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  1. The tripartite motif (TRIM) family proteins exhibit oncogenic roles in various cancers. The roles of TRIM27, a member of the TRIM super family, in renal cell carcinoma (RCC) remained unexplored. In the current...

    Authors: Chengwu Xiao, Wei Zhang, Meimian Hua, Huan Chen, Bin Yang, Ye Wang and Qing Yang
    Citation: BMC Cancer 2021 21:841
    Content type: Research Published on:

  2. The objective of this study was to investigate the survival outcomes of surgical margin width in intrahepatic cholangiocarcinoma (ICC).

    Authors: Hongzhi Liu, Lianku Lin, Ziguo Lin, Yifan Chen, Qizhen Huang, Lei Ding, Jianying Lou, Shuguo Zheng, Xinyu Bi, Jianming Wang, Wei Guo, Fuyu Li, Jian Wang, Yamin Zheng, Jingdong Li, Shi Cheng…
    Citation: BMC Cancer 2021 21:840
    Content type: Research Published on:

  3. The prognosis of oral squamous cell carcinoma (OSCC) patients is difficult to predict or describe due to its high-level heterogeneity and complex aetiologic factors. Ferroptosis is a novel form of iron-depende...

    Authors: Hongyu Li, Xiliu Zhang, Chen Yi, Yi He, Xun Chen, Wei Zhao and Dongsheng Yu
    Citation: BMC Cancer 2021 21:835
    Content type: Research article Published on:

  4. Treatment for radioiodine refractory differentiated thyroid carcinoma (RR-DTC) is challenging. The purpose of this study was to assess the efficacy and safety of ultrasound-guided implantation of radioactive 125I...

    Authors: Wei Chen, Yu kun Luo, Ying Zhang, Qing Song and Jie Tang
    Citation: BMC Cancer 2021 21:834
    Content type: Research Published on:

  5. Epithelioid sarcomas and rhabdoid tumors are rare, aggressive malignancies with poor prognosis. Both are characterized by INI1 alterations and deregulation of growth factor receptors albeit their interaction h...

    Authors: Anne Catherine Harttrampf, Maria Eugenia Marques da Costa, Aline Renoult, Estelle Daudigeos-Dubus and Birgit Geoerger
    Citation: BMC Cancer 2021 21:833
    Content type: Research Published on:

  6. The efficacy of olanzapine as an antiemetic agent in cancer chemotherapy has been demonstrated. However, few high-quality reports are available on the evaluation of olanzapine’s efficacy and safety at a low do...

    Authors: Senri Yamamoto, Hirotoshi Iihara, Ryuji Uozumi, Hitoshi Kawazoe, Kazuki Tanaka, Yukiyoshi Fujita, Masakazu Abe, Hisao Imai, Masato Karayama, Yoh Hayasaki, Chiemi Hirose, Takafumi Suda, Kazuto Nakamura, Akio Suzuki, Yasushi Ohno, Ken-ichirou Morishige…
    Citation: BMC Cancer 2021 21:832
    Content type: Research Published on:

  7. Clear cell renal cell carcinoma (ccRCC) is still highly aggressive and lethal even with various therapeutic approaches. As the kidney is an iron metabolism-related organ, exploring and assessing the clinical v...

    Authors: Yingkai Hong, Mingen Lin, Dehua Ou, Zhuangkai Huang and Peilin Shen
    Citation: BMC Cancer 2021 21:831
    Content type: Research Published on:

  8. Although various clinical trials and real-life studies have tried to explore the value of nab-paclitaxel mono-chemotherapy for metastatic breast cancer (MBC), the safety and efficacy of nab-paclitaxel remain u...

    Authors: Haili Lu, Siluo Zha, Wei Zhang, Qiang Wang, Daozhen Jiang, Xinyun Xu, Xiangmin Zheng, Ming Qiu and Chengxiang Shan
    Citation: BMC Cancer 2021 21:830
    Content type: Research article Published on:

  9. Diffuse large B-cell lymphoma (DLBCL) is the most frequent lymphoid neoplasm among adults,and approximately 30–40% of patients will experience relapse while 5–10% will suffer from primary refractory disease ca...

    Authors: Marijana Nesic, Mads Sønderkær, Rasmus Froberg Brøndum, Tarec Christoffer El-Galaly, Inge Søkilde Pedersen, Martin Bøgsted and Karen Dybkær
    Citation: BMC Cancer 2021 21:829
    Content type: Research Published on:

  10. Autophagy-related proteins may predict postresection overall survival (OS) and disease-free survival (DFS) in patients with combined hepatocellular carcinoma and cholangiocarcinoma (cHCC-CC).

    Authors: Daw-Shyong Perng, Chao-Ming Hung, Hung-Yu Lin, Paul Morgan, Yao-Chun Hsu, Tsung-Chin Wu, Pei-Min Hsieh, Jen-Hao Yeh, Pojen Hsiao, Chih-Yuan Lee, Yu-Chan Li, Ya-Chin Wang, Yaw-Sen Chen and Chih-Wen Lin
    Citation: BMC Cancer 2021 21:828
    Content type: Research Published on:

  11. Hepatocellular carcinoma (HCC) is a common cause of cancer mortality worldwide. Recent studies have shown that the polytopic enzyme membrane associated ring-CH-type finger 6 (MARCH6) participates in tumorigene...

    Authors: Jie Sun, Zheng Dong, Zhengyao Chang, Hongfei Liu, Qiyu Jiang, Deyuan Zhang, Shanshan Lu, Xiaodong Jia, Dawei Wu, Aaron Ge, Pan Zhao, Jing Wang and Yinying Lu
    Citation: BMC Cancer 2021 21:827
    Content type: Research article Published on:

  12. Circulating tumour cell (CTC) and CTC-white blood cell (CTC-WBC) clusters are related to the prognosis of tumour patients. However, the relationship between CTC-WBC clusters and prognosis in renal cell carcino...

    Authors: Yibing Guan, Fangshi Xu, Juanhua Tian, Ke Gao, Ziyan Wan, Yiyuan Wang, Mei Gao, Zhenlong Wang and Tie Chong
    Citation: BMC Cancer 2021 21:826
    Content type: Research Published on:

  13. The prognosis of lung cancer with synchronous brain metastasis (LCBM) is very poor, and patients often die within a short time. However, little is known about the early mortality and related factors in patient...

    Authors: Heng Shen, Gang Deng, Qianxue Chen and Jin Qian
    Citation: BMC Cancer 2021 21:825
    Content type: Research Published on:

  14. The Veterans Health Administration (VHA) is the largest integrated health care system in the United States (US). Among VHA patients, the rate of use of concurrent chemoradiation therapy (CCRT) among those with...

    Authors: Anna Hung, Kyung Min Lee, Julie A. Lynch, Yanhong Li, Pradeep Poonnen, Olga V. Efimova, Bradley J. Hintze, Trudy Buckingham, Candice Yong, Brian Seal, Michael J. Kelley and Shelby D. Reed
    Citation: BMC Cancer 2021 21:824
    Content type: Research Published on:

  15. Tumor mutation burden (TMB) is an emerging prognostic biomarker of immunotherapy for bladder cancer (BLCA). We aim at investigating radiomic features’ value in predicting the TMB status of BLCA patients.

    Authors: Xin Tang, Wen-lei Qian, Wei-feng Yan, Tong Pang, You-ling Gong and Zhi-gang Yang
    Citation: BMC Cancer 2021 21:823
    Content type: Research Published on:

  16. Cervical cancer, one of the most common cancers affecting females in South Africa, commonly requires a cisplatin-based-treatment regimen, which has been associated with ototoxic side effects. However, cisplati...

    Authors: Jessica Paken, Cyril D. Govender, Mershen Pillay, Birhanu T. Ayele and Vikash Sewram
    Citation: BMC Cancer 2021 21:822
    Content type: Research Published on:

  19. Cell division cycle 25A (CDC25A) is a well-recognized regulator of cell cycle progression and is involved in cancer development. This work focused on the function of CDC25A in cervical cancer cell growth and t...

    Authors: Jinhong Qi, Li Zhou, Dongqing Li, Jingyuan Yang, He Wang, Huifang Cao, Yunlan Huang, Zhiming Zhang, Linlin Chang, Chenhao Zhu, Juntong Zhan and Yong Yuan
    Citation: BMC Cancer 2021 21:819
    Content type: Research Published on:

  20. Gemcitabine plus platinum as the first-line chemotherapy for cholangiocarcinoma (CCA) has limited efficacy. The aim of this study was to evaluate the effectiveness of modified FOLFIRINOX (mFOLFIRINOX) compared...

    Authors: Lu Zou, Xuechuan Li, Xiangsong Wu, Jiujie Cui, Xuya Cui, Xiaoling Song, Tai Ren, Xusheng Han, Yidi Zhu, Huaifeng Li, Wenguang Wu, Xu’an Wang, Wei Gong, Liwei Wang, Maolan Li, Wan Yee Lau…
    Citation: BMC Cancer 2021 21:818
    Content type: Research Published on:

  21. Since it’s a challenging task to precisely predict the prognosis of patients with hepatocellular carcinoma (HCC). We developed a nomogram based on a novel indicator GMWG [(Geometric Mean of gamma-glutamyltrans...

    Authors: Liying Ren, Dongbo Chen, Wentao Xu, Tingfeng Xu, Rongyu Wei, Liya Suo, Yingze Huang, Hongsong Chen and Weijia Liao
    Citation: BMC Cancer 2021 21:817
    Content type: Research Published on:

  22. A significant proportion of newly diagnosed patients with cutaneous squamous cell carcinoma (cSCC) have metastasis and eventually die of the disease, necessitating the exploration of novel biomarkers for early...

    Authors: Hui Wang, Hong Li, Qingtao Yan, Sumei Gao, Jianfang Gao, Zhenhua Wang and Yi Sun
    Citation: BMC Cancer 2021 21:816
    Content type: Research Published on:

  23. Changes in calcium metabolism and calcium urinary excretion during chemotherapy have not been thoroughly assessed in patients with early breast cancer (EBC), a population who frequently present vitamin D insuf...

    Authors: Marie Viala, Nelly Firmin, Célia Touraine, Stéphane Pouderoux, Manon Metge, Lobna Rifai, Gilles Romieu, Hélène de Forges, Lise Roca, Séverine Guiu, Véronique D’Hondt and William Jacot
    Citation: BMC Cancer 2021 21:815
    Content type: Research Published on:

  24. The molecular prognostic biomarkers of clear cell renal cell carcinoma (ccRCC) are still unknown. We aimed at researching the candidate biomarkers and potential therapeutic targets of ccRCC.

    Authors: Jing Quan, Yuchen Bai, Yunbei Yang, Er Lei Han, Hong Bai, Qi Zhang and Dahong Zhang
    Citation: BMC Cancer 2021 21:814
    Content type: Research Published on:

  25. This study was aimed to evaluate the value of DNA index(DI) among pediatric acute lymphoblastic leukemia (ALL) treated on Children’s Oncology Group (COG) protocols between 2000 and 2015.

    Authors: Kun-yin Qiu, Xiong-yu Liao, Zhan-wen He, Ruo-hao Wu, Yang Li, Lu-hong Xu, Dun-hua Zhou and Jian-pei Fang
    Citation: BMC Cancer 2021 21:813
    Content type: Research Published on:

  26. Adenoid cystic carcinoma is a rare form of head and neck cancer with a slow, but aggressive growth pattern which remains a challenge for local tumor control. Based on phase II data, radiation treatment using p...

    Authors: Kristin Lang, Sebastian Adeberg, Semi Harrabi, Thomas Held, Meinhard Kieser, Jürgen Debus and Klaus Herfarth
    Citation: BMC Cancer 2021 21:812
    Content type: Study protocol Published on:

  29. Cancer-related fatigue (CRF) is one of the most common and distressing symptoms in people with cancer. Although efficacy of interventions for CRF have been extensively investigated, less has been done to ensur...

    Authors: Oluwaseyifunmi Andi Agbejule, Nicolas H. Hart, Stuart Ekberg, Bogda Koczwara, Rahul Ladwa, Camilla Simonsen, Elizabeth P. Pinkham and Raymond Javan Chan
    Citation: BMC Cancer 2021 21:809
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2021 21:882

  30. Though the gut microbiome has been associated with efficacy of immunotherapy (ICI) in certain cancers, similar findings have not been identified for microbiomes from other body sites and their correlation to t...

    Authors: Justin Chau, Meeta Yadav, Ben Liu, Muhammad Furqan, Qun Dai, Shailesh Shahi, Arnav Gupta, Keri Nace Mercer, Evan Eastman, Taher Abu Hejleh, Carlos Chan, George J. Weiner, Catherine Cherwin, Sonny T. M. Lee, Cuncong Zhong, Ashutosh Mangalam…
    Citation: BMC Cancer 2021 21:808
    Content type: Research article Published on:

  31. Trastuzumab has changed the prognosis of HER2+ breast cancer. We aimed to investigate the prognosis of ER+/HER2+ patients treated with trastuzumab, thus to guide escalation endocrine treatment in ER+ breast ca...

    Authors: Shuai Li, Jiayi Wu, Ou Huang, Jianrong He, Li Zhu, Weiguo Chen, Yafen Li, Xiaosong Chen and Kunwei Shen
    Citation: BMC Cancer 2021 21:807
    Content type: Research Published on:

  32. The incidence rate of adenocarcinoma of the oesophagogastric junction (AEG) has significantly increased over the past decades, with a steady increase in morbidity. The aim of this study was to explore a variet...

    Authors: Jun Wang, Le Shi, Jing Chen, Beidi Wang, Jia Qi, Guofeng Chen, Muxing Kang, Hang Zhang, Xiaoli Jin, Yi Huang, Zhiqing Zhao, Jianfeng Chen, Bin Song and Jian Chen
    Citation: BMC Cancer 2021 21:806
    Content type: Research Published on:

  33. Cancerous cells can recycle metabolic ammonium for their growth. As this ammonium has a low nitrogen isotope ratio (15N/14N), its recycling may cause cancer tissue to have lower 15N/14N than surrounding healthy t...

    Authors: M. Straub, D. M. Sigman, A. Auderset, J. Ollivier, B. Petit, B. Hinnenberg, F. Rubach, S. Oleynik, M.-C. Vozenin and A. Martínez-García
    Citation: BMC Cancer 2021 21:805
    Content type: Research Published on:

  34. In the absence of practical and reliable predictors for whether the endocervical curettage (ECC) procedure should be performed, decisions regarding patient selection are usually based on the colposcopists’ cli...

    Authors: Yuanxing Li, Haixia Luo, Xiu Zhang, Jingjing Chang, Yueyang Zhao, Jing Li, Dongyan Li and Wei Wang
    Citation: BMC Cancer 2021 21:804
    Content type: Research Published on:

  35. Although the major anticancer effect of metformin involves AMPK-dependent or AMPK-independent mTORC1 inhibition, the mechanisms of action are still not fully understood.

    Authors: Se-Kyeong Jang, Sung-Eun Hong, Da-Hee Lee, Ji-Young Kim, Ji Yea Kim, Sang-Kyu Ye, Jungil Hong, In-Chul Park and Hyeon-Ok Jin
    Citation: BMC Cancer 2021 21:803
    Content type: Research Published on:

    The Correction to this article has been published in BMC Cancer 2021 21:881

  36. Afatinib is approved globally for EGFR-TKI treatment-naïve patients with EGFR mutation-positive non-small cell lung cancer (NSCLC). In this Korean expanded access program, we evaluated its ‘real-world’ safety and...

    Authors: Keunchil Park, Jin-Soo Kim, Joo-Hang Kim, Young-Chul Kim, Hoon-Gu Kim, Eun Kyung Cho, Jong-Youl Jin, Miyoung Kim, Angela Märten and Jin-Hyoung Kang
    Citation: BMC Cancer 2021 21:802
    Content type: Research Published on:

  37. DNA methylation alteration is frequently observed in Lung adenocarcinoma (LUAD) and may play important roles in carcinogenesis, diagnosis, and prognosis. Thus, this study aimed to construct a reliable methylat...

    Authors: Xuelong Wang, Bin Zhou, Yuxin Xia, Jianxin Zuo, Yanchao Liu, Xin Bi, Xiong Luo and Chengwei Zhang
    Citation: BMC Cancer 2021 21:801
    Content type: Research article Published on:

  38. Cancer cachexia causes significant morbidity and mortality in advanced lung cancer patients. Clinical benefit of β-hydroxy-β-methylbutyrate, arginine, and glutamine (HMB/Arg/Gln) was assessed in newly diagnose...

    Authors: Jennifer Pascoe, Aimee Jackson, Charlotte Gaskell, Claire Gaunt, Joyce Thompson, Lucinda Billingham and Neil Steven
    Citation: BMC Cancer 2021 21:800
    Content type: Research article Published on:

  39. Ovarian cancer is a common cancer type in women and is often associated with onset of malnutrition. Total parenteral nutrition (TPN) is a nutritional intervention method that has been reported to have controve...

    Authors: Xin Yan, Sanyuan Zhang, Junmei Jia, Jiaolin Yang, Yilai Song and Haoran Duan
    Citation: BMC Cancer 2021 21:799
    Content type: Research Published on:

  40. Tamoxifen (TAM) and Toremifene (TOR), two kinds of selective estrogen receptor modulators (SERMs), have equal efficacy in breast cancer patients. However, TAM has been proved to affect serum lipid profiles and...

    Authors: Dandan Song, Yingying Hu, Biyu Diao, Rongrong Miao, Baodan Zhang, Yangjun Cai, Hanqian Zeng, Yuru Zhang and Xiaoqu Hu
    Citation: BMC Cancer 2021 21:798
    Content type: Research article Published on:

  41. MutL Homolog 1 (MLH1) promotor methylation is associated with microsatellite instability high colorectal cancer (CRC). The strong correlation between methylation status and cancer development and progression has ...

    Authors: Danyi Wang, Dennis O’Rourke, Jorge F. Sanchez-Garcia, Ti Cai, Juergen Scheuenpflug and Zheng Feng
    Citation: BMC Cancer 2021 21:797
    Content type: Research Published on:

  42. Adjuvant chemotherapy has changed the paradigm in resectable gastric cancer. S-1 is an oral chemotherapeutic with promising efficacy in Asia. However, comparisons with close observation or platinum-based doubl...

    Authors: Chih-Chieh Yen, Yan-Shen Shan, Ying-Jui Chao, Ting-Kai Liao, I-Shu Chen, Hsuan-Yi Huang, I-Ting Liu and Chia-Jui Yen
    Citation: BMC Cancer 2021 21:796
    Content type: Research Published on:

  43. Trastuzumab emtansine (T-DM1) is a second-line standard therapy for patients with human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer. Evidence regarding post–T-DM1 treatments is ...

    Authors: Takahiro Nakayama, Tetsuhiro Yoshinami, Hiroyuki Yasojima, Nobuyoshi Kittaka, Masato Takahashi, Shoichiro Ohtani, Seung Jin Kim, Hiroyuki Kurakami, Naoko Yamamoto, Tomomi Yamada, Takehiko Takata and Norikazu Masuda
    Citation: BMC Cancer 2021 21:795
    Content type: Research Published on:

  45. The evolving nature of multiple myeloma (MM) therapies, including the introduction of novel oral agents, has produced a shift in the delivery of care from hospital to home. Within this context, patients and th...

    Authors: Cheryl Pritlove, Mobin Jassi, Bridget Burns and Arleigh McCurdy
    Citation: BMC Cancer 2021 21:793
    Content type: Research article Published on:

  46. The effects of adjuvant chemotherapy in patients with stage II colorectal cancer (CRC) has been in controversy for a long time. Our study aimed to find an effective inflammatory marker to predict the effects o...

    Authors: Yu Fu, Xiaowan Chen, Yongxi Song, Xuanzhang Huang, Quan Chen, Xinger Lv, Peng Gao and Zhenning Wang
    Citation: BMC Cancer 2021 21:792
    Content type: Research article Published on:

  47. Despite the introduction of targeted therapies, most patients with myeloid malignancies will not be cured and progress. Genomics is useful to elucidate the mutational landscape but remains limited in the predi...

    Authors: Mahmoud Hallal, Sophie Braga-Lagache, Jovana Jankovic, Cedric Simillion, Rémy Bruggmann, Anne-Christine Uldry, Ramanjaneyulu Allam, Manfred Heller and Nicolas Bonadies
    Citation: BMC Cancer 2021 21:789
    Content type: Technical advance Published on:

  48. The purpose of this study was to analyze the association between next-generation sequencing (NGS) genotypic profiles and conventional clinicopathologic characteristics in patients with acute myeloid leukemia (...

    Authors: Biao Wang, Bin Yang, Wei Wu, Xuan Liu and Haiqian Li
    Citation: BMC Cancer 2021 21:788
    Content type: Research article Published on:

  49. Chest wall abnormalities are a poorly studied complication after treatment for childhood cancer. Chest wall abnormalities are not well-described in the literature, and little is known on the impact on daily li...

    Authors: Rahel Kasteler, Christa Lichtensteiger, Christina Schindera, Marc Ansari and Claudia E. Kuehni
    Citation: BMC Cancer 2021 21:787
    Content type: Research article Published on:

  50. The clinical pathologic stages (stage I, II, III-IV) of hepatocellular carcinoma (HCC) are closely linked to the clinical prognosis of patients. This study aims at investigating the gene expression and mutatio...

    Authors: Xingjie Gao, Chunyan Zhao, Nan Zhang, Xiaoteng Cui, Yuanyuan Ren, Chao Su, Shaoyuan Wu, Zhi Yao and Jie Yang
    Citation: BMC Cancer 2021 21:786
    Content type: Research Published on:

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