Bart de Keizer, Marcel PM Stokkel, Otto S Hoekstra and Wouter V Vogel
    Citation: BMC Cancer 2014 14:405
    Content type: Study protocol Published on:

  41. The purpose of the PROLUCA study is to investigate the efficacy of preoperative and early postoperative rehabilitation in a non-hospital setting in patients with operable lung cancer with special focus on exer...

    Authors: Maja S Sommer, Karen Trier, Jette Vibe-Petersen, Malene Missel, Merete Christensen, Klaus R Larsen, Seppo W Langer, Carsten Hendriksen, Paul Clementsen, Jesper H Pedersen and Henning Langberg
    Citation: BMC Cancer 2014 14:404
    Content type: Study protocol Published on:

  42. Development of escape pathways from antiangiogenic treatments was reported to be associated with enhanced tumor aggressiveness and rebound effect was suggested after treatment stop. Aim of the study was to eva...

    Authors: Sara Marinelli, Veronica Salvatore, Marco Baron Toaldo, Maddalena Milazzo, Luca Croci, Laura Venerandi, Anna Pecorelli, Chiara Palamà, Alessia Diana, Luigi Bolondi and Fabio Piscaglia
    Citation: BMC Cancer 2014 14:403
    Content type: Research article Published on:

  43. The expression of novel oncogenic kinase (NOK), a member of the protein tyrosine kinase (PTK) family, has been observed in several human malignancies including non-small cell lung cancer (NSCLC). However, the ...

    Authors: Peng Chen, Wei-Miao Li, Qiang Lu, Jian Wang, Xiao-Long Yan, Zhi-Pei Zhang and Xiao-Fei Li
    Citation: BMC Cancer 2014 14:402
    Content type: Research article Published on:

  44. Targeting cell metabolism offers promising opportunities for the development of drugs to treat cancer. We previously found that the fatty acyl-CoA synthetase VL3 (ACSVL3) is elevated in malignant brain tumor t...

    Authors: Peng Sun, Shuli Xia, Bachchu Lal, Xiaohai Shi, Kil Sung Yang, Paul A Watkins and John Laterra
    Citation: BMC Cancer 2014 14:401
    Content type: Research article Published on:

  45. Neoadjuvant chemotherapy (NAC) is one of the standard care regimens for patients with resectable early-stage breast cancer. It would be advantageous to determine the chemosensitivity of tumors before initiatin...

    Authors: Naoki Aomatsu, Masakazu Yashiro, Shinichiro Kashiwagi, Hidemi Kawajiri, Tsutomu Takashima, Masahiko Ohsawa, Kenichi Wakasa and Kosei Hirakawa
    Citation: BMC Cancer 2014 14:400
    Content type: Research article Published on:

  46. Leptomeningeal metastasis, which results from metastasis of tumors to the arachnoid and pia mater, can lead to the dissemination of tumor cells throughout the subarachnoid space via the cerebral spinal fluid, ...

    Authors: Zhenyu Pan, Guozi Yang, Tingting Yuan, Xiaochuan Pang, Yongxiang Wang, Limei Qu and Lihua Dong
    Citation: BMC Cancer 2014 14:399
    Content type: Case report Published on:

  47. To date only a handful of drugs are available for the treatment of melanoma. Among them vemurafenib, a BrafV600E specific inhibitor, showed promising results in terms of response rate and increase in median survi...

    Authors: Madhuri Bhandaru, Gholamreza Safaee Ardekani, Guohong Zhang, Magdalena Martinka, Kevin J McElwee, Gang Li and Anand Rotte
    Citation: BMC Cancer 2014 14:398
    Content type: Research article Published on:

  48. The progression of low-risk del(5q) myelodysplastic syndrome to acute myeloid leukemia is increased when associated with mutations of TP53, or with additional chromosomal abnormalities. However, to date the progn...

    Authors: Alberto L’Abbate, Crocifissa Lo Cunsolo, Ettore Macrì, Paolo Iuzzolino, Cristina Mecucci, Claudio Doglioni, Michelina Coco, Lucia Anna Muscarella, Simona Salati, Enrico Tagliafico, Carla Minoia, Giacoma De Tullio, Attilio Guarini, Nicoletta Testoni, Claudio Agostinelli and Clelia Tiziana Storlazzi
    Citation: BMC Cancer 2014 14:396
    Content type: Case report Published on:

  49. Basaloid squamous cell carcinoma presents with a preference for the head and neck region, and shows a distinct aggressive behavior, with frequent local recurrences, regional and distant metastasis. The alterat...

    Authors: João Adolfo Costa Hanemann, Denise Tostes Oliveira, Suely Nonogaki, Inês Nobuko Nishimoto, Marina Lara de Carli, Gilles Landman and Luiz Paulo Kowalski
    Citation: BMC Cancer 2014 14:395
    Content type: Research article Published on:

  50. An imbalance between cell proliferation and programmed cell death can result in tumor growth. Although most systemic cytotoxic agents induce apoptosis in tumor cells, a high apoptotic rate in primary breast ca...

    Authors: Natalia Krawczyk, Andreas Hartkopf, Malgorzata Banys, Franziska Meier-Stiegen, Annette Staebler, Markus Wallwiener, Carmen Röhm, Juergen Hoffmann, Markus Hahn and Tanja Fehm
    Citation: BMC Cancer 2014 14:394
    Content type: Research article Published on:

Featured videos

View featured videos from across the BMC-series journals

Submit manuscript

Follow

BMC Cancer

ISSN: 1471-2407

Contact us