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  1. The present study was conducted to analyze the value of ([18F] fluoromisonidazole (FMISO) and [18F]-2-fluoro-2'-deoxyglucose (FDG) PET as well as color pixel density (CPD) and tumor perfusion (TP) assessed by col...

    Authors: Bernd Gagel, Marc Piroth, Michael Pinkawa, Patrick Reinartz, Michael Zimny, Hans J Kaiser, Sven Stanzel, Branka Asadpour, Cengiz Demirel, Kurt Hamacher, Heinz H Coenen, Thomas Scholbach, Payam Maneschi, Ercole DiMartino and Michael J Eble
    Citation: BMC Cancer 2007 7:113
    Content type: Research article Published on:

  2. The aim of the study was to determine the maximal tolerated dose (MTD) of gemcitabine every two weeks concurrent to radiotherapy, administered during an aggressive program of sequential and simultaneous radioc...

    Authors: Bernd Gagel, Marc Piroth, Michael Pinkawa, Patrick Reinartz, Thomas Krohn, Hans J Kaiser, Sven Stanzel, Christian Breuer, Branka Asadpour, Axel Schmachtenberg and Michael J Eble
    Citation: BMC Cancer 2007 7:112
    Content type: Research article Published on:

  3. Stat3 has been classified as a proto-oncogene and constitutive Stat3 signaling appears to be involved in oncogenesis of human cancers. However, whether constitutive Stat3 signaling plays a role in the survival a...

    Authors: Chun-Liang Chen, Abbey Loy, Ling Cen, Christina Chan, Fu-Chuan Hsieh, Gong Cheng, Bryant Wu, Stephen J Qualman, Keita Kunisada, Keiko Yamauchi-Takihara and Jiayuh Lin
    Citation: BMC Cancer 2007 7:111
    Content type: Research article Published on:

  4. Setting priorities for the funding of new anti-cancer agents is becoming increasingly complex. The funding of adjuvant trastuzumab for breast cancer has brought this dilemma to the fore. In this paper we revie...

    Authors: Christopher M Booth, George Dranitsaris, M Corona Gainford, Scott Berry, Michael Fralick, John Fralick, Joanna Sue and Mark Clemons
    Citation: BMC Cancer 2007 7:110
    Content type: Research article Published on:

  5. Melanoma is the major cause of skin cancer deaths and melanoma incidence doubles every 10 to 20 years. However, little is known about melanoma pathway aberrations. Here we applied the robust Gene Identificatio...

    Authors: Kuo Ping Chiu, Pramila Ariyaratne, Han Xu, Adrian Tan, Patrick Ng, Edison Tak-Bun Liu, Yijun Ruan, Chia-Lin Wei and Wing-Kin Ken Sung
    Citation: BMC Cancer 2007 7:109
    Content type: Research article Published on:

  6. TRAIL plays an important role in host immunosurveillance against tumor progression, as it induces apoptosis of tumor cells but not normal cells, and thus has great therapeutic potential for cancer treatment. T...

    Authors: Nadarajah Vigneswaran, Darryl C Baucum, Jean Wu, Yahuan Lou, Jerry Bouquot, Susan Muller and Wolfgang Zacharias
    Citation: BMC Cancer 2007 7:108
    Content type: Research article Published on:

  7. Endostatin is a potent endogenous anti-angiogenic agent which inhibits tumour growth. A non-synonymous coding polymorphism in the Endostatin gene is thought to affect Endostatin activity. We aimed to determine...

    Authors: Sabapathy P Balasubramanian, Simon S Cross, Jenny Globe, Angela Cox, Nicola J Brown and Malcolm W Reed
    Citation: BMC Cancer 2007 7:107
    Content type: Research article Published on:

  8. To assess progression-free survival (PFS) as the appropriate end-point for phase II trials for anaplastic gliomas (AGs) and to determine the impact of PFS on survival-based phase III trials.

    Authors: Victor A Levin, Sandra Ictech and Kenneth R Hess
    Citation: BMC Cancer 2007 7:106
    Content type: Research article Published on:

  9. Lymphangiomas are neoplasias of childhood. Their etiology is unknown and a causal therapy does not exist. The recent discovery of highly specific markers for lymphatic endothelial cells (LECs) has permitted th...

    Authors: Susanne Norgall, Maria Papoutsi, Jochen Rössler, Lothar Schweigerer, Jörg Wilting and Herbert A Weich
    Citation: BMC Cancer 2007 7:105
    Content type: Research article Published on:

  10. Intraperitoneal tumor cell attachment after resection of gastrointestinal cancer may lead to a developing of peritoneal carcinosis. Intraabdominal application of phospholipids shows a significant decrease of a...

    Authors: Jens Otto, Petra Lynen Jansen, Stefan Lucas, Volker Schumpelick and Marc Jansen
    Citation: BMC Cancer 2007 7:104
    Content type: Research article Published on:

  12. Quality of life (QOL) issues are of interest in cancer because effective methods of treatment and detection have led to an increase in the number of long-term survivors. The objectives of the study were: to as...

    Authors: Abdel W Awadalla, Jude U Ohaeri, Abdullah Gholoum, Ahmed OA Khalid, Hussein MA Hamad and Anila Jacob
    Citation: BMC Cancer 2007 7:102
    Content type: Research article Published on:

  13. In Taiwan, a distinct ethnic group variation in incidence and mortality rates has been suggested for most carcinomas. Our aim is to identify the role of prognostic factors associated with the survival of oral ...

    Authors: Ping-Ho Chen, Tien-Yu Shieh, Pei-Shan Ho, Chi-Cheng Tsai, Yi-Hsin Yang, Ying-Chu Lin, Min-Shan Ko, Pei-Chien Tsai, Shang-Lun Chiang, Hung-Pin Tu and Ying-Chin Ko
    Citation: BMC Cancer 2007 7:101
    Content type: Research article Published on:

  14. The planned nationwide implementation of mammography screening 2007 in Germany will increase the occurrence of mammographically detected breast abnormalities. These abnormalities are normally evaluated by mini...

    Authors: Alexander Kluttig, Pietro Trocchi, Anke Heinig, Hans-Juergen Holzhausen, Christiane Taege, Steffen Hauptmann, Werner Boecker, Thomas Decker, Thomas Loening, Andrea Schmidt-Pokrzywniak, Christoph Thomssen, Tilmann Lantzsch, Joerg Buchmann and Andreas Stang
    Citation: BMC Cancer 2007 7:100
    Content type: Study protocol Published on:

  15. cMyc and p27 are key genes implicated in carcinogenesis. Whether polymorphisms in these genes affect breast cancer risk or prognosis is still unclear. In this study, we focus on a rare non-synonymous polymorph...

    Authors: Jane C Figueiredo, Julia A Knight, Stewart Cho, Sevtap Savas, U Venus Onay, Laurent Briollais, Pamela J Goodwin, John R McLaughlin, Irene L Andrulis and Hilmi Ozcelik
    Citation: BMC Cancer 2007 7:99
    Content type: Research article Published on:

  16. Recent studies have demonstrated the effectiveness of cisplatin-based combinations in patients with advanced transitional cell carcinoma(TCC) of the urothelium. Concern over cisplatin toxicity instigated a sea...

    Authors: Nong Xu, Xiao Chen Zhang, Jian Ping Xiong, Wei Jia Fang, Lan Fang Yu, Jiong Qian and Ling Zhang
    Citation: BMC Cancer 2007 7:98
    Content type: Research article Published on:

  17. The incidence of oesophageal adenocarcinoma is increasing rapidly in the developed world. The serine-threonine protein kinase and proto-oncogene Akt has been reported to regulate proliferation and apoptosis in...

    Authors: Ian LP Beales, Olorunseun Ogunwobi, Ewen Cameron, Khalid El-Amin, Gabriel Mutungi and Mark Wilkinson
    Citation: BMC Cancer 2007 7:97
    Content type: Research article Published on:

  18. We studied the RNA expression of the genes in response to glucose from 5 mM (condition of normoglycemia) to 20 mM (condition of hyperglycemia/diabetes) by microarray analysis in breast cancer derived cell line...

    Authors: Francesco Turturro, Ellen Friday and Tomas Welbourne
    Citation: BMC Cancer 2007 7:96
    Content type: Research article Published on:

  19. Adenoid cystic carcinoma is a high malignant carcinoma characterized by intensive local invasion and high incidence of distant metastasis. Although many reports have demonstrated that angiogenesis has played a...

    Authors: Jiali Zhang and Bin Peng
    Citation: BMC Cancer 2007 7:95
    Content type: Research article Published on:

  20. The RECIST guidelines are commonly used in phase II and III clinical trials. The correct definition of response can be controversial in some situations, as in the case we describe.

    Authors: Vito Amoroso, Frida Pittiani, Salvatore Grisanti, Francesca Valcamonico, Edda Simoncini, Vittorio D Ferrari and Giovanni Marini
    Citation: BMC Cancer 2007 7:94
    Content type: Case report Published on:

  21. Pregnancy is infrequently complicated by the diagnosis of a concurrent breast cancer. This presents a particularly complicated clinical problem. The treatment of breast cancer in young women involves a number ...

    Authors: Michael J Naughton and Matthew Ellis
    Citation: BMC Cancer 2007 7:93
    Content type: Commentary Published on:

  23. To evaluate the efficacy and the toxicity of front line FOLFOX4 combined with bevacizumab in patients with metastatsic CRC (mCRC).

    Authors: Christos Emmanouilides, Georgia Sfakiotaki, Nikolaos Androulakis, Kostas Kalbakis, Charalambos Christophylakis, Antonia Kalykaki, Lambros Vamvakas, Athanasios Kotsakis, Sofia Agelaki, Eleni Diamandidou, Nikolaos Touroutoglou, Adam Chatzidakis, Vassilis Georgoulias, Dimitris Mavroudis and John Souglakos
    Citation: BMC Cancer 2007 7:91
    Content type: Research article Published on:

  24. The development of effective chemopreventive agents against cigarette smoke-induced lung cancer could be greatly facilitated by suitable laboratory animal models, such as animals treated with the tobacco-speci...

    Authors: Bo Ye, Yu-Xia Zhang, Fei Yang, Hong-Lei Chen, Dong Xia, Ming-Qiu Liu and Bai-Tang Lai
    Citation: BMC Cancer 2007 7:90
    Content type: Research article Published on:

  25. Neuroblastoma patients show heterogeneous clinical courses ranging from life-threatening progression to spontaneous regression. Recently, gene expression profiles of neuroblastoma tumours were associated with ...

    Authors: Patrick Warnat, André Oberthuer, Matthias Fischer, Frank Westermann, Roland Eils and Benedikt Brors
    Citation: BMC Cancer 2007 7:89
    Content type: Research article Published on:

  26. B7 Costimulatory signal is essential to trigger T-cell activation upon the recognition of tumor antigens. This study examined the expression of B7-1 (CD80) and B7-2 (CD86) costimulatory molecules along with HL...

    Authors: Cheng-Shyong Chang, Julia H Chang, Nicholas C Hsu, Hsuan-Yu Lin and Chih-Yuan Chung
    Citation: BMC Cancer 2007 7:88
    Content type: Research article Published on:

  27. The novel cytokine, interleukin (IL)-18, is a strong interferon-γ inducer and costimulatory factor in Th1 cell activation. IL-18 triggers IFN-γ production and enhances cytolytic activity in both T and NK cells...

    Authors: Chi-Young Chang, Jienny Lee, Eun-Young Kim, Hae-Jung Park, Choon-Hyuck Kwon, Jae-Won Joh and Sung-Joo Kim
    Citation: BMC Cancer 2007 7:87
    Content type: Research article Published on:

  28. Colorectal cancer (CRC) is the second most frequent tumor in developed countries. Since survival from CRC depends mostly on disease stage at the time of diagnosis, individuals with symptoms or signs suspicious...

    Authors: Magdalena Esteva, Maria Ramos, Elena Cabeza, Joan Llobera, Amador Ruiz, Salvador Pita, Josep M Segura, Jose M Cortés and Luis González-Lujan
    Citation: BMC Cancer 2007 7:86
    Content type: Study protocol Published on:

  29. The breast cancer susceptibility gene, BRCA1, is implicated in multiple cellular processes including DNA repair, the transactivation of genes, and the ubiquitination of proteins; however its precise functions rem...

    Authors: Sherry L Winter, Lucine Bosnoyan-Collins, Dushanthi Pinnaduwage and Irene L Andrulis
    Citation: BMC Cancer 2007 7:85
    Content type: Research article Published on:

  30. Chronic inflammation is well known to be a risk factor for colon cancer. Previously we established a novel mouse model of inflammation-related colon carcinogenesis, which is useful to examine the involvement o...

    Authors: Rikako Suzuki, Shingo Miyamoto, Yumiko Yasui, Shigeyuki Sugie and Takuji Tanaka
    Citation: BMC Cancer 2007 7:84
    Content type: Research article Published on:

  31. Inactivating and truncating mutations of the nuclear BRCA1-interacting protein 1 (BRIP1) have been shown to be the major cause of Fanconi anaemia and, due to subsequent alterations of BRCA1 function, predispos...

    Authors: Bernd Frank, Kari Hemminki, Alfons Meindl, Barbara Wappenschmidt, Christian Sutter, Marion Kiechle, Peter Bugert, Rita K Schmutzler, Claus R Bartram and Barbara Burwinkel
    Citation: BMC Cancer 2007 7:83
    Content type: Research article Published on:

  33. The nucleotide excision repair (NER) protein, xeroderma pigmentosum C (XPC), participates in recognizing DNA lesions and initiating DNA repair in response to DNA damage. Because mutations in XPC cause a high risk...

    Authors: Yun Bai, Liang Xu, Xiaobo Yang, Zhibin Hu, Jing Yuan, Feng Wang, Minhua Shao, Wentao Yuan, Ji Qian, Hongxia Ma, Ying Wang, Hongliang Liu, Weihong Chen, Lin Yang, Guangfu Jing, Xiang Huo…
    Citation: BMC Cancer 2007 7:81
    Content type: Research article Published on:

  34. A low incidence of breast cancer in the Mediterranean basin suggests that a high consumption of Extra Virgin Olive Oil (EVOO) might confer this benefit. While the anti-HER2 oncogene effects of the main ω-9 fat...

    Authors: Javier A Menendez, Alejandro Vazquez-Martin, Ramon Colomer, Joan Brunet, Alegria Carrasco-Pancorbo, Rocio Garcia-Villalba, Alberto Fernandez-Gutierrez and Antonio Segura-Carretero
    Citation: BMC Cancer 2007 7:80
    Content type: Research article Published on:

  36. Spain has one of the lowest rates of breast cancer in Europe, though estimated incidence has risen substantially in recent decades. Some years ago, the Spanish Cancer Mortality Atlas showed Spain as having a h...

    Authors: Marina Pollán, Rebeca Ramis, Nuria Aragonés, Beatriz Pérez-Gómez, Diana Gómez, Virginia Lope, Javier García-Pérez, Jose Miguel Carrasco, Maria José García-Mendizábal and Gonzalo López-Abente
    Citation: BMC Cancer 2007 7:78
    Content type: Research article Published on:

  37. Adjuvant chemotherapy has been proven to be beneficial for patients with early stage non-small cell lung cancer. However, toxicity and insufficient dose delivery have been critical issues with the chemotherapy...

    Authors: Michael Kreuter, Johan Vansteenkiste, Frank Griesinger, Hans Hoffmann, Hendrik Dienemann, Paul De Leyn and Michael Thomas
    Citation: BMC Cancer 2007 7:77
    Content type: Study protocol Published on:

  38. Most studies have found no increased risk of colon cancer associated with hormone replacement therapy (HRT), or even a decreased risk. But information about the effects of different HRT preparations is lacking.

    Authors: Jürgen C Dinger, Lothar AJ Heinemann, Sabine Möhner, Do Minh Thai and Anita Assmann
    Citation: BMC Cancer 2007 7:76
    Content type: Research article Published on:

  39. Current research evidence indicates that women should return to normal use of their arm after breast cancer surgery. However, it appears some women continue to hold the view that they are supposed to protect t...

    Authors: Teresa S Lee, Sharon L Kilbreath, Gerard Sullivan, Kathryn M Refshauge and Jane M Beith
    Citation: BMC Cancer 2007 7:75
    Content type: Study protocol Published on:

  40. Epidemiological studies indicate that some characteristics of lung cancer among never-smokers significantly differ from those of smokers. Aberrant promoter methylation and mutations in some oncogenes and tumor...

    Authors: Yang Liu, Weimin Gao, Jill M Siegfried, Joel L Weissfeld, James D Luketich and Phouthone Keohavong
    Citation: BMC Cancer 2007 7:74
    Content type: Research article Published on:

  41. Breast cancer is a complex and heterogeneous disease at the molecular level. Evolution is difficult to predict according to classical histoclinical prognostic factors. Different studies highlight the importanc...

    Authors: Stéphanie Fabre-Lafay, Florence Monville, Sarah Garrido-Urbani, Carole Berruyer-Pouyet, Christophe Ginestier, Nicolas Reymond, Pascal Finetti, Richard Sauvan, José Adélaïde, Jeannine Geneix, Eric Lecocq, Cornel Popovici, Patrice Dubreuil, Patrice Viens, Anthony Gonçalves, Emmanuelle Charafe-Jauffret…
    Citation: BMC Cancer 2007 7:73
    Content type: Research article Published on:

  42. The CpG island methylator phenotype (CIMP) with widespread promoter methylation is a distinct epigenetic phenotype in colorectal cancer, associated with microsatellite instability-high (MSI-high) and BRAF mutatio...

    Authors: Shuji Ogino, Takako Kawasaki, Gregory J Kirkner, Mutsuko Ohnishi and Charles S Fuchs
    Citation: BMC Cancer 2007 7:72
    Content type: Research article Published on:

  43. Waiting times for cancer patients are a national priority in the UK. Previous studies have shown variation between cancer networks in the time between diagnosis and start of radiotherapy for all cancer patient...

    Authors: Ruth H Jack, Elizabeth A Davies, David Robinson, Richard Sainsbury and Henrik Møller
    Citation: BMC Cancer 2007 7:71
    Content type: Research article Published on:

  44. The intensity of the inflammation induced by Helicobacter pylori colonization is associated with the development of distal gastric cancer (GC). The host response to H. pylori has been related to genetic polymorph...

    Authors: Elvira Garza-Gonzalez, Francisco J Bosques-Padilla, Sandra I Mendoza-Ibarra, Juan P Flores-Gutierrez, Hector J Maldonado-Garza and Guillermo I Perez-Perez
    Citation: BMC Cancer 2007 7:70
    Content type: Research article Published on:

  45. The high complication rates of surgically implanted port catheter systems (SIPCS) represents a major drawback in the treatment of isolated liver neoplasms by hepatic arterial infusion (HAI) of chemotherapy. In...

    Authors: Bert Hildebrandt, Maciej Pech, Annett Nicolaou, Jan M Langrehr, Jacek Kurcz, Birgit Bartels, Alexandra Miersch, Roland Felix, Peter Neuhaus, Hanno Riess, Bernd Dörken and Jens Ricke
    Citation: BMC Cancer 2007 7:69
    Content type: Research article Published on:

  46. In 1996, Mexico started to register cases of childhood cancer. Here, we describe the incidence of cancer in children, residing in ten Mexican jurisdictions, who were treated by the Instituto Mexicano del Segur...

    Authors: Arturo Fajardo-Gutiérrez, Servando Juárez-Ocaña, Guadalupe González-Miranda, Virginia Palma-Padilla, Rogelio Carreón-Cruz, Manuel Carlos Ortega-Alvárez and Juan Manuel Mejía-Arangure
    Citation: BMC Cancer 2007 7:68
    Content type: Research article Published on:

  48. CYYR1 is a recently identified gene located on human chromosome 21 whose product has no similarity to any known protein and is of unknown function. Analysis of expressed sequence tags (ESTs) have revealed high h...

    Authors: Lorenza Vitale, Flavia Frabetti, Shane A Huntsman, Silvia Canaider, Raffaella Casadei, Luca Lenzi, Federica Facchin, Paolo Carinci, Maria Zannotti, Domenico Coppola and Pierluigi Strippoli
    Citation: BMC Cancer 2007 7:66
    Content type: Research article Published on:

  49. Evaluation of the clinical efficacy and tolerance of metronomic chemotherapy as salvage therapy in a young patient with advanced, platinum resistant, ovarian carcinoma and bad performance status.

    Authors: Riccardo Samaritani, Giacomo Corrado, Enrico Vizza and Carlo Sbiroli
    Citation: BMC Cancer 2007 7:65
    Content type: Case report Published on:

  50. Bcl-2 is positively regulated by hormonal receptor pathways in breast cancer. A study was conducted to assess the prognostic significances of clinico-pathologic variables and of ER, PR, p53, c-erbB2, bcl-2, or...

    Authors: Kyung-Hun Lee, Seock-Ah Im, Do-Youn Oh, Se-Hoon Lee, Eui Kyu Chie, Wonshik Han, Dong-Wan Kim, Tae-You Kim, In Ae Park, Dong-Young Noh, Dae Seog Heo, Sung Whan Ha and Yung-Jue Bang
    Citation: BMC Cancer 2007 7:63
    Content type: Research article Published on:

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