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  1. Transforming growth factor-β (TGF-β) signaling is a double-edged sword in cancer development and progression. TGF-β signaling plays a tumor suppressive role during the early stages of tumor development but pro...

    Authors: Hwa-Kyung Son, Dokyeong Kim, Yongwoon Lim, Jin Kim and Iha Park
    Citation: BMC Cancer 2020 20:1163
    Content type: Research article Published on:

  2. Human CD133+ hematopoietic progenitor cells (HPCs) are a specific subset of cells that can regulate tumor malignancy. However, the mechanism by which CD133+ HPCs affect the malignancy of human breast cancer ha...

    Authors: Zhe Zhang, Qinglian Zheng, Yonghui Liu, Lianqing Sun, Pingping Han, Rui Wang, Jiao Zhao, Shan Hu and Xinhan Zhao
    Citation: BMC Cancer 2020 20:1158
    Content type: Research article Published on:

  3. Patients with relapsed or refractory peripheral T-cell lymphoma (R/R PTCL) treated with pralatrexate have previously shown superior overall survival (OS) compared to those who underwent conventional chemothera...

    Authors: Seonyoung Park, Ah-Young Kim, Hyeonseok Cho, Deborah Baik, Hankil Lee, Sunghwa Cho and Hye-Young Kang
    Citation: BMC Cancer 2020 20:1157
    Content type: Research article Published on:

  5. To compare the survival outcomes between breast-conserving surgery (BCS) and modified radical mastectomy (MRM), and to investigate the role of radiotherapy (RT) in patients with pT1–2N1M0 breast cancer.

    Authors: Guang-Yi Sun, Ge Wen, Yu-Jing Zhang, Yu Tang, Hao Jing, Jian-Yang Wang, Jiang-Hu Zhang, Yong Yang, Xu-Ran Zhao, Si-Ye Chen, Jing Jin, Yong-Wen Song, Yue-Ping Liu, Hui Fang, Hua Ren, Yuan Tang…
    Citation: BMC Cancer 2020 20:1155
    Content type: Research article Published on:

  6. We compared outcomes and toxicities between concurrent retrograde super-selective intra-arterial chemoradiotherapy (IACRT) and concurrent systemic chemoradiotherapy (SCRT) for gingival carcinoma (GC).

    Authors: Yuki Mukai, Yuichiro Hayashi, Izumi Koike, Toshiyuki Koizumi, Madoka Sugiura, Senri Oguri, Shoko Takano, Mitomu Kioi, Mizuki Sato, Kenji Mitsudo and Masaharu Hata
    Citation: BMC Cancer 2020 20:1154
    Content type: Research article Published on:

  7. The aim of this study was to translate and linguistically validate the U.S. National Cancer Institute’s Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE™) into...

    Authors: Cheng KKF, S. A. Mitchell, N. Chan, E. Ang, W. Tam and R. Kanesvaran
    Citation: BMC Cancer 2020 20:1153
    Content type: Research article Published on:

  8. Progressive lung cancer is associated with abnormal coagulation. Platelets play a vital part in evading immune surveillance and angiogenesis in the case of tumor metastasis. The study aimed to analyze the pred...

    Authors: Lu Xu, Fangzhou Xu, Haobo Kong, Meiling Zhao, Yuanzi Ye and Yanbei Zhang
    Citation: BMC Cancer 2020 20:1152
    Content type: Research article Published on:

  9. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Alexander Arnold, Moritz Tronser, Christine Sers, Aysel Ahadova, Volker Endris, Soulafa Mamlouk, David Horst, Markus Möbs, Philip Bischoff, Matthias Kloor and Hendrik Bläker
    Citation: BMC Cancer 2020 20:1151
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2020 20:1038

  10. Whether tumour-infiltrating lymphocytes (TILs) play different roles in different molecular subtypes of breast cancer remains unknown. Additionally, their prognostic and predictive value in different molecular ...

    Authors: Zhao-hua Gao, Cun-xin Li, Ming Liu and Jia-yuan Jiang
    Citation: BMC Cancer 2020 20:1150
    Content type: Research article Published on:

  11. Metastatic colorectal cancer (mCRC) remains a lethal disease. Survival, however, is increasing due to a growing number of treatment options. Yet due to the number of prognostic factors and their interactions, ...

    Authors: Holger Rumpold, Dora Niedersüß-Beke, Cordula Heiler, David Falch, Helwig Valenting Wundsam, Sigrid Metz-Gercek, Gudrun Piringer and Josef Thaler
    Citation: BMC Cancer 2020 20:1149
    Content type: Research article Published on:

  12. Population-based analysis for the short-term non-bladder cancer related mortality among patients with non-metastatic bladder cancer is currently lacking. The objective of the current study was to assess and qu...

    Authors: Menghe Zhai, Chenye Tang, Ming Li, Xin Chen, Yigang Jin, Xiangjun Ying, Zhiling Tang, Xiao Wang, Yuntao Wu, Chun Sun, Kean Chen and Xiao Guo
    Citation: BMC Cancer 2020 20:1148
    Content type: Research article Published on:

  13. When the resected specimen is sent for intraoperative margin assessment, all margins are grossly checked, and selected margins undergo a frozen section (FS) examination. Therefore, there is a possibility of sa...

    Authors: Hana’a Hezam Algadi, Amany Abd-Elhameed Abou-Bakr, Omer Mohammed Jamali and Louloua Mohamed Fathy
    Citation: BMC Cancer 2020 20:1147
    Content type: Research article Published on:

  14. The value of postmastectomy radiotherapy (PMRT) for pathological node-positive triple-negative breast cancers (TNBC) remains debatable. The aim of this population-based retrospective study was to evaluate the ...

    Authors: Lei Zhang, Ru Tang, Jia-Peng Deng, Wen-Wen Zhang, Huan-Xin Lin, San-Gang Wu and Zhen-Yu He
    Citation: BMC Cancer 2020 20:1146
    Content type: Database Published on:

  15. Breast cancer is the most common malignancy in women, and it is also the leading cause of death in female patients; the most common pathological type of BC is infiltrating duct carcinoma (IDC). Some nomograms ...

    Authors: Zhangheng Huang, Chuan Hu, Kewen Liu, Luolin Yuan, Yinglun Li, Chengliang Zhao and Chanchan Hu
    Citation: BMC Cancer 2020 20:1145
    Content type: Research article Published on:

  16. In order to obtain a high dose conformal index of tumor and steep dose fall-off in healthy tissues for brain metastasis stereotactic radiosurgery (SRS), the aim of this study was to investigate SRS planning op...

    Authors: Xuyao Yu, Yuwen Wang, Zhiyong Yuan, Hui Yu, Yongchun Song, Lujun Zhao and Ping Wang
    Citation: BMC Cancer 2020 20:1144
    Content type: Research article Published on:

  17. Interleukin-1 receptor antagonist (IL1RN) has been reported as a biomarker of many cancers. However, the biological function of IL1RN in papillary thyroid carcinoma (PTC) remains undetermined.

    Authors: Zhenyu Xie, Xin Li, Yuzhen He, Song Wu, Shiyue Wang, Jianjian Sun, Yuchen He, Yu Lun, Shijie Xin and Jian Zhang
    Citation: BMC Cancer 2020 20:1143
    Content type: Research article Published on:

  18. Prehabilitation with regular exercise and nutritional care for patients undergoing surgeries for malignant disease was recently introduced to increase physiologic reserve prior to the procedure, accelerate rec...

    Authors: Erik Rupnik, Matevz Skerget, Matjaz Sever, Irena Preloznik Zupan, Maja Ogrinec, Barbara Ursic, Natasa Kos, Peter Cernelc and Samo Zver
    Citation: BMC Cancer 2020 20:1142
    Content type: Research article Published on:

  19. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Zhenhua Yin, Dejun Wu, Jianping Shi, Xiyi Wei, Nuyun Jin, Xiaolan Lu and Xiaohan Ren
    Citation: BMC Cancer 2020 20:1141
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2020 20:1062

  20. Allogeneic stem cell transplantation from haploidentical donor using an unmanipulated graft and post-transplantation cyclophosphamide (PT-Cy) is growing. Haploidentical transplantation with PT-Cy showed a majo...

    Authors: Luca Castagna, Alessandro Busca, Stefania Bramanti, Maria Raiola Anna, Michele Malagola, Fabio Ciceri, William Arcese, Daniele Vallisa, Francesca Patriarca, Giorgina Specchia, Roberto Raimondi, Raynier Devillier, Sabine Furst, Laura Giordano, Barbara Sarina, Jacopo Mariotti…
    Citation: BMC Cancer 2020 20:1140
    Content type: Research article Published on:

  21. The recommended cumulative doxorubicin dose in soft tissue sarcoma (STS) treatment was based on cardiotoxicity data from retrospective studies of breast cancer patients. However, the treatment and prognosis of...

    Authors: Zhichao Tian, Yang Yang, Yonghao Yang, Fan Zhang, Po Li, Jiaqiang Wang, Jinpo Yang, Peng Zhang, Weitao Yao and Xin Wang
    Citation: BMC Cancer 2020 20:1139
    Content type: Research article Published on:

  22. Women with an advantaged socioeconomic position (SEP) have a higher risk of developing breast cancer (BC). The reasons for this association do not seem to be limited to reproductive factors and remain to be un...

    Authors: Eloïse Berger, Noële Maitre, Francesca Romana Mancini, Laura Baglietto, Vittorio Perduca, Hélène Colineaux, Sabina Sieri, Salvatore Panico, Carlotta Sacerdote, Rosario Tumino, Paolo Vineis, Marie-Christine Boutron-Ruault, Gianluca Severi, Raphaële Castagné and Cyrille Delpierre
    Citation: BMC Cancer 2020 20:1138
    Content type: Research article Published on:

  24. Hepatocellular carcinoma (HCC) is among the deadliest forms of cancer. While RNA-binding proteins (RBPs) have been shown to be key regulators of oncogenesis and tumor progression, their dysregulation in the co...

    Authors: Min Wang, Shan Huang, Zefeng Chen, Zhiwei Han, Kezhi Li, Chuang Chen, Guobin Wu and Yinnong Zhao
    Citation: BMC Cancer 2020 20:1136
    Content type: Research article Published on:

  25. The epithelial-mesenchymal transition (EMT) plays a pivotal role in various physiological processes, such as embryonic development, tissue morphogenesis, and wound healing. EMT also plays an important role in ...

    Authors: Zizhen Zhang, Sheng Zheng, Yifeng Lin, Jiawei Sun, Ning Ding, Jingyu Chen, Jing Zhong, Liuhong Shi and Meng Xue
    Citation: BMC Cancer 2020 20:1135
    Content type: Research article Published on:

  26. Research focusing on the relationship between five types of tumor necrosis factor-alpha (TNF-α) SNPs and the risk of hepatocellular carcinoma (HCC) were still controversial. Hereby, we performed a meta-analysi...

    Authors: Citrawati Dyah Kencono Wungu, Fis Citra Ariyanto, Gwenny Ichsan Prabowo, Soetjipto and Retno Handajani
    Citation: BMC Cancer 2020 20:1134
    Content type: Research article Published on:

  27. Cervical cancer (CC) is one of the most common gynaecological cancers. The gene signature is believed to be reliable for predicting cancer patient survival. However, there is no relevant study on the relations...

    Authors: Luya Cai, Chuan Hu, Shanshan Yu, Lixiao Liu, Xiaobo Yu, Jiahua Chen, Xuan Liu, Fan Lin, Cheng Zhang, Wenfeng Li and Xiaojian Yan
    Citation: BMC Cancer 2020 20:1133
    Content type: Research article Published on:

  28. Previous studies have revealed that nearly 15–20% of selected high-risk T1–2N0 breast cancers developed LRR after mastectomy. This study is aim to indentify the risk factors of locoregional recurrence (LRR) in...

    Authors: Jianyang Wang, Yu Tang, Hao Jing, Guangyi Sun, Jing Jin, Yueping Liu, Yongwen Song, Weihu Wang, Hui Fang, Bo Chen, Shunan Qi, Hua Ren, Ning Li, Yuan Tang, Ningning Lu, Yong Yang…
    Citation: BMC Cancer 2020 20:1132
    Content type: Research article Published on:

  29. Hepatocellular carcinoma (HCC) and pancreatic ductal adenocarcinoma (PDAC) are malignancies with a leading lethality. With reference to interferons (IFNs) known to mediate antitumor activities, this study inve...

    Authors: Henriette Huschka and Sabine Mihm
    Citation: BMC Cancer 2020 20:1131
    Content type: Research article Published on:

  30. The translational interest in the intratumoral heterogeneity of hepatocellular carcinoma (HCC) has been increasing. The dismal prognosis of this pathology is linked to the features of the HCC harbouring cancer...

    Authors: Jenny Krause, Johann von Felden, Christian Casar, Thorben W. Fründt, Johanna Galaski, Constantin Schmidt, Caroline Jung, Harald Ittrich, Sören A. Weidemann, Till Krech, Asmus Heumann, Jun Li, Lutz Fischer, Guido Sauter, Ansgar W. Lohse, Henning Wege…
    Citation: BMC Cancer 2020 20:1130
    Content type: Research article Published on:

  31. The 8th edition of the American Joint Committee on Cancer (AJCC) staging system for gallbladder carcinoma (GBC) came into force since 2018. However, the prognostic precision of this staging system has not been...

    Authors: Wei Jiang, Bingqing Zhao, Yongcheng Li, Dunfeng Qi and Daxing Wang
    Citation: BMC Cancer 2020 20:1129
    Content type: Research article Published on:

  32. While immune-checkpoint inhibitors (ICIs) have transformed the field of oncology for advanced-stage cancers, they can lead to serious immune toxicities. Several systematic reviews have evaluated the risk of im...

    Authors: Zahra Karimian, Sandra Mavoungou, Joe-Elie Salem, Florence Tubach and Agnès Dechartres
    Citation: BMC Cancer 2020 20:1128
    Content type: Research article Published on:

  33. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Karolin Ebert, Gwen Zwingenberger, Elena Barbaria, Simone Keller, Corinna Heck, Rouven Arnold, Vanessa Hollerieth, Julian Mattes, Robert Geffers, Elba Raimúndez, Jan Hasenauer and Birgit Luber
    Citation: BMC Cancer 2020 20:1127
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2020 20:1039

  35. An amendment to this paper has been published and can be accessed via the original article.

    Authors: E. B. Elimimian, L. Elson, E. Stone, R. S. Butler, M. Doll, S. Roshon, C. Kondaki, A. Padgett and Z. A. Nahleh
    Citation: BMC Cancer 2020 20:1125
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2020 20:899

  37. Schlafen 11 (SLFN11) was recently identified as a dominant determinant of sensitivity to DNA-targeting agents including platinum-based drugs. SLFN11 also reportedly enhances cellular radiosensitivity. In this ...

    Authors: Takuma Kagami, Mihoko Yamade, Takahiro Suzuki, Takahiro Uotani, Shinya Tani, Yasushi Hamaya, Moriya Iwaizumi, Satoshi Osawa, Ken Sugimoto, Hiroaki Miyajima, Satoshi Baba, Haruhiko Sugimura, Junko Murai, Yves Pommier and Takahisa Furuta
    Citation: BMC Cancer 2020 20:1123
    Content type: Research article Published on:

  38. Peritoneal metastasis (PM) in patients with breast (BC) and endometrial cancer (EC) is rare and treatment options are limited. Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) has demonstrated efficacy...

    Authors: Günther A. Rezniczek, Urs Giger-Pabst, Omar Thaher and Clemens B. Tempfer
    Citation: BMC Cancer 2020 20:1122
    Content type: Research article Published on:

  39. Lung tuberculosis (TB) and lung cancer have a complex relationship. Data concerning TB treatment in lung cancer patients are still incomplete. The aim of this study was to investigate the effects of anti-cance...

    Authors: Mei Chai and Qingming Shi
    Citation: BMC Cancer 2020 20:1121
    Content type: Research article Published on:

  40. Previous research results on the predictive factors of neoadjuvant chemotherapy (NCT) efficacy in breast cancer are inconsistent, suggesting that the ability of a single factor to predict efficacy is insuffici...

    Authors: Shengyu Pu, Ke Wang, Yang Liu, Xiaoqin Liao, Heyan Chen, Jianjun He and Jian Zhang
    Citation: BMC Cancer 2020 20:1120
    Content type: Research article Published on:

  41. Breast cancer (BC) is the second most common type of cancer worldwide. Among targeted therapies for Hormone Receptor-positive (HR+) and Human Epidermal growth factor Receptor 2-negative (HER2−) BC, the Cyclin-Dep...

    Authors: Oliviero Marinelli, Emanuela Romagnoli, Federica Maggi, Massimo Nabissi, Consuelo Amantini, Maria Beatrice Morelli, Matteo Santoni, Nicola Battelli and Giorgio Santoni
    Citation: BMC Cancer 2020 20:1119
    Content type: Research article Published on:

  42. We previously reported that low-dose, short-course sunitinib prior to neoadjuvant doxorubicin-cyclophosphamide (AC) normalised tumour vasculature and improved perfusion, but resulted in neutropenia and delayed...

    Authors: Yvonne L. E. Ang, Gwo Fuang Ho, Ross A. Soo, Raghav Sundar, Sing Huang Tan, Wei Peng Yong, Samuel G. W. Ow, Joline S. J. Lim, Wan Qin Chong, Phyu Pyar Soe, Bee Choo Tai, Lingzhi Wang, Boon Cher Goh and Soo-Chin Lee
    Citation: BMC Cancer 2020 20:1118
    Content type: Research article Published on:

  43. Novel agents such as proteasome inhibitors have been developed for several years to treat multiple myeloma. Although multiple myeloma is a low-risk disease for developing tumor lysis syndrome (TLS), treatment ...

    Authors: Masahiro Kondo, Yuji Hotta, Karen Yamauchi, Akimasa Sanagawa, Hirokazu Komatsu, Shinsuke Iida and Kazunori Kimura
    Citation: BMC Cancer 2020 20:1117
    Content type: Research article Published on:

  44. FOLFOXIRI plus bevacizumab is used as a first-line therapy for patients with unresectable or metastatic colorectal cancer. However, there are no clear recommendations for second-line therapy after FOLFOXIRI pl...

    Authors: Hironaga Satake, Koji Ando, Eiji Oki, Mototsugu Shimokawa, Akitaka Makiyama, Hiroshi Saeki, Akihito Tsuji and Masaki Mori
    Citation: BMC Cancer 2020 20:1116
    Content type: Study protocol Published on:

  45. In patients with metastatic cancer, the bone is the third-most common site of involvement. Radiation to painful bone metastases results in high rates of pain control and is an integral part of bone metastases ...

    Authors: Daniel B. Rosen, Cory D. Benjamin, Joanna C. Yang, Connor Doyle, Zhigang Zhang, Chris A. Barker, Max Vaynrub, T. Jonathan Yang and Erin F. Gillespie
    Citation: BMC Cancer 2020 20:1115
    Content type: Study protocol Published on:

  47. Performance of urinary cytology is recommended as the part of a standard diagnostic workup and base surveillance regimens in upper tract urothelial carcinoma (UTUC). However, the effect of positive voided urin...

    Authors: Wen Liu, Zhankun Wang, Shuai Liu, Yu Yao, Yong Liu and Guiming Zhang
    Citation: BMC Cancer 2020 20:1113
    Content type: Research article Published on:

  48. Nanoparticle albumin-bound paclitaxel (nab-PTX) has shown non-inferiority to paclitaxel (PTX) as second-line therapy for advanced gastric cancer (AGC) with fewer infusion-related reactions. The efficacy and sa...

    Authors: Mashiro Okunaka, Daisuke Kotani, Ken Demachi, Akihito Kawazoe, Takayuki Yoshino, Toshikatsu Kawasaki and Kohei Shitara
    Citation: BMC Cancer 2020 20:1111
    Content type: Research article Published on:

  49. There is no currently available treatment for peritoneal metastasis of gastric cancer. This phase II study aimed to evaluate the efficacy and safety of neoadjuvant systemic chemotherapy and hyperthermic intrap...

    Authors: Pengfei Yu, Zeyao Ye, Gaiguo Dai, Yanqiang Zhang, Ling Huang, Yian Du and Xiangdong Cheng
    Citation: BMC Cancer 2020 20:1108
    Content type: Research article Published on:

  50. Pathologic complete response (pCR) after neoadjuvant chemotherapy (NAC) is a predictor of improved outcomes in breast cancer. In patients with hormone receptor (HR)-positive, human epidermal growth factor rece...

    Authors: In Hee Lee, Soo Jung Lee, Jeeyeon Lee, Jin Hyang Jung, Ho Yong Park, Shin Young Jeong, Sang-woo Lee and Yee Soo Chae
    Citation: BMC Cancer 2020 20:1106
    Content type: Research article Published on:

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