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  1. Cetuximab, in combination with platinum chemotherapy plus 5-fluoruracil (5-FU), is approved for the first-line treatment of recurrent/metastatic squamous cell carcinoma of the head and neck (SCCHN). Cetuximab ...

    Authors: Denis Soulières, Jose Luis Aguilar, Eric Chen, Krzysztof Misiukiewicz, Scott Ernst, Hyun Jung Lee, Katherine Bryant, Shuang He, Coleman K. Obasaju, Shao-Chun Chang, Steve Chin and Douglas Adkins
    Citation: BMC Cancer 2016 16:19
    Content type: Research article Published on:

  2. To assess the clinical value of peritoneal washing cytology (PWC) in women with BRCA1 or BRCA2 mutations and women from a family with hereditary breast and/or ovarian cancer (HBOC) undergoing risk-reducing sal...

    Authors: F. Blok, E. M. Roes, G. J. L. H. van Leenders and H. J. van Beekhuizen
    Citation: BMC Cancer 2016 16:18
    Content type: Research article Published on:

  3. Silvestrol is a cyclopenta[b]benzofuran that was isolated from the fruits and twigs of Aglaia foveolata, a plant indigenous to Borneo in Southeast Asia. The purpose of the current study was to determine if inhibi...

    Authors: Wei-Lun Chen, Li Pan, A. Douglas Kinghorn, Steven M. Swanson and Joanna E. Burdette
    Citation: BMC Cancer 2016 16:17
    Content type: Research article Published on:

  4. FoxC2 is an epithelial–mesenchymal transition (EMT) regulator which induces metastasis. The purpose of this study is to assess the prognostic value of FoxC2 expression in non-small cell lung cancer (NSCLC), al...

    Authors: Wei Jiang, Hong Fan, Cheng Qian, Jianyong Ding, Qun Wang and Xuguang Pang
    Citation: BMC Cancer 2016 16:16
    Content type: Research article Published on:

  5. Hepatocellular carcinoma (HCC) is one of the most fatal malignancies worldwide, and CD133 is a popular cancer stem cell (CSC) marker for HCC. CD133+ CSCs have been reported to resist conventional chemo- and radio...

    Authors: Jian Li, Jin-Na Chen, Ting-Ting Zeng, Fan He, Shu-Peng Chen, Stephanie Ma, Jiong Bi, Xiao-Feng Zhu and Xin-Yuan Guan
    Citation: BMC Cancer 2016 16:15
    Content type: Research article Published on:

  6. The ability of tamoxifen and raloxifene to decrease breast cancer risk varies among different breast cancer subtypes. It is important to determine one’s subtype-specific breast cancer risk when considering che...

    Authors: Hannah Lui Park, Argyrios Ziogas, Jenny Chang, Bhumi Desai, Leona Bessonova, Chad Garner, Eunjung Lee, Susan L. Neuhausen, Sophia S. Wang, Huiyan Ma, Jessica Clague, Peggy Reynolds, James V. Lacey Jr, Leslie Bernstein and Hoda Anton-Culver
    Citation: BMC Cancer 2016 16:14
    Content type: Research article Published on:

  7. Less than 20 % of familial breast cancer patients who undergo genetic testing for BRCA1 and BRCA2 carry a pathogenic mutation in one of these two genes. The GENESIS (GENE SISter) study was designed to identify ne...

    Authors: Olga M. Sinilnikova, Marie-Gabrielle Dondon, Séverine Eon-Marchais, Francesca Damiola, Laure Barjhoux, Morgane Marcou, Carole Verny-Pierre, Valérie Sornin, Lucie Toulemonde, Juana Beauvallet, Dorothée Le Gal, Noura Mebirouk, Muriel Belotti, Olivier Caron, Marion Gauthier-Villars, Isabelle Coupier…
    Citation: BMC Cancer 2016 16:13
    Content type: Research article Published on:

  9. The Ras Association Domain Family Member 1 (RASSF1) is one of the most frequently reported methylation-inactivated tumor suppressor genes in primary pancreatic ductal adenocarcinomas (PDAC). Limited information i...

    Authors: Eliana Amato, Stefano Barbi, Matteo Fassan, Claudio Luchini, Caterina Vicentini, Matteo Brunelli, Giuseppe Malleo, Aldo Scarpa and Giorgio Malpeli
    Citation: BMC Cancer 2016 16:11
    Content type: Research article Published on:

  10. For decades, planar bone scintigraphy has been the standard practice for detection of bone metastases in prostate cancer and has been endorsed by recent oncology/urology guidelines. It is a sensitive method wi...

    Authors: Randi F. Fonager, Helle D. Zacho, Niels C. Langkilde and Lars J. Petersen
    Citation: BMC Cancer 2016 16:10
    Content type: Study protocol Published on:

  11. Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality. We previously showed that the inhibition of placental growth factor (PlGF) exerts antitumour effects and induces vessel normalisat...

    Authors: Yves-Paul Vandewynckel, Debby Laukens, Lindsey Devisscher, Eliene Bogaerts, Annelies Paridaens, Anja Van den Bussche, Sarah Raevens, Xavier Verhelst, Christophe Van Steenkiste, Bart Jonckx, Louis Libbrecht, Anja Geerts, Peter Carmeliet and Hans Van Vlierberghe
    Citation: BMC Cancer 2016 16:9
    Content type: Research article Published on:

  12. Authors: Giovanni Luca Gravina, Andrea Mancini, Patrizia Sanita, Flora Vitale, Francesco Marampon, Luca Ventura, Yosef Landesman, Dilara McCauley, Michael Kauffman, Sharon Shacham and Claudio Festuccia
    Citation: BMC Cancer 2016 16:8
    Content type: Erratum Published on:

    The original article was published in BMC Cancer 2015 15:941

  13. GAGE cancer/testis antigens are frequently expressed in various types of malignancies and represent attractive targets for immunotherapy, however their role in cancer initiation and progression has remained el...

    Authors: Morten Frier Gjerstorff, Mikkel Green Terp, Malene Bredahl Hansen and Henrik Jørn Ditzel
    Citation: BMC Cancer 2016 16:7
    Content type: Research article Published on:

  14. Intravenous leiomyomas are a rare variant of uterine leiomyoma. Although histologically benign, these tumors are associated with a poor prognosis due to propensity for metastasis, high recurrence rate, difficu...

    Authors: Ying Zhang, Leslie H. Clark, Xiugui Sheng and Chunxiao Zhou
    Citation: BMC Cancer 2016 16:6
    Content type: Case report Published on:

  15. Breast and ovarian cancers are predominant female cancers with increasing prevalence. The purpose of this study was to estimate the population attributable risks (PARs) of breast and ovarian cancer occurrence ...

    Authors: Boyoung Park, Sohee Park, Hai-Rim Shin, Aesun Shin, Yohwan Yeo, Ji-Yeob Choi, Kyu-Won Jung, Byoung-Gie Kim, Yong-Man Kim, Dong-Young Noh, Sei-Hyun Ahn, Jae Weon Kim, Sokbom Kang, Jae Hoon Kim, Tae Jin Kim, Daehee Kang…
    Citation: BMC Cancer 2016 16:5
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Cancer 2016 16:181

  16. Healthy lifestyle behaviors have been demonstrated to be beneficial for positive health outcomes and the quality of life in cancer survivors. However, adherence to recommendations is low. More insight is neede...

    Authors: Iris M. Kanera, Catherine A. W. Bolman, Ilse Mesters, Roy A. Willems, Audrey A. J. M. Beaulen and Lilian Lechner
    Citation: BMC Cancer 2016 16:4
    Content type: Research article Published on:

  17. Hepatocellular carcinoma (HCC) is the most common malignant tumor of the liver. Non-alcoholic fatty liver disease (NAFLD) is a frequent chronic liver disorder in developed countries. NAFLD can progress through...

    Authors: Alessandra Tessitore, Germana Cicciarelli, Filippo Del Vecchio, Agata Gaggiano, Daniela Verzella, Mariafausta Fischietti, Valentina Mastroiaco, Antonella Vetuschi, Roberta Sferra, Remo Barnabei, Daria Capece, Francesca Zazzeroni and Edoardo Alesse
    Citation: BMC Cancer 2016 16:3
    Content type: Research article Published on:

  18. Chemotherapy is the only therapy option for the majority of AML patients, however, there are several limitations for this treatment. Our aim was to find a new chemotherapy strategy that is more effective and l...

    Authors: Zhifei Xu, JinJin Shao, Lin Li, Xueming Peng, Min Chen, Guanqun Li, Hao Yan, Bo Yang, Peihua Luo and Qiaojun He
    Citation: BMC Cancer 2016 16:2
    Content type: Research article Published on:

  19. Rising cancer incidence, the cost of cancer pharmaceuticals and the introduction of the Cancer Drugs Fund in England, but not other United Kingdom(UK) countries means evidence of ‘postcode prescribing’ in canc...

    Authors: Charlotte Chamberlain, Amanda Owen-Smith, Jenny Donovan and William Hollingworth
    Citation: BMC Cancer 2015 16:1
    Content type: Research article Published on:

  20. The primary goal of preoperative systemic treatment (PST) in patients with breast cancer is downsizing of tumors to enhance the rate of breast conserving surgery. Additionally, preoperative systemic treatment ...

    Authors: Christoph Suppan, Vesna Bjelic-Radisic, Marlen La Garde, Andrea Groselj-Strele, Katharina Eberhard, Hellmut Samonigg, Hans Loibner, Nadia Dandachi and Marija Balic
    Citation: BMC Cancer 2015 15:1027
    Content type: Research article Published on:

  21. Only 5–10 % of breast cancer cases is linked to germline mutations in the BRCA-1 gene and occurs early in life. Conversely, sporadic breast tumors, which represent 90-95 % of breast malignancies, have lower BRCA-...

    Authors: Donato F. Romagnolo, Andreas J. Papoutsis, Christina Laukaitis and Ornella I. Selmin
    Citation: BMC Cancer 2015 15:1026
    Content type: Research article Published on:

  22. The glycosylphosphatidylinositol-anchored extracellular membrane serine protease prostasin is expressed in normal bladder urothelial cells. Bladder inflammation reduces prostasin expression and a loss of prost...

    Authors: Andreas C. Chai, Andrew L. Robinson, Karl X. Chai and Li-Mei Chen
    Citation: BMC Cancer 2015 15:1025
    Content type: Research article Published on:

  23. Archival formalin-fixed paraffin-embedded (FFPE) cancer tissue samples are a readily available resource for microRNA (miRNA) biomarker identification. No established standard for reference miRNAs in FFPE tissu...

    Authors: Mogens Karsbøl Boisen, Christian Dehlendorff, Dorte Linnemann, Nicolai Aagaard Schultz, Benny Vittrup Jensen, Estrid Vilma Solyom Høgdall and Julia Sidenius Johansen
    Citation: BMC Cancer 2015 15:1024
    Content type: Research article Published on:

  24. Colorectal cancer (CRC) is one of the most common malignances worldwide. Metastasis is responsible for the rapid recurrence and poor prognosis of CRC. However, the underlying molecular mechanism of CRC metasta...

    Authors: Xuehu Xu, Rong Chen, Zhifa Li, Nanqi Huang, Xiaobing Wu, Shuling Li, Yong Li and Shangbiao Wu
    Citation: BMC Cancer 2015 15:1023
    Content type: Research article Published on:

  25. Epidemiological studies show that cigarette smoking increase the risk of nasopharyngeal carcinoma (NPC), however, whether other common, potentially adverse household inhalants increase NPC risk remains uncertain.

    Authors: Yong-Qiao He, Wen-Qiong Xue, Guo-Ping Shen, Ling-Ling Tang, Yi-Xin Zeng and Wei-Hua Jia
    Citation: BMC Cancer 2015 15:1022
    Content type: Research article Published on:

  26. The incidence of meningeal carcinomatosis appears to be higher than in the past due to advances in neuro-imaging diagnostic techniques and improvements in cancer survival. Among solid tumors, breast cancer is ...

    Authors: Gloria Mittica, Rebecca Senetta, Lorenzo Richiardi, Roberta Rudà, Renato Coda, Isabella Castellano, Anna Sapino and Paola Cassoni
    Citation: BMC Cancer 2015 15:1021
    Content type: Research article Published on:

  27. Aberrant activation of the Wnt/β-catenin pathway is a major and frequent event in liver cancer, but inhibition of oncogenic β-catenin signaling has proven challenging. The identification of genes that are synt...

    Authors: Frédéric Canal, Elodie Anthony, Aurianne Lescure, Elaine Del Nery, Jacques Camonis, Franck Perez, Bruno Ragazzon and Christine Perret
    Citation: BMC Cancer 2015 15:1020
    Content type: Research article Published on:

  28. nab-Paclitaxel is an albumin-bound formulation of paclitaxel approved for the treatment of metastatic breast cancer (MBC). This analysis was designed to characterize the treatment patterns, efficacy, and safety o...

    Authors: Caihua Liang, Ling Li, Cindy Duval Fraser, Amy Ko, Deyanira Corzo, Cheryl Enger and Debra Patt
    Citation: BMC Cancer 2015 15:1019
    Content type: Research article Published on:

  29. Breast cancer survival rates are significantly lower among African-American women compared to white women. In addition, African-American women with breast cancer are more likely than white women to die from co...

    Authors: Melinda R. Stolley, Lisa K. Sharp, Giamila Fantuzzi, Claudia Arroyo, Patricia Sheean, Linda Schiffer, Richard Campbell and Ben Gerber
    Citation: BMC Cancer 2015 15:1018
    Content type: Study protocol Published on:

  30. Patient satisfaction is an important element of quality improvement and patient-centered care, and is an indicator of the public’s confidence in the health care system. Although shorter wait times are believed...

    Authors: Maria Mathews, Dana Ryan and Donna Bulman
    Citation: BMC Cancer 2015 15:1017
    Content type: Research article Published on:

  31. Shifts in CD8+ T-cell subsets that are hallmarks of immunosenescence are observed in ageing and in conditions of chronic immune stimulation. Presently, there is limited documentation of such changes in lung ca...

    Authors: Oscar Okwudiri Onyema, Lore Decoster, Rose Njemini, Louis Nuvagah Forti, Ivan Bautmans, Marc De Waele and Tony Mets
    Citation: BMC Cancer 2015 15:1016
    Content type: Research article Published on:

  32. Cancer stem cell markers have become a major research focus because of their relationship with radiation or chemotherapy resistance in cancer therapy. Cancer stem cell markers including OCT4 and SOX2 have been...

    Authors: Bo Wook Kim, Hanbyoul Cho, Chel Hun Choi, Kris Ylaya, Joon-Yong Chung, Jae-Hoon Kim and Stephen M. Hewitt
    Citation: BMC Cancer 2015 15:1015
    Content type: Research article Published on:

  33. Photodynamic therapy (PDT) of solid cancers comprises the administration of a photosensitizer followed by illumination of the photosensitizer-replete tumor with laser light. This induces a state of local oxida...

    Authors: Ruud Weijer, Mans Broekgaarden, Rowan F. van Golen, Esther Bulle, Esther Nieuwenhuis, Aldo Jongejan, Perry D. Moerland, Antoine H. C. van Kampen, Thomas M. van Gulik and Michal Heger
    Citation: BMC Cancer 2015 15:1014
    Content type: Research article Published on:

  34. Treatment possibilities of metastatic renal cell carcinoma (mRCC) have recently changed dramatically prolonging the overall survival of the patients. This kind of development brings new challenges for the care...

    Authors: László Mangel, Krisztina Bíró, István Battyáni, Péter Göcze, Tamás Tornóczky and Endre Kálmán
    Citation: BMC Cancer 2015 15:1013
    Content type: Case report Published on:

  35. Serum 25-hydroxyvitamin D [25(OH)D], the major circulating form of vitamin D used for evaluating the vitamin D status of patients, has been associated with survival in a variety of cancers with conflicting evi...

    Authors: Pankaj G. Vashi, Persis Edwin, Brenten Popiel and Digant Gupta
    Citation: BMC Cancer 2015 15:1012
    Content type: Research article Published on:

  36. Glioblastoma multiforme (GBM) is characterized by extensive local invasion, which is in contrast with extremely rare systemic metastasis of GBM. Molecular mechanisms inhibiting systemic metastasis of GBM would...

    Authors: Se Jeong Lee, Won Young Kang, Yeup Yoon, Ju Youn Jin, Hye Jin Song, Jung Hyun Her, Sang Mi Kang, Yu Kyeong Hwang, Kyeong Jin Kang, Kyeung Min Joo and Do-Hyun Nam
    Citation: BMC Cancer 2015 15:1011
    Content type: Research article Published on:

  37. Transforming growth factor beta (TGFβ) signalling is involved in both tumour suppression and tumour progression. The mRNA expression levels of the TGFβ isoforms and receptors in breast tumours may have prognos...

    Authors: Chenfeng Chen, Kong-Nan Zhao, Paul P. Masci, Sunil R. Lakhani, Annika Antonsson, Peter T. Simpson and Luis Vitetta
    Citation: BMC Cancer 2015 15:1010
    Content type: Research article Published on:

  38. Tumor immune-escape has been related to the ability of cancer cells to inhibit T cell activation and dendritic cell (DC) differentiation. We previously identified a tumor initiating population, expressing the ...

    Authors: Cristina Grange, Marta Tapparo, Stefania Tritta, Maria Chiara Deregibus, Antonino Battaglia, Paolo Gontero, Bruno Frea and Giovanni Camussi
    Citation: BMC Cancer 2015 15:1009
    Content type: Research article Published on:

  39. Signs and symptoms of a rapidly enlarging breast mass are not only important for all clinicians to recognize and assess, but also are not uncommon occurrences. We describe a similar but unique case that develo...

    Authors: Vivek Verma, Sanjay Muttineni, Rajesh R. Kulkarni, Edibaldo Silva-Lopez, William W. West and Robert B. Thompson
    Citation: BMC Cancer 2015 15:1008
    Content type: Case report Published on:

  41. Neuropilin and tolloid-like 2 (NETO2) has been found to be overexpressed in different human cancers, but its expression pattern and clinical relevance in colorectal carcinoma (CRC) remains unknown.

    Authors: Liang Hu, Hai-Yang Chen, Jian Cai, Guang-Zhen Yang, Dan Feng, Yan-Xia Zhai, Hui Gong, Chen-Ye Qi, Yu Zhang, Hao Fu, Qing-Ping Cai and Chun-Fang Gao
    Citation: BMC Cancer 2015 15:1006
    Content type: Research article Published on:

  43. The objective of the study was to explore the clinical expression, radiological and pathological features, differential diagnosis, and biological behavior of a clear cell myomelanocytic tumor. In a case involv...

    Authors: Zu-Sen Wang, Lin Xu, Lin Ma, Meng-Qi Song, Li-Qun Wu and Xuan Zhou
    Citation: BMC Cancer 2015 15:1004
    Content type: Case report Published on:

  44. Thyroid cancer has been indicated to have a higher global proportion of DNA methylation and a decreased level of histone acetylation. Previous studies showed that histone gene reviser and epigenetic changes ro...

    Authors: Seok-Mo Kim, Ki-Cheong Park, Jeong-Yong Jeon, Bup-Woo Kim, Hyeung-Kyoo Kim, Ho-Jin Chang, Seung-Hoon Choi, Cheong-Soo Park and Hang-Seok Chang
    Citation: BMC Cancer 2015 15:1003
    Content type: Research article Published on:

  45. Use of FDG-PET/CT for staging and restaging of lymphoma patients is widely incorporated into current practice guidelines. Our aim was to prospectively evaluate the diagnostic performance of FDG-PET/MRI and WB-...

    Authors: Ken Herrmann, Marcelo Queiroz, Martin W. Huellner, Felipe de Galiza Barbosa, Andreas Buck, Niklaus Schaefer, Paul Stolzman and Patrick Veit-Haibach
    Citation: BMC Cancer 2015 15:1002
    Content type: Research article Published on:

  46. The mixture of volatile organic compounds in the headspace gas of urine may be able to distinguish lung cancer patients from relevant control populations.

    Authors: Peter J. Mazzone, Xiao-Feng Wang, Sung Lim, Humberto Choi, James Jett, Anil Vachani, Qi Zhang, Mary Beukemann, Meredith Seeley, Ray Martino and Paul Rhodes
    Citation: BMC Cancer 2015 15:1001
    Content type: Research article Published on:

  47. People from lower socioeconomic groups have worse survival outcomes for cancer, which in part reflects later-stage disease at diagnosis. The mechanisms underlying delayed cancer symptom presentation in lower s...

    Authors: Grace M. McCutchan, Fiona Wood, Adrian Edwards, Rebecca Richards and Kate E. Brain
    Citation: BMC Cancer 2015 15:1000
    Content type: Research article Published on:

  48. Reactivation of hepatitis B or C virus can occur in patients undergoing chemotherapy. Recommendations for selective or systematic hepatitis B virus testing prior chemotherapy for solid tumors differ. The prima...

    Authors: Mathilde Brasseur, Alexandra Heurgué-Berlot, Coralie Barbe, Cloé Brami, Jean-Baptiste Rey, Juliette Vella-Boucaud, Fadia Dabouz, Gaëtan Deslée, Florent Grange, Julien Volet and Olivier Bouché
    Citation: BMC Cancer 2015 15:999
    Content type: Research article Published on:

  49. Leiomyosarcoma (LMS) is an aggressive soft tissue sarcoma derived from smooth muscle cells typically of uterine, gastrointestinal or soft tissue origin.

    Authors: Alberto Bongiovanni, Nada Riva, Marianna Ricci, Laura Mercatali, Chiara Liverani, Federico La Manna, Alessandro De Vita, Davide Cavaliere, Federica Pieri, Devil Oboldi, Giorgio Maria Verdecchia, Dino Amadori and Toni Ibrahim
    Citation: BMC Cancer 2015 15:998
    Content type: Case report Published on:

  50. Paraneoplastic syndromes are most frequently associated with small cell lung carcinoma, hematologic and gynecologic malignancies while reports in head and neck cancer are rare.

    Authors: Florian Huemer, Thomas Melchardt, Wolfgang Tränkenschuh, Daniel Neureiter, Gerhard Moser, Teresa Magnes, Lukas Weiss, Alexander Schlattau, Clemens Hufnagl, Gerda Ricken, Romana Höftberger, Richard Greil and Alexander Egle
    Citation: BMC Cancer 2015 15:996
    Content type: Case report Published on:

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