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  1. Ovarian cancer (OC) is the most lethal gynecological cancer due to the recurrence of drug-resistance. Cancer initiating cells (CICs) are proposed to be responsible for the aggressiveness of OC. The rarity and ...

    Authors: Yu-An Chen, Chen-Yu Lu, Wen-Fang Cheng, Kuan-Ting Kuo, Chen-Wei Yu, Hon-Nerng Ho, Hsin-Fu Chen and Szu-Hua Pan
    Citation: BMC Cancer 2022 22:967
    Content type: Research Published on:

  2. Pathological stage IB-IIIA lung adenocarcinoma with an epidermal growth factor receptor (EGFR) mutation (Mt) has a high recurrence rate even after complete resection. However, there have been few reports on t...

    Authors: Tetsuya Isaka, Hiroyuki Ito, Tomoyuki Yokose, Haruhiro Saito, Hiroyuki Adachi, Kotaro Murakami, Jun Miura, Noritake Kikunishi and Yasushi Rino
    Citation: BMC Cancer 2022 22:966
    Content type: Research Published on:

  3. To evaluate the impact of intraoperative hypotension and hemodynamic instability on survival outcomes in patients with high-grade serous ovarian carcinoma (HGSOC).

    Authors: Se Ik Kim, Hyung-Chul Lee, Hyun-Kyu Yoon, Hee Seung Kim, Hyun Hoon Chung, Jae-Weon Kim, Noh Hyun Park, Yong-Sang Song and Maria Lee
    Citation: BMC Cancer 2022 22:965
    Content type: Research Published on:

  4.  First-line treatment of nonsquamous non–small cell lung cancer (NSCLC) has undergone a paradigm shift to platinum combination therapy together with immune checkpoint inhibitors (ICIs). However, phase III stud...

    Authors: Yoshimasa Shiraishi, Junji Kishimoto, Takayuki Shimose, Yukihiro Toi, Shunichi Sugawara and Isamu Okamoto
    Citation: BMC Cancer 2022 22:964
    Content type: Study protocol Published on:

  5. Difference in clinical responses to cancer therapy in each patient is from several factors. Gastrointestinal microbiota is one of the reasons. However, this correlation remains unknown. This study aims to expl...

    Authors: Woraseth Saifon, Insee Sensorn, Narumol Trachu, Songporn Oranratnachai, Angkana Charoenyingwattana, Chakkaphan Runcharoen, Nanamon Monnamo, Warawut Sukkasem, Pimpin Inchareon, Thitiporn Suwatanapongched, Phichai Chansriwong, Touch Ativitavas, Ravat Panvichian, Wasun Chantratita and Thanyanan Reungwetwattana
    Citation: BMC Cancer 2022 22:963
    Content type: Research Published on:

  6. Whether preoperative serum carbohydrate antigen 19–9 (CA19-9) is an independent prognostic factor and there are interactions of serum CA19-9 with carcinoembryonic antigen (CEA) on the risk of recurrence in col...

    Authors: Zhenhui Li, Haibin Zhu, Xiaolin Pang, Yun Mao, Xiaoping Yi, Chunxia Li, Ming Lei, Xianshuo Cheng, Lei Liang, Jiamei Wu, Yingying Ding, Jun Yang, Yingshi Sun, Tao Zhang, Dingyun You and Zaiyi Liu
    Citation: BMC Cancer 2022 22:962
    Content type: Research Published on:

  7. Colorectal cancer is one of the most common cancers in the world. Several studies suggest using the Asia-Pacific colorectal screening (APCS) score and its modified versions to select high-risk populations for ...

    Authors: Yunxin Kong, Lin Zhuo, Dong Dong, Lang Zhuo, Peian Lou, Ting Cai, Siting Chen, Jianqiang Pan, Yihuan Gao, Hang Lu, Yue Ma, Zongmei Dong, Xiaohu Luo and Hongying Zhao
    Citation: BMC Cancer 2022 22:961
    Content type: Research Published on:

  8. Breast cancer is the most frequently diagnosed cancer and the leading reason for cancer-related death among women. Neoadjuvant treatment with dual-HER2 (human epidermal growth factor receptor 2) blockade has s...

    Authors: Abolghasem Allahyari, Ali Ehsanpour, Behrouz Najafi, Nafiseh Ansarinejad, Valiollah Mehrzad, Behjat Kalantari, Jahangir Raafat, Mojtaba Ghadiany, Farhad Shahi, Behrooz Gharib, Vahid Moazed, Adnan Khosravi, Mir Hossein Mirpour, Sina Salari, Seyedmohammadreza Mortazavizadeh, Amirabbas Nekoyi…
    Citation: BMC Cancer 2022 22:960
    Content type: Research Published on:

    The Correction to this article has been published in BMC Cancer 2022 22:1348

  10. Pleural deformation is associated with the invasiveness of lung adenocarcinoma(LAC). Our study focused on the pathological components of the area adjacent pleura in pulmonary pure ground-glass nodules(pGGNs) w...

    Authors: Yining Jiang, Ziqi Xiong, Wenjing Zhao, Di Tian, Qiuping Zhang and Zhiyong Li
    Citation: BMC Cancer 2022 22:958
    Content type: Research Published on:

  11. The presence of mesorectal fascia (MRF) invasion, grade 4 extramural venous invasion (EMVI), tumour deposits (TD) or extensive or bilateral extramesorectal (lateral) lymph nodes (LLN) on MRI has been suggested...

    Authors: K. van den Berg, D. P. Schaap, E. L. K. Voogt, T. E. Buffart, H. M. W. Verheul, J. W. B. de Groot, C. Verhoef, J. Melenhorst, J. M. L. Roodhart, J. H. W. de Wilt, H. L. van Westreenen, A. G. J. Aalbers, M. van ‘t Veer, C. A. M. Marijnen, J. Vincent, L. H. J. Simkens…
    Citation: BMC Cancer 2022 22:957
    Content type: Study protocol Published on:

  12. Tregs are able of suppressing tumor-specific effector cells, such as lymphocytes CD8+, CD4+ and Natural Killer cells. Different drugs, especially different schedules of administration, like metronomic chemothe...

    Authors: F. F. Pepe, M. E. Cazzaniga, S. Baroni, F. Riva, F. Cicchiello, S. Capici, V. Cogliati, C. Maggioni, N. Cordani, M. G. Cerrito and S. Malandrin
    Citation: BMC Cancer 2022 22:956
    Content type: Research Published on:

  13. Lipid metabolism has a profound impact on gastric cancer (GC) progression and is a newly targetable vulnerability for cancer therapy. Given the importance of lipids in cancer cellular processes, in this study ...

    Authors: Yanyan Li, Jungang Zhao, Renpin Chen, Shengwei Chen, Yilun Xu and Weiyang Cai
    Citation: BMC Cancer 2022 22:955
    Content type: Research Published on:

  14. Several studies have reported that circulating tumor cells (CTCs) are a promising marker for the diagnosis of thyroid cancer (TC) with recurrence or distant metastasis (DMs). However, some studies emerged with...

    Authors: Ming-Xing Liang, Yin-Jiao Fei, Kai Yang, Wen-Juan Tang, Xin-Hui Cao and Jin-Hai Tang
    Citation: BMC Cancer 2022 22:954
    Content type: Research article Published on:

  15. Adenocarcinomas of the esophagus (AEG) and stomach (AS) are among the most common cancers worldwide. Novel markers for risk stratification and guiding treatment are strongly needed. Activin is a multi-function...

    Authors: J. J. Staudacher, Alexander Arnold, A. A. Kühl, M. Pötzsch, S. Daum, M. Winterfeld, E. Berg, M. Hummel, B. Rau, U. Stein and C. Treese
    Citation: BMC Cancer 2022 22:953
    Content type: Research article Published on:

  16. Single-agent immunotherapy is currently the recommended second-line therapy for patients with advanced non–small cell lung cancer (NSCLC) without targetable mutations; however, the objective response rate (ORR...

    Authors: Yongchang Zhang, Lianxi Song, Liang Zeng, Yi Xiong, Li Liu, Chunhua Zhou, Haiyan Yang, Zhan Wang, Qing Xia, Wenjuan Jiang, Qinqin Xu and Nong Yang
    Citation: BMC Cancer 2022 22:952
    Content type: Research Published on:

  17. Breast cancer is the most common female tumors arising worldwide, and genetic and epigenetic events are constantly accumulated in breast tumorigenesis. The melastatin-related transient receptor potential 7 cha...

    Authors: Yuanyuan Wang, Rong Lu, Pu Chen, Rongrong Cui, Meiju Ji, Xiaozhi Zhang, Peng Hou and Yiping Qu
    Citation: BMC Cancer 2022 22:951
    Content type: Research Published on:

  18. More than 60% of cancer cases occur in older adults, and many are treated with oral anticancer agents. Yet, the treatment tolerability in older adults has not been fully understood due to their underrepresenta...

    Authors: Yun Jiang, Madilyn Mason, Youmin Cho, Ankita Chittiprolu, Xingyu Zhang, Karen Harden, Yang Gong, Marcelline R. Harris and Debra L. Barton
    Citation: BMC Cancer 2022 22:950
    Content type: Research Published on:

  20. One-year S-1 or six-month capecitabine/oxaliplatin (CAPOX) has been the standard adjuvant chemotherapy for gastric cancer (GC). We investigated outcomes according to the cycles of adjuvant chemotherapy, using ...

    Authors: Tae-Hwan Kim, Mi Sun Ahn, Yong Won Choi, Seok Yun Kang, Jin-Hyuk Choi, Hyun Woo Lee, Minae Park and Hasung Kim
    Citation: BMC Cancer 2022 22:948
    Content type: Research Published on:

  21. To explore the diagnostic value of integrated positron emission tomography/magnetic resonance imaging (PET/MRI) for the staging of endometrial carcinoma and to investigate the associations between quantitative...

    Authors: Yang Yu, Le Zhang, Bilkis Sultana, Bo Wang and Hongzan Sun
    Citation: BMC Cancer 2022 22:947
    Content type: Research Published on:

  22. For patients with oesophagogastric adenocarcinoma, surgery is the only curative option and despite the use of multimodality therapy, which combines it with chemotherapy and/or radiotherapy, more than 50% of pa...

    Authors: Elizabeth Smyth, Kelly Cozens, Daniel Griffiths, Kathryn L. Clark, Sean Ewings, Russell Petty, Tim Underwood, Rebecca C. Fitzgerald, James Tanner, Olivier Giger, Shubha Anand and Gareth Griffiths
    Citation: BMC Cancer 2022 22:946
    Content type: Study protocol Published on:

  23. Gut microbiome community composition differs between cervical cancer (CC) patients and healthy controls, and increased gut diversity is associated with improved outcomes after treatment. We proposed that funct...

    Authors: Tatiana V. Karpinets, Xiaogang Wu, Travis Solley, Molly B. El Alam, Travis T. Sims, Kyoko Yoshida-Court, Erica Lynn, Mustapha Ahmed-Kaddar, Greyson Biegert, Jingyan Yue, Xingzhi Song, Huandong Sun, Joseph F. Petrosino, Melissa P. Mezzari, Pablo Okhuysen, Patricia J. Eifel…
    Citation: BMC Cancer 2022 22:945
    Content type: Research article Published on:

  24. Life-threatening cytomegalovirus infection (CMVI) has been reported even in patients with malignant lymphoma (ML) who have not received hematopoietic stem cell transplantation (w/o HSCT) but had been treated w...

    Authors: Kazuya Sato, Sho Igarashi, Nodoka Tsukada, Junki Inamura, Masayo Yamamoto, Motohiro Shindo, Kentaro Moriichi, Yusuke Mizukami, Mikihiro Fujiya and Yoshihiro Torimoto
    Citation: BMC Cancer 2022 22:944
    Content type: Research article Published on:

  25. Vulvar squamous cell carcinoma (VSCC) is an uncommon gynecologic malignancy but with an increasing incidence in recent years. Etiologically, VSCC is classified into two subtypes: HPV-dependent and HPV-independ...

    Authors: Mateja Condic, Thore Thiesler, Christian Staerk, Niklas Klümper, Jörg Ellinger, Eva K. Egger, Kirsten Kübler, Glen Kristiansen, Alexander Mustea and Damian J. Ralser
    Citation: BMC Cancer 2022 22:943
    Content type: Research Published on:

  27. For some patients with advanced cancer not knowing prognosis is essential. Yet, in an era of informed decision-making, the potential protective function of unawareness is easily overlooked. We aimed to investi...

    Authors: Naomi C. A. van der Velden, Hanneke W. M. van Laarhoven, Sjaak A. Burgers, Lizza E. L. Hendriks, Filip Y. F. L. de Vos, Anne-Marie C. Dingemans, Joost Jansen, Jan-Maarten W. van Haarst, Joyce Dits, Ellen MA Smets and Inge Henselmans
    Citation: BMC Cancer 2022 22:941
    Content type: Research Published on:

  28. In human colorectal cancer (CRC), TP53 is one of the most important driver genes. Immunohistochemistry (IHC) has been used most often to assess the variational status of TP53. Recently, next-generation sequencing...

    Authors: Kyoung Min Kim, Ae-Ri Ahn, Ho Sung Park, Kyu Yun Jang, Woo Sung Moon, Myoung Jae Kang, Gi Won Ha, Min Ro Lee and Myoung Ja Chung
    Citation: BMC Cancer 2022 22:940
    Content type: Research Published on:

  29. This analysis presents the outcomes of the operations of the National Cancer Network (NCN) pilot project in Lower Silesian Voivodeship, Poland, for lung cancer for the period of 2019–2021. The results concerni...

    Authors: Łukasz Trembecki, Aleksandra Sztuder, Izabella Dębicka, Rafał Matkowski and Adam Maciejczyk
    Citation: BMC Cancer 2022 22:939
    Content type: Research Published on:

  30. Primary thyroid lymphoma (PTL) and papillary thyroid carcinoma (PTC) are both thyroid malignancies, but their therapeutic methods and prognosis are different. This study aims to explore their sonographic and c...

    Authors: Chanjuan Peng, Dan Yi, Ying Zhou, Jincao Yao, Bo Chen, Chen Yang and Dong Xu
    Citation: BMC Cancer 2022 22:938
    Content type: Research Published on:

  31. Breast cancer-related lymphedema (BCRL) is a frequent issue that arises after mastectomy surgery in women and compromises physical and mental function. Previously published studies have shown positive effects ...

    Authors: Dania Mahmood, Ashfaq Ahmad, Faiza Sharif and Syed Asadullah Arslan
    Citation: BMC Cancer 2022 22:937
    Content type: Research Published on:

  32. Melanoma is a malignant tumor characterized by high proliferation and aggressive metastasis. To address the molecular mechanisms of the proto-oncogene, Rous sarcoma oncogene (Src), which is highly activated an...

    Authors: Kana Mizuta, Takuma Matsubara, Akino Goto, William N. Addison, Mitsushiro Nakatomi, Kou Matsuo, Yukiyo Tada-Shigeyama, Tatsuki Yaginuma, Hiromi Honda, Izumi Yoshioka and Shoichiro Kokabu
    Citation: BMC Cancer 2022 22:936
    Content type: Research Published on:

  33. Long non-coding RNAs (lncRNAs) play a functional role in the progression of prostate cancer (PCa). However, the molecular mechanism, expression, or function of the lncRNA XIST in PCa is not well understood. Th...

    Authors: Jie Wang, Jie Huang, Yingxue Guo, Yuli Fu, Yifang Cao, Kang Zhou, Jianxiong Ma, Bodong Lv and Wenjie Huang
    Citation: BMC Cancer 2022 22:935
    Content type: Research Published on:

  35. The Notch signaling mutation is associated with enhanced anti-tumor immune response in colorectal cancer (CRC). In this study, we aim to investigate the underlying mechanism and the predictive potential of Not...

    Authors: Fei Wang, Chuan Huang, Jie Long, Zhi-Bin Zhao, Hai-Qing Ma, Xue-Qing Yao, Liang Li and Zhe-Xiong Lian
    Citation: BMC Cancer 2022 22:933
    Content type: Research Published on:

  36. Esophageal squamous cell carcinoma (ESCC) has poor prognosis mainly due to lacking of effective diagnostic biomarkers. Aberrant expression of secreted phosphoprotein 1 (SPP1) protein has been observed in sever...

    Authors: Chen Wang, Guiying Sun, Huimin Wang, Liping Dai, Jianying Zhang and Renle Du
    Citation: BMC Cancer 2022 22:932
    Content type: Research Published on:

  37. Hepatectomy is currently the most effective modality for the treatment of intrahepatic cholangiocarcinoma (ICC). The status of the lymph nodes directly affects the choice of surgical method and the formulation...

    Authors: Tingfeng Huang, Hongzhi Liu, Zhaowang Lin, Jie Kong, Kongying Lin, Zhipeng Lin, Yifan Chen, Qizhu Lin, Weiping Zhou, Jingdong Li, Jiang-Tao Li and Yongyi Zeng
    Citation: BMC Cancer 2022 22:931
    Content type: Research Published on:

  38. Colposcopy is a tool for triaging screen positive women regardless of method used for cervical cancer screening. The objective of this study was to evaluate the diagnostic performance of colposcopy in the diag...

    Authors: Namkha Dorji, Sangay Tshering, Sonam Choden, Meera Chhetri, Damanti Bhujel, Tshering Wangden, Birendra Pradhan, Pema Choden Bhutia and Ugyen Tshomo
    Citation: BMC Cancer 2022 22:930
    Content type: Research Published on:

  39. Automated breast ultrasound (ABUS) is a useful choice in breast disease diagnosis. The axillary lymph node (ALN) status is crucial for predicting the clinical classification and deciding on the treatment of ea...

    Authors: Qiucheng Wang, Bo Li, Zhao Liu, Haitao Shang, Hui Jing, Hua Shao, Kexin Chen, Xiaoshuan Liang and Wen Cheng
    Citation: BMC Cancer 2022 22:929
    Content type: Research Published on:

  40. Neuroendocrine differentiation (NED) in colorectal cancer (CRC) cells has been known for decades, and our previous meta-analysis indicated that CRC patients with neuroendocrine differentiation have a lower 5-y...

    Authors: Xiaojun Li, Qiusheng Lan, Wei Lai, Heng Wu, Heyang Xu, Kai Fang, Zhonghua Chu and Yujie Zeng
    Citation: BMC Cancer 2022 22:928
    Content type: Research Published on:

  41. Transthoracic single-port assisted laparoscopic five-step maneuver inferior mediastinal lymphadenectomy for Siewert type II adenocarcinoma of esophagogastric junction (AEG) has superiority in lower mediastinal...

    Authors: Zeyu Lin, Haiping Zeng, Wenjun Xiong, Jin Li, Yan Chen, Lijie Luo, Yansheng Zheng, Zhuoxuan Zhang and Wei Wang
    Citation: BMC Cancer 2022 22:927
    Content type: Research Published on:

  43. The gap in treatment and health outcomes after diagnosis of pancreatic cancer is a major public health concern. We aimed to investigate the differences in the health outcomes and treatment of pancreatic cancer...

    Authors: Sung Hoon Jeong, Hyeon Ji Lee, Choa Yun, Il Yun, Yun Hwa Jung, Soo Young Kim, Hee Seung Lee and Sung-In Jang
    Citation: BMC Cancer 2022 22:925
    Content type: Research Published on:

  46. Lymph node metastasis (LNM) is a critical event during the colorectal cancer (CRC) development and is indicative of poor prognosis. Identification of molecular markers of LNM may facilitate better therapeutic ...

    Authors: Chengxing Wang, Bin Wang, Weijun Liang, Chaorong Zhou, Weixing Lin, Zijie Meng, Wanting Wu, Meimei Wu, Yuehua Liao, Xiaoping Li, Jinglin Zhao and Yaoming He
    Citation: BMC Cancer 2022 22:922
    Content type: Research Published on:

  47. The prognostic values of preoperative aspartate aminotransferase (AST), monocyte-to-lymphocyte ratio (MLR), AST·MLR index (AMLRI) and operation injury condition in patients with colorectal cancer liver metasta...

    Authors: Qichen Chen, Mingxia Li, Jinghua Chen, Zhen Huang, Xiao Chen, Hong Zhao and Jianqiang Cai
    Citation: BMC Cancer 2022 22:921
    Content type: Research Published on:

  48. The incidence and mortality rate of rectal cancer are still high, the metastasis of rectal cancer are main causes of death. The control of the distant metastasis is one of the main concerns in the treatment of...

    Authors: Xue Ding, Danqi Sun, Qiuchen Guo, Yeting Li, Hao Chen, Xiaoxiao Dai, Guohua Fan, Yongyou Wu, Guangqiang Chen and Yonggang Li
    Citation: BMC Cancer 2022 22:920
    Content type: Research Published on:

  49. There are increasing numbers of studies of pleural tags (PTs). The purpose of this case series was to classify the PTs in patients with peripheral pulmonary adenocarcinoma based on radiologic-pathologic compar...

    Authors: Yao Meng, Jie Gao, Chongchong Wu, Mei Xie, Xidong Ma, Xuelei Zang, Jialin Song, Meng Zhou, Shikun Guo, Yemei Huang, Hengyu Deng, Hongli Li, Bo Wei and Xinying Xue
    Citation: BMC Cancer 2022 22:919
    Content type: Research Published on:

  50. Selective activation of Delta-like 1 (DLL1)-Notch signaling is a new approach to activate CD8+ T cell and suppress tumor growth, while the efficacy remains modest. Lentinan (LNT) is a clinically used immunomodula...

    Authors: Haiyan Xu, Ziwei Qi, Qi Zhao, Jiao Xue, Jiaxing Zhu, Yan He, Guirong Liu and Songbing Qin
    Citation: BMC Cancer 2022 22:918
    Content type: Research Published on:

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