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  1. Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are used in treating cardiovascular diseases. Previous studies indicated that ACEIs/ARBs may benefit cancer patients by...

    Authors: Po-Chih Li, Ru-Yu Huang, Yu-Chien Yang, Kun-Pin Hsieh and Yi-Hsin Yang
    Citation: BMC Cancer 2022 22:430
    Content type: Research Published on:

  2. Diabetes is an established risk factor for endometrial cancer development but its impact on prognosis is unclear and epidemiological studies to date have produced inconsistent results. We aimed to conduct the ...

    Authors: Lauren McVicker, Christopher R. Cardwell, Lauren Edge, W Glenn McCluggage, Declan Quinn, James Wylie and Úna C. McMenamin
    Citation: BMC Cancer 2022 22:427
    Content type: Research Published on:

  3. Quality of life (QoL) is an important patient-reported outcome that has been studied extensively as an endpoint. There is a growing interest in factors that may influence QoL, such as personality. This descrip...

    Authors: Veerle Marieke Wintraecken, Sophie Vulik, Sabine de Wild, Carmen Dirksen, Linetta B. Koppert, Jolanda de Vries and Marjolein L. Smidt
    Citation: BMC Cancer 2022 22:426
    Content type: Research article Published on:

  4. Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths worldwide. Sorafenib is the first-line treatment for advanced HCC, but the anti-cancer effects remain to be improved as indi...

    Authors: Zibo Chen, Tao Yuan, Fangjie Yan, Song Ye, Qin Xie, Bo Zhang, Nengmin Lin, Qiaojun He, Bo Yang and Hong Zhu
    Citation: BMC Cancer 2022 22:425
    Content type: Research article Published on:

  6. Liver cancer is a major global health concern due to the steady increases in its incidence and mortality. Transcription factors, yes-associated protein (YAP) and WW domain-containing transcription regulator pr...

    Authors: Hyuk Moon, Hyunjung Park, Min Jee Chae, Hye Jin Choi, Do Young Kim and Simon Weonsang Ro
    Citation: BMC Cancer 2022 22:423
    Content type: Research Published on:

  7. Authors: Lenny Gallardo-Alvarado, David Cantú-de León, Rebeca Ramirez-Morales, Gabriel Santiago-Concha, Salim Barquet-Muñoz, Rosa Salcedo-Hernandez, Cinthya Reyes, Sandra Perez-Alvarez, Delia Perez-Montiel, Carlos Perez-Plasencia, Elizabeth Trejo-Duran and Juan Pablo Galicia
    Citation: BMC Cancer 2022 22:422
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2022 22:401

  8. The architectural transcriptional regulator high-mobility group AT-hook 2 (HMGA2) is an oncofetal protein which has been reported to be ectopically expressed in a variety of cancers. A high expression of HMGA2...

    Authors: Ying Liu, Guangyao Lv, Jianxin Bai, Lingling Song, Elizabeth Ding, Lin Liu, Yuqin Tian, Qian Chen, Kai Li, Xianfeng Liu and Yan Ding
    Citation: BMC Cancer 2022 22:421
    Content type: Research Published on:

  9. The purpose of this study was to investigate and validate multiparametric magnetic resonance imaging (MRI)-based machine learning classifiers for early identification of poor responders after neoadjuvant chemo...

    Authors: Jia Wang, Jingjing Chen, Ruizhi Zhou, Yuanxiang Gao and Jie Li
    Citation: BMC Cancer 2022 22:420
    Content type: Research Published on:

  10. Globally cervical cancer incidence rate has been declining continuously. However, an unfavorable trend has been observed in China during the past decades, and the underlying reasons remain unclear. We hereby e...

    Authors: Ke Li, Huan Xu, Suixiang Wang, Pengzhe Qin and Boheng Liang
    Citation: BMC Cancer 2022 22:419
    Content type: Research Published on:

  11. Immune-check point inhibitors (ICPIs) for treatment of cancer patients sometimes induce potentially life-threatening immune-related adverse events (irAEs), which predict ICPIs treatment efficacy. Prediction of...

    Authors: Tomoyuki Matsunaga, Hiroaki Saito, Hirohiko Kuroda, Tomohiro Osaki, Sadamu Takahashi, Akemi Iwamoto, Yoji Fukumoto, Kenjiro Taniguchi, Kenji Fukuda, Wataru Miyauchi, Yuji Shishido, Kozo Miyatani and Yoshiyuki Fujiwara
    Citation: BMC Cancer 2022 22:418
    Content type: Research article Published on:

  12. Benzamide-based radioligands targeting melanin were first developed for imaging melanoma and then for therapeutic purpose with targeted radionuclide therapy (TRT).

    Authors: Emilie Thivat, Jacques Rouanet, Philippe Auzeloux, Nicolas Sas, Elodie Jouberton, Sophie Levesque, Tommy Billoux, Sandrine Mansard, Ioana Molnar, Marion Chanchou, Giovanna Fois, Lydia Maigne, Jean-Michel Chezal, Elisabeth Miot-Noirault, Michel D’Incan, Xavier Durando…
    Citation: BMC Cancer 2022 22:417
    Content type: Study protocol Published on:

  13. Salvage external beam radiotherapy (sEBRT) for patients with a biochemical recurrence (BCR) after radical prostatectomy provides a 5-year biochemical progression-free survival up to 60%. Multiple studies have ...

    Authors: F. H. E. Staal, J. Janssen, C. L. Brouwer, J. A. Langendijk, K. Ng Wei Siang, E. Schuit, I. J. de Jong, J. F. Verzijlbergen, R. J. Smeenk and S. Aluwini
    Citation: BMC Cancer 2022 22:416
    Content type: Study protocol Published on:

  14. Several bone-seeking radionuclides have been developed for palliation of metastatic bone pain since 1956, however, so far radium-223 dichloride is the first and only Food and Drug Administration (FDA) approved...

    Authors: Zin W. Myint, Riham El Khouli, Bryan Lemieux, Donglin Yan, William H. St. Clair, Xiaoqi Liu and Charles A. Kunos
    Citation: BMC Cancer 2022 22:415
    Content type: Study protocol Published on:

  15. Stomach cancer is one the most common neoplasms with high mortality. However, fear of cancer recurrence (FCR) in stomach cancer survivors has been scarcely evaluated. Thus, the aim of this study was to evaluat...

    Authors: Jinyoung Shin, Dong Wook Shin, Jungkwon Lee, JiHye Hwang, Ji Eun Lee, BeLong Cho and Yun–Mi Song
    Citation: BMC Cancer 2022 22:414
    Content type: Research article Published on:

  16. This study was to determine the prevalence and clinical significance of clonal hematopoiesis (CH)-related variants, and somatic and germline mutations in cancer patients and healthy individuals.

    Authors: Chieh-Min Chang, Kuei-Ching Lin, Nien-En Hsiao, Wei-An Hong, Chia-Yu Lin, Ta-Chih Liu, Ya-Sian Chang and Jan-Gowth Chang
    Citation: BMC Cancer 2022 22:413
    Content type: Research Published on:

  17. Routine measurement of tumor markers is not recommended in daily clinical practice for patients with cancer of unknown primary (CUP). We evaluated the diagnostic value of tumor markers in identifying favorable...

    Authors: Shigemasa Takamizawa, Tatsunori Shimoi, Masayuki Yoshida, Momoko Tokura, Shu Yazaki, Chiharu Mizoguchi, Ayumi Saito, Shosuke Kita, Kasumi Yamamoto, Yuki Kojima, Hitomi Sumiyoshi-Okuma, Tadaaki Nishikawa, Emi Noguchi, Kazuki Sudo and Kan Yonemori
    Citation: BMC Cancer 2022 22:412
    Content type: Research Published on:

  19. Genomic instability and chemoresistance can arise in cancer due to a unique form of plasticity: that of polyploid giant cancer cells (PGCCs). These cells form under the stress of chemotherapy and have higher t...

    Authors: Robert R. Bowers, Maya F. Andrade, Christian M. Jones, Shai White-Gilbertson, Christina Voelkel-Johnson and Joe R. Delaney
    Citation: BMC Cancer 2022 22:410
    Content type: Research Published on:

  20. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12885-019-5656-7.

    Authors: Qi Wang, Zixiang Wu, Tianwei Zhan, Shuai Fang, Sai Zhang, Gang Shen and Ming Wu
    Citation: BMC Cancer 2022 22:409
    Content type: Retraction Note Published on:

  21. Although uveal melanoma (UM) at the early stage is controllable to some extent, it inevitably ultimately leads to death due to its metastasis. At present, the difficulty is that there is no way to effectively ...

    Authors: Xifeng Fei, Xiangtong Xie, Ruwei Qin, Anqi Wang, Xuan Meng, Fei Sun, Yifan Zhao, Dongyi Jiang, Hanchun Chen, Qiang Huang, Xiaoyan Ji and Zhimin Wang
    Citation: BMC Cancer 2022 22:408
    Content type: Research Published on:

  22. Immune checkpoint inhibitor (ICI) therapies represent a major advance in treating a variety of advanced-stage malignancies. Nevertheless, only a subset of patients benefit, even when selected based on approved...

    Authors: Harsha Ranganath, Amit L. Jain, Justin R. Smith, Julie Ryder, Amina Chaudry, Emily Miller, Felicia Hare, Poojitha Valasareddy, Robert S. Seitz, David R. Hout, Matthew G. Varga, Brock L. Schweitzer, Tyler J. Nielsen, Janice Mullins, Douglas T. Ross, David R. Gandara…
    Citation: BMC Cancer 2022 22:407
    Content type: Research Published on:

  23. The SNCA gene is a critical gene in Parkinson’s disease (PD) pathology. Accumulating evidence indicates that SNCA is involved in tumorigenesis; however, the role of SNCA in lung adenocarcinoma (LUAD) remains uncl...

    Authors: Xiuao Zhang, Zhengcun Wu and Kaili Ma
    Citation: BMC Cancer 2022 22:406
    Content type: Research Published on:

    The Correction to this article has been published in BMC Cancer 2022 22:485

  24. There is strong evidence that disease progression, drug response and overall clinical outcomes of CML disease are not only decided by BCR/ABL1 oncoprotein but depend on accumulation of additional genetic and e...

    Authors: Sameer Ahmad Guru, Mamta Pervin Sumi, Rashid Mir, Mirza Masroor Ali Beg, Bidhan Chandra koner and Alpana Saxena
    Citation: BMC Cancer 2022 22:405
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2022 22:439

  25. In this study, we performed a molecular evaluation of primary pancreatic adenocarcinoma (PAAD) based on the comprehensive analysis of energy metabolism-related gene (EMRG) expression profiles.

    Authors: Cong Tan, Xin Wang, Xu Wang, Weiwei Weng, Shu-juan Ni, Meng Zhang, Hesheng Jiang, Lei Wang, Dan Huang, Weiqi Sheng and Mi-die Xu
    Citation: BMC Cancer 2022 22:404
    Content type: Research Published on:

  26. R-CHOP with or without radiotherapy is the standard treatment for limited-stage diffuse large B-cell lymphoma (DLBCL). To prevent overtreatment, we assessed whether four cycles of CHOP plus six applications of...

    Authors: Jia Jin, Dongmei Ji, Zuguang Xia, Kai Xue, Qunling Zhang, Yizhen Liu, Junning Cao, Xiaonan Hong, Juan J. Gu, Ye Guo and Fangfang Lv
    Citation: BMC Cancer 2022 22:403
    Content type: Research Published on:

  27. Extranodal extension (ENE) is a poor prognostic factor for oral squamous cell carcinoma (OSCC). Identifying ENE by clinical and/or radiological examination is difficult, thereby leading to unnecessary neck dis...

    Authors: Yuri Noda, Mitsuaki Ishida, Yasuhiro Ueno, Takuo Fujisawa, Hiroshi Iwai and Koji Tsuta
    Citation: BMC Cancer 2022 22:402
    Content type: Research Published on:

  28. Even with different histologic origins, squamous cell carcinoma (SCC) and adenocarcinoma (AC) are considered a single entity, and the first-line treatment is the same. Locally advanced disease at the diagnosis...

    Authors: Lenny Gallardo-Alvarado, David Cantú-de León, Rebeca Ramirez-Morales, Gabriel Santiago-Concha, Salim Barquet-Muñoz, Rosa Salcedo-Hernandez, Cinthya Reyes, Sandra Perez-Alvarez, Delia Perez-Montiel, Carlos Perez-Plasencia, Elizabeth Trejo-Duran and Juan Pablo Galicia
    Citation: BMC Cancer 2022 22:401
    Content type: Research Published on:

    The Correction to this article has been published in BMC Cancer 2022 22:422

  29. Glioblastoma multiforme (GBM) is the most common high-grade malignant brain tumour in adults and arises from the glial cells in the brain. The prognosis of treated GBM remains very poor with 5-year survival ra...

    Authors: Einthavy Arunachalam, William Rogers, Guy R. Simpson, Carla Möller-Levet, Gemma Bolton, Mohammed Ismael, Christopher Smith, Karl Keegen, Izhar Bagwan, Tim Brend, Susan C. Short, Bangxing Hong, Yoshihiro Otani, Balveen Kaur, Nicola Annels, Richard Morgan…
    Citation: BMC Cancer 2022 22:400
    Content type: Research Published on:

  30. Cancer of Unknown Primary (CUP) is a metastatic cancer for which the primary lesion remains unidentifiable during life and little is also known about the modifiable risk factors that contribute to its developm...

    Authors: Karlijn E. P. E. Hermans, Piet A. van den Brandt, Caroline Loef, Rob L. H. Jansen and Leo J. Schouten
    Citation: BMC Cancer 2022 22:399
    Content type: Research Published on:

  32. A more extensive surgical resection of glioma contributes to improved overall survival (OS) and progression-free survival (PFS). However, some patients miss the chance of surgical resection when the tumor invo...

    Authors: Congxiao Wang, Chao Liu, Jun Chen, Han Jiang, Wei Zhang, Lili Yang, Xueda Li, Zixiang Li, Lijing Peng, Xiaokun Hu and Peng Sun
    Citation: BMC Cancer 2022 22:397
    Content type: Research Published on:

  33. Cancer-therapy related cardiotoxicity (CTRCT) is a significant and frequent complication of monoclonal antibody directed therapy, especially Trastuzumab, for human epidermal growth factor receptor 2 (HER2) ove...

    Authors: Mattia Lunardi, Ahmed Al-Habbaa, Mahmoud Abdelshafy, Matthew G. Davey, Ahmed Elkoumy, Sandra Ganly, Hesham Elzomor, Christian Cawley, Faisal Sharif, James Crowley, Michael Kerin, William Wijns, Aoife Lowery and Osama Soliman
    Citation: BMC Cancer 2022 22:396
    Content type: Research Published on:

  34. Saline hydration with addition of mannitol have commonly been the strategy to avoid cisplatin induced acute kidney injury (AKI). While the initial reports demonstrated that mannitol diuresis decreased cisplati...

    Authors: Andhika Rachman, Syahidatul Wafa, Pringgodigdo Nugroho and Sukamto Koesnoe
    Citation: BMC Cancer 2022 22:395
    Content type: Research Published on:

  35. Recently it has been recognized that stromal markers could be used as a clinically relevant biomarker for therapy response and prognosis. Here, we report on a serum marker for stromal activation, A Disintegrin...

    Authors: Sanne ten Hoorn, Cynthia Waasdorp, Martijn G. H. van Oijen, Helene Damhofer, Anne Trinh, Lan Zhao, Lisanne J. H. Smits, Sanne Bootsma, Gabi W. van Pelt, Wilma E. Mesker, Linda Mol, Kaitlyn K. H. Goey, Miriam Koopman, Jan Paul Medema, Jurriaan B. Tuynman, Inti Zlobec…
    Citation: BMC Cancer 2022 22:394
    Content type: Research Published on:

  36. For CD19-positive relapsed/refractory B-cell acute lymphoblastic leukemia (r/r B-ALL) after treatment with murine CD19 (mCD19) CAR-T, the reinfusion of mCD19 CAR-T cells may be ineffective due to anti-mouse si...

    Authors: Lihong An, Yuehui Lin, Biping Deng, Zhichao Yin, Defeng Zhao, Zhuojun Ling, Tong Wu, Yongqiang Zhao, Alex H. Chang, Chunrong Tong and Shuangyou Liu
    Citation: BMC Cancer 2022 22:393
    Content type: Research Published on:

  38. To present a systematic review of the literature and a meta-analysis evaluating the oncological safety of autologous fat grafting (AFG).

    Authors: Rodrigo Goncalves, Bruna Salani Mota, Bruno Sobreira-Lima, Marcos Desidério Ricci, José Maria Soares Jr, Alexandre Mendonça Munhoz, Edmund Chada Baracat and José Roberto Filassi
    Citation: BMC Cancer 2022 22:391
    Content type: Research Published on:

  39. Adjuvant chemotherapy for stage II colorectal cancer (CRC) is considered appropriate for patients with risk factors for recurrence, rather than for all patients uniformly. However, the risk factors for recurre...

    Authors: Takuki Yagyu, Manabu Yamamoto, Akimitsu Tanio, Kazushi Hara, Ken Sugezawa, Chihiro Uejima, Kyoichi Kihara, Shigeru Tatebe, Yasuro Kurisu, Shunsuke Shibata, Toshio Yamamoto, Hiroshi Nishie, Setsujo Shiota, Hiroaki Saito, Takuji Naka, Kenji Sugamura…
    Citation: BMC Cancer 2022 22:390
    Content type: Research Published on:

  41. Colposcopy alone can result in misidentification of high-grade squamous intraepithelial or worse lesions (HSIL +), especially for women with Type 3 transformation zone (TZ) lesions, where colposcopic assessmen...

    Authors: Bingrui Wei, Bo Zhang, Peng Xue, Samuel Seery, Jiaxu Wang, Qing Li, Yu Jiang and Youlin Qiao
    Citation: BMC Cancer 2022 22:388
    Content type: Research Published on:

  42. Abnormal accumulation of acyl-CoA cholesterol acyltransferase-1 (ACAT1) and ACAT1-mediated cholesterol esterified with fatty acids (CE) contribute to cancer progression in various cancers. Our findings of incr...

    Authors: Vijayalakshmi Ayyagari, Maio Li, Zvi Pasman, Xinjia Wang, Somaja Louis, Paula Diaz-Sylvester, Kathleen Groesch, Teresa Wilson and Laurent Brard
    Citation: BMC Cancer 2022 22:387
    Content type: Research Published on:

  43. Invadopodia, actin-rich structures that release metallo-proteases at the interface with extra-cellular matrix, in a punctate manner are thought to be important drivers of tumour invasion. Invadopodia formation...

    Authors: Valeria Manuelli, Fidelma Cahill, Harriet Wylie, Cheryl Gillett, Isabel Correa, Susanne Heck, Alex Rimmer, Anna Haire, Mieke Van Hemelrijck, Sarah Rudman and Claire M. Wells
    Citation: BMC Cancer 2022 22:386
    Content type: Research Published on:

  44. Little is known about whether age at initial diagnosis influences the prognosis of recurrent metastatic breast cancer (rMBC). Here, we analyzed the association between age at initial diagnosis and rMBC mortali...

    Authors: Yuxin Xie, Qiheng Gou, Yingjie Zhang, Keqi Xie, Dan Zheng, Chuanxu Luo, Jiaojiao Suo, Xiaorong Zhong and Ting Luo
    Citation: BMC Cancer 2022 22:385
    Content type: Research Published on:

  45. A retrospective study and a randomized controlled trial published in a high quality journal in late 2018 have shown that laparoscopic radical hysterectomy (RH) was associated with worse survival than abdominal...

    Authors: Xin Wu, Hao Feng, Shujun Gao, Hua Feng, Wenjing Diao, Hongwei Zhang, Ming Du, Weihua Lou, Xipeng Wang, Tao Zhu, Yuyang Zhang, Weiguo Hu, Xiaohong Xue, Zhiling Zhu, Libing Xiang, Jiarui Li…
    Citation: BMC Cancer 2022 22:384
    Content type: Study protocol Published on:

  46. The accuracy of CT and tumour markers in screening lung cancer needs to be improved. Computer-aided diagnosis has been reported to effectively improve the diagnostic accuracy of imaging data, and recent studie...

    Authors: Han Yang, Hongjie Chen, Guorui Zhang, Hongyi Li, Ran Ni, Yali Yu, Yepeng Zhang, Yongjun Wu and Hong Liu
    Citation: BMC Cancer 2022 22:382
    Content type: Research article Published on:

  47. Tivozanib (Fotivda) is an anti-angiogenic tyrosine kinase inhibitor that was denied access to the US market by the Food and Drug Administration (FDA). In contrast, it was granted approval by the European Medic...

    Authors: Laura Caquelin, Mohamed Gewily, Wendy Mottais, Chloé Tebaldi, Bruno Laviolle, Florian Naudet and Clara Locher
    Citation: BMC Cancer 2022 22:381
    Content type: Research article Published on:

  48. Hepatocellular carcinoma (HCC) is the third-most deadly cancer worldwide. More breakthroughs are needed in the clinical practice for liver cancer are needed, and new treatment strategies are required. This stu...

    Authors: Chenkai Huang, Juanjuan Zhou, Yuan Nie, Guihai Guo, Anjiang Wang and Xuan Zhu
    Citation: BMC Cancer 2022 22:380
    Content type: Research Published on:

  49. The combined application of immune cells and specific biomarkers related to the tumor immune microenvironment has a better predictive value for the prognosis of HCC. The purpose of this study is to construct a...

    Authors: Youpeng Wang, Yeni Yang, Ziyin Zhao, Hongfa Sun, Dingan Luo, Lakshmi Huttad, Bingyuan Zhang and Bing Han
    Citation: BMC Cancer 2022 22:379
    Content type: Research Published on:

  50. Patients with hepatocellular carcinoma (HCC) and Child–Pugh B liver cirrhosis have poor prognosis and are underrepresented in clinical trials. The CELESTIAL trial, in which cabozantinib improved overall surviv...

    Authors: Anthony B. El-Khoueiry, Tim Meyer, Ann-Lii Cheng, Lorenza Rimassa, Suvajit Sen, Steven Milwee, Robin Kate Kelley and Ghassan K. Abou-Alfa
    Citation: BMC Cancer 2022 22:377
    Content type: Research Published on:

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