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3909 result(s) for 'lung cancer prognosis stage 4' within BMC Cancer

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  1. While molecularly targeted therapies and immune checkpoint inhibitors have improved the prognosis of advanced melanoma, biomarkers are required to monitor drug responses. Circulating tumor cells (CTCs) are rel...

    Authors: Yukiko Kiniwa, Kenta Nakamura, Asuka Mikoshiba, Atsuko Ashida, Yasuyuki Akiyama, Atsushi Morimoto and Ryuhei Okuyama
    Citation: BMC Cancer 2021 21:287
    Content type: Research article Published on:

  2. Traumatic brain injury (TBI) has been reported as a risk factor for brain cancer development. However, the magnitude of the impact of TBI on systemic cancer development has not been clarified.

    Authors: Chung-Che Lu, Tee-Tau Eric Nyam, Chung-Han Ho, Jinn-Rung Kuo, Chung-Ching Chio, Jhi-Joung Wang and Che-Chuan Wang
    Citation: BMC Cancer 2022 22:291
    Content type: Research Published on:

  3. Despite the remarkable advances in the early diagnosis and treatment, overall 5-year survival rate of patients with pancreatic cancer is less than 10%. Gemcitabine (GEM), a cytidine nucleoside analogue and rib...

    Authors: Toshinori Ozaki, Meng Yu, Danjing Yin, Dan Sun, Yuyan Zhu, Youquan Bu and Meixiang Sang
    Citation: BMC Cancer 2018 18:309
    Content type: Review article Published on:

  4. Mitofusin 2 (MFN2) plays an important role in many tumors, but how its role in renal clear cell carcinoma needs further research.

    Authors: Bin Zhang, Dali Han, LiMing Yang, Yang He, Shujun Yang, Hongbo Wang, Xingxing Zhang, Yuelin Du, Wei Xiong, Hualan Ha and Panfeng Shang
    Citation: BMC Cancer 2023 23:986
    Content type: Research Published on:

  5. Estrogen receptor (ER) positive breast cancer is often effectively treated with drugs that inhibit ER signaling, i.e., tamoxifen (TAM) and aromatase inhibitors (AIs). However, 30% of ER+ breast cancer patients...

    Authors: Maryam Soleimani Dodaran, Simone Borgoni, Emre Sofyalı, Pernette J. Verschure, Stefan Wiemann, Perry D. Moerland and Antoine H. C. van Kampen
    Citation: BMC Cancer 2020 20:676
    Content type: Research article Published on:

  6. The present study aims to evaluate long-term side-effects and outcomes and confirm prognostic factors after stereotactic body radiotherapy (SBRT) of pulmonary lesions. This is the first work that combines the ...

    Authors: Kerstin A. Kessel, Rebekka C. E. Grosser, Kim Melanie Kraus, Hans Hoffmann, Markus Oechsner and Stephanie E. Combs
    Citation: BMC Cancer 2020 20:442
    Content type: Research article Published on:

  7. In the recent phase III trial MPACT the combination of gemcitabine and nab-paclitaxel (Gem/NabP) showed increased overall survival compared to gemcitabine alone in the treatment of advanced pancreatic ductal a...

    Authors: Hakon Blomstrand, Ursula Scheibling, Charlotte Bratthäll, Henrik Green and Nils O. Elander
    Citation: BMC Cancer 2019 19:40
    Content type: Research article Published on:

  8. Emerging evidence has demonstrated that Neutrophil gelatinase-associated lipocalin (NGAL) is up-regulated in multiple malignancies, including oesophagus cancer, and plays a critical role in tumorigenesis and p...

    Authors: Xiu-Feng Zhang, Ying Zhang, Xiao-Hua Zhang, Su-Mei Zhou, Guan-Gen Yang, Ou-Chen Wang, Gui-Long Guo, Gao-Yi Yang and Xiao-Qu Hu
    Citation: BMC Cancer 2009 9:134
    Content type: Research article Published on:

  9. Participants considering early-phase cancer clinical trials (CTs) need to understand the unique risks and benefits prior to providing informed consent. This qualitative study explored the factors that influenc...

    Authors: Jonathan Avery, Jennifer A.H. Bell, Khotira Baryolay, Gary Rodin, Rinat Nissim and Lynda G. Balneaves
    Citation: BMC Cancer 2024 24:373
    Content type: Research Published on:

  10. The Neutrophil to lymphocyte ratio (NLR) has prognostic value in patients with a variety of cancers. However, its prognostic significance in oral squamous cell carcinoma (OSCC) patients has not been fully expl...

    Authors: Hikaru Nakashima, Yuichiro Matsuoka, Ryoji Yoshida, Masashi Nagata, Akiyuki Hirosue, Kenta Kawahara, Junki Sakata, Hidetaka Arita, Akimitsu Hiraki and Hideki Nakayama
    Citation: BMC Cancer 2016 16:41
    Content type: Research article Published on:

  11. Breast cancer is a potentially fatal malignancy in females despite the improvement in therapeutic techniques. The identification of novel molecular signatures is needed for earlier detection, monitoring effect...

    Authors: Emman Shubbar, Anikó Kovács, Shahin Hajizadeh, Toshima Z Parris, Szilárd Nemes, Katrin Gunnarsdóttir, Zakaria Einbeigi, Per Karlsson and Khalil Helou
    Citation: BMC Cancer 2013 13:1
    Content type: Research article Published on:

  13. Concomitant diseases often occur in cancer patients and are important in decision-making regarding treatments. However, information regarding the prognostic relevance of comorbidities for mortality risk is sti...

    Authors: Ju Wu, Simiao Tian, Jian Xu, Nan Cheng, Xi Chen, Jiajun Yin and Zhequn Nie
    Citation: BMC Cancer 2023 23:916
    Content type: Research Published on:

  14. Patients with hepatocellular carcinoma (HCC) who undergo transarterial chemoembolization (TACE) may have varied outcomes based on their liver function and tumor burden diversity. This study aims to assess the ...

    Authors: Jiawei Lin, Jie Li, Yifan Kong, Junhui Yang, Yunjie Zhang, Guoqing Zhu, Zhijie Yu and Jinglin Xia
    Citation: BMC Cancer 2024 24:306
    Content type: Research Published on:

  15. Long non-coding RNAs (LncRNAs) are dysregulated in multiple human cancers and they are highly involved in tumor progression. Previous studies have identified the oncogenic lncRNA HOXD cluster antisense RNA 1 (...

    Authors: Shaozheng Chen and Kejun Li
    Citation: BMC Cancer 2020 20:924
    Content type: Research article Published on:

  16. The REversion-inducing Cysteine-rich protein with Kazal motif (RECK) is a well-known inhibitor of matrix metalloproteinases (MMPs) and cellular invasion. Although high expression levels of RECK have already be...

    Authors: Luciana R. Gomes, André Fujita, Joni D. Mott, Fernando A. Soares, Leticia Labriola and Mari C. Sogayar
    Citation: BMC Cancer 2015 15:660
    Content type: Research article Published on:

  17. Elevated Glasgow Prognostic Score (GPS) has been related to poor prognosis in patients with hepatocellular carcinoma (HCC) undergoing surgical resection or receiving sorafenib. The aim of this study was to inv...

    Authors: Akiyoshi Kinoshita, Hiroshi Onoda, Nami Imai, Akira Iwaku, Mutumi Oishi, Ken Tanaka, Nao Fushiya, Kazuhiko Koike, Hirokazu Nishino, Masato Matsushima, Chisato Saeki and Hisao Tajiri
    Citation: BMC Cancer 2013 13:52
    Content type: Research article Published on:

  18. Here we describe the treatments and prognosis for metachronous metastases from gastroenteropancreatic neuroendocrine tumors (GEP-NETs) after initial R0 surgical resection at a large center in China.

    Authors: Yang Lv, Xu Han, Xue-Feng Xu, Yuan Ji, Yu-Hong Zhou, Hui-Chuan Sun, Jian Zhou, Jia Fan, Wen-Hui Lou and Cheng Huang
    Citation: BMC Cancer 2019 19:335
    Content type: Research article Published on:

  19. This study aimed to answer the question ‘for which cancers, in a symptomatic patient, does expediting the diagnosis provide an improvement in mortality and/or morbidity?’

    Authors: Willie Hamilton, Sally Stapley, Christine Campbell, Georgios Lyratzopoulos, Greg Rubin and Richard D. Neal
    Citation: BMC Cancer 2015 15:820
    Content type: Research article Published on:

  20. Polymorphisms in angiogenesis-related genes and metabolic syndrome (MetS) risk factors play important roles in cancer development. Moreover, recent studies have reported associations between a number of 3′-UTR...

    Authors: Young Joo Jeon, Jong Woo Kim, Hye Mi Park, Hyo Geun Jang, Jung O Kim, Jisu Oh, So Young Chong, Sung Won Kwon, Eo Jin Kim, Doyeun Oh and Nam Keun Kim
    Citation: BMC Cancer 2014 14:881
    Content type: Research article Published on:

  21. The evidence about the effects of trace elements on overall survival(OS) of patients with esophageal squamous cell carcinoma(ESCC) is limited. This study aims to evaluate mixed effects of plasma trace elements...

    Authors: Kaili Yu, Shuang Liu, Zheng Lin, Jianyu Song, Qiaoyan Zeng, Jinsong Zhou, Juwei Zhang, Suhong Zhang, Jianbo Lin, Zhisheng Xiang and Zhijian Hu
    Citation: BMC Cancer 2024 24:24
    Content type: Research Published on:

  22. Recent evidence suggests that albumin-to-Alkaline Phosphatase Ratio (AAPR) functions as a novel prognostic marker in several malignancies. However, whether it can predict the prognosis of unresectable pancreat...

    Authors: Ke Zhang, Shu Dong, Yan-Hua Jing, Hui-Feng Gao, Lian-Yu Chen, Yong-Qiang Hua, Hao Chen and Zhen Chen
    Citation: BMC Cancer 2020 20:541
    Content type: Research article Published on:

  24. A higher density of tumor-infiltrating lymphocytes (TILs) can lead to greater therapeutic effects and improved prognoses in cancer treatment. Similar results have been observed in breast cancer, particularly i...

    Authors: Koji Takada, Shinichiro Kashiwagi, Yuka Asano, Wataru Goto, Katsuyuki Takahashi, Hisakazu Fujita, Tsutomu Takashima, Shuhei Tomita, Kosei Hirakawa and Masaichi Ohira
    Citation: BMC Cancer 2019 19:615
    Content type: Research article Published on:

  25. Growing evidence indicates that the systemic inflammatory response plays an important role in cancer development and progression. Several inflammatory markers have been reported to be associated with clinical ...

    Authors: Shuxin Sun, Chaobin He, Jun Wang, Xin Huang, Jiali Wu and Shengping Li
    Citation: BMC Cancer 2020 20:981
    Content type: Research article Published on:

  27. Chemotherapy with gemcitabine and cisplatin has been the standard of care in first-line chemotherapy for advanced biliary tract cancer (BTC) since the trial ABC-02 was published in 2010. We aimed to investigat...

    Authors: Chiao-En Wu, Wen-Chi Chou, Chia-Hsun Hsieh, John Wen-Cheng Chang, Cheng-Yu Lin, Chun-Nan Yeh and Jen-Shi Chen
    Citation: BMC Cancer 2020 20:422
    Content type: Research article Published on:

  28. Patients with rheumatologic preexisting autoimmune disease (PAD) have not been enrolled in clinical trials of immune checkpoint inhibitors (ICIs). Therefore, the risks and benefits of ICI therapy in such patie...

    Authors: Xin Liu, Su Li, Liyuan Ke and Hongxia Cui
    Citation: BMC Cancer 2024 24:490
    Content type: Systematic Review Published on:

  29. As a critical feature of cancers, stemness is acknowledged as a contributor to the development of drug resistance in gastric cancer (GC). LncRNAs have been revealed to participate in this process. In this stud...

    Authors: Quan Jiang, Hao Chen, Zhaoqing Tang, Jie Sun, Yuanyuan Ruan, Fenglin Liu and Yihong Sun
    Citation: BMC Cancer 2021 21:1067
    Content type: Research Published on:

  30. A minority of European countries have participated in international comparisons with high level data on lung cancer. However, the nature and extent of data collection across the continent is simply unknown, an...

    Authors: Anna Rich, David Baldwin, Inmaculada Alfageme, Paul Beckett, Thierry Berghmans, Stephen Brincat, Otto Burghuber, Alexandru Corlateanu, Tanja Cufer, Ronald Damhuis, Edvardas Danila, Joanna Domagala-Kulawik, Stefano Elia, Mina Gaga, Tuncay Goksel, Bogdan Grigoriu…
    Citation: BMC Cancer 2018 18:1144
    Content type: Research article Published on:

  31. Aldehyde deyhdrogenase 1 (ALDH1) has been characterised as a cancer stem cell marker in different types of tumours. Additionally, it plays a pivotal role in gene regulation and endows tumour cells with augment...

    Authors: Christoph Kahlert, Frank Bergmann, Janine Beck, Thilo Welsch, Carolin Mogler, Esther Herpel, Shamik Dutta, Thomas Niemietz, Moritz Koch and Jürgen Weitz
    Citation: BMC Cancer 2011 11:275
    Content type: Research article Published on:

  32. Breast malignancies are now the most common and deadliest type of neoplasms among women worldwide. Novel therapeutic approaches are needed to combat advanced stages of breast cancer. In this study, we aimed to...

    Authors: Mohammadhossein Pournabee, Mahsa Keshavarz-Fathi, Pooyesh Esmaeili, Pouya Mahdavi Sharif, Fatemeh Nili and Behnaz Jahanbin
    Citation: BMC Cancer 2023 23:495
    Content type: Research Published on:

  33. There is growing evidence that the transcription factor nuclear factor E2-related factor 2 (Nrf2) is the major participant in regulating antioxidants and pathways for detoxifying reactive oxygen species (ROS),...

    Authors: Akinori Nukui, Takahiro Narimatsu, Tsunehito Kambara, Hideyuki Abe, Setsu Sakamoto, Ken-Ichiro Yoshida and Takao Kamai
    Citation: BMC Cancer 2018 18:493
    Content type: Research article Published on:

  34. Breast cancer anti-estrogen resistance 1 (BCAR1/p130cas) is a hub for diverse oncogenic signaling cascades and promotes tumor development and progression.

    Authors: Asmus Heumann, Nina Heinemann, Claudia Hube-Magg, Dagmar S. Lang, Katharina Grupp, Martina Kluth, Sarah Minner, Christina Möller-Koop, Markus Graefen, Hans Heinzer, Maria Christina Tsourlakis, Waldemar Wilczak, Corinna Wittmer, Frank Jacobsen, Hartwig Huland, Ronald Simon…
    Citation: BMC Cancer 2018 18:37
    Content type: Research article Published on:

  35. Immunoglobulin lambda (Igλ) has been reported to be expressed in many normal and tumor tissues and cells. However, the function and clinical significance of tumor-derived Igλ remain unclear.

    Authors: Juping Wang, Jiangni Huang, Hao Ding, Jing Ma, Haohua Zhong, Fanlu Wang, Yupeng Chen and Hui Peng
    Citation: BMC Cancer 2023 23:929
    Content type: Research Published on:

  36. Immunosuppression is a significant factor contributing to the poor prognosis of cancer. S100P, a member of the S100 protein family, has been implicated in various cancers. However, its role in the tumor microenvi...

    Authors: Weiwei Hao, Yanyan Zhang, Jingwen Dou, Pu Cui and Jicun Zhu
    Citation: BMC Cancer 2023 23:997
    Content type: Research Published on:

  37. One-third of diffuse large B-cell lymphoma (DLBCL) patients suffer relapse after standard treatment. Eukaryotic initiation factor 3a (eIF3a) is a key player in the initial stage of translation, which has been ...

    Authors: Hongkun Sun, Juanjuan Shang, Xiao Liu, Shuai Ren, Shunfeng Hu and Xin Wang
    Citation: BMC Cancer 2024 24:432
    Content type: Research Published on:

  38. Oral mucosal melanoma (OMM) is a clinically rare disease with poor prognosis. Various treatment methods have been investigated with the aim of improving the prognosis. This study aimed to analyze the data of a...

    Authors: Xi Yang, Guo-xin Ren, Chen-ping Zhang, Guo-yu Zhou, Yong-jie Hu, Wen-jun Yang, Wei Guo, Jiang Li and Lai-ping Zhong
    Citation: BMC Cancer 2010 10:623
    Content type: Research article Published on:

  39. Circular RNAs (circRNAs) feature prominently in tumor progression. However, the biological function and molecular mechanism of circ_0003266 in colorectal cancer (CRC) require further investigation.

    Authors: Caihong Wen, Xiaoqing Feng, Honggang Yuan, Yong Gong and Guangsheng Wang
    Citation: BMC Cancer 2021 21:284
    Content type: Research article Published on:

  40. A large number of epigenetic alterations has been found to be implicated in the etiology of gastric cancer. We have studied the DNA methylation status of 27 500 gene promoter regions in 24 gastric adenocarcino...

    Authors: Lars Lohne Eftang, Jovana Klajic, Vessela N. Kristensen, Jörg Tost, Qin Ying Esbensen, Gustav Peter Blom, Ida Rashida Khan Bukholm and Geir Bukholm
    Citation: BMC Cancer 2016 16:225
    Content type: Research article Published on:

  41. Since the development of three-dimensional conformal radiotherapy and intensity-modulated radiotherapy (IMRT), no prospective study has investigated whether concurrent chemoradiotherapy (SIB-IMRT with 60 Gy) r...

    Authors: Lin-rui Gao, Xin Wang, Weiming Han, Wei Deng, Chen Li, Xiaomin Wang, Yidian Zhao, Wenjie Ni, Xiao Chang, Zongmei Zhou, Lei Deng, Wenqing Wang, Wenyang Liu, Jun Liang, Tao Zhang, Nan Bi…
    Citation: BMC Cancer 2020 20:901
    Content type: Study protocol Published on:

  42. Cyclooxygenase (COX) is the rate-limiting enzyme that catalyzes the formation of prostaglandins. The inducible isoform of COX (COX-2) is highly expressed in aggressive metastatic breast cancers and may play a ...

    Authors: Teri L Larkins, Marchele Nowell, Shailesh Singh and Gary L Sanford
    Citation: BMC Cancer 2006 6:181
    Content type: Research article Published on:

  43. The efficacy and safety of lapatinib plus capecitabine (LC or LX) versus trastuzumab plus chemotherapy in patients with HER-positive metastatic breast cancer who are resistant to trastuzumab is unknown.

    Authors: Fan Yang, Xiang Huang, Chunxiao Sun, Jianbin Li, Biyun Wang, Min Yan, Feng Jin, Haibo Wang, Jin Zhang, Peifen Fu, Tianyu Zeng, Jian Wang, Wei Li, Yongfei Li, Mengzhu Yang, Jun Li…
    Citation: BMC Cancer 2020 20:255
    Content type: Research article Published on:

  44. von Willebrand factor (vWF) is a potent regulator of angiogenesis, tumor growth, and metastasis. Yet, the expression pattern of vWF in human gastric cancer (GC) tissues and its relation to clinicopathological ...

    Authors: Xia Yang, Hai-jian Sun, Zhi-rong Li, Hao Zhang, Wei-jun Yang, Bing Ni and Yu-zhang Wu
    Citation: BMC Cancer 2015 15:80
    Content type: Research article Published on:

  46. Relapses of epithelial ovarian carcinoma (EOC) have a poor prognosis and are almost always fatal. The aim of this study was to evaluate the clinical outcome and toxicity of intraoperative electron beam radiati...

    Authors: Ying Gao, Zi Liu, Xi Chen, Wei Luo, Long Zhang and Juan Wang
    Citation: BMC Cancer 2011 11:439
    Content type: Research article Published on:

  47. The S100 protein family comprises 22 members whose protein sequences encompass at least one EF-hand Ca2+ binding motif. They were involved in the regulation of a number of cellular processes such as cell cycle pr...

    Authors: Ji Liu, Xue Li, Guang-Long Dong, Hong-Wei Zhang, Dong-Li Chen, Jian-Jun Du, Jian-Yong Zheng, Ji-Peng Li and Wei-Zhong Wang
    Citation: BMC Cancer 2008 8:261
    Content type: Research article Published on:

  48. [18 F]-Fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) has the ability to detect local and/or regional recurrence as well as distant metastasis. We aimed to evaluate the prog...

    Authors: Zhe Dong, Gao-Yuan Wang, Dong-Yu Dai, Guan-Jie Qin, Ling-Long Tang, Cheng Xu and Jun Ma
    Citation: BMC Cancer 2024 24:466
    Content type: Research Published on:

    The Correction to this article has been published in BMC Cancer 2024 24:528

  50. Metastatic pancreatic cancer has a median overall survival of less than 12 months, even if treated with chemotherapy. Selected patients with oligometastatic disease could benefit from multimodal treatments con...

    Authors: D. M. Filippini, E. Grassi, A. Palloni, R. Carloni, R. Casadei, C. Ricci, C. Serra, G. Ercolani, G. Brandi and M. Di Marco
    Citation: BMC Cancer 2020 20:271
    Content type: Case report Published on:

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