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906 result(s) within Volume 17 of BMC Cancer

Page 6 of 19

  1. As more men survive a diagnosis of prostate cancer, alternative models of follow-up care that address men’s enduring unmet needs and are economical to deliver are needed. This paper describes the protocol for ...

    Authors: Jane Frankland, Hazel Brodie, Deborah Cooke, Claire Foster, Rebecca Foster, Heather Gage, Jake Jordan, Ines Mesa-Eguiagaray, Ruth Pickering and Alison Richardson
    Citation: BMC Cancer 2017 17:656
    Content type: Study protocol Published on:

  2. Non-small cell lung cancer (NSCLC) has led to the highest cancer-related mortality for decades. To enhance the efficiency of early diagnosis and therapy, more efforts are urgently needed to reveal the origins ...

    Authors: Rong-quan He, Xiao-jiao Li, Lu Liang, You Xie, Dian-zhong Luo, Jie Ma, Zhi-gang Peng, Xiao-hua Hu and Gang Chen
    Citation: BMC Cancer 2017 17:655
    Content type: Research article Published on:

  4. Clinical trials are necessary for the advancement of cancer treatment and care, however low rates of participation in such trials limit the generalisability of findings. The objective of this study was to exam...

    Authors: Mariko Carey, Allison W. Boyes, Rochelle Smits, Jamie Bryant, Amy Waller and Ian Olver
    Citation: BMC Cancer 2017 17:653
    Content type: Research article Published on:

  5. The increasing incidence and poor outcome associated with malignant pleural effusion (MPE) requires finding an effective treatment for this disease. Inhibitory B7-H4 is expressed in many different human cancer...

    Authors: Cheng Chen, Qiu-Xia Qu, Fang Xie, Wei-Dong Zhu, Ye-Han Zhu and Jian-An Huang
    Citation: BMC Cancer 2017 17:652
    Content type: Research article Published on:

  6. Five-year survival in patients with localized prostate cancer (PCa) is nearly 100%, but metastatic disease still remains incurable. Clinical management of metastatic patients has become increasingly complex as...

    Authors: Mariarosa Pascale, Che Ngwa Azinwi, Barbara Marongiu, Gianfranco Pesce, Flavio Stoffel and Enrico Roggero
    Citation: BMC Cancer 2017 17:651
    Content type: Research article Published on:

  7. Tartrate-resistant acid phosphatase (TRAP/ACP5), a metalloenzyme that is characteristic for its expression in activated osteoclasts and in macrophages, has recently gained considerable focus as a driver of metast...

    Authors: Anja Reithmeier, Elena Panizza, Michael Krumpel, Lukas M. Orre, Rui M. M. Branca, Janne Lehtiö, Barbro Ek-Rylander and Göran Andersson
    Citation: BMC Cancer 2017 17:650
    Content type: Research article Published on:

  8. In patients with BRAFV600 mutated unresectable stage IIIc or metastatic melanoma, molecular targeted therapy with combined BRAF/MEK-inhibitor vemurafenib plus cobimetinib has shown a significantly improved pro...

    Authors: Bernies van der Hiel, John B.A.G. Haanen, Marcel P.M. Stokkel, Daniel S. Peeper, Connie R. Jimenez, Jos H. Beijnen, Bart A. van de Wiel, Ronald Boellaard and Alfons J.M. van den Eertwegh
    Citation: BMC Cancer 2017 17:649
    Content type: Study protocol Published on:

  9. FOXP3 has been discovered to be expressed in tumor cells and participate in the regulation of tumor behavior. Herein, we investigated the clinical relevance and biological significance of FOXP3 expression in h...

    Authors: Jie-Yi Shi, Li-Jie Ma, Ji-Wei Zhang, Meng Duan, Zhen-Bin Ding, Liu-Xiao Yang, Ya Cao, Jian Zhou, Jia Fan, Xiaoming Zhang, Ying-Jun Zhao, Xiao-Ying Wang and Qiang Gao
    Citation: BMC Cancer 2017 17:648
    Content type: Research article Published on:

  10. The belief that early detection is the best protection against cancer underlies cancer screening. Emerging research now suggests harms associated with early detection may sometimes outweigh the benefits. Gover...

    Authors: S. Michelle Driedger, Gary Annable, Melissa Brouwers, Donna Turner and Ryan Maier
    Citation: BMC Cancer 2017 17:647
    Content type: Research article Published on:

  11. Human epidermal growth factor receptor 3 (HER3) is important in maintaining epidermal growth factor receptor-driven cancers and mediating resistance to targeted therapy. A phase I study of anti-HER3 monoclonal...

    Authors: Kerry Lynn Reynolds, Philippe L. Bedard, Se-Hoon Lee, Chia-Chi Lin, Josep Tabernero, Maria Alsina, Ezra Cohen, José Baselga, George Blumenschein Jr, Donna M. Graham, Ignacio Garrido-Laguna, Dejan Juric, Sunil Sharma, Ravi Salgia, Abdelkader Seroutou, Xianbin Tian…
    Citation: BMC Cancer 2017 17:646
    Content type: Research article Published on:

  12. Sorafenib and transarterial chemoembolization (TACE) are recommended therapies for advanced hepatocellular carcinoma (HCC), but their combined efficacy remains unclear.

    Authors: Fei-Xiang Wu, Jie Chen, Tao Bai, Shao-Liang Zhu, Tian-Bo Yang, Lu-Nan Qi, Ling Zou, Zi-Hui Li, Jia-Zhou Ye and Le-Qun Li
    Citation: BMC Cancer 2017 17:645
    Content type: Research article Published on:

  13. Integrator complex subunit 6 (INTS6) was found to play a tumour suppressing role in certain types of solid tumours. In this study, we wanted to determine the expression level of INTS6 in hepatocellular carcino...

    Authors: Ka Yin Lui, Hui Zhao, Chunhui Qiu, Chuo Li, Zhigang Zhang, Haoran Peng, Rongdang Fu, Hu-an Chen and Min-qiang Lu
    Citation: BMC Cancer 2017 17:644
    Content type: Research article Published on:

  14. Volumetric tumor staging has been shown as superior prognostic tool compared to the conventional TNM system in patients undergoing definitive intensity-modulated radiotherapy (IMRT) for head and neck cancer. R...

    Authors: Cédric Panje, Oliver Riesterer, Christoph Glanzmann and Gabriela Studer
    Citation: BMC Cancer 2017 17:643
    Content type: Research article Published on:

  15. A fusion gene is a hybrid gene consisting of parts from two previously independent genes. Chromosomal rearrangements leading to gene breakage are frequent in high-grade serous ovarian carcinomas and have been ...

    Authors: Marianne Lislerud Smebye, Antonio Agostini, Bjarne Johannessen, Jim Thorsen, Ben Davidson, Claes Göran Tropé, Sverre Heim, Rolf Inge Skotheim and Francesca Micci
    Citation: BMC Cancer 2017 17:642
    Content type: Research article Published on:

  16. Male breast cancer (MBC) represents a poorly characterised group of tumours, the management of which is largely based on practices established for female breast cancer. However, recent studies demonstrate biol...

    Authors: Siddhartha Deb, Kylie L. Gorringe, Jia-Min B. Pang, David J. Byrne, Elena A. Takano, kConFab Investigators, Alexander Dobrovic and Stephen B. Fox
    Citation: BMC Cancer 2017 17:641
    Content type: Research article Published on:

  17. Breast cancer is the most common cancer in females and is ranked second in cancer-related deaths all over the world in women. Despite improvement in diagnosis, the survival rate of this disease has still not i...

    Authors: Azhar R. Hussain, Abdul Khalid Siraj, Maqbool Ahmed, Rong Bu, Poyil Pratheeshkumar, Alanood M. Alrashed, Zeeshan Qadri, Dahish Ajarim, Fouad Al-Dayel, Shaham Beg and Khawla S. Al-Kuraya
    Citation: BMC Cancer 2017 17:640
    Content type: Research article Published on:

  18. Uterine leiomyosarcoma (ULMS) is an aggressive form of soft tissue tumors. The molecular heterogeneity and pathogenesis of ULMS are not well understood.

    Authors: Yang An, Shuzhen Wang, Songlin Li, Lulu Zhang, Dayong Wang, Haojie Wang, Shibai Zhu, Wan Zhu, Yongqiang Li, Wenwu Chen, Shaoping Ji and Xiangqian Guo
    Citation: BMC Cancer 2017 17:639
    Content type: Research article Published on:

  19. Phosphatase and Tensin homolog (PTEN) is a tumor suppressor gene. Loss of its function is the most frequent genetic alteration in endometrioid endometrial cancers (70–80%) and high grade tumors (90%). We asses...

    Authors: Charles-André Philip, Ido Laskov, Marie-Claude Beauchamp, Maud Marques, Oreekha Amin, Joanna Bitharas, Roy Kessous, Liron Kogan, Tahira Baloch, Walter H. Gotlieb and Amber Yasmeen
    Citation: BMC Cancer 2017 17:638
    Content type: Research article Published on:

  20. Evidence from clinical trial populations suggests low-dose aspirin reduces the risk of colorectal cancer (CRC). Part of this reduction in risk might be due to protection against metastatic disease.

    Authors: Luis A. García Rodríguez, Montse Soriano-Gabarró, Susan Bromley, Angel Lanas and Lucía Cea Soriano
    Citation: BMC Cancer 2017 17:637
    Content type: Research article Published on:

  21. The insulin growth factor (IGF) pathway has been proposed as a potential therapeutic target in bladder cancer. We characterized the expression of components of the IGF pathway — insulin growth factor receptors...

    Authors: Yann Neuzillet, Elodie Chapeaublanc, Clémentine Krucker, Leanne De Koning, Thierry Lebret, François Radvanyi and Isabelle Bernard-Pierrot
    Citation: BMC Cancer 2017 17:636
    Content type: Research article Published on:

  23. Prostate cancer (PCa) is a heterogeneous disease with a variable natural history, genetics, and treatment outcome. The Hedgehog (Hh) signaling pathway is increasingly recognized as being potentially important ...

    Authors: Annelies Gonnissen, Sofie Isebaert, Christiaan Perneel, Chad M. McKee, Clare Verrill, Richard J. Bryant, Filip Van Utterbeeck, Evelyne Lerut, Karin Haustermans and Ruth J. Muschel
    Citation: BMC Cancer 2017 17:634
    Content type: Research article Published on:

  24. Extranodal NK/T-cell lymphoma (ENKTCL) reports from sub-Saharan Africa (SSA) are remarkably rare, despite early childhood acquisition and high prevalence of the causative infectious agent, Epstein-Barr virus (...

    Authors: Tamiwe Tomoka, Eric Powers, Toon van der Gronde, Amy Amuquandoh, Bal Mukunda Dhungel, Coxcilly Kampani, Steve Kamiza, Nathan D. Montgomery, Yuri Fedoriw and Satish Gopal
    Citation: BMC Cancer 2017 17:633
    Content type: Case report Published on:

  25. The numerous side effects of chemotherapy in patients with breast cancer are well known. However, the precise effects of chemotherapy on ovarian function in premenopausal women are poorly investigated. The pat...

    Authors: Antonia Wenners, Jana Grambach, Juliane Koss, Nicolai Maass, Walter Jonat, Andreas Schmutzler and Christoph Mundhenke
    Citation: BMC Cancer 2017 17:632
    Content type: Research article Published on:

  26. Neoplastic cells proliferate rapidly and obtain requisite building blocks by reprogramming metabolic pathways that favor growth. Previously, we observed that prostate cancer cells uptake and store lipids in th...

    Authors: Ranjana Mitra, Thuc T. Le, Priyatham Gorjala and Oscar B. Goodman Jr.
    Citation: BMC Cancer 2017 17:631
    Content type: Research article Published on:

  27. Acute myeloid leukemia (AML) is an aggressive malignancy only cured by intensive therapy. However, many elderly and unfit patients cannot receive such treatment due to an unacceptable risk of treatment-related...

    Authors: Håkon Reikvam, Randi Hovland, Rakel Brendsdal Forthun, Sigrid Erdal, Bjørn Tore Gjertsen, Hanne Fredly and Øystein Bruserud
    Citation: BMC Cancer 2017 17:630
    Content type: Research article Published on:

  28. The discrepant concordance between biopsy and radical prostatectomy (RP) specimen are well reported. To validate the clinical usefulness of neutrophil-lymphocyte ratio (NLR) in discriminating real GS â‰¥ 7 PCa f...

    Authors: Hanfeng Wang, Liangyou Gu, Yongjie Wu, Dan Feng, Junyao Duan, Xiaocong Wang, Yong Huang, Shengpan Wu, Jianwen Chen, Guangda Luo and Xu Zhang
    Citation: BMC Cancer 2017 17:629
    Content type: Research article Published on:

  29. The skeletal system is the most common site of distant metastasis in nasopharyngeal carcinoma (NPC); various prognostic factors have been reported for skeletal metastasis, though most studies have focused on a...

    Authors: Lin Yang, Liangping Xia, Yan Wang, Shasha He, Haiyang Chen, Shaobo Liang, Peijian Peng, Shaodong Hong and Yong Chen
    Citation: BMC Cancer 2017 17:628
    Content type: Research article Published on:

  30. Cancer Patient Pathways (CPPs) were introduced in 2000–2015 in several European countries, including Denmark, to reduce the time to diagnosis and treatment initiation and ultimately improve patient survival. Y...

    Authors: Henry Jensen, Marie Louise Tørring and Peter Vedsted
    Citation: BMC Cancer 2017 17:627
    Content type: Research article Published on:

  31. Gastric cancer (GC) accounts for the fourth most occurring malignancy and the third major cause of cancer death. Identifying novel molecular signaling pathways participating in gastric tumorigenesis and progre...

    Authors: Jianxin Ye, Jinsheng Huang, Jie Xu, Qiang Huang, Jinzhou Wang, Wenjing Zhong, Xinjian Lin, Yun Li and Xu Lin
    Citation: BMC Cancer 2017 17:626
    Content type: Research article Published on:

  32. Light at night creates a conflicting signal to the biological clock and disrupts circadian physiology. In rodents, light at night increases the risk to develop mood disorders, overweight, disrupted energy meta...

    Authors: Natalí N. Guerrero-Vargas, Raful Navarro-Espíndola, Mara A. Guzmán-Ruíz, María del Carmen Basualdo, Estefania Espitia-Bautista, Ana López-Bago, Ricardo Lascurain, Cinthya Córdoba-Manilla, Ruud M. Buijs and Carolina Escobar
    Citation: BMC Cancer 2017 17:625
    Content type: Research article Published on:

  33. Smoking is associated with an increased incidence of hormone receptor positive breast cancer. Data regarding worse breast cancer outcome in smokers are accumulating. Current literature regarding the impact of ...

    Authors: Hadar Goldvaser, Omer Gal, Shulamith Rizel, Daniel Hendler, Victoria Neiman, Tzippy Shochat, Aaron Sulkes, Baruch Brenner and Rinat Yerushalmi
    Citation: BMC Cancer 2017 17:624
    Content type: Research article Published on:

  34. Genetic counselling and testing for Lynch syndrome (LS) have recently been introduced in several Latin America countries. We aimed to characterize the clinical, molecular and mismatch repair (MMR) variants spe...

    Authors: Benedito Mauro Rossi, Edenir Inêz Palmero, Francisco López-Kostner, Carlos Sarroca, Carlos Alberto Vaccaro, Florencia Spirandelli, Patricia Ashton-Prolla, Yenni Rodriguez, Henrique de Campos Reis Galvão, Rui Manuel Reis, André Escremim de Paula, Luis Gustavo Capochin Romagnolo, Karin Alvarez, Adriana Della Valle, Florencia Neffa, Pablo German Kalfayan…
    Citation: BMC Cancer 2017 17:623
    Content type: Research article Published on:

  35. Replication-competent adenoviruses (Ad) produced cytotoxic effects on infected tumors and have been examined for the clinical applicability. A biomarkers to predict the cytotoxicity is valuable in a clinical s...

    Authors: Suguru Yamauchi, Boya Zhong, Kiyoko Kawamura, Shan Yang, Shuji Kubo, Masato Shingyoji, Ikuo Sekine, Yuji Tada, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima and Masatoshi Tagawa
    Citation: BMC Cancer 2017 17:622
    Content type: Research article Published on:

  36. Prostate cancer is a major contributor to mortality worldwide, and significant efforts are being undertaken to decipher specific cellular and molecular pathways underlying the disease. Chronic stress is known ...

    Authors: Ivan E. Flores, Jorge A. Sierra-Fonseca, Olinamyr Davalos, Luis A. Saenz, Maria M. Castellanos, Jaidee K. Zavala and Kristin L. Gosselink
    Citation: BMC Cancer 2017 17:621
    Content type: Research article Published on:

  37. Several susceptibility genes have been established for female breast cancer, of which mutations in BRCA1 and especially in BRCA2 are also known risk factors for male breast cancer (MBC). The role of other breast ...

    Authors: Sanna Hallamies, Liisa M. Pelttari, Paula Poikonen-Saksela, Antti Jekunen, Arja Jukkola-Vuorinen, Päivi Auvinen, Carl Blomqvist, Kristiina Aittomäki, Johanna Mattson and Heli Nevanlinna
    Citation: BMC Cancer 2017 17:620
    Content type: Research article Published on:

  38. Breast cancer is the common cancer in China. In previous study, we determined that 3,6-dihydroxyflavone (3,6-DHF) increases miR-34a significantly in breast carcinogenesis, but the mechanism remains unclear.

    Authors: Xiaoli Peng, Hui Chang, Junli Chen, Qianyong Zhang, Xiaoping Yu and Mantian Mi
    Citation: BMC Cancer 2017 17:619
    Content type: Research article Published on:

  39. Programmed cell death 1 (PD1) inhibitors have recently shown promising anti-cancer effects in a number of solid tumor types. A predictive biomarker to this class of drugs has not been clearly identified; howev...

    Authors: Basile Tessier-Cloutier, Steve E. Kalloger, Mohammad Al-Kandari, Katy Milne, Dongxia Gao, Brad H. Nelson, Daniel J. Renouf, Brandon S. Sheffield and David F. Schaeffer
    Citation: BMC Cancer 2017 17:618
    Content type: Research article Published on:

  40. The malignant potential of triple negative breast cancer (TNBC) is also dependent on a sub-population of cells with a stem-like phenotype. Among the cancer stem cell markers, CD133 and EpCAM strongly correlate...

    Authors: Federica Brugnoli, Silvia Grassilli, Paola Lanuti, Marco Marchisio, Yasamin Al-Qassab, Federica Vezzali, Silvano Capitani and Valeria Bertagnolo
    Citation: BMC Cancer 2017 17:617
    Content type: Research article Published on:

  41. To assess the trends in risk classification and primary therapy of Japanese prostate cancer patients who were diagnosed between 2004 and 2012.

    Authors: Nobumichi Tanaka, Yasushi Nakai, Makito Miyake, Satoshi Anai, Takeshi Inoue, Tomomi Fujii, Noboru Konishi and Kiyohide Fujimoto
    Citation: BMC Cancer 2017 17:616
    Content type: Research article Published on:

  42. We aimed to explore the clinical benefit of adjuvant chemotherapy (AC) with fluoropyrimidine in patients with ypT0-3N0 rectal cancer after preoperative chemoradiation therapy (CRT) followed by total mesorectal...

    Authors: Chang Gon Kim, Joong Bae Ahn, Sang Joon Shin, Seung Hoon Beom, Su Jin Heo, Hyung Soon Park, Jee Hung Kim, Eun Ah Choe, Woong Sub Koom, Hyuk Hur, Byung Soh Min, Nam Kyu Kim, Hoguen Kim, Chan Kim, Inkyung Jung and Minkyu Jung
    Citation: BMC Cancer 2017 17:615
    Content type: Research article Published on:

  43. Identifying older people affected by cancer who are more at risk of negative health outcomes is a major issue in health initiatives focusing on medical effectiveness. In this regard, psychological risk factors...

    Authors: Sarah Schroyen, Pierre Missotten, Guy Jerusalem, M. Van den Akker, F. Buntinx and Stéphane Adam
    Citation: BMC Cancer 2017 17:614
    Content type: Research article Published on:

  44. The optimal postoperative treatment strategy for small cell lung cancer (SCLC) remains unclear, especially in patients with lymph node metastasis. We aimed to compare the outcomes of patients with SCLC and lym...

    Authors: Hirokazu Urushiyama, Taisuke Jo, Hideo Yasunaga, Yasuhiro Yamauchi, Hiroki Matsui, Wakae Hasegawa, Hideyuki Takeshima, Yoshihisa Hiraishi, Akihisa Mitani, Kiyohide Fushimi and Takahide Nagase
    Citation: BMC Cancer 2017 17:613
    Content type: Research article Published on:

  45. A solitary fibrous tumour is a rare, mainly benign spindle cell mesenchymal tumour most commonly originating from the pleura. An intrapericardial location of a solitary fibrous tumour is extremely unusual. We ...

    Authors: Csilla Czimbalmos, Ibolya Csecs, Miklos Polos, Elektra Bartha, Nikolette Szucs, Attila Toth, Pal Maurovich-Horvat, David Becker, Zoltan Sapi, Zoltan Szabolcs, Bela Merkely and Hajnalka Vago
    Citation: BMC Cancer 2017 17:612
    Content type: Case report Published on:

  46. Throughout most of sub-Saharan Africa (and, indeed, most resource-limited areas), lack of death registries prohibits linkage of cancer diagnoses and precludes the most expeditious approach to determining cance...

    Authors: Aggrey Semeere, Esther Freeman, Megan Wenger, David Glidden, Mwebesa Bwana, Micheal Kanyesigye, Fredrick Chite Asirwa, Elyne Rotich, Naftali Busakhala, Emmanuel Oga, Elima Jedy-Agba, Vivian Kwaghe, Kenneth Iregbu, Clement Adebamowo, Antoine Jaquet, Francois Dabis…
    Citation: BMC Cancer 2017 17:611
    Content type: Research article Published on:

  47. Molecular biomarkers capable of predicting recurrence patterns and prognosis are helpful for risk stratification and providing appropriate treatment to patients with hepatocellular carcinoma (HCC). In this stu...

    Authors: Shinichi Umeda, Mitsuro Kanda, Hiroyuki Sugimoto, Haruyoshi Tanaka, Masamichi Hayashi, Suguru Yamada, Tsutomu Fujii, Hideki Takami, Yukiko Niwa, Naoki Iwata, Chie Tanaka, Daisuke Kobayashi, Michitaka Fujiwara and Yasuhiro Kodera
    Citation: BMC Cancer 2017 17:610
    Content type: Research article Published on:

  48. Larynx preservation (LP) is recommended for up to low-volume T4 laryngeal cancer as an evidence-based treatment option that does not compromise survival. However, a reevaluation of the current literature raise...

    Authors: Gerhard Dyckhoff, Peter K. Plinkert and Heribert Ramroth
    Citation: BMC Cancer 2017 17:609
    Content type: Research article Published on:

  49. Protein Induced by Vitamin K Absence or Antagonist-II (PIVKA-II) is an efficient biomarker specific for hepatocellular carcinoma (HCC). Some researchers have proved that levels of PIVKA-II reflect HCC oncogene...

    Authors: Rentao Yu, Zhaoxia Tan, Xiaomei Xiang, Yunjie Dan and Guohong Deng
    Citation: BMC Cancer 2017 17:608
    Content type: Research article Published on:

  50. MiRNAs are often deregulated in colorectal cancer and might function as tumor suppressors or as oncogenes. They participate in controlling key signaling pathways involved in proliferation, invasion and apoptos...

    Authors: Edita Baltruskeviciene, Diana Schveigert, Vaidotas Stankevicius, Ugnius Mickys, Tadas Zvirblis, Jaroslav Bublevic, Kestutis Suziedelis and Eduardas Aleknavicius
    Citation: BMC Cancer 2017 17:607
    Content type: Research article Published on:

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