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  1. Hypoxia-inducible factor-1 (HIF-1) overexpression has been linked to tumor progression and poor prognosis. We investigated whether targeting of HIF-1 using chetomin, a disrupter of the interaction of HIF-1 wit...

    Authors: Adrian Staab, Jürgen Loeffler, Harun M Said, Désirée Diehlmann, Astrid Katzer, Melanie Beyer, Markus Fleischer, Franz Schwab, Kurt Baier, Hermann Einsele, Michael Flentje and Dirk Vordermark
    Citation: BMC Cancer 2007 7:213
    Content type: Research article Published on:

  2. Genetic instability is a hallmark of tumours and preneoplastic lesions. The predominant form of genome instability in human cancer is chromosome instability (CIN). CIN is characterized by chromosomal aberratio...

    Authors: Laura Lentini, Angela Amato, Tiziana Schillaci and Aldo Di Leonardo
    Citation: BMC Cancer 2007 7:212
    Content type: Research article Published on:

  3. Bone morphogenetic protein-6 (BMP-6) is critically involved in many developmental processes. Recent studies indicate that BMP-6 is closely related to tumor differentiation and metastasis.

    Authors: Shuang Yang, Jun Du, Zhaoqi Wang, Wei Yuan, Yuhuan Qiao, Ming Zhang, Jie Zhang, Songyuan Gao, Jian Yin, Baocun Sun and Tianhui Zhu
    Citation: BMC Cancer 2007 7:211
    Content type: Research article Published on:

  4. Hodgkin's lymphoma survivors (HLSs) commonly report chronic fatigue, defined as high levels of fatigue for 6 months or more. Underlying mechanisms are poorly understood. Based upon knowledge from other populat...

    Authors: Line M Oldervoll, Jon H Loge, Stein Kaasa, Stian Lydersen, Marianne J Hjermstad, Lene Thorsen, Harald Holte Jr, Anne B Jacobsen and Sophie D Fosså
    Citation: BMC Cancer 2007 7:210
    Content type: Research article Published on:

  5. Smad4 is a tumour suppressor frequently inactivated in pancreatic and colorectal cancers. We have recently reported loss of Smad4 in every fourth carcinoma of the uterine cervix. Smad4 transmits signals from t...

    Authors: Susanne Klein-Scory, Marc Zapatka, Christina Eilert-Micus, Sabine Hoppe, Elisabeth Schwarz, Wolff Schmiegel, Stephan A Hahn and Irmgard Schwarte-Waldhoff
    Citation: BMC Cancer 2007 7:209
    Content type: Research article Published on:

  6. Hepatocellular carcinoma (HCC) is the most invasive and frequently diagnosed malignancy and the second leading cause of cancer death in many regions of Asia. The PI3K/Akt/mTOR signal pathway is involved in mul...

    Authors: Xinxin Bu, Fengqi Jia, Weifeng Wang, Xianling Guo, Mengchao Wu and Lixin Wei
    Citation: BMC Cancer 2007 7:208
    Content type: Research article Published on:

  7. The objective of this study was to gain insight into the molecular mechanism of induced cell death (apoptosis) by PYRROLO [1,2-b][1,2,5]BENZOTHIADIAZEPINES (PBTDs) series compounds, using human (K562) cells as a ...

    Authors: Gabriella Marfe, Carla Di Stefano, Romano Silvestri, Elisabetta Abruzzese, Gianfranco Catalano, Livia Di Renzo, Giuseppe Filomeni, Ezio Giorda, Giuseppe La Regina, Emanuela Morgante, Maria Rosa Ciriolo, Matteo Antonio Russo, Sergio Amadori and Paola Sinibaldi-Salimei
    Citation: BMC Cancer 2007 7:207
    Content type: Research article Published on:

  8. The distribution and the potential gene-gene and gene-environment interaction of selected metabolic genetic polymorphisms was investigated in relation to gastric cancer risk in an Italian population.

    Authors: Stefania Boccia, Fakhredin A Sayed-Tabatabaei, Roberto Persiani, Francesco Gianfagna, Stefano Rausei, Dario Arzani, Antonio La Greca, Domenico D'Ugo, Giuseppe La Torre, Cornelia M van Duijn and Gualtiero Ricciardi
    Citation: BMC Cancer 2007 7:206
    Content type: Research article Published on:

  9. The aim of the present work was to explore signal transduction pathways used in the regulation of S100A7 (psoriasin). Members of the S100 gene family participate in many important cellular functions. Psoriasin...

    Authors: Stina Petersson, Anna Bylander, Maria Yhr and Charlotta Enerbäck
    Citation: BMC Cancer 2007 7:205
    Content type: Research article Published on:

  10. Despite being a mainstay for treating superficial bladder carcinoma and a promising agent for interstitial cystitis, the precise mechanism of Bacillus Calmette-Guerin (BCG) remains poorly understood. It is par...

    Authors: Marcia R Saban, Helen L Hellmich, Cindy Simpson, Carole A Davis, Mark L Lang, Michael A Ihnat, Michael A O'Donnell, Xue-Ru Wu and Ricardo Saban
    Citation: BMC Cancer 2007 7:204
    Content type: Research article Published on:

  11. Prognostic factors in locally advanced breast cancer treated with neoadjuvant chemotherapy differ from those of early breast cancer. The purpose of this study was to identify the clinical significance of poten...

    Authors: Bhumsuk Keam, Seock-Ah Im, Hee-Jun Kim, Do-Youn Oh, Jee Hyun Kim, Se-Hoon Lee, Eui Kyu Chie, Wonshik Han, Dong-Wan Kim, Woo Kyung Moon, Tae-You Kim, In Ae Park, Dong-Young Noh, Dae Seog Heo, Sung Whan Ha and Yung-Jue Bang
    Citation: BMC Cancer 2007 7:203
    Content type: Research article Published on:

  12. Neurotrophins are growth factors that regulate cell growth, differentiation and apoptosis in the nervous system. Their diverse actions are mediated through two different transmembrane – receptor signaling syst...

    Authors: Martha Assimakopoulou, Maria Kondyli, George Gatzounis, Theodore Maraziotis and John Varakis
    Citation: BMC Cancer 2007 7:202
    Content type: Research article Published on:

  13. Breast cancer is the most commonly diagnosed cancer among the rapidly growing population of Asian Americans; it is also the most common cause of cancer mortality among Filipinas. Asian women continue to have l...

    Authors: Scarlett Lin Gomez, Susanna Tan, Theresa HM Keegan and Christina A Clarke
    Citation: BMC Cancer 2007 7:201
    Content type: Research article Published on:

  14. The 5-year survival rate in patients with gastric cancer is still poor, and lymph node metastasis is considered one of the most important prognostic factors. However, there are controversies in the classificat...

    Authors: Caigang Liu, Ping Lu, Yang Lu, Huimian Xu, Shubao Wang and Junqing Chen
    Citation: BMC Cancer 2007 7:200
    Content type: Research article Published on:

  15. Polymorphisms in Epidermal Growth Factor Receptor (EGFR) gene may influence EGFR production and/or activity, thereby modulating susceptibility to lung cancer. To test this hypothesis, we investigated the associat...

    Authors: Jin Eun Choi, Sun Ha Park, Kyung Mee Kim, Won Kee Lee, Sin Kam, Sung Ick Cha, Chang Ho Kim, Young Mo Kang, Young-Chul Kim, Sung Beom Han, Tae Hoon Jung and Jae Yong Park
    Citation: BMC Cancer 2007 7:199
    Content type: Research article Published on:

  16. LIM and SH3 protein 1 (LASP-1), initially identified from human breast cancer, is a specific focal adhesion protein involved in cell proliferation and migration, which was reported to be overexpressed in 8–12 ...

    Authors: Thomas GP Grunewald, Ulrike Kammerer, Michaela Kapp, Matthias Eck, Johannes Dietl, Elke Butt and Arnd Honig
    Citation: BMC Cancer 2007 7:198
    Content type: Research article Published on:

  17. Previous pharmacokinetic studies with docetaxel have mostly used 3-weekly (75 mg/m2 and 100 mg/m2) or weekly regimens (35–40 mg/m2). The pharmacokinetics and radiosensitizing efficacy of weekly 20 mg/m2 docetaxel...

    Authors: Paal Fr Brunsvig, Anders Andersen, Steinar Aamdal, Vessela Kristensen and Harald Olsen
    Citation: BMC Cancer 2007 7:197
    Content type: Research article Published on:

  18. Despite the fact that morphological and physiological observations suggest that the tight junction (TJ)-based permeability barrier is modified/disrupted in tumorigenesis, the role of members of the Claudin (Cl...

    Authors: Azadeh Arabzadeh, Tammy-Claire Troy and Kursad Turksen
    Citation: BMC Cancer 2007 7:196
    Content type: Research article Published on:

  19. The telomeric region of mouse chromosome 12 has previously shown frequent allelic loss in murine lymphoma. The Bcl11b gene has been identified and suggested as a candidate tumor suppressor gene within this region...

    Authors: Anneli Karlsson, Amanda Nordigården, Jan-Ingvar Jönsson and Peter Söderkvist
    Citation: BMC Cancer 2007 7:195
    Content type: Research article Published on:

  20. Nasopharyngeal carcinoma is endemic in Southern China, displays a strong relationship with genetic susceptibility and associates with Epstein-Barr virus infection. Toll-like receptor 3 (TLR3) plays an importan...

    Authors: Jun-Fang He, Wei-Hua Jia, Qin Fan, Xin-Xi Zhou, Hai-De Qin, Yin Yao Shugart and Yi-Xin Zeng
    Citation: BMC Cancer 2007 7:194
    Content type: Research article Published on:

  21. Colorectal cancer, if detected early, has greater than 90% 5-year survival. However, survival has been shown to vary across racial/ethnic groups in the United States, despite the availability of early detectio...

    Authors: Scarlett Lin Gomez, Cynthia D O'Malley, Antoinette Stroup, Sarah J Shema and William A Satariano
    Citation: BMC Cancer 2007 7:193
    Content type: Research article Published on:

  22. It has recently been shown that NDRG2 mRNA is down-regulated or undetectable in several human cancers and cancer cell-lines. Although the function of NDRG2 is unknown, high NDRG2 expression correlates with improv...

    Authors: Anders Lorentzen, Lotte K Vogel, Rikke H Lewinsky, Mona Sæbø, Camilla F Skjelbred, Sine Godiksen, Geir Hoff, Kjell M Tveit, Inger Marie Bowitz Lothe, Tone Ikdahl, Elin H Kure and Cathy Mitchelmore
    Citation: BMC Cancer 2007 7:192
    Content type: Research article Published on:

  24. A verifiable consequence of the mutator hypothesis is that even low grade neoplasms would accumulate a large number of mutations that do not influence the tumor phenotype (clonal mutations). In this study, we ...

    Authors: Anjan Misra, Parthaprasad Chattopadhyay, Kunzang Chosdol, Chitra Sarkar, Ashok K Mahapatra and Subrata Sinha
    Citation: BMC Cancer 2007 7:190
    Content type: Research article Published on:

  27. Matrix metalloproteinase (MMP) is known to be involved in the initial and progressive stages of cancer development, and in the aggressive phenotypes of cancer. This study examines the association of single nucleo...

    Authors: Rishiho Nishizawa, Masaki Nagata, Arhab A Noman, Nobutaka Kitamura, Hajime Fujita, Hideyuki Hoshina, Takehiko Kubota, Manami Itagaki, Susumu Shingaki, Makoto Ohnishi, Hiroshi Kurita, Kouji Katsura, Chikara Saito, Hiromasa Yoshie and Ritsuo Takagi
    Citation: BMC Cancer 2007 7:187
    Content type: Research article Published on:

  28. A set of consistent, standardized definitions of intervals and populations on which to report across provinces is needed to inform the Provincial/Territorial Deputy Ministries of Health on progress of the Ten-...

    Authors: Marcy Winget, Donna Turner, Jon Tonita, Charlotte King, Zoann Nugent, Riaz Alvi and Richard Barss
    Citation: BMC Cancer 2007 7:186
    Content type: Research article Published on:

  29. Lymphomatous meningitis (LM) represents a severe complication of malignant lymphomas. While clinical suspicion is raised by symptoms ranging from mild disturbances of sensation to severe pain or impaired consc...

    Authors: B Hildebrandt, C Müller, A Pezzutto, PT Daniel, B Dörken and C Scholz
    Citation: BMC Cancer 2007 7:185
    Content type: Research article Published on:

  30. Despite significant advancement in breast cancer therapy, there is a great need for a better understanding of the mechanisms involved in breast carcinogenesis and progression, as well as of the role of epigene...

    Authors: Esteban N Gurzov, Sanaa M Nabha, Hamilto Yamamoto, Hong Meng, O Graciela Scharovsky and R Daniel Bonfil
    Citation: BMC Cancer 2007 7:184
    Content type: Research article Published on:

  31. Dietary isothiocyanates (ITCs) are electrophilic compounds that have diverse biological activities including induction of apoptosis and effects on cell cycle. They protect against experimental carcinogenesis i...

    Authors: Janet V Cross, Frank W Foss, Joshua M Rady, Timothy L Macdonald and Dennis J Templeton
    Citation: BMC Cancer 2007 7:183
    Content type: Research article Published on:

  32. Published prognostic gene signatures in breast cancer have few genes in common. Here we provide a rationale for this observation by studying the prognostic power and the underlying biological pathways of diffe...

    Authors: Jack X Yu, Anieta M Sieuwerts, Yi Zhang, John WM Martens, Marcel Smid, Jan GM Klijn, Yixin Wang and John A Foekens
    Citation: BMC Cancer 2007 7:182
    Content type: Research article Published on:

  33. The sex hormone estrogen (E2) is pivotal to normal mammary gland growth and differentiation and in breast carcinogenesis. In this in silico study, we examined metabolic differences between ER(+)ve breast cancer c...

    Authors: Soma Mandal and James R Davie
    Citation: BMC Cancer 2007 7:181
    Content type: Research article Published on:

  35. Feline mammary carcinoma has been proposed as a natural model of highly aggressive, hormone-independent human breast cancer. To further explore the utility of the model by adding new similarities between the t...

    Authors: Javier Ordás, Yolanda Millán, Rafaela Dios, Carlos Reymundo and Juana Martín de las Mulas
    Citation: BMC Cancer 2007 7:179
    Content type: Research article Published on:

  36. For patients suffering of recurrent breast cancer within the irradiated breast, generally mastectomy is recommended. The normal tissue tolerance does not permit a second full-dose course of radiotherapy to the...

    Authors: Uta Kraus-Tiefenbacher, Lelia Bauer, Antonella Scheda, Carola Schoeber, Joerg Schaefer, Volker Steil and Frederik Wenz
    Citation: BMC Cancer 2007 7:178
    Content type: Research article Published on:

  37. The present study evaluates the outcome of 19 children with rhabdomyosarcoma of the head-and-neck region treated with Intensity Modulated Radiotherapy (IMRT) or Fractionated Stereotactic Radiotherapy (FSRT) be...

    Authors: Stephanie E Combs, Wolfgang Behnisch, Andreas E Kulozik, Peter E Huber, Jürgen Debus and Daniela Schulz-Ertner
    Citation: BMC Cancer 2007 7:177
    Content type: Research article Published on:

  38. Interleukin-8 (IL-8) is a cytokine that plays an important role in tumor progression in a variety of cancer types; however, its regulation is not well understood in oral cancer cells. In the present study, we ...

    Authors: Hwa-Jeong Lee, Jun Lee, Sun-Kyung Lee, Suk-Keun Lee and Eun-Cheol Kim
    Citation: BMC Cancer 2007 7:176
    Content type: Research article Published on:

  40. Previously, 50% of patients with breast ductal carcinoma in situ (DCIS) had more than one nuclear grade, and neither worst nor predominant nuclear grade was significantly associated with development of invasive c...

    Authors: Judith-Anne W Chapman, Naomi A Miller, H Lavina A Lickley, Jin Qian, William A Christens-Barry, Yuejiao Fu, Yan Yuan and David E Axelrod
    Citation: BMC Cancer 2007 7:174
    Content type: Research article Published on:

  41. The host immunogenetic background plays an important role in the development of breast cancer. Cytotoxic T-lymphocyte antigen-4 (CTLA-4) is a molecule expressed predominantly on activated T cells and is import...

    Authors: Lihong Wang, Dalin Li, Zhenkun Fu, Heng Li, Wei Jiang and Dianjun Li
    Citation: BMC Cancer 2007 7:173
    Content type: Research article Published on:

  42. The prognosis of patients with hepatocellular carcinoma (HCC) still remains very dismal, which is mainly due to metastasis. In our previous studies, we found that chromosome 8p deletions might contribute to me...

    Authors: Ke-Feng Lei, Yan-Fang Wang, Xiao-Qun Zhu, Peng-Cheng Lu, Bing-Sheng Sun, Hu-Liang Jia, Ning Ren, Qing-Hai Ye, Hui-Chuan Sun, Lu Wang, Zhao-You Tang and Lun-Xiu Qin
    Citation: BMC Cancer 2007 7:172
    Content type: Research article Published on:

  43. Contrast enhanced ultrasound (CEUS) is an imaging technique which appeared on the market around the year 2000 and proposed for the detection of liver metastases in gastrointestinal cancer patients, a setting i...

    Authors: Fabio Piscaglia, Francesco Corradi, Mikaela Mancini, Francesco Giangregorio, Stefano Tamberi, Giampaolo Ugolini, Bruno Cola, Alberto Bazzocchi, Roberto Righini, Patrizia Pini, Fabio Fornari and Luigi Bolondi
    Citation: BMC Cancer 2007 7:171
    Content type: Research article Published on:

  44. Male breast cancer (MBC) is a rare disease and little is known about its aetiology. Germ-line mutations of BRCA2 and, at lower frequency, of BRCA1 are implicated in a relatively small proportion of MBC cases. Com...

    Authors: Domenico Palli, Mario Falchetti, Giovanna Masala, Ramona Lupi, Francesco Sera, Calogero Saieva, Cristina D'Amico, Marco Ceroti, Piera Rizzolo, Maria Adelaide Caligo, Ines Zanna and Laura Ottini
    Citation: BMC Cancer 2007 7:170
    Content type: Research article Published on:

  45. The functional and clinical significance of 14-3-3 proteins in human cancers remain largely undetermined. Earlier, we have reported differential expression of 14-3-3ζ mRNA in oral squamous cell carcinoma (OSCC...

    Authors: Ajay Matta, Sudhir Bahadur, Ritu Duggal, Siddhartha D Gupta and Ranju Ralhan
    Citation: BMC Cancer 2007 7:169
    Content type: Research article Published on:

  46. p53 is commonly inactivated by mutations in the DNA-binding domain in a wide range of cancers. As mutant p53 often influences response to therapy, effective and rapid methods to scan for mutations in TP53 are lik...

    Authors: Michael Krypuy, Ahmed Ashour Ahmed, Dariush Etemadmoghadam, Sarah J Hyland, Anna deFazio, Stephen B Fox, James D Brenton, David D Bowtell and Alexander Dobrovic
    Citation: BMC Cancer 2007 7:168
    Content type: Research article Published on:

  48. Many patients suffer from severe shoulder complaints after breast cancer surgery and axillary lymph node dissection. Physiotherapy has been clinically observed to improve treatment of these patients. However, ...

    Authors: Carien HG Beurskens, Caro JT van Uden, Luc JA Strobbe, Rob AB Oostendorp and Theo Wobbes
    Citation: BMC Cancer 2007 7:166
    Content type: Research article Published on:

  49. Inflammatory cells in the tumour stroma has gained increasing interest recently. Thus, we aimed to study the frequency and prognostic impact of stromal mast cells and tumour infiltrating eosinophils in invasiv...

    Authors: Rose-Marie Amini, Kirsimari Aaltonen, Heli Nevanlinna, Ricardo Carvalho, Laura Salonen, Päivi Heikkilä and Carl Blomqvist
    Citation: BMC Cancer 2007 7:165
    Content type: Research article Published on:

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